• Korean Journal of Hospice Care
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• v.6 no.2
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• pp.55-68
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• 2006

In Korea, there are constantly increasing number of cancer patients with reaching 65,000 deaths and it was 26.3% of the total number of death in 2004. Many cancer patients suffer from surgery, chemotherapy, and radiotherapy after being diagnosed as cancer. And many of them are facing fear of death because they can't be perfectly cured. Due to patients' physical, psychological, and spiritual pain, quality of life drops dramatically. Patients' families also suffer from huge medical expenses while they have to take care of patients's suffering from pain. At the same time, family's attitude can influence on the quality of patients' life. The purpose of this study is to investigate the relationship between the death orientation of first care giver and the quality of life of hospice patient. The subjects of the study were 80 hospice patients registered at ten hospice institutions with hospice team and medical practitioners in six cities including Seoul as well as their first care givers. This study used 13 questions for the hospice patients and nine questions for the first care givers to recognize general characteristic. To measure death orientation of the first care giver the tool developed by Noh, Soon-hee (2003) was used. And to measure quality of life of the hospice patients Yoo, Seung-yeon's structured tool was used. The data were collected for a month through interview method. SPSS win 12.0 was used to analyze the data by using frequency, percentage, t-test, Pearson correlation. The study result is as follows. In relationship between general characteristic of hospice patient and quality of life, the highest suffering was pain (60%) and the second suffering was anorexia (23.8%). There was no significant relationship between physical pain and general characteristics of hospice patient. In psychological aspects, religion (p=.044) showed significant difference (p<.05). In existential aspects, age (p=.035) showed significant difference (p<.05). There was no significant difference variable in support aspects. And religion (p=.000) was statistically significant variable in spiritual aspects (p<.001). Age (p=0.025) and religion (p=.050) were the variable showed significant difference according to general characteristics of first care giver's death orientation. Although the relation between death orientation of first care giver and quality of life of hospice patient was not statistically significant correlation. In conclusion, while death orientation of first care giver and hospice patient's quality of life are not statistically significant in correlation analysis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.169-176
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• 2017

This study, a non-equal prior and post quasi-experimental research on a control group, investigates the nursing students' change of perception on the meaning of life, death, well-dying and hospice in order to elucidate its effect. The study subjects were 38 students registered in the Department of Nursing Science in C University located in A city as the experimental group and another 36 students registered in the Department of Nursing Science in P University in P city as the control group. Death preparation education was conducted from February 29 through April 20, 2016. A 90-minute session was conducted each week for eight weeks and the data were analyzed by $x^2-test$ and t-test. In line with four domains of death education, i.e., cognition, emotion, practice and value, death preparation education was composed by imparting meaning to life and focusing on the perception on death, well-dying and hospice. From the study results, death preparation education enhanced nursing students' perception on the meaning of life, well-dying and hospice, and hence helped nursing students grant meaning to their lives and establish right values of life. Thus, it acted as a driving force for nursing students to live positive lives and is expected to be utilized as useful education which cultivates right perception on well-dying and hospice. However, in the absence of any significant difference in perception of death, repeated follow-up studies are required to verify the effect on the perception on death and the change in the perception of well-dying depending on the period of application.

• BMB Reports
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• v.45 no.8
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• pp.482-487
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• 2012

To identify the novel inhibitors of endoplasmic reticulum stress-induced cell death, we performed a high throughput assay with a chemical library containing a total of 3,280 bioactive small molecules. Cyclosporine A and bromocriptine were identified as potent inhibitors of thapsigargiin-induced cell death (cut-off at $4{\sigma}$ standard score). However, U74389G, the potent inhibitor of lipid peroxidation had lower activity in inhibiting cell death. The inhibition effect of cyclosporine A and bromocriptine was specific for only thapsigargin-induced cell death. The mechanism of inhibition by these compounds was identified as modification of the expression of glucose regulated protein-78 (GRP-78/Bip) and inhibition of phosphorylation of p38 mitogen activated protein kinase (MAPK). However, these compounds did not inhibit the same events triggered by tunicamycin, which was in agreement with the cell survival data. We suggest that the induction of protective unfolded protein response by these compounds confers resistance to cell death. In summary, we identified compounds that may provide insights on cell death mechanisms stimulated by ER stress.

• The Journal of Korean Academic Society of Nursing Education
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• v.16 no.1
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• pp.72-82
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• 2010

Purpose: The purpose of this study is to understand the meaning of dignified dying expressed by undergraduate nursing students. Method: Data were collected by in-depth interviews with fifteen nursing students. Conventional qualitative content analysis was used to analyze the data. Result: There were six major themes and eleven sub-categories from the analysis. Six major themes include death with no artificial life support, obedient death as a human nature, death with family members, meaningful death, no self destructive death, and sympathized death receiving from health care providers. Conclusion: The result of this study suggests that the nursing curriculum related to dignified dying can be developed and may affect the teaching and learning settings to improve end-of-life care performance among undergraduate nursing students, as well as, students in human service areas and health care providers.

• Journal of Microbiology and Biotechnology
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• v.33 no.8
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• pp.992-997
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• 2023

Ferroptosis is a new kind of programmed cell death of which occurrence in microorganisms is not clearly verified. The elevated level of reactive oxygen species (ROS) influences cellular metabolisms through highly reactive hydroxyl radical formation under the iron-dependent Fenton reaction. Iron contributes to ROS production and acts as a cofactor for lipoxygenase to catalyze poly unsaturated fatty acid (PUFA) oxidation, exerting oxidative damage in cells. While ferroptosis is known to take place only in mammalian cells, recent studies discovered the possible ferroptosis-like death in few specific microorganisms. Capacity of integrating PUFA into intracellular membrane phospholipid has been considered as a key factor in bacterial or fungal ferroptosis-like death. Vibrio species in bacteria and Saccharomyces cerevisiae in fungi exhibited certain characteristics. Therefore, this review focus on introducing the occurrence of ferroptosis-like death in microorganisms and investigating the mode of action underlying the cells based on contribution of lipid peroxidation and iron-dependent reaction.

