• Bulletin of the Korean Chemical Society
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• 제32권10호
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• pp.3566-3570
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• 2011

A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2':6',2"-terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2"-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2002년도 춘계 기술심포지움 논문집
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• pp.69-73
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• 2002

In ceramic systems, many components including embedded passives and TRL(transmission line) are used for composition of 3-dimensional circuit. So the exact analysis on this components, As for the TRL's, material properties including electrical conductivity of metal, loss factor and effective dielectric constant of dielectric material and geometrical factors like roughness of surface, vias, dimension of stripline structure have a large effect on the charactersistics of transmission lines. In this research, of effect of material and geometrical factors on the characteristics of stripline structure is analyzed and quantified by simulation and measurement.

• 한국실내디자인학회논문집
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• 제25권4호
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• pp.35-42
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• 2016

The purpose of this study is the analyze the spatial structure and housing component of the prairie style house of Frank Lloyd Wright during the Prairie Era which is between 1893-1910. The research results can be summarized as follows 1) In spite of European style influences which were fashionable at the time, Wright tried to attempt altering the space and form of his works (houses) from his unique architectural style. 2) All solid walls which are usually inside the square prairie and the cross floor plans were removed for interaction between the outside and inside spaces in a house creating an organic space. So the inside space of the house feels wider than the original space because of the available natural light. 3) Frank Lloyd Wright's early works were similar to the homes built at that time. However, as time passed, he remembered and was influenced by the Frobel's educational system blocks he played with as a child as well as the surrounding Midwestern USA prairies where he grew up. 4) The early prairie floor plan was square divided into nine equal parts which is classic floor planning. Wright, however, created his new unique architectural style. His style has developed into the prairie style and various floor plans. 5) Wright introduced a 3-dimensional architectural form of composition (cantilever, long eaves, etc.) to express symmetry and horizontal lines of the house. 6) Rather than emphasizing vertical lines in his works, Wright began emphasizing more horizontal lines like the horizontal lines of the actual prairies. This meant the surrounding environment of a house is always in nature.

• 한국전자파학회논문지
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• 제26권5호
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• pp.463-470
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• 2015

본 논문은 SIR 구조의 피드라인과 공진기를 이용한 새로운 구조의 마이크로스트립 이중대역 대역통과여파기(BPF)를 제안한다. SIR 구조의 피드라인을 이용하여 이중대역 BPF의 두 통과대역 각각에서 입력과 출력 피드라인의 자기장 최대 지점을 서로 일치시켜 공진기와 피드라인 사이의 결합을 최대화하여 여파기 손실을 감소시켰다. 또한, 이중대역 BPF의 제1통과대역 공진기에도 SIR 구조를 적용하여 1) 두 통과대역 사이의 저지대역 특성을 개선시키고, 2) 제2통과대역 공진기와의 결합을 최소화시켜 공진기 간격을 감소시켜 소형화에 기여하였다. 이렇게 하여 이중대역 BPF 통과대역의 중심주파수와 대역폭을 독립적으로 변경시키는 것은 물론, 필터링 성능을 개선하였다. WLAN 규격을 만족하는 이중대역 BPF를 제작하고, 측정 결과와 비교하여 제안한 여파기 설계 방법이 유용하다는 것을 입증하였다.

• 한국전자통신학회논문지
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• 제17권3호
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• pp.459-466
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• 2022

개폐서지는 전력시스템에서 발생하는 과전압 현상 중의 하나이며 변전소의 차단기 등 개폐장치의 동작이나 송전선로의 고장으로 인해 발생한다. 특히 송전선로의 절연설계를 위하여 개폐서지의 피크를 산정하는 것은 매우 중요하고 AC/DC 병가선로의 안정적인 운영을 위한 절연협조의 기본적인 검토항목이다. 본 논문에서는 새로운 AC/DC 병가구조의 전력시스템에 대한 상정해석을 위하여 AC 765kV와 DC ±500kV Bi-Pole 시스템이 조합된 송전선로를 대상으로 하였다. 일반적으로 교류 송전시스템의 절연설계를 위한 비정상적인 과전압은 외부과전압으로 낙뢰에 의한 과전압과 내부과전압으로 개폐에 의한 과전압을 고려한다. 직류 송전시스템의 경우에는 개폐에 의한 과전압 보다 송전선로의 중간에서 지락고장이 발생하면 인접한 정상선로에 유기되는 내부과전압을 개폐서지라하며 직류송전선로에 유기되는 가장 큰 일시적인 과전압을 의미한다. 본 논문의 연구목적으로 구성된 선로에 대하여 EMTDC 소프트웨어를 사용하여 모의하였으며, 다양한 AC/DC 혼합 형태에 대한 개폐과전압의 영향을 검토하였다.

