• 식품과학과 산업
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• 제52권3호
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• pp.241-260
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• 2019

Prebiotics are defined as substrates that are selectively utilized by host microorganisms conferring various health benefits. Current prebiotic researches not only focus on non-digestible oligosaccharides, but also extend to polyphenols and peptides. However, the extended scope of prebiotic research pertains its original purposes: promotion of beneficial bacteria in host guts and production of valuable metabolites. Maintenance of optimal gut microflora plays a key role in host health care benefits including anti-cancer activity, immune response modulation, blood lipid level reduction, increased mineral absorption, and weight loss. With increasing probiotics markets, prebiotics have also received much attention in functional food markets. Hence, many global food companies tempt to develop new prebiotics applicable for preventing human diseases as well as modulating immune system. In this review, we discuss current status of prebiotics research, market progress, and future perspectives of prebiotics.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.287.1-287.1
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• 2003

F$_2$-isoprostanes are derived in vivo principally from the formation of positional peroxyl radicals of arachidonic acid, endocyclization to prostaglandin G$_2$-like structures, and reduction to PGF$_2$-like compounds. F$_2$-isoprostanes have been proposed as biomarkers of lipid peroxidation, oxidative stress status, and oxidation of low density lipoprotein (LDL) in atherogenesis. Especially, elevated 8-iso-PGF$\sub$2a/ is known as a useful clinical biomarker of oxidative stress in-end stage renal disease (ESRD) patients receiving hemodialysis (HD). (omitted)

• 한국식품영양과학회지
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• 제34권1호
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• pp.42-56
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• 2005

본 연구는 건강검진센터 검진자 중 혈청 중성지방 농도가 150 mg/dL 이상이거나 총 콜레스테롤이 200 mg/dL 이상인 고지혈증 초기 판정자 43명을 대상으로 12주 동안 의학영양치료와 병행하여 한방 기능성 차를 섭취하게 한 후 혈청 지질농도와 항산화에 미치는 영향을 조사한 것이다. 그 결과를 요약하면 다음과 같다. 총 대상자 43명의 평균 연령은 49.41$\pm$5.2세였으며, 남성의 비율이 53.5%였다. 대상자의 51.2%가 혈중 콜레스테를 수치만 높은 제 II a형이었으며, 대상자의 37.2%는 혈중 중성지방과 콜레스테롤이 함께 높은 제IIb형, 11.6%는 중성지방만 높은 제 IV형이었다 모든 대상자는 2003년 건강검진결과 처음으로 고지혈증을 진단받았으며, 지질저하제를 복용하지 않았다. 또한 모든 대상자는 의학영양치료를 받아본 경험이 없었다. 체중은 남여 대상자 모두 군간의 차이가 없었으며, 실험 전과 후의 변화가 관찰되지 않았다. 남성의 경우, 허리둘레가 HFT군에서 유의적으로 감소하였으며, 혈압 또한 HFT군에서 유의적으로 감소하였다. 여성의 경우는 BMI가 FFT군에서 실험 후 유의적으로 감소하였으며, 체지방 비율은 모든 군에서 감소하였다. 식사량, 식사의 규칙성, 식품군의 배합 및 짠 음식 에 대한 기호도 등을 조사한 결과 실험 전 식사량은 만복이 될 때까지 섭취하는 경우가 많았고, 사 시 배합에는 별로 관심이 없었으며, 평균 주 2∼3회의 식사를 거르고 있는 것으로 나타났다. 그러나 실험 후의 이와 같은 양상은 많은 변화를 보였다. 기능성차 섭취와 의학영양치료 전후의 식품 섭취 빈도는 실험 전 콜레스테롤이 많은 음식, 간식의 빈도가 실험 후 유의적으로 감소하였다. 모든 군에서 평균 섭취 열량이 실험 전보다 유의적으로 감소하였다. 총 지방의 섭취량도 유의적으로 섭취 감소를 보였으며, 포화지방산의 경우 HFT군에서 가장 큰 감소를 보였다. 다가 불포화지방산 또한 HFT군에서 감소하였다. 대상자의 P/M/S섭취 비율은 실험 전 0.73/1.l1/1에서 실험 후 0.98/1.38/l로 다가 불포화지방산의 섭취량과 단일 불포화지방산의 섭취 비율이 증가한 것으로 나타났다. 12주간의 식이 콜레스테롤 섭취량도 모든 군에서 매우 큰 감소를 보였다. 혈중 총 콜레스테롤 농도를 비교한 결과 기능성차군에서 유의적으로 감소하였다, 중성지방 농도 또한 총 콜레스테롤 농도와 마찬가지로 기능성차군에서 유의적으로 감소하였다. 혈중 LDL-콜레스테롤과 HDL-콜레스테롤 농도는 실험 전과 후의 유의적인 변화는 없었다, 고지혈증의 발병율과 밀접한 상관관계를 보이는 동맥경화지수는 기능성차군에서 유의적으로 감소하였다. 혈중 호모시스테인 농도의 측정 결과 FFT군의 경우 실험 전 정상범위를 초과하였으나 실험 후 정상 범위에 속하게 되었다. 항산화 물질 2항목(SOD, GPx) 측정결과 SOD는 실험 후 HFT군에서 유의적으로 증가하였다.(13.3%). GPx는 실험 후 FFT군에서 유의적으로 증가되었다.(12.8%). 결론적으로 의학영양치료는 식습관 및 식품섭취의 패턴을 변화시켰고, 총열량과 동물성 단백질, 지방질, 콜레스테롤 섭취의 저하를 유도하였으나 혈중 지질 농도에는 유의적인 변화를 나타내지 못하였다. 그러나 대상자 개인에 맞는 의학영양치료의 적용은 약물요법 이전에 식습관과 섭취량을 조절하는데 매우 유효할 것으로 사료된다. 한편 의학영양치료와 병행한 기능성차(상엽, 구기자, 국화, 대추, 참깨, 나복자가 복합 처방)의 섭취는 혈중 지질 농도를 저하시켰으며, 또한 항산화 효과도 나타내었다. 이와 같이 임상 효능이 확인된 한방재료로 제조된 기능성차의 섭취는 동맥경화증, 허혈성 심장질환, 뇌졸중 등 심혈관계 질환의 주요 원인인 고지혈증에 효과가 있는 것으로 나타났으며, 또한 혈중 지질 농도를 저하시킴으로써 질환을 예방하는데 의학영양치료의 보조적인 역학을 할 수 있는 기능성차로 차별화 될 수 있을 것으로 사료된다.

