• BMB Reports
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• v.56 no.2
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• pp.49-55
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• 2023

Aging is characterized by a gradual decline in biological functions, leading to the increased probability of diseases and deaths in organisms. Previous studies have identified biological factors that modulate aging and lifespan, including non-coding RNAs (ncRNAs). Here, we review the relationship between aging and tRNA-derived small RNAs (tsRNAs), ncRNAs that are generated from the cleavage of tRNAs. We describe age-dependent changes in tsRNA levels and their functions in age-related diseases, such as cancer and neurodegenerative diseases. We also discuss the association of tsRNAs with aging-regulating processes, including mitochondrial respiration and reduced mRNA translation. We cover recent findings regarding the potential roles of tsRNAs in cellular senescence, a major cause of organismal aging. Overall, our review will provide useful information for understanding the roles of tsRNAs in aging and age-associated diseases.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.01a
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• pp.345-348
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• 2022

본 논문에서는 유체 시뮬레이션(Fluid simulation)중 화염에서 표현되는 불똥 입자(Fire-flake particle)의 생성, 움직임과 삭제를 효율적으로 학습하고 표현할 수 있는 인공지능 기법에 대해 소개한다. 유체 시뮬레이션을 계산하기 위해서는 일반적으로 수치해석학과 같은 학문의 이해가 필요하며 불똥이나 거품과 같은 유체의 2차 효과(Secondary effect)는 기반유체(Underlying fluids)를 통해 추출되기 때문에 복잡하고 계산양이 많아진다. 이러한 문제를 완화하고자 본 논문에서는 인공신경망을 이용한 분류 모델 학습을 통해 격자 내에서 표현되어야 하는 불똥 입자의 생성을 학습하고, 다항 회귀 모델 학습을 통해 불똥 입자의 움직임을 예측한다. 또한, 불똥 입자가 삭제되어야하는 상태를 네트워크 학습을 통해 얻어내며, 수명(Lifespan) 임계값 조절하여 다양한 장면에서 불똥을 제어할 수 있다. 결과적으로 화염의 움직임을 기반으로 불똥의 움직임을 복잡한 수학식이나 디자이너에게 의존하지 않고 인공지능 학습을 통해 쉽게 제어하고 예측하는 결과를 보여준다.

• Journal of the Korean Society for Heat Treatment
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• v.36 no.6
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• pp.412-421
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• 2023

As the demand for mechatronic systems and high performance increases in the machinery industry, the importance of improving friction characteristics is emphasized. During relative movement of objects, friction and wear occur on two surfaces in contact, and various methods are being designed to increase the lifespan and energy efficiency of machines. The energy increase effect using lubricants is a well-known method. In this study, a micro-sized rectangular grid pattern was produced by applying a precise micro-pattern photo lithography process. Rectangular grid patterns of the same shape and friction behavior according to the size of the pattern were produced in convex and concave shapes, and the tribological characteristics of each were analyzed.

• Journal of Ginseng Research
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• v.48 no.1
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• pp.20-30
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• 2024

Red ginseng (RG) is widely used as a herbal medicine. As the human lifespan has increased, numerous diseases have developed, and RG has also been used to treat various diseases. Neurodegenerative diseases are major problems that modern people face through their lives. Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are featured by progressive nerve system damage. Recently, neuroinflammation has emerged as a degenerative factor and is an immune response in which cytokines with nerve cells that constitute the nervous system. RG, a natural herbal medicine with fewer side effects than chemically synthesized drugs, is currently in the spotlight. Therefore, we reviewed studies reporting the roles of RG in treating neuroinflammation and neurodegenerative diseases and found that RG might help alleviate neurodegenerative diseases by regulating neuroinflammation.

• International Journal of Internet, Broadcasting and Communication
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• v.16 no.2
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• pp.93-102
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• 2024

We introduce a novel outdoor linear LED luminaire enhanced with Gore-Tex filters, designed to overcome the challenges of moisture and thermal management in harsh environments. This luminaire integrates expanded polytetrafluoroethylene (ePTFE)-commercially known as Gore-Tex-achieving superior waterproofing and dustproof qualities while maintaining breathability to prevent internal condensation. The design process, from conceptualization through prototyping and testing, is detailed, highlighting the luminaire's improved durability and stability under varying conditions. Experimental results demonstrate that our design significantly extends the operational lifespan and reliability of outdoor LED lighting systems by mitigating thermal and moisture-related degradation. This study not only advances ePTFE's application in lighting technologies but also offers a scalable model for enhancing the performance of LED luminaires in outdoor settings.

• Molecules and Cells
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• v.47 no.2
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• pp.100011.1-100011.3
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• 2024

Online application for survival analysis (OASIS) and its update, OASIS 2, have been widely used for survival analysis in biological and medical sciences. Here, we provide a portable version of OASIS, an all-in-one offline suite, to facilitate secure survival analysis without uploading the data to online servers. OASIS portable provides a virtualized and isolated instance of the OASIS 2 webserver, operating on the users' personal computers, and enables user-friendly survival analysis without internet connection and security issues.

