• 대한기계학회논문집A
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• 제21권3호
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• pp.511-518
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• 1997

The technique of fretting fatigue test was developed and fretting fatigue tests of A12024-T4 were conducted under several conditions. The newly developed calibration methods for measuring surface contact tractions showed good linearity and repeatability. The plate type specimen to which tow bridge type pads were attached and vision system was used to observe the crack behaviour. The oblieque cracks appeared in the early stage of crack growth and they became mode I cracks as they grow about 1 mm. The mode I transition points were found to be longer when surface tractions are higher or bulk stress is lower. Before the crack becomes mode I crack, 'well point' where crack grow about rate is minimum, was detected under every experimental condition. The crack behaviour was found to be affected by surface tractions, contact area, bulk stress. It was also found that partial slip and stick condition is most detrimental and the crack starts from the boundary of stick and slip. For gross slip crack started at the outside edge of pad. After crack mode transition, fretting fatigue cracks showed almost same behaviour of plain mode I fatigue cracks. Equivalent stress intensity factor was used to analyze the behaviour of fretting fatigue cracks and it was found that stress intensity factors can be applied to fretting fatigue cracks.

• 한국방사선학회논문지
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• 제12권5호
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• pp.575-582
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• 2018

PET와 PET/CT의 검사 영상품질관리를 위해서는 F-18 방사능측정기의 정도관리가 필요하다. Ge-68/Ga-68 Rod Sources을 선원을 이용하여 의료기관에서 사용하고 있는 5종류의 방사능측정기의 방사능 측정의 정확도와 정밀도를 확인하였다. CRC-15R, CRC-15 PET, CRC-712M, CRC-15 베타 및 CRC-25PET에 대한 측정값과 기준값 사이의 방사능 양에 따른 상관관계는 0.99999 (P <0.0001)로 매우 높은 선형성을 보였다. 정확도 테스트에서 CRC-15R, CRC-15 PET, CRC-712M, CRC-15 베타 및 CRC-25PET 모델은 각각 -3.232 %, -1.342 %, -2.815 %, -2.913 % 및 -3.089 %를 이었다. 국내와 국제기준인 정확도 ${\pm}10%$, 정밀도 ${\pm}5%$ 이내로 기준을 만족하였고 반감기가 짧은 F-18에 비하여 경제성 있고 비교적 긴 기간 동안 안정적으로 정도관리가 가능하다는 것을 확인하였다.

• 생약학회지
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• 제45권4호
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• pp.300-314
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• 2014

An ultra-performance liquid chromatography-electrospray ionization-mass spectrometer (UPLC-ESI-MS) method was established for the simultaneous quantification of eighteen marker compounds in traditional Korean formula, Cheonwangbosimdan (CWBSD). In addition, we evaluated the antioxidant effects of CWBSD. Eighteen marker components were separated on a UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}m$) and kept at $45^{\circ}C$ by gradient elution with 0.1% (v/v) formic acid in water and acetonitrile as mobile phase. The flow rate was 0.3 mL/min and the injection volume was $2.0{\mu}L$. The antioxidant activities of CWBSD were assessed by measuring free radical scavenging activities on 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 1-1-diphenyl-2-picrylhydrazyl (DPPH). The calibration curves of all analytes showed good linearity (correlation coefficient ${\geq}0.9937$) within the test ranges. The limits of detection and quantification for the 18 marker compounds were 0.01-4.71 ng/mL and 0.03-14.13 ng/mL, respectively. The contents of the 18 compounds in CWBSD extract ranged from none to $1701.00{\mu}g/g$. The CWBSD showed the radical scavenging activity in a dose-dependent manner. The concentration required for 50% reduction ($RC_{50}$) against ABTS and DPPH radicals were $149.42{\mu}g/mL$ and $339.24{\mu}g/mL$.

