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The penetration enhancement and the lipolystic effects of TAT-GKH, in both In vitro, Ex vivo, and In vivo.

  • Lim, J.M.;Chang, M.Y.;Park, S.G.;Kang, N.G.;Song, Y.S.;Lee, Y.H.;Yoo, Y.C.;Cho, W.G.;Han, S.G.;Kang, S.H.
    • Proceedings of the SCSK Conference
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    • 2003.09b
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    • pp.87-107
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    • 2003
  • It was demonstrated that Transactivating transcriptional activator(TAT) protein from HIV-1 shown to enter cells when added to the surrounding media. TAT peptide chemically attached to various proteins was able to deliver these proteins to various cell and even in tissues in mice with high levels in heart and spleen. In this study, the tripeptide GKH(Glycine-Lysine-Histidine) derived from Parathyroid hormone (PTH), which was known as lipolytic peptide, is attached to 9-poly Lysine(TAT) to be used as a cosmetic ingredient for slimming products. When Glycerol release, expressed as extracellular glycerol concentration, is lipolysis index, TAT-GKH at $10^{-5}$mo1/L induces approximately 41.5% maximal lipolytic effects in epididymal adipocytes isolated from rats, compared with basal lipolysis. Epididymal adipose tissues of male rats is assessed ex vivo by microdialysis. Probes are perfused with Ringer solution in which increasing concentrations of TAT-GKH. The perfusion of TAT-GKH induces lipolytic effect. Penetration study showed that TAT-GKH efficiently elevates 36 times higher penetration into the excised hairless mice skin than GKH. in vivo study showed that TAT-GKH had a better effect upon the relative volume of eye bag after 28 days of application on twenty(+2) healthy female volunteers. It was identified that TAT-GKH increases penetration enhancement and lipolytic effects in both in vitro, ex vivo and in vivo.

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STUDIES ON BIOCHEMICAL POLYMORPHISM OF MILK PROTEIN AS GENETIC MARKERS IN PIGS

  • Chung, E.R.;Han, S.K.;Shin, Y.C.;Chung, H.Y.;Kim, J.E.
    • Asian-Australasian Journal of Animal Sciences
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    • v.5 no.2
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    • pp.285-294
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    • 1992
  • Biochemical polymorphisms of sow's milk proteins, $\beta$-casein ($\beta$-CN), $\beta$-lactoglobulin ($\beta$-LG), post-lactoglobulin (post-LG), $\alpha$-lactalbumin ($\alpha$-LA) and X-protein, as genetic markers for major pig breeds (Landrace, Yorkshire, Duroc, Hampshire and cross bred) in Korea were determined by starch gel electrophoresis. Phenotype and gene frequencies at all marker loci were estimated and genetic differences among breed populations were analyzed. Three $\beta$-CN phenotypes (AA, AB and BB) controlled by two codominant alleles (${\beta}-CN^A$ and ${\beta}-CN^B$), four $\beta$-LG phenotypes (AA, AC, $AC^{\pm}$ and CC) controlled by two codominant alleles (${\beta}-LG^A$ and ${\beta}-LG^C$) and ten X-protein phenotypes (AA, BB, CC, DD, AB, AC, AD, BC, BD and CD) controlled by four codominant alleles ($X^A,\;X^B,\;X^C\;and\;X^D$) were identified. In addition, a genetically controlled polymorphism of post-LG was found for the first time in sow's milk protein. Three different phenotypes (AA, AB and BB) were designated $post-LG^A$ and $post-LG^B$. Of the five marker loci examined, $\alpha$-LA locus was observed to lack any individual variation in all breeds studied. All populations were in Hardy-Weinberg equilibrium for all loci. There were marked breed differences for phenotype and gene frequencies in the post-LG and X-protein marker loci. However, there were little differences between breeds in the gene frequencies at the $\beta$-CN and $\beta$-LG marker loci.

Effects of $H_2$ vs. $O_2$ Plasma Pretreatment of Gate Oxide on the Degradation Phenomenon of Low-Temperature Polysilicon Thin-Film Transistors

  • Lee, Seok-Woo;Kang, Ho-Chul;Yang, Joon-Young;Kim, Eu-Gene;Kim, Sang-Hyun;Lim, Kyoung-Moon;Kim, Chang-Dong;Chung, In-Jae
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.1254-1257
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    • 2004
  • Comparative study on the effects of $H_2$ vs. $O_2$ plasma pretreatment of gate oxide on the degradation phenomenon of p-channel low-temperature polysilicon (LTPS) thin-film transistors (TFTs) were performed. After high drain current stress (HDCS) with $V_{gs}$ = $V_{ds}$, the p-channel TFTs pretreated by $O_2$ plasma showed increased immunity to the degradation of device characteristics such as threshold voltage and maximum field effect mobility because of the higher binding energy of Si-O bond than that of Si-H bond. The investigation of degradation phenomenon of these parameters with the applied power suggests that self-heating can be the major cause of degradation of polysilicon TFTs.

