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http://dx.doi.org/10.5012/bkcs.2004.25.12.1784

Synthesis of Tetrahydrocarbazole Derivatives as Potent β3-Adrenoceptor Agonists  

Ha, Jae-Du (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Kang, Seung-Kyu (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Cheon, Hyae-Gyeong (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Choi, Joong-Kwon (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.12, 2004 , pp. 1784-1790 More about this Journal
Abstract
A series of 2-(3-chlorophenyl)-2-hydroxyethylamine derivatives containing a tetrahydrocarbazole linker were prepared and evaluated for their ${\beta}_3$-adrenoceptor agonistic activity. Several compounds showed potency comparable to CL-316243.
Keywords
${\beta}_3$-Adrenoceptor; Tetrahydrocarbazole; Arylethanolamine; Antiobesty;
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