• Molecules and Cells
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• v.24 no.1
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• pp.60-68
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• 2007

Microsatellites, also called simple sequence repeats (SSR), are very useful molecular genetic markers commonly used in crop breeding, species identification and linkage analysis. In the present study, we constructed a microsatellite-enriched genomic library of Panax ginseng, and identified 251 novel microsatellite sequences. Tri-nt repeat units were the most abundant (46.6%), followed by di-nt repeats (35.5%). The $(AG)_n$ motif was most common (23.1%), followed by the $(AAC)_n$ motif (22.3%). From the genotyping of 94 microsatellites using marker-specific primer sets, we identified 11 intraspecific polymorphic markers as well as 14 possible interspecific polymorphic markers differing between P. ginseng and P. quinquefolius. The exact allele structures of the polymorphic markers were determined and the alleles were named. This study represents the first report of the bulk isolation of microsatellites by screening a microsatellite-enriched genomic library in P. ginseng. The microsatellite markers could be useful for linkage analysis, genetic breeding and authentication of Panax species.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.4
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• pp.213-223
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• 2004

In the machine tool industry, direct drive linear motor technology is of increasing interest as a means to achieve high acceleration, and to increase reliability. The advantages of such a motor are that it has a good linearity and has no need of such mechanical energy conversion parts, which change rotary motion into linear motion, as screws, gears, chains etc In this paper, two structures of LOA are analyzed. One is the moving-coil type LOA and the other is moving-magnet type LOA. Two types of LOA are analyzed, with reference to the following parameters as variables: magnetic field, flux linkage, motor thrust and back emf. These variables are derived by the use of analytical method in terms of two-dimensional rectangular coordinate system. The maximum values of thrust according to such design parameters as air-gap length and magnet height for each model is also represented. The results are validated extensively by comparison with finite element method. In particular, we experiment moving-coil LOA which is already manufactured and confirm that the experimental results are shown in good agreement with analysis through the comparison of between analytical and experimental results

• Genomics & Informatics
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• v.21 no.3
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• pp.28.1-28.13
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• 2023

Mild cognitive impairment (MCI) is a clinical syndrome characterized by the onset and evolution of cognitive impairments, often considered a transitional stage to Alzheimer's disease (AD). The genetic traits of MCI patients who experience a rapid progression to AD can enhance early diagnosis capabilities and facilitate drug discovery for AD. While a genome-wide association study (GWAS) is a standard tool for identifying single nucleotide polymorphisms (SNPs) related to a disease, it fails to detect SNPs with small effect sizes due to stringent control for multiple testing. Additionally, the method does not consider the group structures of SNPs, such as genes or linkage disequilibrium blocks, which can provide valuable insights into the genetic architecture. To address the limitations, we propose a Bayesian bi-level variable selection method that detects SNPs associated with time of conversion from MCI to AD. Our approach integrates group inclusion indicators into an accelerated failure time model to identify important SNP groups. Additionally, we employ data augmentation techniques to impute censored time values using a predictive posterior. We adapt Dirichlet-Laplace shrinkage priors to incorporate the group structure for SNP-level variable selection. In the simulation study, our method outperformed other competing methods regarding variable selection. The analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) data revealed several genes directly or indirectly related to AD, whereas a classical GWAS did not identify any significant SNPs.

• Geosciences Journal
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• v.22 no.6
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• pp.871-880
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• 2018

During and shortly after the 2017 Pohang Earthquake ($M_w$ 5.4), sand blows were observed around the epicenter for the first time since the beginning of instrumental seismic recording in South Korea. We carried out field surveys plus satellite and drone imagery analyses, resulting in observation of approximately 600 sand blows on Quaternary sediment cover in this area. Most were observed within 3 km of the epicenter, with the farthest being 15 km away. In order to investigate the ground's susceptibility to liquefaction, we conducted a trench study of a 30 m-long sand blow in a rice field 1 km from the earthquake epicenter. The physical characteristics of the liquified sediments (grain size, impermeable barriers, saturation, and low overburden pressure) closely matched the optimum ground conditions for liquefaction. Additionally, we found a series of soft sediment deformation structures (SSDSs) within the trench walls, such as load structures and water-escaped structures. The latter were vertically connected to sand blows on the surface, reflecting seismogenic liquefaction involving subsurface deformation during sand blow formation. This genetic linkage suggests that SSDS research would be useful for identifying prehistoric damage-inducing earthquakes ($M_w$ > 5.0) in South Korea because SSDSs have a lower formation threshold and higher preservational potential than geomorphic markers formed by surface ruptures. Thus, future combined studies of Quaternary surface faults and SSDSs are required to provide reliable paleoseismological information in Korea.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.10a
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• pp.686-686
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• 2013

Automotive turbochargers have become common in gasoline engines as well as diesel engines. They are excellent devices to effectively increase fuel efficiency and power of the engines, but they unfortunately cause several noise problems. The noises are classified into mechanical noises induced from movement of a rotating shaft and aerodynamic noises by air flow in turbochargers. In addition to, there is a mechanical noise caused from movement of an actuator, electronically controlling a wastegate valve. It is called as valve rattle noise. The actuator is connected to a valve through a linkage. The noise occurs only if the valve is open, where the linkage is freely contact to neighbor structures without being constrained by any external forces. This condition allows impacts by the pulsation of exhaust gas, and the vibration from the impacts spreads out through turbine housing, causing the rattle noise. The noise is not in mechanical operating wastegate turbochargers because the linkage of an actuator is strongly connected by actuating force. For the electronic wastegate turbocharger, this paper proposed a test device to show the noise generating mechanism with a small vibration motor having an unbalanced shaft. It also shows how to reduce the noise - reduction of linkage clearances, inserting wave washers into a connection, and applying loose fitting in bushing embracing a valve lever to turbine housing.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.48 no.8
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• pp.598-604
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• 1999

