• The Journal of Korean Physical Therapy
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• 제30권6호
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• pp.239-245
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• 2018

Purpose: This study was to identify international classification of functioning, disability and health (ICF) categories that could be linked conceptually to disability of arm, shoulder and hand (DASH) items and short form of health survey 36 (SF-36) items for persons with shoulder pain. Methods: Linkage between each item in DASH and SF-36 and the categories in the ICF were assessed. The linking process was performed by ten health professionals following the linking rule. One hundred four patients with shoulder pain were enrolled from 12 private clinic outpatient departments and participated in this study. Pearson correlation coefficients were used to assess the relationships between each scale item and the linked ICF code. Results: Thirty DASH items were able to be linked to 30 ICF codes, whereas the 36 items in SF-36 were only linked to 17 ICF codes. General health items included in SF-36 could not be linked to a relevant ICF concept. There was a high correlation between the two measurement tools and the linked ICF codes, DASH and its ICF code list (r =0.91), SF-36-Physical Health and its code list (r =-0.62), and SF-36-Mental Health and its code list (r =-0.72). Conclusion: The results suggest that concepts within each item in DASH can be linked to ICF codes for patients with shoulder pain, however, the concepts in the SF-36 items had limited linkage to ICF codes. The shoulder-specific functional tool, DASH can be expressed with ICF codes and, therefore, its use can promote data standardization and improve communication between professionals.

• Earthquakes and Structures
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• 제17권2호
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• pp.143-162
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• 2019

Motivated by a simpler and more compact hybrid active tuned mass damper (ATMD) system with wide frequency spacing (i.e., high robustness) but not reducing the effectiveness using the least number of ATMD units, the active tuned tandem mass dampers (ATTMD) have been proposed to attenuate undesirable oscillations of structures under the ground acceleration. Likewise, it is expected that the frequency spacing of the ATTMD is comparable to that of the active multiple tuned mass dampers (AMTMD) or the multiple tuned mass dampers (MTMD). In accordance with the mode generalised system in the specific vibration mode being controlled (simply referred herein to as the structure), the closed-form expression of the dimensionless displacement variances has been derived for the structure with the attached ATTMD. The criterion for the optimum searching may then be determined as minimization of the dimensionless displacement variances. Employing the gradient-based optimization technique, the effects of varying key parameters on the performance of the ATTMD have been scrutinized in order to probe into its superiority. Meanwhile, for the purpose of a systematic comparison, the optimum results of two active tuned mass dampers (two ATMDs), two tuned mass dampers (two TMDs) without the linking damper, and the TTMD are included into consideration. Subsequent to work in the frequency domain, a real-time Simulink implementation of dynamic analysis of the structure with the ATTMD under earthquakes is carried out to verify the findings of effectiveness and stroke in the frequency domain. Results clearly show that the findings in the time domain support the ones in the frequency domain. The whole work demonstrates that ATTMD outperforms two ATMDs, two TMDs, and TTMD. Thereinto, a wide frequency spacing feature of the ATTMD is its highlight, thus deeming it a high robustness control device. Furthermore, the ATTMD system only needs the linking dashpot, thus embodying its simplicity.

• 한국농촌건축학회논문집
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• 제25권4호
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• pp.37-44
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• 2023

