Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

  • Choi, Ha-Neul (Department of Smart Food and Drugs, School of Food and Life Science, Inje University) ;
  • Jang, Yang-Hee (Department of Smart Food and Drugs, School of Food and Life Science, Inje University) ;
  • Kim, Min-Joo (Laboratory of Nutritional Analysis, Hurom Co., Ltd.) ;
  • Seo, Min Jeong (Department of Biotechnology, Dong-A University) ;
  • Kang, Byoung Won (Medi-Farm Industrialization Research Center, Dong-A University) ;
  • Jeong, Yong Kee (Department of Biotechnology, Dong-A University) ;
  • Kim, Jung-In (Department of Smart Food and Drugs, School of Food and Life Science, Inje University)
  • Received : 2013.07.09
  • Accepted : 2013.08.16
  • Published : 2014.04.01
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Abstract

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

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