• 대한한의학회지
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• 제31권2호
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• pp.149-157
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• 2010

Objective: The purpose of this study was to investigate the level of safety on liver functions when Korean herbal medicine was taken internally. Method: 101 inpatients who took Korean herbal medicine were enrolled and liver function test (aspartic aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, gamma glutamyltranspeptidase, albumin, lactate dehydrogenase) was performed on admission and 1 month later. Results: In 101 patients, alkaline phosphatase and gamma glutamyltranspeptidase decreased significantly compared with the value taken on admission (p<0.05) but aspartic aminotransferase, alanine aminotransferase, total bilirubin, albumin, and lactate dehydrogenase were not significantly changed (p>0.05). In the patients who took Scutellaria baicalensis (n=34), alkaline phosphatase decreased and albumin increased significantly (p<0.05). Among the patients who took Atractylodes macrocephala (n=29), alkaline phosphatase decreased significantly (p<0.05). In the patients who took Glycyrrhiza uralensis or Paeonia lactiflora, liver function parameters were not significantly changed (p>0.05). On admission 11 patients had abnormal liver function and 2 patients had liver injury while 7 patients had abnormal liver function and 2 patients showed liver injury 1 month later. Conclusions: This study suggests that prescribed Korean herbal medicine does not injure liver function.

• 동의생리병리학회지
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• 제22권6호
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• pp.1390-1396
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• 2008

The aim of this study is to analyze literatures researching changes of liver function parameters after administration of herbal medicine and the safety of herbal medicine on hepato-biliary system. Eight Korean databases were searched for researches on the safety of oriental herbal medicine. According to inclusion criteria, nineteen studies were selected and analyzed. As a result, seventy outcomes in five parameters(aspartate transaminase, alanine transaminase, gamma(${\gamma}$)-glutamyl transferase, alkaline Phosphatase, total bilirubin) were obtained. After administration, parameters decreased or sustained in fifty seven outcomes. In thirteen outcomes, parameters slightly increased. In two outcomes, parameters increased but not severely. The change of liver function parameters after administration of herbal medicine is expected to be harmless. But it requires additional large scale studies and modification in method to corroborate the safety of herbal medicine.

• Environmental Analysis Health and Toxicology
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• 제18권1호
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• pp.33-44
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• 2003

The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20∼75 years) at 4 survey sites throughout seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 $\mu\textrm{g}$/1, It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.385.2-385.2
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• 2002

Cornus officinalis has been used as protective drug for liver and kidney function. In order to evaluate the effect on renal function of Corni Fructus. We measured urine volume, chemical parameters(urea nitrogen. creatinine, uric acid). electrolytes($Na^{+}$, $K^{+}$, $Cl^{-}$) in serum and urine. Furosemide showed significant urine volume. serum and urine parameters, but Corni Fructus showed normal level parameters by dose increasing in rats.

• Advances in Traditional Medicine
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• 제7권1호
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• pp.74-78
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• 2007

The plants, Trianthema decandra and Glinus oppositifolius are commonly used by tribal people in India for the treatment of liver diseases. Hepatoprotective activity of methanol extracts of Glinus oppositifolius and Trianthema decandra at the dose of 250 and 500 mg/kg body weight administered orally was evaluated against paracetamol induced liver damage in rats. Biochemical parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, total serum protein, lipid peroxide and glutathione content of the liver were estimated to determine liver function and metabolism. From the biochemical observations, it was concluded that methanol extracts of Glinus oppositifolius and Trianthema decandra significantly restored the altered biochemical parameters towards normal condition in paracetamol induced liver damage.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권4호
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• pp.215-223
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• 2024

Purpose: Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan^®) for assessing liver fibrosis in patients with pediatric cancer. Methods: We enrolled 106 consecutive cases of acute leukemia in individuals under 21 years of age. The participants were followed for 2 years. Based on their serum ferritin (SF) levels, the patients were divided into two groups: group 1 (SF≥300 ng/mL) and group 2 (SF<300 ng/mL). A liver FibroScan^® was performed, and a p-value of less than 0.05 was considered statistically significant. Results: Among the various parameters in the liver function test (LFT), alkaline phosphatase was significantly higher in a subgroup of patients aged 5-8 years in group 2 compared to those in group 1. The indices of liver fibrosis determined by TE, including the FibroScan score, controlled attenuation parameter score, steatosis percentage, and meta-analysis of histological data in viral hepatitis score, as well as indirect serum markers of liver fibrosis such as the aminotransferase (AST)/alanine aminotransferase (ALT) ratio, Fibrosis 4 score, and AST to platelet ratio index, did not differ significantly between the two groups. The association between the TE results and LFT parameters was only significant for ALT. Conclusion: Transfusion-associated iron overload does not have a significant correlation with severe liver fibrosis. FibroScan^® is not a sensitive tool for detecting early stages of fibrosis in survivors of pediatric leukemia.

