• BMB Reports
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• v.46 no.2
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• pp.97-102
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• 2013

The use of various cancer cell lines can recapitulate known tumor-associated mutations and genetically define cancer subsets. This approach also enables comparative surveys of associations between cancer mutations and drug responses. Here, we analyzed the effects of ~40,000 compounds on cancer cell lines that showed diverse mutation-dependent sensitivity profiles. Over 1,000 compounds exhibited unique sensitivity on cell lines with specific mutational genotypes, and these compounds were clustered into six different classes of mutation-oriented sensitivity. The present analysis provides new insights into the relationship between somatic mutations and selectivity response of chemicals, and these results should have applications related to predicting and optimizing thera-peutic windows for anti-cancer agents.

• Journal of electromagnetic engineering and science
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• v.11 no.1
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• pp.1-4
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• 2011

In this letter, we propose a novel tag antenna that has low performance degradation with nearby dielectric material. We obtained a stable reading performance and a broad matching bandwidth on nearby dielectric materials by employing a T-matching network with thick line width and capacitively slot-loaded arms. We then built the proposed antenna and measured the tag sensitivity to examine the reading characteristics with nearby dielectric materials. The measured results clearly demonstrate stable tag sensitivity with various nearby dielectric materials, such as foam, acrylic-plastic, glass, and ceramic plates. To more closely observe the antenna characteristics with nearby dielectric materials, we also examined the impedance variation and surface current distribution with respect to the dielectric constant of nearby target objects, which ranged from $1{\times}{\varepsilon}_0$ to $16{\times}{\varepsilon}_0$.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.12
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• pp.2131-2134
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• 2010

In this paper, the on-line system schemes for coordinated control system of multiple FACTS were presented to enhance the voltage stability around the metropolitan areas. In order to coordinated control system of FACTS devices, MFC on-line system calculates the optimal set point(Vref, Qrev) of FACTS devices using the coordinated control algorithm with real time network data which is transferred from SCADA/EMS system. If the system is unstable after contingencies, the new operation set-point of FACTS would be determined using bus sensitivity from tangent vector at voltage instability point. Otherwise, we would determine the new operation set-point of FACTS for considering economical operation, like as active power loss minimization using Optimal Power Flow algorithm. As the test, MFC(Multiple FACTS Coordinated control) on-line system will be installed in Korea power system.

• Proceedings of the KIEE Conference
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• 2000.07a
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• pp.16-18
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• 2000

The recent movement to deregulated and competitive electricity market changes the role of Security Constrained Optimal Power Flow (SCOPF) and increases the importance for real-time computation. communication, and on-line data control. As power systems tend to be operated more closely to their ultimate ratings, more rapid updates of telemetered data and faster solutions times are becomimg necessary to better track the changes in systems. This paper presents an on-line SCOPF application exploiting the state-of-art OPF tools and corresponding interfacing technologies. The significance of the proposed mechanism is demonstrated with a case study system.

• Journal of Korean Society of Water and Wastewater
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• v.23 no.1
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• pp.107-112
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• 2009

This study was conducted for verification and systematization of estimation method about the headloss using CFD(Computational Fluid Dynamics). Head loss which happens between the inlet and outlet of in-line mixer can be a major factor for the design and construction. Also, this Case studies about the sensitivity related to the velocity in the piping system. As result, program's default calculation function was used to get each side's total pressure and the differential of each total pressure could be defined as head loss from in-line mixer. In the case of adopting pipe surface friction factor and geometry loss, Calculation residual can be much more reduced. It was found that residual of value between CFD method and field test ranged about 3 through 18 precent.

• Proceedings of the KIEE Conference
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• 1989.07a
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• pp.707-711
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• 1989

This system exchange half-duplex serial data at 1200 baud by FSK modulating a carrier frequency at 200KHz over the 110V A.C. power line. Transmitter output voltage to A.C. line is 4V p-p and line sensitivity is selected 2.54mV because CISPR Noise limitation is $66dB{\mu}V$ at 150 ${\sim}$ 500KHz. The designed and realized system has abtained system margin of 58 dB and probability of error, Pe = $1.78{\times}10^{-7}$ was obtained

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.80-80
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• 1993

(목적) 본 연구에서 사용된 바이러스는 HIV-1 nef유전자가 일부 삭제되고 대신 Chloramphenicol acetyltransferase(CAT)가 pSVCAT recombinant 바이러스다. 이러한 recombinant 바이러스를 사용하는 이유는 첫째, CAT activity가 매우 민감하므로 바이러스의 복제억제 정도를 정확하게 측정 할 수 있고 둘째, simian immunodeficiency virus(SIV)의 경우 nef 유전가 in vivo에서는 바이러스의 복제에 필수적이므로 HIV가 SIV와 유사한 것으로 미루어 본 연구에서 사용되는 recombinant SVCAT 바이러스가 안전한 것으로 고려되기 때문이다. (방법) 특히 화합물이 HIV-1의 복제에 얼마나 영향이 있는가는 1) 어느정 도의 virus inoculm을 넣었는지 2) 사용하는 cell line 3) 사용한 cell line의 infection kinetics 4) 실험의 지속기간 5) 테스트하는 assay의 sensitivity에 의존한다. 따라서 $10^{5}$ cell의 H9과 sup T1을 24 well plate에 넣고 sup T1 cell line의 경우 3일 후 항 화합물에 의한 syncytia 형성 및 CAT activity의 억제정도를 현재 AIDS drug으로 쓰이고 있는 Zidovudine을 control로 비교 관찰하였다. H9 cell line의 경우 3일 간격으로 media의 3/4을 fresh media로 바꾸어 주고 9일 후 CAT assay를 하였다. 이러한 assay에서 activity를 보이는 화합물을 reverse transcriptase와 P24 ELISA assay를 재확인하였다.다.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.2
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• pp.140-145
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• 2001

The tape carrier package(TCD) is one of the most important components in a liquid crystal display(LCD) module. It has a role to transmit electrical signals from a printed circular board(PCB) to a display panel. If TCP is damaged under mechanical shock, the signals can not be transmitted to the panel and as a result, some dead lines are generated on the panel. This kind of phenomenon is commonly called as 'line defects'. In this paper, new structural design concepts of TCP are proposed to guarantee its reliability by using Taguchi's approach and dynamic FE-analysis. The line defects problem of TCP module is solved by replacing the original TCP with the newly designed one.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.6
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• pp.115-121
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• 2011

Intelligent distribution equipment is inevitable to realize self-healing which is one of smart grid functions in distribution network. Therefore, most of distribution equipment have been developed with self diagnostic sensors. However, it is not effective to construct on-line monitoring system for underground distribution cable because of high cost and low sensitivity. Recently, optical fiber composite cable is being considered for communication and power delivery in order to cope with increasing communication in distribution network. This paper presents the design and performance assessment results of underground cable on-line monitoring system using DTS(Distributed Temperature Sensing) and optical fiber composite underground cable.

• Proceedings of the KIEE Conference
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• 1995.07b
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• pp.588-590
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• 1995

This paper presents a new algorithm for the countermeasure to alleviate the line overloads in a power system. This method utilizes network sensitivity factors which are establised from DC load flow solutions. The line outage distribution factors(LODF) are formulated using changes in network power generations to simulate the outaged line from the network. The proposed algorithm has been validated in tests on a 6-bus test system.