• Parasites, Hosts and Diseases
• /
• v.46 no.3
• /
• pp.145-151
• /
• 2008

During Toxoplasma gondii infection, macrophages, dendritic cells, and neutrophils are important sources of pro-inflammatory cytokines from the host. To counteract the pro-inflammatory activities, T. gondii is known to have several mechanisms inducing down-regulation of the host immunity. In the present study, we analyzed the production of pro- and anti-inflammatory cytokines from a human myelomonocytic cell line, THP-1 cells, in response to treatment with T. gondii lysate or lipopolysaccharide (LPS). Treatment of THP-1 cells with LPS induced production of IL-12, TNF-$\alpha$, IL-8, and IL-10. Co-treatment of THP-1 cells with T. gondii lysate inhibited the LPS-induced IL-12, IL-8 and TNF-$\alpha$ expression, but increased the level of IL-10 synergistically. IL-12 and IL-10 production was down-regulated by anti-human toll-like receptor (TLR)-2 and TLR4 antibodies. T. gondii lysate triggered nuclear factor (NF)-${\kappa}B$-dependent IL-8 expression in HEK293 cells transfected with TLR2. It is suggested that immunosuppression induced by T. gondii lysate treatment might occur via TLR2-mediated NF-${\kappa}B$ activation.

• Journal of Surface Science and Engineering
• /
• v.32 no.3
• /
• pp.239-243
• /
• 1999

At Present, 200mm wafer technology is being applied for commercial fabrications of 64, 128, and 256 M DRAM devices, and 300mm technology will be evolved for 1G DRAM devices in the early 21th century, recognizing limitations of several process technologies. In particular recognition has been realized in harmful effects of surface contamination of trace metals introduced during devicing processes. Such a guide line for surface metal contamination has been proposed as 1E9 and 1E10 atoms/$\textrm{cm}^2$ of individual metal contamination for wafering and devicing of 1G DRAM, respectively, and so its measurement limit should be at least 1E8 atoms/$\textrm{cm}^2$. The detection limit of present measurement systems is 2E9 atoms/$\textrm{cm}^2$ obtainable with TRXFA(Total Reflection X-Ray Fluorescence Analysis). TRXFA is nondestructive and the simplest in terms of operation, and it maps the whole wafer surfaces but needs detection improvement. X-Ray intensity produced with synchrotron accelerator is much higher than that of conventional X-ray sources by order of 4-5 magnitudes. Hence theoretically its reactivity with silicon surfaces is expected to be much higher than the conventional one, realizing improvement of detection limit. X-ray produced with synchrotron accelerator is illuminated at a very low angle with silicon wafer surfaces such as 0.1 degree and reflects totally. Hence informations only from surface can be collected and utilized without overlapping with bulk informations. This study shows the total reflection phenomenon and quantitative improvement of detection limit for metallic contamination. It is confirmed that synchrotron X-ray can be a very promising alternative for realizing improvement of detection limit for the next generation devices.

• Laboraroty Animal Research
• /
• v.34 no.4
• /
• pp.232-238
• /
• 2018

Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed to help overcome potential drawbacks related to animal experiments and avoid ethical issues, their use remains vital for the testing of new drug candidates and to identify the most effective strategies for therapeutic intervention. Particularly, the study of metabolic diseases requires the use of animal models to monitor whole-body physiology. In line with this, the National Institute of Food and Drug Safety Evaluation (NIFDS) in Korea has established their own animal strains to help evaluate both efficacy and safety during new drug development. The objective of this study was to characterize the response of C57BL/6NKorl mice from the NIFDS compared with that of other mice originating from the USA and Japan in a chemical-induced diabetic condition. Multiple low-dose treatments with streptozotocin were used to generate a type-1 diabetic animal model which is closely linked to the known clinical pathology of this disease. There were no significantly different responses observed between the varying streptozotocin-induced type-1 diabetic models tested in this study. When comparing control and diabetic mice, increases in liver weight and disturbances in serum amino acids levels of diabetic mice were most remarkable. Although the relationship between type-1 diabetes and BCAA has not been elucidated in this study, the results, which reveal a characteristic increase in diabetic mice of all origins are considered worthy of further study.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.16 no.4
• /
• pp.653-660
• /
• 2021

