• 한국가구학회지
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• 제27권3호
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• pp.237-245
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• 2016

Single households currently account for 26.5% of all households and their number is expected to continue to rise, reaching 34.5% by 2035. An analysis of the consumption trends and needs of single households shows that they are rising as a new consumer group with a focus on investment on the individual and favouring: small but high-tech products: efficient use of limited resources: safety and peace of mind: self-improvement and leisure. Products which meet such demands are having an impact on the growth of home-furnishing market. An analysis of companies in Korea's home-furnishing market, with examples like the lifestyle company IKEA, shows a variety of brands such as SPA brand, furniture specialist, distributor and character products. And yet most are OEM products which lack differentiated product lines and compete with similar display and distribution structure. We needs the Single household consumption tendency of home-furnishing market and differentiation strategy through product analysis. In order to increase the value of companies in the home-furnishing market, in addition to differentiated design, product competitiveness must aspire to higher customer satisfaction with easy assembly, innovation in logistics, innovative sales methods such as virtual-reality simulation for products and space, individually-tailored furniture for the needs of single household and products which combine smart technology. For home-grown home-furnishing brands to have competitiveness, they must leverage on the strengths of the industry, offering differentiated and competitive products in a wider range of areas with convergence functions as well as differentiation in consumer interface and application of advancing technology; in-depth product research is called for.

• 공업화학
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• 제28권3호
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• pp.351-354
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• 2017

역미셀법을 이용하여 열적 안정성이 우수한 감마-알루미나의 합성 공정을 최적화하기 위하여 실험계획법을 사용하였다. 먼저 합성공정에 주 요소인 계면활성제, 물 및 오일의 비에 대한 최적의 실험조건을 설계하기 위하여 혼합물 실험법을 이용하여 12가지 실험조건을 도출하였다. 설계된 조건에서 역미셀법을 이용하여 합성한 입자를 $900^{\circ}C$에서 소성한 결과 입자의 크기에 차이는 있었지만 모두 감마-알루미나 결정구조를 가졌다. 도출된 실험결과를 이용하여 계산된 2차 회귀모델의 결정계수는 93.68%이었으며, P- 값이 0.002로서 유의하다고 할 수 있다. 다양한 입자크기를 가지는 감마-알루미나의 합성조건을 모든 범위에서 대하여 표면도와 등고선도를 이용하여 제시하였다. 그 결과 Surfactant/Water/Oil의 질량비가 0.3450/0.0729/0.5821인 조건에서 합성할 때 약 2.8 nm의 가장 작은 입자가 합성되는 것으로 계산되었다.

• 천문학논총
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• 제27권4호
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• pp.219-220
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• 2012

We present the results of far-infrared spectroscopic observations of the Large Magellanic Cloud (LMC) with FIS-FTS. We covered a large area across the LMC, including 30 Doradus (30 Dor) and N44 star-forming regions, by 191 pointings in total. As a result, we detect the [OIII] and [CII] line emission as well as far-infrared dust continuum emission throughout the LMC. We find that the [OIII] emission is widely distributed around 30 Dor. The observed size of the distribution is too large to be explained by massive stars in 30 Dor, which are assumed to be enshrouded by clouds with the constant gas density estimated from the [OIII] line intensities. Therefore the surrounding structure is likely to be highly clumpy. We also find a global correlation between the [OIII] and the far-infrared continuum emission, suggesting that the gas and dust are well mixed in the highly-ionized region where the dust survives in clumpy dense clouds shielded from energetic photons. Furthermore we find that the ratios of [CII]/CO are as high as 110,000 in 30 Dor, and 45,000 even on average, while they are typically 6,000 for star-forming regions in our Galaxy. The unusually high [CII]/CO is also consistent with the picture of clumpy small dense clouds.

