• Journal of Interdisciplinary Genomics
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• 제1권1호
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• pp.6-9
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• 2019

In this report, the phenotypes of three patients from two families with mucopolysaccharidosis type II (MPS II) are compared: a novel variant and recombinant variant of IDS gene. The results of urine in patients showed a pronounced increase in glycosaminoglycan excretion with decreased iduronate-2-sulfatase enzyme activity in leukocyte, leading to a diagnosis of MPS II. A patient has a novel variant with 1 bp small insertion, c.1224_1225insC in exon 9, which caused frameshifts with a premature stop codon, and two patients have a recombination variant, c.418+495_1006+1304del, leading to the loss of exons 4, 5, 6, and 7 in genomic DNA, which is relatively common in Korean patients. They had different phenotypes even in the same mutation. The patients have now been enzyme replacement therapy with a significant decrease in glycosaminoglycan excretion. Further study on residual enzyme activity, as well as experience with more cases, may shed light on the relationship between phenotypes in MPS II and gene mutations.

• 지역사회간호학회지
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• 제31권4호
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• pp.447-458
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• 2020

Purpose: The purpose of this study was to identify the effects of auricular acupressure therapy on sleep disorder and fatigue in menopausal women. Methods: The study design was a non-equivalent control group pretest-posttest design. The participants were 40~60 years old women, assigned to the experimental group (n=25) or the control group (n=27). Auricular acupressure using vaccaria seeds was administered to the experimental group. The sessions continued for 6 weeks. Outcome measures included Pittsburgh sleep quality index, sleep meter, sleep diary, fatigue assessment instrument, serum cortisol, and serum serotonin. Results: Menopausal women in the experimental group showed significant increases in deep sleep, light sleep, serotonin level and sleep duration compared with the control group. Also, the experimental group reported decreases in PSQI, sleep latency, awakening time, fatigue and cortisol level compared with the control group. Conclusion: Results show that auricular acupressure using vaccaria seeds is considered as an effective treatment for sleep disorder and fatigue in menopausal women. We conclude that it can be used as a nursing intervention method proven to reduce sleep disorder and fatigue in menopausal women.

• Medical Lasers
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• 제10권3호
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• pp.176-180
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• 2021

Several methods have been used to treat androgenetic hair loss, ranging from hair transplants to finasteride and minoxidil. Sometimes platelet-rich plasma injection therapy may be used to increase the satisfaction of patients who come to the hospital. However, some patients are sensitive to pain and are subjected to the inconvenience of requiring treatment after each blood sampling. The author had reported the effects of using a hair growth-promoting solution and Jetpeel^TM in parallel with a painless hair loss treatment method. However, the author was interested in more effective methods for patients with M-shaped or vertex hair loss who do not want to take medications or undergo hair transplant. In addition to the existing light-emitting diode therapy and electromagnetic field treatment, the author has made considered attempts to use various laser wavelength bands. However, the equipment for these methods can be expensive and are not suitable for patients who emphasize on cost-effectiveness. Therefore, the author used an existing reported method and a device based on the fractional erbium:YAG laser to provide the hair growth-promoting solution in parallel. The author chose a fractional 2940 nm-based laser device as a medium that could efficiently increase the growth phase, reduce the catagen phase, and facilitate intradermal product and drug delivery. As a result, there was a therapeutic benefit without any significant side effects such as redness and itching. Among the patients, the author reported the effects of the treatment on one patient with frontal M-shaped, mid, and vertex hair loss.

• 대한화장품학회지
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• 제41권4호
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• pp.325-331
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• 2015