Renewable energy resources are rapidly becoming an integral part of electricity generation portfolios around the world due to declining costs, government subsidies, and corporate sustainability goal. Interacting wind, solar, and load forecast errors can create significant unpredictable impacts on the distribution system, feeder congestion, voltage standard and reactive power stability margins. These impacts will be increasing with the increasing penetration levels of variable renewable generation in the power systems. There is a limit to the maximum amount of renewable energy sources that can be connected in a distribution feeder by the connection rule of transmission & distribution facility in Korea. This study represents the decision plans of hosting capacity for distribution feeders without the need for significant upgrades to the existing transmission infrastructure. Especially, the paper suggests and discusses the hosting capacity standard of feeder cables and minimum load calculation of distribution feeders.

• Journal of the Korean Society of Systems Engineering
• /
• v.16 no.2
• /
• pp.97-109
• /
• 2020

On March 11, 2011, an earthquake followed by a tsunami caused an extended station blackout (SBO) at the Fukushima Dai-ichi NPP Units. The accident was initiated by a total loss of both onsite and offsite electrical power resulting in the loss of the ultimate heat sink for several days, and a consequent core melt in some units where proper mitigation strategies could not be implemented in a timely fashion. To enhance the plant's coping capability, the Diverse and Flexible Strategies (FLEX) were proposed to append the Emergency Operation Procedures (EOPs) by relying on portable equipment as an additional line of defense. To assess the success window of FLEX strategies, all sources of uncertainties need to be considered, using a physics-based model or system code. This necessitates conducting a large number of simulations to reflect all potential variations in initial, boundary, and design conditions as well as thermophysical properties, empirical models, and scenario uncertainties. Alternatively, data-driven models may provide a fast tool to predict the success window of FLEX strategies given the underlying uncertainties. This paper explores the applicability of Artificial Intelligence (AI) to identify the success window of FLEX strategy for extended SBO. The developed model can be trained and validated using data produced by the lumped parameter thermal-hydraulic code, MARS-KS, as best estimate system code loosely coupled with Dakota for uncertainty quantification. A Systems Engineering (SE) approach is used to plan and manage the process of using AI to predict the success window of FLEX strategies under extended SBO conditions.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.17 no.5
• /
• pp.815-824
• /
• 2022

The growing integration of intermittent renewable sources like offshore wind energy increases the need for transferring electric energy over long distances, which may include sea crossings. One of the solutions available for bulk electric power transmission across large distances encompassing wide and deep sea is using HVDC submarine power cables. However, there are no standards or research related to the calculation of the continuous allowable current with various ocean conditions of a DC power cable that does not have an alternating magnetic field. In this study, assuming the typical two types of subsea cable models and two areas of the south coast and the west coast marine conditions, a continuous allowable current simulation of DC cables was performed. As a simulation result, the DC cable continuous allowable current find out the gradient reduction characteristics based on subsea base depth.

• Journal of Christian Education in Korea
• /
• v.65
• /
• pp.103-131
• /
• 2021

The purpose of this study is to identify the direction of future Christian ministry by examining the educational/pastoral ministries of Korean churches during the COVID-19 period. The study used the case study method, where pastors from four different churches were the primary sources of data. Although each church has its own unique ministry, special early morning prayer meetings, family worship services, family Vacation Bible Schools, Bible writing and reading programs, and on-line discipleship training programs were common. In addition, each church implemented special programs that reflected the characteristics and needs of the church, like a talk show, visible radio, surfing meeting, and book-making of Bible manuscripts. Based on these results, ministry programs reflecting the church's pastoral philosophy, strengthening community consciousness, restoring the spiritual function of the family, utilizing online teaching methods, and psychological support for the underprivileged are proposed. In addition, the recovery of Christian publicity and the help from denomination or specialized institutions to develop the programs and online materials were suggested. Through this study, the direction of educational/pastoral ministry in a time of COVID-19 and post-COVID-19 is proposed.

