• Journal of radiological science and technology
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• v.42 no.6
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• pp.413-422
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• 2019

Heavy ion particle, represented carbon ion, radiotherapy is currently most advanced radiation therapy technique. Conventional radiation therapy has made remarkable changes over a relatively short period of time and leading various developments such as intensity modulated radiation therapy, 4D radiation therapy, image guided radiation therapy, and high precisional therapy. However, the biological and physical superiority of particle radiation, represented by Bragg peak, can give the maximum dose to tumor and minimal dose to surrounding normal tissues in the treatment of cancers in various areas surrounded by radiation-sensitive normal tissues. However, despite these advantages, there are some limitations and factors to consider. First, there is not enough evidence, such as large-scale randomized, prospective phase III trials, for the clinical application. Secondly, additional studies are needed to establish a very limited number of treatment facilities, uncertainty about the demand for heavy particle treatment, parallel with convetional radiotherapy or indications. In addition, Bragg peak of the heavy particles can greatly reduce the dose to the normal tissues front and behind the tumor compared to the photon or protons. High precision and accuracy are needed for treatment planning and treatment, especially for lungs or livers with large respiratory movements. Currently, the introduction of the heavy particle therapy device is in progress, and therefore, it is expected that more research will be active.

• Toxicological Research
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• v.23 no.3
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• pp.197-205
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• 2007

Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for $TGF-{\beta}$ in human cancer progression. The complex pattern on cross-talk of $TGF-{\beta}$ and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of $TGF-{\beta}$ in cancer progression. This review summarizes some of the current understanding of $TGF-{\beta}$ signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) $TGF-{\beta}$ signaling, (2) $TGF-{\beta}$ and EMT, (3) $TGF-{\beta}$ and MMP, (4) $TGF-{\beta}$ and Ras, and (5) Role of $TGF-{\beta}$ in invasion and metastasis. Due to the bifunctional cellular effects of $TGF-{\beta}$, as a tumor promoter and a tumor suppressor, more precisely defined $TGF-{\beta}$ signaling pathways need to be elucidated. According to the current literature, $TGF-{\beta}$ is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of $TGF-{\beta}$ in invasion and metastasis will provide valuable information on establishing strategies to manipulate $TGF-{\beta}$ signaling which should be a high priority for the development of anti-metastatic therapeutics.

• Journal of Preventive Medicine and Public Health
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• v.40 no.6
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• pp.422-430
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• 2007

The socioeconomic inequalities in health have recently become an important public health concern in South Korea, and the issue has gained increasing attention from many South Korean researchers due to the increasing income inequality and Widening social polarization following its economic crisis in the late 1990s. However, despite the mounting literature on health inequalities published in recent years, the history of research on health inequality in South Korea is premature in comparison to the long histories in several Western countries. Understanding the historical background underlying the issue of health inequality research may aid in establishing and accumulating scientifically solid evidence in South Korea. It may also direct the South Korean research community to develop research agendas that are. more politically and academically appropriate for South Korean society. This paper describes the historical development of health inequality research in the West and introduces several important issues contributing to the advancement of health inequality research. Specifically, the major studies conducted before and after the UK Black Report are presented. In addition, the history and current status of health inequality research in South Korea are documented and evaluated. Finally, several research agendas for the quantitative and qualitative improvement of health inequality research in South Korea are proposed.

• Journal of Chest Surgery
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• v.14 no.2
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• pp.127-130
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• 1981

A 39-year-old male was admitted to Dept. of Thoracic Cardiovasc. Surgery, Korea University Hospital with the chief complaints of progressively enlarged mass on right upper lung which revealed on routine chest P-A since 4 Years ago. Chest PA and tomography revealed well circumscribed huge mass of 7cm. in diameter without invasion on bronchus. so, right upper lobectomy was performed under impression of lung cancer. Postoperative pathologic examination revealed pulmonary blastoma. Pulmonary blastoma is accepted as a distinctive neoplasm recently. One case of typical pulmonary blastoma is reported, and the previous literature is reviewed. There are no specific clinical or radiologic feature of pulmonary blastoma. The presentation is can be that of any other pulmonary tumor although a peripheral situation is usual and a large size is often attained before detection. Pulmonary blastoma is a mixed tumor with malignant epithelial and connective tissue components with a distinctive resemblance to fetal lung. The treatment of choice is surgical excision but the overall prognosis is poor. There is no evidence of recurrence or metastasis on follow-up study during 6 months period after right upper lobectomy.

• Advances in nano research
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• v.8 no.4
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• pp.307-322
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• 2020

In this article, free vibration of double-walled carbon nanotubes (DWNT) based on nonlocal Kelvin's model have been investigated. For this purpose, a nonlocal Kelvin's model is established to observe the small scale effect. The wave propagation is employed to frame the governing equations as eigenvalue system. The influence of nonlocal parameter subjected to different end supports has been overtly examined. The new set of inner and outer tubes radii investigated in detail against aspect ratio. The influence of boundary conditions via nonlocal parameter is shown graphically. Due to small scale effect fundamental frequency ratio decreases as length to diameter ratio increases. Small scale effect becomes negligible on all end supports for the higher values of aspect ratio. With the smaller inner tube radius double-walled CNT behaves more sensitive towards nonlocal parameter. The results generated furnish the evidence regarding applicability of nonlocal model and also verified by earlier published literature.