• Nutritional Sciences
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• 제6권4호
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• pp.195-200
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• 2003

In recent years, the prevalence of type 2 diabetes mellitus has dramatically increased in Korea as the diet has rapidly become westernized. We determined the effect of long-term cola intakes on glucose metabolism and oxidative stress in weanling male Sprague Dawley rats consuming a moderate fat diet Thirty male rats, born from 6 female rats, were randomized into cola or water drinking groups. For 28 weeks, all rats were provided with an ad lib solid diet having 33 percent of its metabolisable energy as fat In addition, rats of the cola group were provided with ad lib cola instead of water. The daily total caloric intake did not differ between groups. The rats in the cola group consumed a higher proportion of carbohydrates, and their mean body weight and fasting serum insulin level were lower than that of the control group. Whole-body glucose disposal rates measured by an euglycemic hyperinsulinemic clamp were higher in the cola group. However, lipid peroxide levels in kidney tissue were higher in the cola group than in the control group. Superoxide dismutase activity in kidney tissues was lower in the cola group compared to the control group, while glutathion peroxidase and catalase activities were not significantly different between the two groups. In conclusion, long-term cola intakes decreased insulin resistance, but increased oxidative stress in kidney tissue due to decreased SOD activities, which may lead to kidney damage. Thus, moderate changes in insulin resistance may not affect the status of oxidative stress, and vice versa.

• Journal of Nutrition and Health
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• 제36권6호
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• pp.635-645
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• 2003

This study was conducted to investigate the effects of smoking on nutrient intake and blood mineral status. The subjects were composed of two groups.55 smokers and 52 non-smokers. A 24-hour recall method was used along with questionnaires and serum mineral levels were analyzed by ICP spectrometer. The average ages of the smokers and non-smokers were 55.5 and 59.3 years old, respectively. The height, obesity degree, BMI, and WHR of the smokers were significantly higher than those of the non-smokers (p < 0.05, p < 0.05, p < 0.05, p < 0.01) Approximately 45.5% of the smokers smoked 16-20 cigarettes per day. The average age that the smokers started smoking was 22.0 years old and their smoking history was 33.5 years. About 74.5% of the smokers drank alcoholic beverages, while 44.2% of the non-smokers did. The smokers tended to eat less meals and breakfast meal, but drink coffee more often compared to the non-smokers. The mean daily energy intake and CPF energy intake ratio were 1231.8 ㎉ and 69.8 : 14.8 : 14.7 in the smokers and 1210.2 ㎉ and 72.1 : 14.7 12.7 in the non-smokers, respectively. The results show that the smokers tended to consume more energy, lipid, and cholesterol compared to the non-smokers. The results also show that in both groups, nutrient intake was lower than the RDA. The two groups were not significantly different in terms of the intake frequency of green-yellow vegetables and fresh fruits. There were no significant differences in serum levels of Ca, P, Mg, Cu, Fe, Mn, and Zn. However, serum Se level of the smokers was significantly higher than that of the non-smokers. In conclusion, the subjects of this study showed a serious imbalance in the nutrient intake, and the smokers showed a more undesirable dietary intake in the light of their high intake of energy, lipid, cholesterol, alcoholic beverages, and coffee. The serum Se level of the smokers was higher than that of the non-smokers, showing that Se is involved in smoking, Therefore, it could be suggested that more systematic research be conducted with respect to Se and smoking and that increased nutrition education and guidelines for smokers are required.