• 제어로봇시스템학회논문지
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• 제6권2호
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• pp.207-216
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• 2000

This paper introduces an effective system design method to develop a customer oriented product using a design optimization process and to select a set of critical design paramenters,. The process results in the development of a successful product satisfying customer needs and reducing development risk. The proposed scheme adopted a five step QFD(Quality Function Deployment) in order to extract design parameters from customer needs and evaluated their priority using risk factors for extracted design parameters. In this process we determine critical design parameters and allocate them to subsystem designers. Subsequently design engineers develop and test the product based on these parameters. These design parameters capture the characteristics of customer needs in terms of performance cost and schedule in the process of QFD, The subsequent risk management task ensures the minimum risk approach in the presence of design parameter uncertainty. An application of this approach was demonstrated in the development of weld quality monitoring system. Dominant design parameters affect linearity characteristics of weld defect feature vectors. Therefore it simplifies the algorithm for adopting pattern classification of feature vectors and improves the accuracy of recognition rate of weld defect and the real time response of the defect detection in the performance. Additionally the development cost decreases by using DSP board for low speed because of reducing CPU's load adopting algorithm in classifying weld defects. It also reduces the cost by using the single sensor to measure weld defects. Furthermore the synergy effect derived from the critical design parameters improves the detection rate of weld defects by 15% when compared with the implementation using the non-critical design parameters. It also result in 30% saving in development cost./ The overall results are close to 95% customer level showing the effectiveness of the proposed development approach.

• 대한기계학회논문집A
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• 제28권1호
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• pp.1-10
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• 2004

This paper presents a navigation garde capacitive microaccelerometer, whose low-noise high-resolution detection capability is achieved by a new electrode design based on a high-amplitude anti-phase sense voltage. We reduce the mechanical noise of the microaccelerometer to the level of 5.5$\mu\textrm{g}$/(equation omitted) by increasing the proof-mass based on deep RIE process of an SOI wafer. We reduce the electrical noise as low as 0.6$\mu\textrm{g}$/(equation omitted) by using an anti-phase high-amplitude square-wave sense voltage of 19V. The nonlinearity problem caused by the high-amplitude sense voltage is solved by a new electrode design of branched finger type. Combined use of the branched finger electrode and high-amplitude sense voltage generates self force-balancing effects, resulting in an 140％ increase of the bandwidth from 726㎐ to 1,734㎐. For a fixed sense voltage of 10V, the total noise is measured as 2.6$\mu\textrm{g}$/(equation omitted) at the air pressure of 3.9torr, which is the 51％ of the total noise of 5.1$\mu\textrm{g}$/(equation omitted) at the atmospheric pressure. From the excitation test using 1g, 10㎐ sinusoidal acceleration, the signal-to-noise ratio of the fabricated microaccelerometer is measured as 105㏈, which is equivalent to the noise level of 5.7$\mu\textrm{g}$/(equation omitted). The sensitivity and linearity of the branched finger capacitive microaccelerometer are measured as 0.638V/g and 0.044％, respectively.

• 대한기계학회논문집B
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• 제40권9호
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• pp.613-620
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• 2016

유체의 전도율(conductivity)이 전자기유량계의 특성에 미치는 영향을 평가하기 위해 소형 전자기 유량계를 설계 제작하였다. 유량계의 측정관(measuring tube)은 $4mm{\times}3mm$의 직사각형 단면을 가지며 길이는 9 mm이다. 전극은 직경이 1.5 mm인 점전극과 단면이 $2mm{\times}3mm$인 면전극으로 설계하였다. 코일의 열 발생에 영향을 미치는 자화주파수, 회전수 및 굵기를 변화시키면서 최적값을 찾았다. 최적화된 측정관은 자속밀도(magnetic flux density) 0.04 T (400 gauss)를 발생시키며 안정되고, 선형적인 유량신호를 얻을 수 있었다. 유량계를 특성을 평가하기 위해 중량식 유량계 교정 장치를 제작하였다. 유동율 범위는 최대 $1.17{\times}10^{-5}m^3/s$(700 cc/min)이며 ISO규격에 따라 유동량 결정의 불확도를 평가하였으며 크기는 0.06 % 이내이었다. 유체의 전도율은 $3-11{\mu}S/cm$ 사이에서 조절하였다.

• 생약학회지
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• 제45권1호
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• pp.84-87
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• 2014

A high performance liquid chromatography (HPLC) method for the quantitation of ellagic acid in Nymphaea tetragona was developed for the quality control of functional cosmetic ingredient, the extract of N. tetragona. Separation and quantitation were successfully achieved with a Kromasil C18 column ($5{\mu}m$, $250mm{\times}4.6mm$, i.d.) by isocratic elution of a mixture of acetonitrile containing 0.1% trifluoroacetic acid and water containing 0.03% phosphoric acid at a flow rate of 1.0 ml/min. The UV detector was used for the detection and the wavelength for quantitation was set at 254 nm. The presence of ellagic acid in the extract was determined by comparison of retention time and spiking with authentic standard. Analytical results showed good linearity ($R^2=0.99996$) in relatively wide concentration ranges. The R.S.D. for precision test was less than 3.0%. Recovery of the compound was 98.55~101.72% with R.S.D values less than 4.0%. In conclusion, this method has been successfully applied to the determination of ellagic acid in N. tetragona.

