• Molecules and Cells
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• v.45 no.7
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• pp.444-453
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• 2022

Multivalent macromolecular interactions underlie dynamic regulation of diverse biological processes in ever-changing cellular states. These interactions often involve binding of multiple proteins to a linear lattice including intrinsically disordered proteins and the chromosomal DNA with many repeating recognition motifs. Quantitative understanding of such multivalent interactions on a linear lattice is crucial for exploring their unique regulatory potentials in the cellular processes. In this review, the distinctive molecular features of the linear lattice system are first discussed with a particular focus on the overlapping nature of potential protein binding sites within a lattice. Then, we introduce two general quantitative frameworks, combinatorial and conditional probability models, dealing with the overlap problem and relating the binding parameters to the experimentally measurable properties of the linear lattice-protein interactions. To this end, we present two specific examples where the quantitative models have been applied and further extended to provide biological insights into specific cellular processes. In the first case, the conditional probability model was extended to highlight the significant impact of nonspecific binding of transcription factors to the chromosomal DNA on gene-specific transcriptional activities. The second case presents the recently developed combinatorial models to unravel the complex organization of target protein binding sites within an intrinsically disordered region (IDR) of a nucleoporin. In particular, these models have suggested a unique function of IDRs as a molecular switch coupling distinct cellular processes. The quantitative models reviewed here are envisioned to further advance for dissection and functional studies of more complex systems including phase-separated biomolecular condensates.

• Journal of the Korean Statistical Society
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• v.27 no.4
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• pp.407-420
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• 1998

This paper is concerned with selecting covariates to be included in building linear random effects models designed to analyze clustered response normal data. It is based on a Bayesian approach, intended to propose and develop a procedure that uses probabilistic considerations for selecting premising subsets of covariates. The approach reformulates the linear random effects model in a hierarchical normal and point mass mixture model by introducing a set of latent variables that will be used to identify subset choices. The hierarchical model is flexible to easily accommodate sign constraints in the number of regression coefficients. Utilizing Gibbs sampler, the appropriate posterior probability of each subset of covariates is obtained. Thus, In this procedure, the most promising subset of covariates can be identified as that with highest posterior probability. The procedure is illustrated through a simulation study.

• The Korean Journal of Applied Statistics
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• v.15 no.1
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• pp.73-84
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• 2002

Linear regression models with inequality constraints on the coefficients are frequently used in economic models due to sign or order constraints on the coefficients. In this paper, we propose a Bayesian approach to selecting significant explanatory variables in linear regression models with inequality constraints on the coefficients. Bayesian variable selection requires computation of posterior probability of each candidate model. We propose a method which computes all the necessary posterior model probabilities simultaneously. In specific, we obtain posterior samples form the most general model via Gibbs sampling algorithm (Gelfand and Smith, 1990) and compute the posterior probabilities by using the samples. A real example is given to illustrate the method.

• Journal of the Korean Data and Information Science Society
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• v.14 no.2
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• pp.209-216
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• 2003

Contingent valuation method (CVM) is a main evaluation method of nonmarket goods for which markets either do not exist at all or do exist only incompletely; an example is environmental good. A dichotomous choice approach, the most popular type of CVM in environmental economics, employs binary discrete choice models as statistical estimation models. In this paper, we propose a semiparametric dichotomous choice CVM method using local linear model of Fan and Gijbels (1996) in which probability distribution of error term is specified parametrically but latent structural function is specified nonparametrically. The computation procedures of the proposed method are illustrated with a simple design of simulations.

• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.241-250
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• 2015

An important scientific objective of longitudinal studies involves tracking the probability of a subject having certain health condition over the course of the study. Proper definitions and estimates of disease risk tracking have important implications in the design and analysis of long-term biomedical studies and in developing guidelines for disease prevention and intervention. We study in this paper a class of rank-tracking probabilities to describe a subject's conditional probabilities of having certain health outcomes at two different time points. Linear mixed effects models are considered to estimate the tracking probabilities and their ratios of interest. We apply our methods to an epidemiological study of childhood cardiovascular risk factors.