As a basic study to analyze the relative importance of external space in urban development projects, this study selects evaluation indicators for external space planning and then analyzes systematic external space planning through expert surveys. The scope of the study is to examine the criteria of evaluation items for external space derived from existing studies and to suggest the importance and priority of evaluation items. As a research method, we reviewed the legal and research literature on landscape planning and external space-related guidelines, and conducted a primary review of external space planning evaluation items analyzed by questionnaire. The reviewed items were again reviewed and selected through expert group discussions (FGI). The selected evaluation items were surveyed by expert groups and analyzed in depth using the hierarchical analysis method (AHP). Looking at the relative importance of the calculated sub-items, among the 17 sub-items, 'planning open space' (.096) is the largest, followed by 'pedestrianization' (.082), 'linking with adjacent buildings, streets, parks, and green areas' (.077), 'securing public space through various planning techniques such as linking with pedestrian paths' (.066), 'Plan the placement, form, and scale of buildings in consideration of the identity of the destination' (.065), 'Plan buildings, streets, parks, and green spaces in an integrated and holistic manner' (.065), 'Harmonize with the surrounding environment (landscape)' (.063), 'Harmonize with surrounding buildings and apply landscape planning in urban planning' (.063), 'Entrances and lower floors of buildings are planned as parks for users and pedestrians' (.060), 'Preserve and expand green areas and establish maintenance plans for urban greening' (.054), 'Form the basis for a comfortable life for urban residents by providing long-term development directions' (.047), 'Activate community activities and plan pedestrian environments and streetscapes considering human scale' (.047), 'Establish and propose basic directions for urban greening' (.046), 'Plan buildings, streets, parks, and green areas considering the hierarchy and characteristics of the landscape structure' (.045), 'Plan for integrated land use' (.045), 'Create green axes in connection without cutting them due to development activities' (.044), and 'Apply barrier free design' (.034).

• 디지털융복합연구
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• 제10권10호
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• pp.457-463
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• 2012

소셜네트워크게임(SNG)은 말 그대로 사회적인 연결망이나 관계에 기반한 게임이다. 사람들과의 관계가 게임에 있어서 중요한 요소가 되어 이를 잘 활용해야 원활한 진행을 할 수 있다는 점이다. 소셜네트워크 서비스에 바탕을 둔 소셜네트워크 게임의 활동은 실제 기업상품과 연결시켜 구매를 유도할 수도 있고 또 소셜네트워크 게임 상의 가게를 기업의 웹사이트나 쇼핑몰과 연결하여 게임 속에서 광고를 통한 마케팅도 가능하다. 본 연구에서는 개발게임을 사례를 들어 소셜커머스에 기반한 새로운 SNG 비즈니스 모델을 제안하고 차후 SNG 수익모델 연계방식을 제시하였다.

• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.83-87
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• 2006

Poly(acrylic acid) (PAA) was identified to possess good mucoadhesive properties ensuring its application to extend the retention times of the formulations at the oral cavity, intended route of administration using the polymer. In the noncross-linked state, PAA will swell and become eroded owing to the presence of salivary flow from the site of application. The formation of cross-links between the polymer chains will allow swelling but prevents the erosion of the dosage form. In the current study, cross-linking was achieved by esterification of the PAA chains with sucrose. The density of crosslinking was modified by changing sucrose concentration and the duration of cure time. The cross-linking density of the polymer hydrogel was assessed by equilibrium swelling studies. The mucoadhesion testing method allowed a comparative study of the hydrogels prepared. An inverse relationship between equilibrium swelling and peak detachment force showed that increased PAA chain density per unit area enhanced the mucoadhesive interaction.

• KSBB Journal
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• 제29권1호
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• pp.1-8
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• 2014

Tyrosinases catalyze the hydroxylation of monophenolic compounds and the conversion of o-diphenols to oquinones. The enzymes are mainly involved in the modification of tyrosine into L-3,4-dihydroxyphenyl-alanine (L-DOPA) and DOPA/DOPAquinone-drived intermolecular cross-linking, which play the key roles of pigmentation to the cells. It is ubiquitously distributed in microorganisms, plants, and animals all around the nature world. They are classified as copper- containing dioxygen activating enzymes; two copper ions are coordinated with six histidine residues in their active sites and they are distinguished as met-, deoxy-, and oxy-form depending on their oxidative states. Natural extraction and recombinant protein approaches have been tried to obtain practical amounts of the enzymes for industrial application. Tyrosinases have been widely applied to industrial and biomedical usages such as detoxification of waste water containing phenolic compounds, L-DOPA as a drug of Parkinson's disease, biomaterials preparation based on the cross-linking ability and biosensors for the detection of phenolic compounds. Therefore, this review reports the mechanism of tyrosinase, biochemical and structural features and potential applications in industrial field.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.197-199
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• 2007

Four banana-shaped compounds have beene synthesized introducing ester linking group into mesogenic unit, varying the central core with 1,6-, 1,7-, 2,3-, and 2,7-naphthylene units, and introducing the dodecyloxy group as the terminal flexible unit. All obtained compounds except one with 1,7-naphthylene unit were reversibly thermotropically liquid crystalline. The compound with 1,7-naphthylene unit could not form the mesophase due to its asymmetrical and sharp substitution angle. The compounds with 1,6- and 2,3-naphthylene units showed an antiferroelectric switchable smectic phase, which has been designated B2 phase. Interestingly, the compound with the 2,3-naphthylene unit showed the two mesophases of B2 and nematic phase.