• 보건행정학회지
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• 제28권2호
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• pp.128-137
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• 2018

Background: This study aims to utilize Organization for Economic Cooperation and Development (OECD) data to identify macroscopic determinants of health at national level and to utilize it in health policy development through comparison and analysis with Korea. Methods: The potential years of life lost (PYLL) were used as dependent variables and 19 indicators were selected as health determinants to be independent variables based on the results of previous studies. Data analysis was done using SAS ver. 9.4 package (SAS Institute Inc., Cary, NC, USA) and model used in technical statistics concerning PYLL by countries, multi-linearity test between independent variables and OECD economic studies were modified and used. Results: From 1994 to 2012, the average PYLL for OECD countries was 4,262.9 years, the highest in Estonia and the lowest in Iceland. As a result of the analysis using the fixed effect model, the significant variables affecting PYLL were four variables: gross domestic product, nitric oxide, tobacco consumption, and number of doctors. The health determinants that had more influence on the PYLL of Korean people compared to other OECD countries were tobacco consumption, calorie consumption, fat intake and total health expenditure. Conclusion: In order to effectively reduce unnecessary deaths, we must continue to strengthen our smoking policy and nutrition policies such as calorie and fat intake. It is necessary to prevent the increase of total health expenditure due to the increase in the prevalence of chronic diseases and to strengthen the public health aspect.

• 분석과학
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• 제12권1호
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• pp.28-33
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• 1999

생체 시료내의 glutathione(GSH)을 monobromobimane(MBB)이나 4-fluoro-7-sulfobenzofurazan(SBD-F)으로 최적 유도체화 조건을 확립하였고 고성능 액체 크로마토그래피(HPLC)/형광 검출기(FLD)를 사용하여 정량분석 하였다. MBB로 유도체화한 경우에는 검출한계가 $0.03{\mu}g/mL$으로서 SBD-F를 사용한 경우보다 감도가 약 200배 정도 향상되었다. 이때 내부표준물질로서 N-acetylcysteine을 사용하였으며, MBB 유도체의 분리능을 개선시키기 위해 tetrabutylammonium 이온을 counter 이온으로 선택하였다. 위의 조건의 이온쌍 크로마토그래피를 이용하여 분석한 결과 $0.08{\sim}8.33{\mu}g/mL$ 농도 범위에서 상관계수가 0.998 이상으로 좋은 직선성을 보여주고 있다. 재현성을 조사한 결과 세 가지 다른 농도에서 상대 표준 편차가 5% 이내로 나타났다. 이 방법은 혈장, 조직 등의 생체 시료중 GSH의 분석법으로 적합하다는 것을 확인하였다.

• Journal of Astronomy and Space Sciences
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• 제32권2호
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• pp.145-149
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• 2015

A newly designed Tissue Equivalent Proportional Counter (TEPC) has been developed for the CubeSat mission, SIGMA (Scientific cubesat with Instruments for Global Magnetic field and rAdiation) to investigate space radiation. In order to test the performance of the TEPC, we have performed heavy ion beam experiments with the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. In space, human cells can be exposed to complex radiation sources, such as X-ray, Gamma ray, energetic electrons, protons, neutrons and heavy charged particles in a huge range of energies. These generate much a larger range of Linear Energy Transfer (LET) than on the ground and cause unexpected effects on human cells. In order to measure a large range of LET, from 0.3 to $1,000keV/{\mu}m$, we developed a compact TEPC which measures ionized particles produced by collisions between radiation sources and tissue equivalent materials in the detector. By measuring LET spectra, we can easily derive the equivalent dose from the complicated space radiation field. In this HIMAC experiment, we successfully obtained the linearity response for the TEPC with Fe 500 MeV/u and C 290 MeV/u beams and demonstrated the performance of the active radiation detector.