• Biomolecules & Therapeutics
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• 제30권5호
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• pp.455-464
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• 2022

Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential inhibitor of c-Jun N-terminal kinase 3 (JNK3). Although its antihypertensive effect is widely known, the role of efonidipine in the central nervous system has remained elusive. The present study investigated the effects of efonidipine on the inflammation and cell migration induced by lipopolysaccharide (LPS) using murine BV2 and human HMC3 microglial cell lines and elucidated signaling molecules mediating its effects. We found that the phosphorylations of JNK and its downstream molecule c-Jun in LPS-treated BV2 cells were declined by efonidipine, confirming the finding from virtual screening. In addition, efonidipine inhibited the LPS-induced production of pro-inflammatory factors, including interleukin-1β (IL-1β) and nitric oxide. Similarly, the IL-1β production in LPS-treated HMC3 cells was also inhibited by efonidipine. Efonidipine markedly impeded cell migration stimulated by LPS in both cells. Furthermore, it inhibited the phosphorylation of inhibitor kappa B, thereby suppressing nuclear translocation of nuclear factor-κB (NF-κB) in LPS-treated BV2 cells. Taken together, efonidipine exerts anti-inflammatory and anti-migratory effects in LPS-treated microglial cells through inhibition of the JNK/NF-κB pathway. These findings imply that efonidipine may be a potential candidate for drug repositioning, with beneficial impacts on brain disorders associated with neuroinflammation.

• KEPCO Journal on Electric Power and Energy
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• 제3권2호
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• pp.99-105
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• 2017

기존의 송전탑 좌표 측정방식은 송전탑 지상중심에서 GPS를 이용하여 좌표를 측정하고 일반적으로 측정시간은 수십 분 정도 소요되었다. 그러나 이러한 방법은 종종 거대한 철골구조물인 송전탑 간섭으로 인해 수십 미터의 좌표 오차를 발생하거나 수 시간씩 측정시간이 소요되기도 한다. 이러한 문제점을 해결하기 위해 본 논문에서는 송전탑의 새로운 GPS 측정 방법을 제안한다. 먼저, 송전탑의 중앙을 측정하던 방법 대신, 3개의 GPS로 구성된 측정장치를 이용하여 송전탑 가장자리 4 지점의 GPS 좌표를 측정하고 그 값들을 평균하여 송전탑의 중앙을 구한다. 측정된 값이 전파간섭에 의해 상당히 벗어난 경우, 새롭게 제시하는 알고리즘이 부정확한 좌표를 걸러내고 다른 가장자리 좌표로 대체하여 송전탑의 중심을 효과적으로 계산할 수 있다. 현장 측정시험을 통해 본 논문에서 제시하는 새로운 알고리즘은 전파간섭 환경에서 송전탑 측정의 효율성과 정확도를 향상시킬 수 있다.

• 한국전자통신학회논문지
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• 제9권2호
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• pp.243-248
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• 2014

영구자석 선형 동기 전동기는 회전기기에 비해 구조적으로 간단하여 보수 점검이 용이하고 정밀, 고속, 고추력화 등의 많은 장점을 가지고 있다. 하지만 반송경로 전장에 전기자를 설치해야 하는 구조적 특성으로 인해 반송경로가 길어지면 길어질수록 초기 설치비용이 상승하게 된다. 이러한 문제점을 해결하기 위해 전기자를 분산시켜 배치하는 방식을 제시하였으나 전기자를 분산시켜 배치할 경우 전기자 양 끝단에는 구조상 반드시 단부가 존재하게 되며 이러한 단부는 추력 맥동을 야기하는 코깅력을 크게 발생시켜 기기의 소음과 진동 및 기기의 성능 저하의 원인이 된다. 따라서 본 연구에서는 기기의 운전특성을 향상시키기 위해 전기자의 스큐에 따른 단부특성을 3D FEM 수치해석을 이용하여 파악하고 단부 코깅력을 가장 저감시키는 전기자 스큐를 제안하고자 한다.

• Steel and Composite Structures
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• 제1권1호
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• pp.17-32
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• 2001

The Rosette-joining system is a completely new press-joining method for cold-formed steel structures. One Rosette-joint has a shear capacity equal to that of approximately four screws or rivets. The Rosette thin-walled steel truss system presents a new fully integrated prefabricated alternative to light-weight roof truss structures. The trusses are built up on special industrial production lines from modified top hat sections used as top and bottom chords and channel sections used as webs which are joined together with the Rosette press-joining technique to form a completed structure easy to transport and install. A single web section is used when sufficient but can be strengthened by double-nesting two separate sections or by using two lateral profiles where greater compressive axial forces are met. An individual joint in the truss can be strengthened by introducing a hollow bolt into the joint hole. The bolt gives the connection capacity a boost of approximately 20%. A series of laboratory tests have been carried out in order to verify the Rosette truss system in practice. In addition to compression tests on individual sections of different lengths, tests have also been done on small structural assemblies and on actual full-scale trusses of a span of 10 metres. Design calculations have been performed on selected roof truss geometries based on the test results, FE-analysis and on the Eurocode 3 and U.S.(AISI) design codes.