• BMB Reports
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• 제47권3호
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• pp.130-134
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• 2014

The combination of a high-affinity antibody to a hapten, and hapten-conjugated compounds, can provide an alternative to the direct chemical cross-linking of the antibody and compounds. An optimal hapten for in vitro use is one that is absent in biological systems. For in vivo applications, additional characteristics such as pharmacological safety and physiological inertness would be beneficial. Additionally, methods for cross-linking the hapten to various chemical compounds should be available. Cotinine, a major metabolite of nicotine, is considered advantageous in these aspects. A high-affinity anti-cotinine recombinant antibody has recently become available, and can be converted into various formats, including a bispecific antibody. The bispecific anti-cotinine antibody was successfully applied to immunoblot, enzyme immunoassay, immunoaffinity purification, and pre-targeted in vivo radioimmunoimaging. The anti-cotinine IgG molecule could be complexed with aptamers to form a novel affinity unit, and extended the in vivo half-life of aptamers, opening up the possibility of applying the same strategy to therapeutic peptides and chemical compounds.

• 한국콘텐츠학회논문지
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• 제3권2호
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• pp.39-45
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• 2003

자바의 동적인 클래스 로딩은 자바 플랫폼에서 실행시간에 소프트웨어 컴포넌트를 동적으로 로딩하기 위한 강력한 메커니즘이다. 다른 시스템에서도 동적 로딩과 링킹을 제공하지만 지연 로딩, 타입안전 링크, 사용자 정의 로딩정책, 다중 이름 공간 등은 자바가 가진 중요한 특징들이다. 클래스 로딩에서 핵심은 타입 안전을 보장하는 것이다. 타입 안전은 자바 보안에서 아주 중요한 부분을 차지한다. 하지만 자바 가상 머신에서 타입 안전에 대한 메커니즘은 매우 복잡하고, 접근이 명확하지 않아서 지금 까지 많은 버그가 발생하여 타입 안전에 문제가 되었다. 본 논문은 자바 가상 머신에서 동적인 클래스 로더의 동작을 분석하고, 연산적 의미론(operational semantics)으로 추상화하고 현재 로드되어진 클래스와 추가된 제한 등을 이용하여 이전에 제시되었던 타입 안전에 대한 문제를 분석한다.

• 한국미생물·생명공학회지
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• 제24권3호
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• pp.290-298
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• 1996

In an effort to understand the role of the conserved domain and of the heterologous one-third part of the carboxy terminal domain of transglutaminase C (TGase II), attempts were made to express TGase II cDNA of human origin in yeast Saccharomyces cerevisiae as in a full-length form as well as in a form of C-terminal truncation. The 2$\mu$-based expression plasmids which contained the TGase II cDNA under the gal inducible promoter were introduced into yeast and the maintenance of the full-length and truncated form of the TGase II gene plasmids were confirmed by Southern blot. The expression of the TGase II gene was analysed by reverse transcription polymerase chain reaction (RT-PCR), and western blot analyses. As assayed by [1,4$^{14}$C]-putrescine incorporation into succinylated casein, the full-lenth as well as the truncated forms of recombinant TGase II showed some catalytic activity. These results indicate that the N-terminal homologous domain of human TGase II retains a catalytically active domain. The level of TGase II expressed in yeast, however, was far lower than satisfactory and other expression system should be sought further chracterization of the enzyme. The negative effect of TGase II on the growth of yeast is interesting with respect to the physiological effect of TGase II in cornification of epidermal keratinocytes.