• Biomedical Science Letters
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• v.27 no.3
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• pp.121-133
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• 2021

Antibody-drug conjugates (ADCs) are drawing much interest due to its great potential to be one of the important options in cancer treatments. ADCs are acting like a magic bullet which delivers cytotoxic drugs specifically to cancerous cells throughout the body, thus attacks these cells, while not harming healthy cells. ADCs are complex molecules that are composed of an antibody having targeting capability and linked-payload or cytotoxic drug killing cancerous cells. The key factors of the success in the development of ADC are selection of appropriate antibody, cytotoxic payload and linker for conjugation. Recently there was considerable progress in ADCs development, and a large number of ADCs gained US FDA approval. About 80 new ADCs are under active clinical studies. In this review we present a brief introduction of the US-FDA approved ADCs and global situation in the clinical studies of ADC pipelines. We address an overview on each component of an ADC design such as target antigens, payloads, linkers, conjugation methods, drug antibody ratio. In addition, we discuss on the trend of ADC market where global big pharmas and domestic biopharmaceutical companies are competing to develop safer and more effective ADCs.

• BMB Reports
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• v.57 no.8
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• pp.369-374
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• 2024

Antigen 43 (Ag43) proteins, found on the outer membrane of Escherichia coli, are β-sheets that fold into a unique cylindrical structure known as a β-barrel. There are several known structural similarities between bacterial Ag43 autotransporters and physical components; however, the factors that stabilize the barrel and the mechanism for Ag43 passenger domain-mediated translocation across the pore of the β-barrel remain unclear. In this study, we analyzed Ag43β-enhanced green fluorescent protein chimeric variants to provide new insights into the autotransporter Ag43β-barrel assembly, focusing on the impact of the α-helical linker domain. Among the chimeric variants, Ag43β700 showed the highest surface display, which was confirmed through extracellular protease digestion, flow cytometry, and an evaluation of outer membrane vesicles (OMVs). The Ag43β700 module offered reliable information on stable barrel folding and chimera expression at the exterior of the OMVs.

• Polymer(Korea)
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• v.33 no.6
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• pp.615-619
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• 2009

Pd-POSS nanoparticles were produced from the reaction of palladium (II) acetate and octa(3-aminopropyl)octasilsesquioxane octahydrochloride (POSS-${NH_3}^+$) in methanol at room temperature. Pd-POSS nanoparticles with a mean diameter of 60-80 nm were the highly ordered spherical aggregates. In contrast, Pd nanoparticles with a size of 4.0 nm were obtained when POSS-${NH_3}^+$ was not introduced. Pd-POSS/PAA nanocomposites of Pd-POSS nanoparticles and poly(acrylic acid) (PAA) were fabricated by utilizing ionic interactions between positively charged Pd-POSS nanoparticles and negatively charged carboxylate groups of PAA. PAA was used as a cross-linker for the preparation of hybrid nanocomposites with the controlled organized structures of Pd-POSS nanoparticles. That is, the self-organization of Pd-POSS nanoparticles was formed into the shape of continuous lines by using PAA as a cross-linker. The composition, structure, surface morphology, and thermal stability of the Pd-POSS/PAA nanocomposites were studied by FE-SEM, AFM, TEM, FT-IR, and TGA.

• Korean Chemical Engineering Research
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• v.57 no.1
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• pp.1-4
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• 2019

In this study, an anthracene cross-linker is introduced to enhance the catalytic activity of glucose oxidase (GOx) based catalysts and to increase the amount of enzyme loading. The crosslinked GOx is bonded with the CNT/PEI support using the electrostatic interaction (AC[CNT/PEI/GOx]). Electrochemical evaluations are done to evaluate the performance of this catalyst and the performance of CNT/PEI/GOx catalyst is also measured as a control. According to the measurements, it is confirmed that the amount of loaded GOx increases, while $K_m$ value calculated by Lineweaver-Burk plot shows that AC[CNT/PEI/GOx] ($K_m$ : 0.73 mM) is superior to CNT/PEI/GOx ($K_m$ : 1.71 mM) without cross-linking reaction. Based on these effects, it is demonstrated that the maximum power density of the enzymatic biofuel cell using AC[CNT/PEI/GOx] increases from $21.2{\mu}W/cm^2$ to $57.4{\mu}W/cm^2$.

• Proceedings of the KAIS Fall Conference
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• 2009.12a
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• pp.785-788
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• 2009

본 논문에서는 기존의 멀티어학실습실을 그룹별 독립적 수업을 진행하거나 그룹 끼리 대화, 강사와 수강 그룹 또는 개인과의 쌍방향 어학실습이 가능하도록 한다. 또한 실습실 구축이 손�Z게 될수 있을 뿐만아니라 수강생의 이동이 가능하도록 완전히 무선으로 구축할 수 있도록 불루투스 송수신기를 헤트�V에 장착하였으며, 그룹별 영상 시청이 가능하도록 무선 A/V Linker와 같이 사용할 수 있도록 인터페이스를 손쉽게 하였다.

• Bulletin of the Korean Chemical Society
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• v.27 no.12
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• pp.2084-2086
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• 2006

• Bulletin of the Korean Chemical Society
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• v.25 no.12
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• pp.1784-1790
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• 2004

A series of 2-(3-chlorophenyl)-2-hydroxyethylamine derivatives containing a tetrahydrocarbazole linker were prepared and evaluated for their ${\beta}_3$-adrenoceptor agonistic activity. Several compounds showed potency comparable to CL-316243.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.3085-3088
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• 2009

• Proceedings of the Korean Information Science Society Conference
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• 2004.04b
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• pp.841-843
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• 2004

응용프로그램 로더와 동적 링커는 응용프로그램이 실제로 실험되기까지의 준비 과정을 담당하는 프로그램들이다. 최근의 WIPI 표준은 휴대폰에 새로운 응용프로그램을 전송 받아 수행할 수 있는 환경을 제안하고 있지만, 휴대폰과 같은 제한된 이동단말기에서 사용할 안한 로더와 동적 링커는 공개되어 있지 않다. 본 논문에서는 이동단말기 환경에서 응용프로그램 로더와 동적 링커를 개발하는 과정을 설명한다. 개발에 참가한 연구진의 경험을 소개함으로써 이후의 비슷한 환경에서 로더와 링커를 개발하려는 연구자들에게 중요한 참고자료로 활용될 수 있을 것이다.

• Proceedings of the Korean Biophysical Society Conference
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• 1997.07a
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• pp.25-25
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• 1997

Cyclic nucleotide-gated channels (CNGC's) contain a putative N-glycosylation site (Asn-X-Ser/Thr) in the linker regions connecting the fourth transmembrane domain (S4) and the ion conduction pore (P-region). This putative N-glycosylation site is highly conserved and thus found in many different CNGC in various organisms, from fruit to human.(omitted)