• Journal of Wellbeing Management and Applied Psychology
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• v.3 no.1
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• pp.21-31
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• 2020

As people's income rises dramatically, people's happiness seems not as high as expected. In fact, there are two different arguments about the relationship between income level and happiness. The focus of the debate is whether the correlation between income and probability of happiness is positive or negative. Therefore, we hypothesizes that the relationship between income and probability of happiness presents an inverted U-shaped curve. Then, this paper sets China as an example to explore the effect of income on happiness. The data from the Chinese General Social Survey (CGSS) in 2015 is employed to conduct empirical analyses under the Probit model and the Zero-Inflation-Passion model. The empirical findings indicate that the effect of income on happiness presents an inverted U-shaped curve and significantly in statistic. Meanwhile, spouse's income, educational level, marriage time and house property have a positive and significant effect on happiness. Conversely, age and local living standards have a negative and significant effect on happiness. Unfortunately, even though registered residence and children have a negative effect on happiness, they do not get through the significant test. In order to ensure the robustness of our empirical results, we test the robustness of the above empirical results by adjusting the sample size. The results of robustness test verify that our empirical results are robust. Moreover, this paper also makes a small contribution to the current literature with a sample from China.

• Journal of Korean Physical Therapy Science
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• v.27 no.2
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• pp.63-79
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• 2020

Background: A physical therapy is required to restore motor function of stroke patients, especially gait function improvement is very important to them. Design: Systemic review. Methods: The purpose of this study is to provide objective evidence for the effectiveness of the treadmill training method applied to stroke patients. The literature search for a systematic review was performed on domestic data published from 2010 to 2020 at KISS, RISS, and DBpia. Results: 40 papers meeting the inclusion/exclusion criteria were finally selected. Data analysis was performed according to the research type, intervention method and process, measurement variables, and the risk of bias assessment was conducted as quality evaluation. Conclusion: Various training methods have been suggested and proved that treadmill intervention is an effective method for improving gait and balance. As the goal of rehabilitation for stroke patients is to improve walking and balance, we expect continuous clinical research to continue to establish a more systematic training program and present a new paradigm.

• Journal of the Korean Society of Food Culture
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• v.19 no.5
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• pp.556-565
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• 2004

This study examined dietary culture in Korea regarding collectivism through literature review. Based on the evidence from the origin of lineage and traditional customs, the Koreans' traditional collectivity appeared to have been grounded upon the northen nomadic culture emphasizing sentimental collectivity and harmonized with the characteristics of southern agrarian society related to mutual support and sociability. The inseparable relationship between collectivity and food was well revealed in the occasions such as rice-planting, kimchi and jang makings in which pooled labor was common as well as the gathering of mutual aid association. In these occasions, foods were offered and shared among members. Food sharing was a main activity and almost play a central role regarding the promotion of friendly relations among each other. In sacrificial memorials, food sharing was extended not only to the live persons but also to the passing spirits. Collectivity was also disclosed in the eating or table manners of Koreans. Koreans quite literally share food at every meal since the side dishes placed centrally on the table. The taste of Korean foods is completed inside the mouth by mixing foods with various combination, which let people create their own choice of taste. Therefore, the collectivity manners at the table appeared to be harmonized with individual freedom of creating his/her own taste of foods. The collectivity is still a very important concept in modem Korean dietary culture, as reflected by an increase of restaurants sewed shared dishes.

• Journal of Information Technology Applications and Management
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• v.10 no.1
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• pp.1-17
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• 2003

As the increase of internal users, there are many enterprises and organizations that regard the internal as the great ■marketing superhighway■. But the entrance of too many e-Business enterprises and shopping sites makes them to compete each other Consequently many sites are created and disappeared in the cyberspace. Although fascination and speculation surrounds the impact of the e-Business on business models via benefit-based concept, there is little evidence underlying all this speculation. This article provides on such data set. It reports on critical Issues that e-Business enterprises found salient as they browsed through e-Business model infrastructure on the world wide web, internet-based. We gathered domestic e-Business enterprise's kinds of business model during 2000∼2002 via KMAC's (Korea Management Association Consultants) K-WPI and K-WPC. We classified e-Business models as shopping mall, auction, community. value-chain, collaboration, information brokerage, advertising, Internet service, marketing that we had identified from the existing literature on business models. This study translated these models to the e-Business model context and explored their relative salience. The results suggest that e-Business manager need to think more about how they perform on the issues known to affect decision making for designing e-Business models. We offer advice for enhancing the effectiveness of business models.

• Journal of Sasang Constitutional Medicine
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• v.28 no.3
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• pp.205-214
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• 2016

Objectives This paper was aimed to review the preceding research on the origins, changes and constructive principle of Taeeumjowi-tang.Methods We reviewed Jema Lee's original works including Dongyisusebowon and relevant books to analyze Taeeumjowi-tang-related items. To compensate insufficient evidence of literature, we also refocued physiological and pathological pecularities of Taeeumin and relevant symptomatology.Results and Conclusions 1) The origins of Taeeumjowi-tang should be Mahwang-tang, Saengmaek-san, Seokchangpowonji-san, and Gondam-san. 2) Taeeumjowi-tang went through Saengmaek-san, Sanyakhwawi-jeon, Bopyesaengmaek-tang, Gilgyungsaengmaek-san, and Bopyewon-tang before it was built as the final version. 3) Taeeumjowi-tang consists of a) big blue lilyturf (麥門冬) and Omija (五味子) which are directly of help to exhale and disperse qi-fluid of Lung, b) balloon-flower (桔梗) which helps circulation of qi-fluid from Head to Lung, c) adlay (薏苡仁) and dry nut (乾栗) which are directly of help to raise up qi-fluid of Wiwan, d) ephedra (麻黃) which helps circulation of qi-fluid from Wiwan to skin, e) calamus (石菖蒲) which directly helps the psychological function of Ear, and f) radish seed (蘿葍子) which slightly eliminate the excessive function of Small intestine, treating Wiwanhan symptomatology in Taeeumin.