• The Research Journal of the Costume Culture
• /
• v.31 no.1
• /
• pp.70-90
• /
• 2023

This study aims to use Art brut works-the artwork of the socially underprivileged and alienated-to influence social roles in fashion design, employing a formative expression method to promote social acceptance of diversity in the industry. The research method involved investigating Art brut's concept and evolution in domestic and foreign literature and previous studies. The formative characteristics of the movement were derived by analyzing the works of Art brut artist Johann Hauser. One hundred and twenty images of Johann's work were collected through online sources like the Gugging Museum's website, Christian Berst Gallery's website were developed as fashion design using the CLO 3D program. The formative characteristics of Johann's works appeared to be transparent overlapping, divisional decorativeness emphasized simplicity, and vibrant chromaticity. Based on this analysis, the results of the 3D digital fashion designs were as follows. First, the characteristics of the atypical objects and figures in Johann's works were applied to the design silhouette, revealing a uniquely beautiful form. Second, Johann used a method in which numerous line shapes overlap and fill the area. The point of connecting the work is expressed as a graphic pattern by decorating the lines of the hem and hem of the garment with piping or attaching overlapping straps on top of pants and dresses. Third, the combination of overlapping colors used in Johann's work is a color block design of fashion, which utilizes the formative fun.

• The Research Journal of the Costume Culture
• /
• v.32 no.1
• /
• pp.70-85
• /
• 2024

This study aimed to examine the recent Hanbok school uniform design directions to contribute to the distribution of Hanbok school uniforms and the accumulation of Hanbok-inspired fashion design sources. We reviewed 16 academic papers published on Hanbok school uniform designs from 1998 to 2023 and summarized the design features proposed therein. We also analyzed 172 items of Hanbok school uniform designs developed under the Hanbok school uniform promotion project hosted by the Hanbok Advancement Center between 2019 and 2022. We found that the recent Hanbok school uniform design characteristics conformed to the design directions proposed in previous studies in terms of line, color, fabric, and textile pattern. Conforming design characteristics include the following. Overall, silhouettes were straight and moderately fitting to the body. Detailed straight and curved lines from Hanbok were applied. Designs showed traditional Hanbok colors, including white, black, and navy. Machine washable cotton and various blended fabrics were used. Modernized traditional patterns such as Saekdong, cloud, and Gwae were applied to textile designs. In contrast, some characteristics of recent designs deviated from the proposed design directions. Barrel silhouettes were found in casual styles of uniform items, including sweatshirts, hoodies, and jumpers. A wider range of materials, including fleece, quilted fabric, brocade, and Jinju silk, were used. Uniforms had looser silhouettes and were made with modern washable materials to meet students' preference for casual uniforms.

• Korean Journal of Radiology
• /
• v.25 no.9
• /
• pp.773-787
• /
• 2024

Local ablation for hepatocellular carcinoma (HCC), a non-surgical option that directly targets and destroys tumor cells, has advanced significantly since the 1990s. Therapies with different energy sources, such as radiofrequency ablation, microwave ablation, and cryoablation, employ different mechanisms to induce tumor necrosis. The precision, safety, and effectiveness of these therapies have increased with advances in guiding technologies and device improvements. Consequently, local ablation has become the first-line treatment for early-stage HCC. The lack of organized evidence and expert opinions regarding patient selection, pre-procedure preparation, procedural methods, swift post-treatment evaluation, and follow-up has resulted in clinicians following varied practices. Therefore, an expert consensus-based practical recommendation for local ablation was developed by a group of experts in radiology and hepatology from the Research Committee of the Korean Liver Cancer Association in collaboration with the Korean Society of Image-guided Tumor Ablation to provide useful information and guidance for performing local ablation and for the pre- and post-treatment management of patients.