• Journal of Sensor Science and Technology
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• v.33 no.3
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• pp.147-151
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• 2024

The importance of Wireless Sensor Networks is becoming more evident owing to their practical applications in various areas. However, the energy problem remains a critical barrier to the progress of WSNs. By reducing the energy consumed by the sensor nodes that constitute WSNs, the performance and lifespan of WSNs will be enhanced. In this study, we introduce an energy-efficient ternary modulator that employs multi-threshold CMOS for logic conversion. We optimized the design with a low-power ternary gate structure based on a pass transistor using the MTCMOS process. Our design uses 71.69% fewer transistors compared to the previous design. To demonstrate the improvements in our design, we conducted the HSPICE simulation using a CMOS 180 nm process with a 1.8V supply voltage. The simulation results show that the proposed ternary modulator is more energy-efficient than the previous modulator. Power-delay product, a benchmark for energy efficiency, is reduced by 97.19%. Furthermore, corner simulations demonstrate that our modulator is stable against PVT variations.

• Advances in nano research
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• v.17 no.1
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• pp.51-59
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• 2024

Nanotechnology, the science of manipulating matter at the nanoscale, offers remarkable opportunities for innovation across various fields. Nanomaterials, which form the cornerstone of advanced materials, drive forward new ideas and groundbreaking applications. In the textile industry, traditional antibacterial and antifungal garments are typically treated with chemical compounds to inhibit bacterial growth. However, these treatments often lack durability, losing effectiveness after multiple washes. To address this limitation, the application of green nanotechnology in developing high-performance textiles emerges as a promising solution. This study explores the integration of nanocomposites into the polymer layers of footballs to enhance their stability and performance. By embedding nanoparticles within the polymer matrix, the durability and resilience of the footballs are significantly improved, leading to better control and performance on the field. This innovative approach not only extends the lifespan of the footballs but also provides economic advantages by reducing the frequency of replacements. Additionally, the enhanced stability contributes to a more consistent and reliable playing experience, promoting improved safety and performance for athletes.

• Journal of Korean Society of Forest Science
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• v.112 no.3
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• pp.280-289
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• 2023

Diverse native tree species are distributed in Korean forests; however, information on their regeneration strategies is limited. This study analyzed seed rain from 2011 to 2013, seedling emergence, seedling survival, lifespan distribution, and the relationship between seedling mortality and herbaceous vegetation for 3 years, from 2012 to 2014, to understand the natural regeneration and early survival characteristics of Fraxinus rhynchophylla Hance in natural broad-leaved forests. Seed rain and emerged seedling density significantly differed among the years (p < .05). An increase in seed rain was followed by an increase in seedling emergence in the following year. Seed rain in 2013 and seedling emergence in 2014 showed a significant correlation (p < .05), confirming the trait of F. rhynchophylla seeds that germinate in the following year after seed production. Seedlings emerged in late spring and early summer. Of the seedlings, 78% emerged in the early summer of 2014. Most seedlings died immediately after emergence. Of the seedlings that emerged in August 2012, 56% died within 2 months, and 38% of those that emerged in July 2014 died within 1 month. Shade and competition against ground vegetation chiefly affected the seedling survival of F. rhynchophylla. Fraxinus rhynchophylla showed mast seeding, with a large number of seed production in a particular year. A surge of seedling emergence followed in the early summer of the next year. However, most seedlings died in the same year of emergence. Fraxinus rhynchophylla has a high seedling mortality, but mast seeding and the resulting high seedling emergence produce a few survived seedlings, enabling the continuation of the F. rhynchophylla population. Efforts and research on the natural regeneration of native tree species are required to effectively manage natural forests in Korea.

• Journal of Korean Society on Water Environment
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• v.32 no.1
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• pp.36-45
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• 2016

Sand filters are widely used in infiltration systems to manage polluted urban runoff. Clogging, which is mainly caused by the deposition of sediments on the filter media, reduces the filter system's infiltration capacity, which further limits its lifespan and function. The physical, chemical and biological clogging characteristics of sand filter, therefore, need to be known for effective design and maintenance. Physical clogging behavior and variations in the characteristics of sand filters according to different media depths are examined in this paper. The variations were observed from laboratory column infiltration tests conducted in a vertical flow and fluctuating head condition. It can be seen that an increase in filter media depth results in a high sediment removal performance; however, it leads to a shorter lifespan due to clogging. In the choice of filter media depth to be used in field applications, therefore, the purpose of facilities as well as maintenance costs need to be considered. At all filter media depth configurations, premature clogging occurred because sediments of 100~250 μm clogged the top 15% of filter media depth. Thus, scrapping the top 15% of filter media may be suggested as the first operational maintenance process for the infiltration system.