• 한국광학회지
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• 제19권1호
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• pp.73-79
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• 2008

금속선 도파로 면과 금속 평면이 수직으로 적층된 장거리 표면-플라즈몬 도파로 구조를 제안하였으며, 표면-플라즈몬 모드의 특성을 유전체의 굴절율과 두께 변화에 대하여 이론적으로 분석하고 실험적으로 검증하였다. 위층의 금속선 도파로를 S-곡선과 Y-분기 형태로 변형시킨 이중-금속 도파로를 제작하여, 제안된 이중-금속 도파로 구조의 광 소자 응용 가능성을 살펴보았다. 제안된 이중금속 구조에서는 도파로 코어에 해당하는 두 금속 박막 사이의 유전체 굴절률을 임의로 선택하여도 장거리 표면 플라즈몬 모드가 존재할 수 있으며, 표면-플라즈몬 모드의 전파거리는 두 금속 박막 사이의 유전체 두께를 조절함으로써 증가시킬 수 있다. 또한, 이중-금속 도파로는 표면-플라즈몬을 전달할 뿐만 아니라, 삽입된 코어 유전체에 전압 및 전류를 인가하기에도 매우 적합한 구조로서, 표면-플라즈몬 능동소자 및 비선형 소자 구현에 많은 가능성을 열어줄 것으로 기대된다.

• Journal of Ginseng Research
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• 제44권2호
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• pp.215-221
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• 2020

Background: Panax ginseng has been used for a variety of medical purposes in eastern countries for more than two thousand years. From the extensive experiences accumulated in its long medication use history and the substantial strong evidence in modern research studies, we know that ginseng has various pharmacological activities, such as antitumor, antidiabetic, antioxidant, and cardiovascular system-protective effects. The active chemical constituents of ginseng, ginsenosides, are rich in structural diversity and exhibit a wide range of biological activities. Methods: Ginsenoside constituents from P. ginseng flower buds were isolated and purified by various chromatographic methods, and their structures were identified by spectroscopic analysis and comparison with the reported data. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide method was used to test their cytotoxic effects on three human cancer cell lines. Results: Six ginsenosides, namely 6'-malonyl formyl ginsenoside F₁ (1), 3β-acetoxyl ginsenoside F₁ (2), ginsenoside Rh₂₄ (6), ginsenoside Rh₂₅ (7), 7β-hydroxyl ginsenoside Rd (8) and ginsenoside Rh₂₆ (10) were isolated and elucidated as new compounds, together with four known compounds (3-5 and 9). In addition, the cytotoxicity of these isolated compounds was shown as half inhibitory concentration values, a tentative structure-activity relationship was also discussed based on the results of our bioassay. Conclusion: The study of chemical constituents was useful for the quality control of P. ginseng flower buds. The study on antitumor activities showed that new Compound 1 exhibited moderate cytotoxic activities against HL-60, MGC80-3 and Hep-G2 with half inhibitory concentration values of 16.74, 29.51 and 20.48 μM, respectively.

• 한국철도학회논문집
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• 제11권6호
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• pp.550-561
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• 2008

본 연구에서는 도시권역의 대중교통수단과는 여러 가지 측면에서 차별화 되는 지역 간 철도의 특징을 반영한 대중교통 통행배정모형을 제시하였다. 경로구간 기반으로 대중교통 네트워크를 확장하고, 경로구간을 운행하는 노선의 선택확률을 통행배정모형 내에서 결정하는 것이 아닌 외부적으로 결정하는 방식을 적용하여, 직접 네트워크를 확장하는 방법보다 네트워크 확장 규모를 줄일 수 있었다. 지역간 철도의 특징을 반영할 수 있도록 적정한 가정을 통해서 경로구간 기반의 결정적 대중교통 통행배정모형과 해법을 제시하였다. 현실을 최대한 반영한 소규모 네트워크에서 기존의 대표적인 대중교통 통행배정모형과 비교한 결과 본 연구에서 제시한 모형의 예측력이 우수한 것으로 분석되었다.