• The Korean Journal of Health Service Management
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• v.6 no.1
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• pp.129-140
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• 2012

The purpose of this study was to identify attitude of hospital nurse's on death with dignity. The subjects of the study were 516 nurses. The data was analyzed by SPSS PC 19.0 program. 1) 82.8% participants agree to death with dignity, and they and their family will ask death with dignity in actual situations. 2) The average score of overall attitude on death with dignity was $3.13{\pm}0.52$. 3) With respect to the general characteristics of participants there were statistically significant difference in total score according to age, Marital Status, education level, religion, career, position, and existence of patients with incurable disease around. 4) With respect to the death with dignity related characteristics of participants there were statistically significant difference in total score according to agreement to death with dignity, request to my death with dignity, in case my family member requests death with dignity. Although many nurses had a positive concept of death with dignity, they still have ethical dilemmas in life-sustaining care. Therefore training programs on moral rights are necessary to provide guidelines foe end-of-life care.

• Korean Journal of Adult Nursing
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• v.24 no.6
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• pp.647-658
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• 2012

Purpose: This study was to analyzed the types of subjectivity that elderly who live alone caregivers have about the lonely death. Methods: This study objectified the subjective area by applying the Q methodology. It studied 24 caregivers in H region, who responded to 34 Q sample statements. The method of forced distribution was practiced regarding the results on a 9 points Q sample distribution chart. The collected data was analyzed using PC QUANL program. Results: The caregivers' perception of lonely death has been classified into four types: Type 1 ('type of fate-receptive invitation of lonely death'), Type 2 ('type of afterlife-expectantly invitation of lonely death'), Type 3 ('type of death preparation invitation of lonely death'), and type 4 ('type of rejection of lonely death due to attachment with life'). Conclusion: The present study attempts to provide basic resources for the development of nursing-intervention program to solve the problems with lonely death by grasping and understanding the types of the caregivers' perception of lonely death through which it also aims to yield information necessary to improve the quality of life in their remaining years.

• Journal of Hospice and Palliative Care
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• v.25 no.1
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• pp.42-49
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• 2022

As population aging increases the burden of cancer, the quality of death of patients with cancer is emerging as an important issue alongside their quality of life. To improve the quality of death, it is necessary to prepare for death, allowing patients to die comfortably and with dignity at the end. Considering these issues, I aim to discuss the practical aspects of notifying the patient of the terminal phase of cancer and planning for end-of-life care (i.e., advance care planning). When cancer treatment that can extend the patent's lifespan becomes difficult, the patient enters a treatment transition period. Treatment is shifted from life-prolonging care to life-enhancing care, and end-of-life care must be well planned. Medical providers often worry too much about whether the patient will be disappointed or psychologically traumatized when notified of the terminal phase of their cancer, thus delaying plans for end-of-life care. In fact, patients can accept their condition and prepare for end-of-life care better than we expect. During the treatment transition period, notification of terminal status should be given, and a well-prepared advance care plan should be established early when the patient has decision-making ability. In addition to conveying information, it is always necessary to be sensitive to whether the patient and caregiver understand the information and respond to their emotions.

• Journal of Korean Academy of Nursing
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• v.48 no.1
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• pp.59-69
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• 2018

Purpose: The purpose of this study was to investigate variables and construct paths that affect complicated grief. Methods: Participants in this cross-sectional, descriptive study were 164 bereaved spouses of cancer patients at least 12 months before the death. Data were collected from October 2016 to February 2017 using self-report structured questionnaires and were analyzed using IBM SPSS 21.0 and AMOS 20.0. Results: The variables affecting complicated grief of bereaved spouses of cancer patients were the quality of end-of-life care (${\gamma}=.15$, p<.001), preparedness for death (${\beta}=-.06$, p=.005), and coping with bereavement (${\beta}=-.24$, p<.001), whereas the quality of death and dying did not show any effects. Preparedness for death had multiple mediating effects in the relationship between the quality of end-of-life care and complicated grief (z=-2.20, p=.028), and in the relationship between the quality of end-of-life care and coping with bereavement (z=2.11, p=.035). Coping with bereavement had a mediating effect on the relationship between preparedness for death and complicated grief (z=-2.39, p=.017). Conclusion: This study revealed that preparedness for death and coping with bereavement play a prominent role in complicated grief. Therefore, it is important to help in preparing for death and enhancing coping with bereavement of spouses providing end-of-life care to cancer patients. In addition, investigating cultural differences in the relationship between the quality of end-of-life care and complicated grief is recommended.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.688-698
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• 2021

The purpose of this study was to determine the effects of perception of good death and knowledge toward advance directive on attitude toward withdrawal of life-sustaining treatment among university hospital nurses. The subjects of this study were 207 university hospital nurses. Data were analyzed using the SPSS Statistics 24.0 version. The results showed that factors influencing attitude toward withdrawal of life-sustaining treatment were perception of good death (𝛽=-.32, p<.001), education experience for good death (𝛽=.15, p=.024), and knowledge toward advance directive (𝛽=.14, p=.036). They explained 14.2% of attitude toward withdrawal of life-sustaining treatment. Based on the results of this study, it suggests the development of education programs for good death and life-sustaining treatment to improve the perception of good death, knowledge toward advance directive of university hospital nurses.