This paper describes the research to minimize the film stress and maximize the aspect ratio of photoresist structure, especially about SU-8 for electroplating mold. UV LIGA process using SU-8 allows fabricating high aspect ratio polymer structures. However, it is hard to get fine patterns in the high aspect ratio structures because of high internal stress and difficulty of removing SU-8. The purpose of this paper is to setup the process condition for the obtainment of both low film stress and high aspect ratio and to find design rules that make the pattern be less dependent on stress problem. Firstly, the process of heat treatment and exposure of SU-8 are proposed. These two conditions control the amount of cross-linkage in polymer structure, which is the most important parameter of both pattern generation and remaining stress. Heat treatment is dealed with soft bake and post-exposure-bake. Temperature and time duration of each step are varied with heat treatment condition. Some test patterns are fabricated to evaluate the proposed process. Nickel electroplating is performed with the mold fabricated through the proposed process to confirm the SU-8 as a good electroplating mold.

• Wind and Structures
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• v.19 no.3
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• pp.233-247
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• 2014

Vortex-induced oscillation is a type of aeroelastic phenomenon, to which extended structures such as long-span bridges are most susceptible. The vortex-induced vibration (VIV) behaviors of a concerned bridge were investigated conventionally in virtue of wind tunnel tests on string-mounted sectional models. This necessitates the building of a linkage between the response of the sectional model and that of the prototype structure. Although many released literatures have related to this issue and provided suggestions, there is a lack of consistency among them. In this study, some theoretical models describing the vortex-induced structural motion, including the linear empirical model, the nonlinear empirical model and the modified (or generalized) nonlinear empirical model, are firstly reviewed. Then, the concept of equivalent mass density is introduced based on the principle that an equal input of energy should result in identical structural amplitudes. Based on these, the theoretical linkages between the amplitude of a section model and that corresponding to the prototype bridge are discussed with different analytical models. Theoretical derivation indicates that such connections are dependent mainly on two factors, one is the presupposed shape of deformation, and the other is the theoretical VIV model employed. The theoretical analysis in this study shows that, in comparison to the nonlinear empirical models, the linear one can result in obvious larger estimations of the full bridges' responses, especially in cases of cable-stayed bridges.

• Bulletin of the Korean Chemical Society
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• v.23 no.12
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• pp.1778-1784
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• 2002

Novel membrane lipids containing the unusual very long chain fatty $acid{\alpha}{\omega}-1316-dimethyloctacosanedioate$, dimethyl. Ester (DME C30) was isolated and purified from thermophilic anaerobic eubacterium, Thermoanaerobacter ethanolicus. Structures of the lipids containing the bifunctional fatty acyl components were proposed by various analyses such as $^1H,\;^{13}C,\;^{31}P$ nuclear magnetic resonance (NMR), Fourier transform infrared(FTIR) spectroscopy, gas chromatography/mass spectrometry (GC/MS) and fast atom bombardment mass spectrometry (FAB/MS). Combined with the GC/MS, $^1H,\;and\;^{13}C$NMR data, we confirmed that the head groups of the lipids contained the glycerol and/or glucosamine molecules. $^{31}P$ NMR spectrum also showed that the lipids contained phosphate in a phosphodiester linkage. The proposed structures of these novel lipid components were the ones in which two head groups were linked by the membrane spanning fatty acyl component(DME C30)and regular chain fatty acids on glycerol moiety of each head group.

• Structural Engineering and Mechanics
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• v.65 no.3
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• pp.291-302
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• 2018

Rigid body spring method (RBSM) is an effective tool to simulate the cracking process of structures, and has been successfully applied to investigate the behavior of reinforced concrete (RC) members. However, the theoretical researches and engineering applications of this method mainly focus on two-dimensional problems as yet, which greatly limits its applications in actual engineering projects. In this study, a three-dimensional (3-D) RBSM for RC structures is proposed. In the proposed model, concrete, reinforcing steels, and their interfaces are represented as discrete entities. Concrete is partitioned into a collection of rigid blocks and a uniform distribution of normal and tangential springs is defined along their boundaries to reflect its material properties. Reinforcement is modeled as a series of bar elements which can be freely positioned in the structural domain and irrespective of the mesh geometry of concrete. The bond-slip characteristics between reinforcing steel and concrete are also considered by introducing special linkage elements. The applicability and effectiveness of the proposed method is firstly confirmed by an elastic T-shape beam, and then it is applied to analyze the failure processes of a Z-type component under direct shear loading and a RC beam under two-point loading.

• Proceedings of the KIEE Conference
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• 1996.07a
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• pp.358-360
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• 1996

LPM(Linear pulse motor) has made linear motions by itself. And the LPM has higher thrust force ratio to mass and more wide driving speed lunges comparing with the conventional rotating type motors. However, there are the thrust force ripples in the LPM, which are produced by the mechanical structures and nonlinear back emf. It makes to hesitate the practical applications of LPM. Especially, it becomes needed to reduce the thrust force ripples for practical, which needs relative low driving speeds. For reducing the thrust force ripples, in the first place, it was built a new nonlinear linkage flux equations of the LPM. In these equations, the influence of permanent magnetic and variable reluctance thrust force components were considered. In this paper, some experimental results in the modeling of LPM are shown and detent lone and holding force characteristics of LPM are measured.