• 대한화장품학회지
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• 제49권4호
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• pp.291-298
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• 2023

본 연구에서는, 화장품 중 로션, 크림, 클렌저 제형에 적용된 세라마이드엔피(ceramide NP)의 함량을 분석하고자 high-performance liquid chromatography (HPLC)를 이용한 정량 분석 방법을 개발하였다. 분석은 C18 칼럼을 이용하고 이동상은 아세토니트릴과 메탄올을 70 : 30 비율로, 유속은 0.8 mL/min으로 하고 칼럼 온도는 20 ℃로 조건을 설정하였다. 분석 방법은 ICH 가이드라인에 따라 특이성, 직선성, 검출한계(LOD) 및 정량한계(LOQ), 정확성, 정밀성을 분석하여 검증하였다. 분석 방법의 유효성 검증 결과, 검량선의 직선성(R²)은 0.99984로 우수한 직선성을 보였다. 로션, 크림, 클렌저 제형에 대한 정확성은 95.11 ~ 100.48%의 회수율을 통해 확인하였고, 정밀성 분석 결과 상대 표준 편차(RSD)는 0.26% 이하로 나타났다. 검출한계는 0.902 ㎍/mL, 정량한계는 2.733 ㎍/mL로 확인되었다. 이를 통해, 화장품에 적용된 세라마이드엔피의 정량 분석 시, 방해 물질의 영향으로 인해 주피크 분리가 어려운 경우 측정이 가능하게 하여 제품의 품질관리에 도움이 될 것으로 기대된다.

• 한국철도학회논문집
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• 제19권2호
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• pp.187-194
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• 2016

철도교량의 신뢰도 기반 한계상태설계법 도입 시 목표신뢰도지수 산정을 위하여 기존 철도교량의 신뢰도지수 산정이 선행되어야 한다. 대표적인 복선 철도교량 중 하나인 6주형 PSC-I형 거더교량에 대해 신뢰도지수를 산정하였다. 최외측 거더의 휨모멘트에 대한 신뢰도 해석을 수행하였다. 휨저항강도 및 고정하중효과는 도로교 한계상태설계법 도입 시 적용된 선행연구자들의 평균과 변동계수를 활용하였고, 열차의 활하중 효과는 여객/화물 혼용선 중 중량화차 통행이 빈번한 중앙선에서 현장계측 데이터를 활용하였다. 한계상태방정식에 대하여 개선된 일계이차 모멘트법(AFOSM)으로 신뢰도 분석을 수행하였으며, 하중효과와 저항효과의 각 요소가 신뢰도지수에 미치는 민감도를 분석하여 중요도를 검토하였다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2004년도 춘계학술발표회
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• pp.146-153
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• 2004

The goals of this study are to investigate the feasibility of the reference state approach in determining the generalized soil-water characteristic curve that is essential for characterization of unsaturated soil behavior. The soil-water characteristic curves are obtained from a number of specimens of fine-grained residual soils compacted with different void ratios. Based on the experimental test results, the feasibility of using the liquid limit state as the reference state for predicting the soil-water characteristic curve are verified. Finally, through the regression analysis of experimental data using the equation of Fredlund and Xing (1994), a reliable method is proposed to predict the generalized soil-water characteristic curve of fine-grained residual soils using the liquid limit state as the reference.

• Steel and Composite Structures
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• 제20권2호
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• pp.295-316
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• 2016

This paper presents the results of experimental investigation, numerical calculation and theoretical analysis on axial compression ratio limit values for steel reinforced concrete (SRC) special shaped columns. 17 specimens were firstly intensively carried out to investigate the hysteretic behavior of SRC special shaped columns subjected to a constant axial load and cyclic reversed loads. Two theories were used to calculate the limits of axial compression ratio for all the specimens, including the balanced failure theory and superposition theory. It was found that the results of balanced failure theory by numerical integration method cannot conform the reality of test results, while the calculation results by employing the superposition theory can agree well with the test results. On the basis of superposition theory, the design limit values of axial compression ratio under different seismic grades were proposed for SRC special shaped columns.

• Structural Engineering and Mechanics
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• 제36권5호
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• pp.529-544
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• 2010

Nonlinear equations of structures are generally solved numerically by the iterative solution of linear equations. However, this iterative procedure diverges when the tangent stiffness is ill-conditioned which occurs near limit points. In other words, a major challenge with simple iterative methods is failure caused by a singular or near singular Jacobian matrix. In this paper, using the Newton-Raphson algorithm based on Davidenko's equations, the iterations can traverse the limit point without difficulty. It is argued that the propose algorithm may be both more computationally efficient and more robust compared to the other algorithm when tracing path through severe nonlinearities such as those associated with structural collapse. Two frames are analyzed using the proposed algorithm and the results are compared with the previous methods. The ability of the proposed method, particularly for tracing the limit points, is demonstrated by those numerical examples.

