• BMB Reports
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• v.41 no.11
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• pp.751-756
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• 2008

Aging and cancer both occur as a result of accumulated cellular damage, and both are related to the regulation of specific genes in the damage response. Recent research has unveiled connections between the mechanisms of aging and cancer, but how to prevent the development of cancer and increase longevity remain unknown. SIRT1 (the mammalian Sir2), which has $NAD^+$-dependent class III histone deacetylase activity, may be a key gene linking the modulation of cancer and aging. SIRT1 has broad biological functions in growth regulation, stress response, tumorigenesis, endocrine signaling, and extended lifespan. Here, we focus on the current knowledge regarding the role of SIRT1 in aging and cancer, and discuss the implications of SIRT1 as a therapeutic target for the optimal balance between anti-aging and anti-cancer activities.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2005.11a
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• pp.21-21
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• 2005

• Journal of Applied Reliability
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• v.8 no.2
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• pp.87-100
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• 2008

The rubber fender is used to absorb the berthing energy that is produced when a ship is near a port, and it prevents collision between the ship and port. If the rubber fender becomes defective, the berthing energy cannot be absorbed when it is near the port, and damage can result from collisions due to the hardening process. In this research, when the rubber fender is heated, collisions can cause cracks and other damage. It is also confirmed from the research the lifetime distribution of the rubber fender. The researcher has predicted using different variables and elongation that a rubber fender has an 11year lifespan at $20^{\circ}C$.

• The Zoological Society Korea : Newsletter
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• v.18 no.1
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• pp.10-15
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• 2001

사람의 체세포가 분열수명에 한계가 있다는 것은 1960년대 초기에 보고되었으며 이것은 artifact가 아니며 세포자신이 가지는 프로그램에 의한 것임이 보고된 것은 최근의 일이다. 그러나 이 프로그램 안에 체세포가 실지로 증식을 정지하는 시기, 모든 세포노화의 타이밍이 어떻게 설정되는가\ulcorner 에 대해서는 아직 알 수 없다. 한편 노화세포가 왜 증식할 수 없는가\ulcorner 에 대해서는 세포주기를 조절하는 유전자에 관한 최근의 연구에 의해 상당부분 밝혀졌다. 또한 분열회수를 인식하는 분열시계의 진행은 세포증식을 억제하는 유전자의 발현을 촉진하여 증식을 정지시킨다. 분열시계를 정지시킨 세포는 기본적으로 무한히 분열하는 것이 가능하다. 분열시계를 정지시키는 주역은 telomerase이다. 정상 세포에서는 생식소(生殖巢)에 존재한다. 대부분의 정상체세포, 세포조직에는 없으나 대부분의 암에서 존재한다. 본 논단에서는 전반부에 노화를 후반부에 암에 관해서 분자세포생물학 차원에서 최근 연구성과를 중심으로 살펴보고자 한다.

• Journal of Life Science
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• v.10 no.2
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• pp.164-168
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• 2000

To understand the biological characteristics of Corythucha ciliata occurring in Korea, developmental periods and its susceptibility to several insecticides were examined under growth chamber condition at $25^{\circ}C$. It took 11.1 day from egg to hatch. And duration of each stage up to the 5th nymph after hatching was 4.0, 2.1, 2.0, 2.9, and 4.0 days, respectively. Total duration from egg to adult was 26.1 days, preoviposition period was 12.2 days, and average number of eggs laid by a female was 83.0. Sex ratio of female was 51.6% and lifespan of female adult was 43.2% days. LC50 value of deltamethrin and esfenvalerate were 0.8 and 0.9 ppm, respectively. Insecticidal effects were better in pyrethroids than organophosphates and carbamates.

• Journal of Information Processing Systems
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• v.14 no.3
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• pp.631-644
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• 2018

Many studies on flash memory-based buffer replacement algorithms that consider the characteristics of flash memory have recently been developed. Conventional flash memory-based buffer replacement algorithms have the disadvantage that the operation speed slows down, because only the reference is checked when selecting a replacement target page and either the reference count is not considered, or when the reference time is considered, the elapsed time is considered. Therefore, this paper seeks to solve the problem of conventional flash memory-based buffer replacement algorithm by dividing pages into groups and considering the reference frequency and reference time when selecting the replacement target page. In addition, because flash memory has a limited lifespan, candidates for replacement pages are selected based on the number of deletions.

• Proceedings of the KIPE Conference
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• 2012.07a
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• pp.486-487
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• 2012

In this paper, novel three-port active power decoupling (APD) method for applying 250[W] micro-inverter. This type using third port for active power decoupling stores the surplus energy and supplies sufficient energy to grid. Conventional decoupling circuit is applied in single phase grid connected micro-inverter especially single-stage configuration like flyback-type DC-AC inverter. In this passive power decoupling method, electrolytic capacitor with large capacitance is needed for decoupling from constant DC power and instantaneous AC power. However the decoupling capacitor is replaced with film capacitor by using APD, thus the overall system can achieve smaller size and long lifespan. Proposed three-port flyback inverter is verified by design and simulation.

• Korean Institute of Interior Design Journal
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• v.15 no.1 s.54
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• pp.158-165
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• 2006

The space of leisure boats & yachts is formed by interior design elements and shapes are formed by combination of those elements. By means of configuration of the design elements, space is made in a ship and patterns in an inside space are made through production. These space can be categorized as (1) cabin(common cabin, staterooms, one-cabin), (2) salon, (3) galleys & dinette, (4) heads(showers, toilets, bidets, sinks), (5) cockpit, (6) wheelhouses, navigation stations, (7) fore peaks, (8) engine room, (9) deck etc. Interior materials are classified into (1) walls(bulkheads & lining wall), (2) floors(sole), (3) ceilings(overheads), (4) doors & windows, (5) furniture, (6) lightings and (7) Hardware & decoration in large, medium and small sizes, which constitute interior design elements of a leisure boat & yacht. The materials used in leisure boats & yachts have properties of lightweight, noise and vibration resistance, fire & flame retardant, stability, strengths, lifespan, appearance and special operation in construction.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.07a
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• pp.170-171
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• 2005

Generally when Power MOSFET is operated, a heat sink is attached to it to emit heat caused by the operation. As the surface area of a heat sink is smaller, the thermal impedance is larger, which causes a negative influence on the characteristics of the chips and the devices and shortens the lifespan of them. In this experiment, we've compared and analysed different effects of heat sinks with 5 different surface areas on the characteristics of Thermal Transient when they are applied respectively.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.07a
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• pp.133-134
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• 2005

When Power MOSFET is operated, it causes lots of heat, which influences negatively on the characteristics of the devices and shorten the lifespan of them. Therefore, a heat sink should be mounted on to emit the heat. In this experiment, we've found the changes of the characteristics of Thermal Transient of MOSFET when a heat sink is applied. In addition, we've found other changes when heat sink compound is applied as well.