• 대한기계학회논문집A
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• 제39권9호
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• pp.937-945
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• 2015

본 연구에서는 코팅 공정에 사용되는 슬롯다이(slot-die)에 대해 조건에 따른 코팅 성능을 연구하였다. 슬롯다이 코팅은 코팅 되는 필름의 속도, 코팅액의 점도 그리고 슬롯다이로 주입 되는 압력에 따라 코팅 품질이 많이 달라진다. 따라서 본 논문에서는 CFD 코드를 이용하여 안정적인 코팅을 위한 최적의 조건을 찾았다. 다양한 코팅액의 점도와 슬롯다이 입구의 압력 그리고 코팅 필름의 속도에 대해서 해석을 수행하였다. 그 결과로 $5kgf/cm^2$의 압력과 100cps 의 점도 그리고 20m/min 의 속도 조합에서 가장 안정적으로 코팅액이 잘 도포되었다.

• 한국태양에너지학회 논문집
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• 제32권6호
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• pp.127-133
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• 2012

This paper is an experimental study on the freezing protection valve used for solar water heating, air-conditioning systems, and plumbing systems. When the phase change occurs from liquid to solid, most of the substances except water volumetrically shrink. And referred to as PCM(Phase Change Material) a substance with such properties, the phase change temperature varies depending on the material. To prevent the freezing of the plumbing system, such as air-conditioning system in the winter season, we developed a several types of freezing protection valve using PCM whose freezing temperature are $2-4^{\circ}C$. The working principle of the freezing protection valve is that the fluid inside the pipe is released to prevent the system-collapse when fluid temperature reaches the freezing temperature of the PCM. And then the valve is closed and returned to the original position automatically when the temperature of the operating fluid rises. In this paper, the operating temperatures, discharge flow rate and the response characteristics of the valve during the operation are tested and investigated. From the results of this research the freezing protection valves employing PCM are expected to be commercialized in the near future.

• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2760-2764
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• 2013

Geniposide is a biologically active ingredient of gardenia fruit. A liquid chromatography-tandem mass spectrometric method was developed and validated for the determination of geniposide in rat plasma. The plasma samples were pretreated by solid-phase extraction and introduced into a BDS Hypersil $C_{18}$ column ($50{\times}2.1mm$, $5{\mu}m$) for chromatographic separation. The mobile phase consisted of 0.1% formic acid and 0.1% formic acid in acetonitrile, and gradient elution was performed at a flow rate of 0.25 mL/min. For mass spectrometric detection, multiple reaction monitoring was performed via an electrospray ionization source in positive mode. The calibration curve for geniposide was linear ($r^2=0.997$) in the concentration range of $0.005-1{\mu}g/mL$. The intra- and inter-day accuracies and precisions fulfilled the required criteria (${\pm}15%$). The developed method was subsequently used for pharmacokinetic analysis of geniposide after oral administration to rats at a dose of 50 mg/kg. The mean maximum plasma concentration of geniposide was $0.68{\pm}0.29{\mu}g/mL$ at $0.44{\pm}0.13h$, and the mean area under the plasma concentration versus time curve was $1.46{\mu}g{\cdot}h/mL$.

• 대한기계학회논문집
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• 제19권6호
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• pp.1518-1528
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• 1995

The deformation and departure processes of a bubble attached to the wall are studied experimentally and numerically to understand the phenomena of the nucleate boiling heat transfer enhancement under DC electric field. An air-bubble is injected in a dielectric liquid with different electric fields generated by changing three types of electrode system (Type 1,2 and 3) in the bubble generator. Experimental variables are the electric field strength and the distance and the shape of the electrodes under DC electric field. From experimental results, it is observed that the bubble under Dc electric field is elongated in the same direction as the electric field and the contact angle increases. For the parallel plate electrode which generates a uniform electric field, bubble departure volume doesn't seem to decrease within our experimental range. However, when a needle is raised a few millimeters from the lower electrode to make a nonuniform electric field around the needle, bubble departure volume decreases continuously with the increase of an applied voltage. The reduction effect of bubble departure volume is the most effective under a strong nonuniform electric field generated with Type 3. As the nonuniformity of the electric field due to the shape of a electrode increases, the terminal velocity and the acceleration of a bubble increase largely. For the comparison with visualization results, the deformation of a bubble attached to the electrode is carried out by a numerical method. Numerical results show good agreement qualitatively with experimental results.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
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• pp.269-273
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• 2005