• Safety and Health at Work
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• 제10권3호
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• pp.389-392
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• 2019

When conducting an exposure assessment, the primary goal of the industrial hygienist is to fully characterize the worker's exposure during a work shift to compare it with an occupational exposure limit. This applies regardless of the duration of the work activity as an activity that is relatively short in duration can still present exposure in excess of the occupational exposure limit even when normalized over an 8-hr shift. This goal, however, is often impeded by the specification of a minimum sample volume in the published sampling method, which may prevent the sample from being collected or submitted for analysis. Removing the specification of minimum sample volume (or adjusting it from a requirement to a recommendation), in contrast, allows for a broader assessment of jobs that consist of short-duration and high-exposure activities and also eliminates the unnecessary practice of running sampling pumps in clean air to collect a specified, minimum volume.

• 한국구조물진단유지관리공학회 논문집
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• 제8권3호
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• pp.225-233
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• 2004

본 연구에서는 응답면기법을 이용하여 격납건물의 내진안전성 평가를 하였다. ABAQUS를 이용하여 하중, 저항과 해석에서의 랜덤변수를 고려한 구조해석을 수행하였고 이로부터 변수의 다항식으로 표현되는 구조물의 응답을 얻었다. 그리고 Level II에 의해 신뢰성해석을 하였다. 한계상태함수로는 콘크리트의 2축응력 상태를 고려하기 위해 Drucker-Prager 파괴기준을 이용하였다. 구조물의 수명, 지진의 연발생율과 조건부 파괴확률을 고려하여 격납건물의 파괴확률을 계산하였다. 또한 응답면기법의 안정적인 결과를 얻기 위해 표본점 선정에 대한 민감도해석을 수행하였다.

• Nuclear Engineering and Technology
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• 제46권4호
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• pp.481-488
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• 2014

An analysis of the uncertainty quantification related to LBLOCA using the Monte-Carlo calculation has been performed and compared with the tolerance level determined by the Wilks' formula. The uncertainty range and distribution of each input parameter associated with the LOCA phenomena were determined based on previous PIRT results and documentation during the BEMUSE project. Calulations were conducted on 3,500 cases within a 2-week CPU time on a 14-PC cluster system. The Monte-Carlo exercise shows that the 95% upper limit PCT value can be obtained well, with a 95% confidence level using the Wilks' formula, although we have to endure a 5% risk of PCT under-prediction. The results also show that the statistical fluctuation of the limit value using Wilks' first-order is as large as the uncertainty value itself. It is therefore desirable to increase the order of the Wilks' formula to be higher than the second-order to estimate the reliable safety margin of the design features. It is also shown that, with its ever increasing computational capability, the Monte-Carlo method is accessible for a nuclear power plant safety analysis within a realistic time frame.

• Journal of Microbiology and Biotechnology
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• 제32권8호
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• pp.976-981
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• 2022

Phenanthrenes are bioactive phenolic compounds found in genus Dioscorea, in which they are distributed more in peel than in flesh. Recent studies on phenanthrenes from Dioscorea sp. peels have revealed the potential for valuable biomaterials. Herein, an analytical method using high-performance liquid chromatography (HPLC) for quantitation of bioactive phenanthrenes was developed and validated. The calibration curves were obtained using the phenanthrenes (1-3) previously isolated from Dioscorea batatas concentrations in the range of 0.625-20.00 ㎍/ml with a satisfactory coefficient of determination (R²) of 0.999. The limit of detection (LOD) and the limit of quantification (LOQ) values of the isolated phenanthrenes ranged from 0.78-0.89 and 2.38-2.71 ㎍/ml, respectively. The intraday and interday precision ranged from 0.25-7.58%. The recoveries of the isolated phenanthrenes were from 95 to 100% at concentrations of 1.25, 2.5, and 5.0 ㎍/ml. Additionally, phenanthrenes (1-3) were found in all investigated peel extracts. Hence, the developed method was encouraging for the quantitative analysis of phenanthrenes in genus Dioscorea.

• Geomechanics and Engineering
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• 제36권6호
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• pp.631-640
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• 2024

In the traditional slope stability analysis, ignoring the spatial variability of slope soil will lead to inaccurate analysis. In this paper, the K-L series expansion method is adopted to simulate random field of soil strength parameters. Based on Random Limit Equilibrium Method (RLEM), the influence of variation coefficient and fluctuation range on reliability of soil slope supported by micro-pile is investigated. The results show that the fluctuation ranges and the variation coefficients significantly influence the failure probability of soil slope supported by micro-pile. With the increase of fluctuation range of soil strength parameters, the mean safety factor of the slope increases slightly. The failure probability of the soil slope increases with the increase of fluctuation range when the mean safety factor of the slope is greater than 1. The failure probability of the slope increases by nearly 8.5% when the fluctuation range is increased from δ_v=2 m to δ_v =8 m. With the increase of the variation coefficient of soil strength parameters, the mean safety factor of the slope decreases slightly, and the probability of failure of soil slope increases accordingly. The failure probability of the slope increases by nearly 31% when the variation coefficient increases from COV_c=0.2, COV_φ=0.05 to COV_c=0.5, COV_φ=0.2.