피부는 낮 동안 태양빛과 인공 빛에 끊임없이 노출되어 있으며, 그중 5%는 UV 영역, 50%는 가시광선, 나머지 45%는 적외선 영역으로 구성되어 있다. 이중 자외선의 피부에 대한 영향은 많은 연구가 되어 왔으나, 나머지 영역에 대한 연구는 미진한 실정이다. 이에, 가시광선에서 적외선 사이의 파장이 피부 섬유아세포에 어떤 영향을 미치는지 연구하고자 하였다. 광처리에 의한 효과는 광파장, 처리 시간, 광세기, 광조합 등 다양한 파라미터들의 조합에 의해 그 효능이 결정되므로, 본 연구에서는 섬유아세포의 성장 및 콜라겐 합성과 관련된 기능을 촉진시킬 수 있는 광처리 조건을 찾아내고자 하였다. 가시광선과 적외선 영역 사이의 6개의 파장을 처리한 결과, 레드(630 nm)와 그린(520 nm) 파장에 의해 섬유아세포의 증식이 증가함을 확인하였다. 광처리 시간은 콜라겐 합성량 증가를 위해서는 10 min의 광처리가 30 min의 광처리 보다 적합한 조건이었다. 광세기는 $0.05{\sim}0.75mW/cm^2$에서 6개의 광세기로 분할하여 실험한 결과, 레드 $0.3mW/cm^2$와 그린파장 0.15, $0.3mW/cm^2$ 세기가 type I collagen의 mRNA의 양을 증가시킬 수 있었다. 마지막으로 두 개 파장을 순차적으로 조합 처리하였을 때의 효과를 확인한 결과, 레드와 그린파장의 조합 조건은 섬유아세포의 수적증가를 목적으로 할 때 효율적인 방법이며, 콜라겐 합성에는 레드 단독처리가 보다 효과적인 방법이었다. 따라서 본 연구에서 제시하는 광처리 조건을 이용시 피부 세포의 성장이나 콜라겐 합성에 긍정적 영향을 유도할 수 있으며, 재생 및 피부 미용 등에 활용할 수 있는 가능성이 클 것으로 기대된다.

• The Journal of Korean Physical Therapy
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• 제12권3호
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• pp.319-329
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• 2000

The purpose of this study w8s to evaluate the effects of pulsed electromagnetic energy(Diapulse) and microcurrent on the wound healing in rabbits. 15 domestic rabbits were randomly assigned to the PRME(n=5). MC(n=5) and CON(n=91 group. Each rabbits were anesthetized with lidocaine HCL $2\%$. Skin wounds were created laterally on the back of IS domestic rabbits(33cm). From 24 hours after being injured, the rabbits of the PEME group were irradiated with an intensity of 3 at a 300 pulses per second, which were applied for 15 minutes every day during the 12 days. The MC group were stimulated with an intensity of $50{\mu}A$ at frequency of40 pulses per second, which were applied for 15 minutes every day during the 12 days. The CON group were not stimulated. The rabbits were sacrificed and the incised wound pans were processed appropriately for the light microscopic examination on the 3rd day, 6th day and 12th day before the beginning of wound treatment. The areas of wound were measured with metric graph paper. The results were as tallows. 1 The PRME and MC group compared with control group showed that wound closure rate increased on 6th, 12th day. 2. It was found that the CON group did not show a complete maturation and had a chronic inflammatory response. Judging from the irregularity of intercellular space and the loose alignment of connective tissue. these findings showed that wound healing was delayed. 3. It showed that inflammatory cells. fibroblasts and epithelial cells activity rapidly processed in the PEME group compared with the CON group. It was found that the PEMI; group showed a advanced remodeling of epithelial layer and a positive repair of connective tissue. 4. It showed that fibroblasts, epithelial cells and inflammatory cells activity rapidly processed in the MC group compared with the CON group. It was found that the MC group showed a improved remodeling of epithelial layer and a dense connective tissue.

• 한국콘텐츠학회논문지
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• 제13권8호
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• pp.324-333
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• 2013

본 연구는 재활치료를 받는 뇌졸중과 척수손상 외래환자를 대상으로 주거 유형, 장애유형, 일상생활 수행 정도에 따른 주거환경개선에 대한 요구도를 알아보고자 하였다. 서울 경기 지역의 재활병원이나 종합병원에서 재활치료를 받는 환자 54명을 대상으로 2012년 1월 2일부터 2월 4일까지 설문조사를 실시하여 기술통계와 $x^2$검정을 이용하여 분석하였다. 연구결과를 살펴보면 주거환경개선에 대한 요구도가 장애 유형에 따라 현관의 계단이나 출입문의 폭, 욕실의 공간이용, 세면대, 양변기, 욕조, 샤워기 걸이와 세면대 높이, 거실과 침실 부엌, 베란다 공간이용 등에서 통계학적으로 유의미한 차이를 보였다. 주거 유형에 따른 주거환경 개선요구는 출입문의 센서 등, 욕실의 휴지걸이와 콘센트 덮개의 개선이 통계학적으로 유의미한 것으로 나타났으며 일상생활 수행정도에 따라 출입문의 폭과 문턱, 욕실의 휴지걸이와 수건걸이, 미끄럼 방지 바닥재, 샤워기, 부엌의 공간과 식탁, 의자, 베란다의 공간이용과 문턱, 조명 밝기의 개선 요구에서 통계적으로 유의미한 차이를 보였다. 본 연구를 통하여 주거 환경 개선에 대한 요구 정도가 장애유형, 주거 유형, 일상생활 수행 정도에 따라 다르다는 것을 확인할 수 있었으며 앞으로 주거환경개선에 대한 평가와 치료적인 접근의 기초자료로써 활용될 수 있을 것이다.