• Nutritional Sciences
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• 제8권4호
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• pp.262-267
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• 2005

Reactive oxygen species can be generated in the skin by hair dyeing. The aim of this study was to find out the effects of the oxidative-type hair dye application in young women on the antioxidant systems. We investigated the lipid peroxide levels, glutathione (GSH) levels, and the antioxidant enzyme activities including superoxide dismutase (SOD), glutathione peroxidase (GSHPx) in plasma and erythrocytes and catalase (CAT) in erythrocytes, and DNA damages in lymphocytes. Also, plasma concentrations of antioxidant vitamins, vitamin A and E, were measured and the correlations between various antioxidant parameters and oxidative damages were evaluated The antioxidant enzyme activities in plasma (GSHPx) and in erythrocytes (SOD and CAT) were decreased significantly after hair dyeing. 1be lipid peroxide and GSH levels were not affected in both plasma and erythrocytes. No significant difference was found in the concentrations of both vitamin A and E between before and after hair dyeing. However, DNA damages expressed as the tail extent moment (TEM) and tail length (TL) were significantly (p<0.001) increased. The plasma vitamin E concentration was correlated with DNA damages (TEM: r=-0.590, p<0.01 and TL: r=-0.533. p<0.01) and RBC SOD activity (r=0.570, p<0.05). In turn, RBC SOD activity was significantly correlated with both plasma MDA levels (r=-0.412, p<0.05) and DNA damages (TM: r=-0.546, p<0.01, TL: r=-0.493, p<0.01). Our results demonstrated that the exposure to hair dyeing produced lymphocyte DNA damage and modification of the antioxidant enzyme activities. Also, there were very strong associations between plasma vitamin E concentration, RBC SOD activity and DNA damage induced by hair dyeing. It suggests that the antioxidant status of a subject is likely to be related to the extent of the harmful effects caused by hair dyeing.

• 대한한의학회지
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• 제32권6호
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• pp.74-84
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• 2011

Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats. Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes. Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.

• Nutrition Research and Practice
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• 제8권2호
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• pp.172-176
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• 2014

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2571-2576
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• 2012

Breast cancer is the first of the most common ten cancers in Iraq. Its etiology is multifactorial, oxidative stress and lipid peroxidation being suggested to play important roles in carcinogenesis. The purpose of this study was to investigate the oxidant-antioxidant status in breast cancer patients, by measuring SOD isoenzyme activities (total SOD, CuZn-SOD, Mn-SOD and EC-SOD) in plasma and breast tumors, and by estimating thiobarbituric reactive substances (TBRS) in tissue homogenates. General increase in total SOD activity was observed in plasma and tissue samples of breast tumors, greater in the malignant when compared to benign group (p<0.05). Mn-SOD showed a significant decrease in tissue malignant samples (p<0.05), and insignificant decrease in plasma malignant samples compared with control and benign samples. Plasma EC-SOD activity in both patient benign and malignant breast tumors demonstrated 3.5% and 22.8% increase, respectively. However, there was a decrease in tissue EC-SOD activity in malignant breast tumors when compared with benign. A similar tendency was noted for TBRS. We suggest that elevated total SOD might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. If there is proteolytic removal of the heparin binding domain, EC-SOD will lose its affinity for the extracellular matrix and diffuse out of the tissue. This will result in a decreased EC-SOD activity, thus leading to an increase in the steady-state concentration of $O^{2-}$ in this domain, and increase in EC-SOD activity in the extracellular fluid. This might explain the results recorded here concerning the decrease in tissue EC-SOD activity and increase in plasma of breast cancer patients.

• Nutrition Research and Practice
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• 제5권1호
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• pp.28-33
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• 2011

Limited information from human studies indicates that dietary quercetin supplementation influences blood lipid profiles, glycemic response, and inflammatory status, collectively termed cardiometabolic risks. We tested the hypothesis that quercetin-rich supplementation, derived from onion peel extract, improves cardiometabolic risk components in healthy male smokers in a randomized, double blinded, placebo-controlled parallel design. Randomly assigned subjects were instructed to take either the placebo (n=43) or 100 mg quercetin capsules each day (n=49) for 10 weeks. Anthropometric parameters and blood pressure were measured, and blood lipids, glucose, interleukin-6, and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined at baseline and after 10 weeks of quercetin supplementation. Quercetin-rich supplementation significantly reduced serum concentrations of total cholesterol (P<0.05) and LDL-cholesterol (P<0.01), whereas these effects were not shown in the placebo group. Furthermore, significant increases were observed in serum concentrations of HDL-cholesterol both in the placebo (P<0.005) and quercetin-rich supplementation group (P<0.001); however, changes in HDL-cholesterol were significantly greater in subjects receiving quercetin-rich supplementation than the placebo. Both systolic (P<0.05) and diastolic blood pressure (P<0.01) decreased significantly in the quercetin-rich supplementation group. Glucose concentrations decreased significantly after 10 weeks of quercetin-rich supplementation (P<0.05). In contrast, no effects of quercetin-rich supplementation were observed for the inflammatory markers-IL-6 and sVCAM-1. Daily quercetin-rich supplementation from onion peel extract improved blood lipid profiles, glucose, and blood pressure, suggesting a beneficial role for quercetin as a preventive measure against cardiovascular risk.