• The Korean Journal of Applied Statistics
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• v.30 no.1
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• pp.95-102
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• 2017

Gamma generalized linear models have received less attention than Poisson and binomial generalized linear models. Therefore, many old-established statistical techniques are still used in gamma generalized linear models. In particular, existing literature and textbooks still use approximate estimates for the dispersion parameter. In this paper we study the efficiency of various dispersion parameter estimators in gamma generalized linear models and perform numerical simulations. Numerical studies show that the maximum likelihood estimator and Cox-Reid adjusted maximum likelihood estimator are recommended and that approximate estimates should be avoided in practice.

• Communications for Statistical Applications and Methods
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• v.6 no.2
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• pp.523-532
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• 1999

Generalized linear models have various applications for data arising from many kinds of statistical studies. Although the response variable is generally assumed to be generated from a wide class of probability distributions we focus on count data that are most often analyzed using binomial models for proportions or poisson models for rates. The methods and results presented here also apply to many other categorical data models in general due to the relationship between multinomial and poisson sampling. The novelty of the approach suggested here is that all conditional distribution s can be specified directly so that staraightforward Gibbs sampling is possible. The prior distribution consists of two stages. We rely on a normal nonconjugate prior at the first stage and a vague prior for hyperparameters at the second stage. The methods are demonstrated with an illustrative example using data collected by Rosenkranz and raftery(1994) concerning the number of hospital admissions due to back pain in Washington state.

• Journal of Internet Computing and Services
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• v.19 no.6
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• pp.101-112
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• 2018

A lot of manpower and budgets are being used to prevent fires, and only a small portion of the data generated during this process is used for disaster prevention activities. This study develops a prediction model of fire occurrence probability based on data mining in order to more actively use these data for disaster prevention activities. For this purpose, variables for predicting fire occurrence probability of various buildings were selected and data of construction administrative system, national fire information system, and Korea Fire Insurance Association were collected and integrated data set was constructed. After appropriate data cleansing and preprocessing, various data mining methodologies such as artificial neural network, decision trees, SVM, and Naive Bayesian were used to develop a prediction model of the fire occurrence probability of buildings. The most accurate model among the derived models is Linear SVM model which shows 68.42% as experimental data and 63.54% as verification data and it is the best model to predict fire occurrence probability of buildings. As this study develops the prediction model which uses only the set values of the specific ranges, future studies may explore more opportunites to use various setting values not shown in this study.

• Journal of Pharmacopuncture
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• v.26 no.1
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• pp.67-76
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• 2023

Objectives: Medical services are closely related to individual health and welfare, and health status in childhood or adolescence is widely recognized to be related to many socioeconomic outcomes. Therefore, providing appropriate medical services in childhood and adolescence is important. We aimed to investigate the determinants of traditional Korean medical services (TKMS) usage by children aged < 19 years. The focus was on the role of their parents' experiences with TKMS in determining TKMS use by children. Methods: Using a representative sample in South Korea, we conducted a regression analysis to assess how parents' experience with TKMS affects the probability of their children using TKMS. Results: We found parents' experience with TKMS to have a significantly positive effect on the probability of TKMS use by children and parents' biological information, such as age and sex, to affect the probability of TKMS use. Specifically, parents' experiences with TKMS generally increased the probability of children using TKMS by approximately 20%. Conclusion: This study's results suggest that considering parents' opinions and providing them the opportunity to participate in programs that enhance young children's use of TKMS may be effective.

• Communications for Statistical Applications and Methods
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• v.16 no.4
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• pp.587-594
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• 2009

In this paper the change point problem of the error terms in linear regression models is considered. Since fixed or stochastic independent variables and weakly dependent errors are assumed, usual multiple regression models and time series models including ARMA are covered. We use the estimates of probability density function based on residuals in order to test the distribution change of the unobserved errors. Under some mild conditions, the test using the residuals is proved to have the same limiting distribution as the test based on true errors.