• 한방안이비인후피부과학회지
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• 제29권4호
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• pp.14-23
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• 2016

Objectives : One of major complications of diabetes, diabetic ulcer is also one of the main reasons for amputation, and the prevalence rate is 4-10%. Laser therapy is widely used for leg ulcer and diabetic ulcer, and it is known to improve wound epithelialization, cellular content, and collagen deposition. The purpose of this study is to investigate the properties of the laser and the spectrum of laser instruments for diabetic ulcer. Methods : We performed literature search using the PubMed, Cochrane, CINAHL and Web of science for the data in English. In addition, other databases were checked for different languages such as OASIS and NDSL for the literature in Korean, CNKI in Chinese, and CiNii and J-STAGE written in Japanese. We excluded all review article and experimental studies, and only clinical studies using laser or light emitting diode (LED) for diabetic ulcer were selected. Results : A total twenty papers were selected. Different light sources were used as follows: LED, HeNe, InGaAlP, GaAlAs, GaAs, CO2, and KTP. The number of LED studies was 9, and HeNe laser was 7, and InGaAlP and GaAlAs laser was 2, GaAs, CO2, and KTP laser was 1 for each. Various energy density of the clinical study were reported. Conclusions : It is suggested that to select appropriate laser type and give the adequate output power to treat diabetic ulcer. Further evaluation and research for the condition of laser therapy to treat diabetic ulcers are warranted.

• Journal of Korean Neurosurgical Society
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• 제54권5호
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• pp.426-430
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• 2013

The prognosis of solitary plasmacytoma varies greatly, with some patients recovering after surgical removal or local fractional radiation therapy, and others progressing to multiple myeloma years later. Primary detection of progression to multiple myeloma is important in the treatment of solitary plasmacytoma. There have been several analyses of the risk factors involved in the early progression to multiple myeloma. We describe one case of solitary plasmacytoma of the lumbar vertebra that was treated with surgical decompression with stabilization and additional radiotherapy. The patient had no factors associated with rapid progression to multiple myeloma such as age, size, immunologic results, pathological findings, and serum free light chain ratio at the time of diagnosis. However, his condition progressed to multiple myeloma less than two months after the initial diagnosis of solitary plasmacytoma. We suggest that surgeons should be vigilant in watching for rapid progression to multiple myeloma even in case that the patient with solitary plasmacytoma has no risk factors for rapid progression to multiple myeloma.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 추계학술대회
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• pp.470-472
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• 2017

현재 항암치료는 외과적 수술, 방사선 또는 광학을 이용한 치료법, 그리고 약물을 이용한 치료법 등을 활용한 다양연구가 진행되고 있다. 또한 고가의 항암 치료제와 대형화된 장비가 개발되어 정확도 및 치료효과를 높이고 있으나, 광원의 종류, 방사선, 항암치료제 등의 오남용에 기인한 많은 부작용이 초래되었다. 따라서 본 논문에서는, 상대적으로 저렴하고 조작이 간편하며, 다양한 파장대 광원의 사용이 가능한 마이크로컨트롤러 기반 맞춤형 암세포 증식 억제 키트를 개발하여 그 효과를 보임으로써 새로운 항암치료법을 제시하고자 한다.

• 한국정밀공학회지
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• 제27권6호
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• pp.75-81
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• 2010

The purpose of this study was to investigate the short-term effects of electrical massager on stress-related parameters including heart rate variability (HRV), heart rate (HR) using the photoplethysmogram (PPG) signal with motion artifact correction. Twenty healthy subjects were randomly allocated to receive a 15-min section of three types ((1) resting mode (control group), (2) light massage mode, (3) strong massage mode). Results indicated that self-report, VAS (Visual Analog Scale) significantly decreased for two massage modes after massage except control group. In strong massage mode, it was associated with significant increases in HF, but significant decreases in LF and LH/HF ratio compared with the light massage mode. For all outcomes, similar changes were not observed in the control group. Also, the result founded that mean HR of all groups decrease. We conclude that electrical massager reduces perceived stress and improves adaptive autonomic response to stress in healthy adults.