• Advances in Traditional Medicine
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• 제4권2호
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• pp.100-103
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• 2004

The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.

• Journal of Nutrition and Health
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• 제31권1호
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• pp.28-35
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• 1998

This study was done to investigate the relationship between ultrasonograph fat density (ULFD) using objective measurement and serum enzymes for testing liver function in 101 healthy adults(43 males and 58 females). Average serum enzyme activities in males and females were GOT27.111U/L and 22.46IU/L, GPT 34.06IU/L and 18.501U/L, and ${\gamma}$-GTP 37.67IU/L and 17.201U/L, respectively. Males showed significantly higher activities of GPT and ${\gamma}$-GTP than females. ULFD of the obese group (BMI$\geq$25) was significantly higher than that of the nonobese group. GOT, GPT, and ${\gamma}$-GTP tended to be high in the obese group. GPT and ${\gamma}$-GTP of the high TG group (TG$\geq$170) tended to be markedly high for males, but not for females. GPT was positively correlated with ULFD, body weight , and weight-to-height, ratio, and ${\gamma}$-GTP was positively correlated with body weight, weight-to-height ratio. BNI, and KI. ULFD and ${\gamma}$-GTP were positively correlated with serum TG. These results suggests that , among serum enzymes for testing liver function, GPT has a close relationship with ULFD using objective measurement, while GOT does not. Also , ${\gamma}$-GTP has a close relationship with parameters for obesity.

• 한국식품영양과학회지
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• 제24권5호
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• pp.713-719
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• 1995

본 연구는 3주간 $CCl_4$를 투여한 랫트를 이용하여 각 장기 및 혈액 생화학치의 변화를 조사, 과산화지질가를 감도가 좋은 형광발광 액체 크로마토그래피를 이용해 측정, 간세포를 전자현미경적으로 관찰 등의 방밥으로 간기능에 미치는 PRC의 효과를 알아보기 위하여 실시하였다. 그 결과, PRC투여군은 정상대조군에 비하여 체중은 감소하고, 상대적 간장 중량의 감소경향, GOT 및 GPT의 수치가 감소하였으며, 특히 과산화물가가 유의하게(p<0.001) 감소하였다. 이로 인한 결과를 명확히 뒷받침해 주고 있는 간세포에 대한 전자현미경적 관찰의 결과는 RPC투여의 효과를 간세포의 형태학적 관찰에서 간세포에 대한 PRC의 효과를 나타내 주었다. 이 결과는 칡 카테킨이 사염화탄소로 유도된 간장의 과산화지질의 형성을 방지해서 간기능을 회복시키는데 효과적이라는 것을 시사한다 하겠다.

• 한국식품영양과학회지
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• 제22권2호
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• pp.132-137
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• 1993

본 연구는 장기간의 에탄올을 섭취시킨 흰쥐에 있어서 최근에 개발된 CL-HPLC를 이용해 측정한 과산화물 및 혈액 생화학치의 변화를 조사하고, 또한 이들 수치에 미치는 아스코르빈산, 알파토코페롤 및 아스코르빈산 알파토코페롤 병합투여의 영향을 알아보기 위하여 실시하였다. 그 결과, 에탄올 투여군은 대조군에 비하여 체중은 감소하였으나, 상대적 간장중량, GPT의 수치가 증가하였으며, 특히 과산화물가가 유의하게(p<0.001) 증가하였다. 반면에 에탄올 투여군에 3주동안 아스코르빈산, 알파토코페롤 및 아스코르빈산.알파토코페롤 병합 투여를 한 결과, 알파토코페롤 투여군 및 아스코르빈산.알파토코페롤 병합투여군에서 상대적 간장중량, 콜레스테롤함량, GPT의 수치 및 과산화물가가 회복되었다. 이 결과는 식이중의 알파토코페롤 및 아스코르빈산.알파토코페롤 투여가 에탄올로 유도된 간장의 과산화지질의 형성을 방지해, 간기능을 회복시키는데 효과적이라는 것을 시사한다 하겠다.