• Journal of Astronomy and Space Sciences
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• 제32권1호
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• pp.73-80
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• 2015

The Yang-gyeong-gyu-il-ui (兩景揆日儀) is a kind of elevation sundial using three wooden plates. Sang-hyeok Lee (李尙爀, 1810~?) and Byeong-cheol Nam (南秉哲, 1817~1863) gave descriptions of this sundial and explained how to use it in their Gyu-il-go (揆日考) and Ui-gi-jip-seol (儀器輯說), respectively. According to Gyu-il-go (揆日考) there are two horizontal plates and two vertical plates that have lines of season and time. Subseasonal (節候) lines are engraved between seasonal (節氣) lines, subdividing the interval into three equal lines of Cho-hu (初候, early subseason), Jung-hu (中候, mid subseason) and Mal-hu (末候, late subseason); there are 13 seasonal lines for a year, thus resulting in 37 subseasonal lines; also, there are 12 double-hour (時辰) lines for a day engraved on these plates. The only remaining artifact of Yang-gyeong-gyu-il-ui was made in 1849 (the $15^{th}$ year of Heon-jong) and is kept at the Korea University Museum. We have compared and analyzed Yang-gyeong-gyu-il-ui and similar western sundials. Also, we have reviewed the scientific aspect of this artifact and built a replica. Yang-gyeong-gyu-il-ui is a new model enhanced from the miniaturization development in the early Joseon Dynasty and can be applied to the southern part of the tropic line through a structure change.

• 한국작물학회지
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• 제39권1호
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• pp.63-72
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• 1994

보리의 이용성을 검토하기 위하여, 찰성 부정형 Shrunken endosperm 유전자를 결합하여 육성한 Isogenic line을 이용하여, 취반 및 제분에 대한 제특성을 조사한 바 그 결과를 요약하면 다음과 같다. 1. 보리의 배유 전분 특성이 다른 Isogenic type 간에 정곡 천립중, 회분, 단백질 함량은 별차이가 없었으나 Amylose함량, $\beta$-glucan viscosity와 취반특성은 뚜렷한 차이를 보였다. 2. 취반특성중 흡수율과 퍼짐성은 천립중, Amylose 함량과 부의 상관이 있었고, 용출고형물량과 점도간에도 부의 상관이 있었다. 3, 흡수율과 퍼짐성은 배유 전분 특성과 입의 크기에 의해 영향을 받았으며 그 결과 찰성 Isogenic type이 높았고 부정형 전분 Isogenic type이 가장 낮았으며 종실의 크기가 작은 것이 큰 것에 비해 높았다. 4. 보리밥의 Mixogram pattern은 전분 특성에 따라 차이가 있었으며 부정형 전분이 가장 많이 으깨어졌다. 5. 제분 특성은 메성이면서 부정형인 Isogenic type이 좋았고 찰성의 Shrunken endosperm Isogenic type은 대단히 불량하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제17권6호
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• pp.517-523
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• 2013

Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These compounds have been investigated as potential anticancer agents, and several compounds are now part of clinical trials. A series of naphthyridine derivatives were evaluated for their in vitro cytotoxic activities against human cervical cancer (HeLa), leukemia (HL-60), and prostate cancer (PC-3) cell lines using an MTT assay. Some compounds (14, 15, and 16) were more potent than colchicine against all three human cancer cell lines and compound (16) demonstrated potency with $IC_{50}$ values of 0.7, 0.1, and $5.1{\mu}M$, respectively. Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used for quantitative structure-activity relationship (QSAR) molecular modeling of these compounds. We obtained accurate and predictive three-dimensional QSAR (3D-QSAR) models as indicated by the high PLS parameters of the HeLa ($q^2$, 0.857; $r^2$, 0.984; $r^2\;_{pred}$, 0.966), HL-60 ($q^2$, 0.777; $q^2$, 0.937; $r^2\;_{pred}$, 0.913), and PC-3 ($q^2$, 0.702; $q^2$, 0.983; $r^2\;_{pred}$, 0.974) cell lines. The 3D-QSAR contour maps suggested that the C-1 NH and C-4 carbonyl group of the naphthyridine ring and the C-2 naphthyl ring were important for cytotoxicity in all three human cancer cell lines.

• Journal of Electrical Engineering and Technology
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• 제6권6호
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• pp.760-768
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• 2011

The performance of transmission lines and its shielding design during a lightning phenomenon are quite essential in the maintenance of a reliable power supply to consumers. The leader progression model, as an advanced approach, has been recently developed to calculate the shielding failure rate (SFR) of transmission lines using geometrical data and physical behavior of upward and downward lightning leaders. However, such method is quite time consuming. In the present paper, an effective method that utilizes artificial neural networks (ANNs) to create a metamodel for calculating the SFR of a transmission line based on shielding angle and height is introduced. The results of investigations on a real case study reveal that, through proper selection of an ANN structure and good training, the ANN prediction is very close to the result of the detailed simulation, whereas the Processing time is by far lower than that of the detailed model.

• 한국전기전자재료학회논문지
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• 제15권6호
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• pp.529-534
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• 2002

Recently, As the higher frequency in clock of digital system being demanded and the density of circuits gets high for purpose of making light and minimizing system, the study for solution of digital signal distortion being interested. In this paper, the distortion of square pulse caused by dispersion as it propagates along a single microstrip line and crosstalk between lines on the Multi-Transmission Lines (MTL) is investigated. The dispersion and crosstalk of pulse signals is analyzed regarding to the structure of transmission line such as relative permittivity, substrate height, strip width of the microstrip line and pulse width of signal pulse.