• Proceedings of the PSK Conference
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• 2002.10a
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• pp.194-199
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• 2002

Many oxidative metabolites of tetrahydrocannabinols (THCs), active components of marijuana, were pharmacologically active, and 11-hydroxy-THCs, 11-oxo-${\Delta}^8$-THC, 7-oxo-${\Delta}^8$-THC, 8$\beta$, 9$\beta$-epoxyhexahydrocannabinol (EHHC), 9$\alpha$, l0$\alpha$-EHHC and 3'-hydroxy-${\Delta}^9$-THC were more active than THC in pharmacological effects such as catalepsy, hypothermia and barbiturate synergism in mice. Cannabidiol (CBD), another major component, was biotransfomred to two novel metabolites, 6-hydroxymethyl-${\Delta}^9$-THC and 3-pentyl-6, 7, 7a, 8, 9, lla-hexahydro-I, 7-dihydroxy-7, 1O-dimethyldibenzo[b, d]oxepin (PHDO) through 8R, 9-epoxy-CBD and 85, 9-epoxy-CBD, respectively. Both metabolites exhibited some pharmacological effects comparable to d9 - THe. Cannabinol (CBN), the other major component, was mainly metabolized to ll-hydroxy-CBN by hepatic microsomes of animals including humans. The pharmacological effects of the metabolite were higher than those of CBN demonstrating that II-hydroxylation of CBN is metabolic activation pathway of the cannabinoid as is the case in THCs. Tolerance and reciprocal cross-tolerance developed to pharmacological effects d8 - THC and ll-hydroxy-d8-THC , and the magnitude of tolerance development produced by the metabolite was significantly higher than that by d8-THC. The results indicate that ll-hydroxy-d8-THC has an important role not only in the pharmacological effects but also its tolerance development of d8 - THe. THCs and their metabolites competed to the specific binding of CP-55, 940, an agonist of cannabinoid receptor, to synaptic membrane from bovine cerebral cortex. The Ki value of THCs and their metabolites were closely paralleled to their pharmacological effects in mice. A novel cytochrome P450 (cyp2c29) was purified and identified as a major enzyme responsible for the metabolic activation of d8-THC at the II-position in the mouse liver. cDNA of CYP2C29 was cloned from a mouse cDNA library and its sequence was determined. The oxidation mechanism of THC by cyp2c29 was proposed.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.1 s.343
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• pp.79-84
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• 2006

This paper proposed a novel H.264 deblocking filter for low-power mobile multimedia SoCs. In H.264 deblocking filter, filtering can be skipped on some pixels when pixel value differences satisfy some specific conditions. Furthermore, whole filtering can be skipped when quantization parameter is less than 16. Based on these features, power consumption can be significantly reduced by shutting down deblocking filter partially or as a whole. The proposed deblocking filter can shut down partial or whole blocks with simple control circuits. Common hardware performs both horizontal filtering and vertical filtering. It was implemented in silicon chip using $0.35{\mu}m$ standard cell library technology. The gate count is about 20,000 gates. The maximum operation frequency is 108MHz. The maximum throughput is 30 frame/s with CCIR601 image format.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.411-420
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• 2015

Ki-67 has been widely used as an indicator of cell proliferation in gliomas. However, the role of Ki-67 as a prognostic marker is still undefined. Thus, we conducted a meta-analysis of the published literatures in order to clarify the impact of Ki-67 on survival in glioma cases. Eligible studies were identified in PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, Science Direct and Wiley Online Library with the last search updated on August 31, 2014. The clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with Ki-67 expression at different time points were extracted. A total of 51 studies, covering 4,307 patients, were included in the current meta-analysis. The results showed that overexpression of Ki-67 can predict poor OS (HR=1.66, 95%CI: 1.53-1.80; Z=11.87; p=0.000) and poor PFS (HR=1.67, 95%CI: 1.47-1.91; Z=7.67; p=0.000) in gliomas. Moreover, subgroup analyses also indicated that high level of Ki-67 expression was related to poor OS and PFS in glioma patients regardless of region, pathology type, cut-off value and statistical method. In conclusion, the current meta-analysis revealed that Ki-67 expression might be a predicative factor for poor prognosis of glioma patients, emphasizing its importance as a predictor.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.4
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• pp.217-224
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• 2020

In this study, a framework for optimizing the opening in an outrigger wall is proposed. To solve a constrained bounded optimization problem, an in-house finite element program and SQP algorithm in Python SciPy library are utilized. The openings of the outrigger wall are located according to the strut-tie behavior of the outrigger wall deep beam. A linear interpolation method is used to obtain differentiable continuous functions required for optimization, whereas a database is used for the efficiency of the optimization program. By comparing the result of the two-variable optimization through the moving path of the search algorithm, it is confirmed that the algorithm efficiently determines the optimized result. When the size of each opening is set to individual variables rather than the same width of all openings, the value of the objective function is minimized to obtain better optimization results. It was confirmed that the optimization time can be effectively reduced when using the database in the optimization process.