실용형이라 할 수 있는 30 tonf급의 연소기가 설계/제작되어 연소 시험을 마쳤다. 첫 연소 시험은 연소기의 기능 점검을 위해 저유량 공급을 통한 저압 조건에서 이루어졌다. 설계 연소 조건은 저압 단계를 거쳐 도달하였으며, 모든 압력 및 추력 형성이 정상적으로 이루어졌다. 연소실 및 매니폴드에서 측정된 동압 또한 특별한 주파수 대역을 보이지 않으면서 안정적인 연소 특성을 보였으며 동압 섭동 세기가 허용 수준이내에서 발생하였다. 수회의 연소 시험 결과, 연소기의 물리적 손상은 발생하지 않았으며, 만족할 만한 기능적 특성을 나타내었다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
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• pp.299-304
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• 2005

본 논문에서는 연소실 압력 53bara, 추진제 유량 90kg/s, 연소효율 $94\%$, 지상 비추력 253sec을 갖는 액체로켓엔진 실물형 연소기의 설계 전반에 대해 기술하였다. 연소기의 성능에 미치는 연소가스의 물성치, 특성속도, 추력계수 그리고 비추력에 대해 알아보았고, 연소기의 기하학적인 형상에 대해서도 기술하였다. 연소기는 분사기를 장착한 연소기 헤드, 재생냉각 채널을 가지고 있는 연소실로 구성되어 있다. 지상연소시험을 위해 제작한 내열재 삭마 방식의 연소실, SUS 배플을 장착하고 실린더부와 노즐부가 분리된 연소기, 배플 분사기를 장착하고 제생냉각부가 일체형인 연소기에 대해 기술하였다.

• Macromolecular Research
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• 제17권5호
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• pp.332-338
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• 2009

Rheological behavior of natural hydrogel produced from seeds of three Salvia spp. (S. miltiorrhiza (SM), S. sclarea (SS), S. viridis (SV)) was investigated by using a Rheometer equipped with a cone and plate geometry measuring system under never-dried condition. Different chemical contents of such hydrogels give significant effects on their rheological properties. Because of incomplete penetration of water inside the hydrogels after drying before-dried hydrogels were used for rheological analysis. To know molecular interactions which predominated in the gel formation, some constituents were externally added to the 1.0% (w/w) hydrogel. Addition of urea to disrupt hydrogen bonds reduced 3.4-67% viscosity of the untreated hydrogels and changed viscoelastic properties from gel to liquid-like behavior. Neutral salts added to the hydrogel solution at 0.1 M also lowered the viscosity in a manner related with increase in size of cations and temperature. Changing from gel state to liquid-like state was also easily confirmed by oscillation measurement (storage, G', and loss, G", modulii) typically observed in the cases of potassium sulfate and potassium thiocyanate. Influence of pH variation on the viscosity explained that weak alkaline condition (pH 8-9) creates a higher resistance to flow due to increasingly electrostatic repulsions between negative charges ($COO^-$) Importance of calcium bridges was also demonstrated by recovery of viscosity of the hydrogels by addition of calcium after acidification. The summarized results indicate that electrostatic repulsion is a major contributor for production of hydrogel structure.