• Journal of Digital Contents Society
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• v.18 no.7
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• pp.1427-1434
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• 2017

Due to the acceleration of the 4th industrialization, the data around us rapidly increased. Therefore, it is necessary to be able to more easily grasp the nature and meaning of data obtained through data analysis than to collect data, and apply it flexibly to the value judgment of data. Visualization technology is now attracting attention in many fields. Visualization allows the user to more easily grasp the information of the data with graphs, charts, etc. so that the data analysis result can be understood more easily, so that the user can make an immediate judgment and make a quick decision. Among them, there is a high degree of interest in visualization using public data, which is highly useful to users. In this paper, we implemented R - library and R Studio to visualize public data at the installation sites of bicycle storage sites among various software that can express visualization.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.1
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• pp.205-212
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• 2010

This paper describes a core generator (FCore_Gen) which generates Verilog-HDL models of 640 different FFT/IFFT cores with selected parameter value for OFDM-based communication systems. The generated FFT/IFFT cores are based on in-place single memory architecture and use a hybrid structure of radix-4 and radix-2 DIF algorithm to accommodate various FFT lengths. To achieve both memory reduction and the improved SQNR, a conditional scaling technique is adopted, which conditionally scales the intermediate results of each computational stage. The cores synthesized with a $0.35-{\mu}m$ CMOS standard cell library can operate with 75-MHz@3.3-V, and a 8,192-point FFT can be computed m $762.7-{\mu}s$, thus the cores satisfy the specifications of wireless LAN, DMB, and DVB systems.

• KIEAE Journal
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• v.13 no.5
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• pp.89-96
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• 2013

Green roofs can reduce surface water runoff, provide a habitat for wildlife moderate the urban heat island effect, improve building insulation and energy efficiency, improve the air quality, create aesthetic and amenity value, and preserve the roof's waterproofing. Green roofs are mainly divided into three types : intensive, simple-intensive, and extensive. Especially, extensive roof environment is a harsh one for plant growth; limited water availability, wide temperature fluctuations, high exposure to wind and solar radiation create highly stressed environment. This study, aimed at extensive green roof, was carried out on the rooftop of the library at Seoul Women's Univ. from October to November, 2012 and from March to August, 2013. To suggest the most effective vegetation model for biodiversity and heat island mitigation, surface temperatures were monitored by each vegetation model. We found that herbaceous plants of Aster sphathulifolius, Aceriphyllum rossii and Belamcanda chinensis, shrub of Syringa patula 'Miss Kim', Thymus quinquecostatus var. japonica, Sedum species can mixing each other. Among them, the vegetation models including Sedum takesimense, Aster sphathulifolius, Thymus quinquecostatus var. japonica was more effective on the surface temperature mitigation, because the species have the tolerance and high ratio of covering, and also in water. Especially, in the treatment of bark mulching, they helped to increase the temperature of vegetation models. In the case of summer, temperature mitigation of vegetation models were no significant difference among vegetation types. Compared to surface temperature of June, July and August were apparent impact of temperature mitigation, it shows that temperature mitigation are strongly influenced by substrate water content.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.12
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• pp.66-72
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• 2009

This paper proposes an efficient binary arithmetic encoder for CABAC which is used one of the entropy coding methods for H.264/AVC. The present binary arithmetic encoding algorithm requires huge complexity of operation and data dependency of each step, which is difficult to be operated in fast. Therefore, renormalization exploits 2-stage pipeline architecture for efficient process of operation, which reduces huge complexity of operation and data dependency. Context model updater is implemented by using a simple expression instead of transIdxMPS table and merging transIdxLPS and rangeTabLPS tables, which decreases hardware size. Arithmetic calculator consists of regular mode, bypass mode and termination mode for appearance probability of binary value. It can operate in maximum speed. The proposed binary arithmetic encoder has 7282 gate counts in 0.18um standard cell library. And input symbol per cycle is about 1.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2010.05a
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• pp.18-18
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• 2010

Glucosinolates(GSLs) are major secondary products($\beta$-thioglucoside N-hydroxysulfates) containing sulfates that are found mainly in Cruciferae family such as cabbage, broccoli, radish, turnip, kale, mustard and rapeseed as the important crops in agronomic and economic aspects. Especially, isothiocyanates(ITCs) have been shown to inhibit carcinogenesis with regulation cancer cell development followed by regulating target enzymes, inducing cell cycle arrest and apoptosis against various human cancer cell lines. Total desulfo(DS)-GSLs of nine type in 210 Korean leaf mustard accessions were isolated and confirmed using electrospray ionization mass spectrometric(ESI-MS/MS) method and DS-GSLs powerful library maked from several reference data. The isolated individual DS-GSLs were identified by removed $\beta$-D-glucopyranose residue ($C_6H_{11}O_5$, MW 163) from MS/MS data. Among them sinigrin(41.7%), glucoiberverin(21.7%) and gluconasturtiin(12.6%) were major components, Especially, despite gluconapin was minor component, accession K046197-1 and K046197-2 showed higher content of 4.11 and 3.31 mg/g(DW), respectively. The total GSLs contents in 210 accessions were ranged from 5.3 to 23.2 mg/g(DW) with a mean value of 13.0 mg/g(DW). As a result of principal component analysis(PCA), the individual GSLs loading plots were composed of three groups and components belonged to each group showed correlationship in quantitative pattern.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.14 no.2
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• pp.29-42
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• 2019

Objectives : This study aimed to review the effects of Daoyin exercise on stroke patients in clinical studies. Methods : In this study, we reviewed 11 electronic databases (CAJ, EMBASE, Cochrane Library, Web of Science, Pubmed, RISS, Dbpia, NDSL, KISTI, KISS, KMBASE) on October 27, 2019. We included only randomized controlled trials (RCTs) which evaluated the effect of Daoyin exercise on stroke patients. The methodological quality of the included studies was checked using the Cochrane risk of bias tool. Results : After screening the papers, eleven RCTs fulfilled the inclusion criteria. The results of the meta-analysis showed that Daoyin exercise improves the measurement value on the Fugl-Meyer Assessment, Modified Barthel Index and National Institutes of Health Stroke Scale in stroke patients. Conclusions : We concluded that Daoyin exercise has therapeutic effects in functional recovery and in enhancing the independence of daily living activities for stroke patients. However, the quality of the original articles was low and the number of papers included were few. Thus, to confirm these results, further well-designed RCTs should be conducted.