• 약학회지
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• 제50권5호
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• pp.301-307
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• 2006

A simple and sensitive high-performance liquid chromatographic method for quantitation of hydrochlorothiazide in human plasma was developed and bioavailability parameters of hydrochlorothiazide were assessed in Korean healthy male volunteers. Caffeine was used as an internal standard. Hydrochlorothiazide and internal standard in plasma sample were extracted using tert-butylmethylether (TBME). A centrifuged upper layer was then evaporated and reconstituted with mobile phase of acetonitrile-25 mM phosphate buffer (20/80, pH 2.5). The reconstituted samples were injected into a Luna C18 column $(250{\times}4.6\;mm,\;5{\mu}m)$ at a flow-rate of 1.0 ml/min. The wavelength was set at 230 nm and no endogenous substances were found to interfere, A linear relationship for hydrochlorothiazide was found in the range of $10{\sim}300\;ng/ml$. The lower limit of quantitation (LLOQ) was 10 ng/ml with acceptable precision and accuracy. Assayed in plasma, the intra- and inter-day validation for all coefficients of variation (R.S.D.%) were found less than 15%. Main pharmacokinetic parameters of 50mg of hydrochlorothiazide were revealed as follows: $AUC_t\;1761{\pm}509.0\;ng{\cdot} hr\;ml,\;C_{max}\;296.5{\pm}95.5\;ng/ml,\;T_{max}\;1.94{\pm}0.85hr,\;K_{el}\;0.12{\pm}0.04\;hr^{-1}\;and T_{12}\;6.81{\pm}2.92\;hr.\;C_{max}\;and\;T_{max}$ were in accordance with the values $(270{\sim}350\;ng/ml\;and\;1.9{\sim}2.7\;hr)$ of Caucasian.

• KSBB Journal
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• 제13권5호
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• pp.577-584
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• 1998

A sensitive membrane strip assay for plasma lipoprotein cholesterol that can be performed without handling reagents has been investigated. We previously developed an assay system with immobilized enzymes (cholesterol esterase and cholesterol oxidase) on the surfaces of nitrocellulose membrane(1). In such a case, the amount of enzymes present on the membrane was limited by its surface area and, thus, the detection capability was relatively poor (> 50 mg/dL cholesterol). To overcome this problem, we devised a new system with non-immobilized enzymes by placing them within interstitial spaces of a celullose membrane pad in a dry state. Upon contact with sample medium, the enzymes were immediately dissolved and participated in the reactions with cholesterol in a liquid phase. We constructed a user-friendly system consisting of four membrane pads fro sample application, cholesterol decomposition, color development as signal, and medium absorption to invoke a continuous flow (sequential location from the bottom). A sample containing lipoproteins was added into the application pad by capillary action and transferred to the next pad for decomposition. The decomposition pad (namely, enzyme pad) contained a detergent (sodium cholate) for the destruction of lipoprotein particles, the two enzymes for cholesterol decomposition, and a chromogen (3,3'-diaminobenzidine). As a consequence of the enzyme reactions, hydrogen peroxide was produced, and then reacted in the presence of the chromogen with horseradish peroxidase immobilized on the signal generation pad. Finally, a colorimetric signal directly proportional to the cholesterol concentration was produced. The detection limit determined from this system under optimal conditions was at least 2 times lower than of the enzyme-immobilized system.

• 한국세라믹학회지
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• 제44권2호
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• pp.124-131
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• 2007

In this study, first the ADU gel particle, an intermediate for final $UO_2$ kernel of a HTGR nuclear fuel, was prepared from sol-gel method using the broth solution which was made by mixing of the uranyl nitrate, poly vinyl alcohol and tetra-hydrofurfuryl alcohol. The prepared dried-ADU gel particles were converted to the $UO_2\;via\;UO_3$ from thermal treatment with the 4% $H_2$ atmosphere. The sizes of the spherical liquid droplets appeared $1900{\sim}2100{\mu}m$, and the harmony between the flow rate of the broth solution and the frequency and the amplitude of a vibrating system are important factors for the spherical ADU gel particles via the mono size spherical droplets. From the XRD and FT-IR analyses, the prepared ADU gel particles were judged to be a $UO_3{\cdot}xNH_3{\cdot}yH_2O$ form, and the most important factor during the thermal treatment of the dried-ADU gel particle must be avoided a rapidly heating rate in the range of $180{\sim}400^{\circ}C$, and the heating rate should be kept below $5^{\circ}C/min$.