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A Superior Optical Performance of advanced S-IPS LCDs with Fine Pitch Electrode and Robust Design

  • Kwon, Jang-Un;Lee, Su-Woong;Jung, Il-Ki;Han, Hwa-Dong;Park, In-Chul;Lee, Kyung-Ha;Moon, Hong-Man;Shin, Hyun-Ho
    • 한국정보디스플레이학회:학술대회논문집
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    • 2008.10a
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    • pp.333-336
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    • 2008
  • We have studied on optical properties of advanced S-IPS with a fine pitch electrode and a new finger design. Transmittance of panel increases with decreasing of width and angle of finger electrode. In order to improve transmittance, fine pitch electrode of ${\sim}2{\mu}m$ and rubbing angle of 10 degree have been adopted. Various optical performances are defined as the function of finger design and field intensify across the IPS pixel electrodes. We have developed the advanced electrode structures with a high performance. As a result, the optical properties of 42" full HD with 120Hz frequency shows high transmittance over 5%, contrast ratio of 1800:1, gray-to-gray response time of 4.4ms, respectively. And also we have studied that the moving picture quality of IPS LCD is related with design parameters of IPS cells and finger shape.

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The improvement of GTG response time using new concept LC mixture in S-IPS Mode for high frame frequency technologies

  • Kim, D.K.;Lim, C.S.;Lee, D.J.;Hwang, J.I.;Jung, H.G.;Lee, S.W.;Oh, C.H.;Kang, I.B.;Jin, Min-Ok;Jin, Heui-Seok;Lee, Seung-Eun;Jacob, Thomas;Czanta, Markus;Tarumi, Kazuaki
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.864-867
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    • 2006
  • In order to satisfy with the clear visibility without any difficulties such as blurring and tailing, the high refreshing rate technology and fast response time of LC itself were applied to TFT-LCDs. In proportion to the decrease of holding time of 1 frame, the fast transition of LC behavior was necessary to both maintain the luminance and minimize the tailing appearance. The introduction of a new LC mixture for faster response times was realized by the good combination of newly introduced dielectrically neutral LC material so called 'Super Low Viscosity' (SLV) and highly polar $CF_2O-linkage$ LC material. This resulted in about a 20% reduction in the ${\gamma}_1$ of the new LC mixture compared to the references. In accordance with a new LC mixture with low ${\gamma}_1$, fast response time of 5ms has been made for S-IPS LCD TV application. Consequently, by applying the high frame frequency of 120Hz driving alongside the 5ms response time characteristics, the MPRT value was reduced by half.

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The World's Largest 100inch TFT-LCD for HDTV and Public Display Application

  • Kang, I.B.;Jin, H.C.;Lee, S.H.;Jang, E.S.;Moon, H.M.;Oh, C.H.;Yeo, S.D.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.281-285
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    • 2006
  • Recently LG.Philips LCD (hereafter "LPL") has announced the development of the world's largest 100-inch TFT-LCD with Advanced Super IPS technology. This magnificent LCD achieves the feature of a full high definition resolution $1920{\times}1080(16:9)$, 600nit brightness, 3000:1 dynamic contrast ratio, 92% color gamut, 180 degree viewing angle, and 5msec response time at all grays, targeted for HDTV and public display applications. Some unique technologies such as Cu bus line, advanced wide view polarizer, and high color gamut lamp were applied. A new stitching free technology was developed to overcome the size limitation of photo mask in both the TFT and CF processes. The size of the panel (100-inch) based on the wide format (16:9) is determined by the maximum efficiency of world's $1^{st}$ seventh generation line (glass size:$1950{\times}2250mm$) in LPL's Paju display cluster. In this paper, we will discuss the issues of 100-inch TFT-LCD.

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Inhibitors of Melanogenesis from the Roots of Peucedanum praeruptorum (전호의 멜라닌 생성 억제 물질)

  • Kim, Won-Chan;Jin, Mu-Hyun;Kim, Ho-Jeong;Kang, Sang-Jin;Kang, Seh-Hoon;Jung, Min-Hwan;Lim, Young-Hee;Kim, Cheong-Taek
    • Korean Journal of Pharmacognosy
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    • v.33 no.4 s.131
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    • pp.395-398
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    • 2002
  • A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structlues of isolated compounds were identified as 3',4'- diangeloyl-cis-khellactone, 3'-angeloyl- 4'- senecioyl-cis-khel- lactone and,3', 4'-disenecioyl-cis-khellactone by $^1H\;NMR$, $^{13}C\;NMR$ and mass spectral studies and by comparisons of spectral data with reported literatures.

The Analysis of strengthening IT service performance through ALP(Active learning program) of LG CNS (ALP(Active learning program) 과정을 통한 LG CNS의 IT서비스 역량강화 사례)

  • Kang, Cheong-Woon;Park, Jai-Hyoung;Kim, Heung-Soo;Jang, Byeong-Kug;Won, Yong-Chun
    • 한국IT서비스학회:학술대회논문집
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    • 2009.11a
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    • pp.225-233
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    • 2009
  • 날이 갈수록 치열해지는 글로벌 경쟁 환경하에서 살아남기 위해 많은 기업들은 조직 구성원들의 역량 강화를 통한 기업의 경쟁력 강화를 위하여 다양한 활동들을 하고 있으며, 이러한 활동중 하나로 액션러닝을 많은 기업들이 채택하여 활용하고 있다. 그러나 액션러닝 과정은 경영층과 팀 리더 차원에서의 적극적인 지원 및 관심뿐만 아니라 참여하는 구성원들도 적극성을 갖고 수행되어야 역량 향상을 기대할 수 있다. 또한 기업의 문화 및 제도 역시 액션러닝이 원활하게 진행될 수 있도록 뒷받침되어야만 성공할 수 있다. 본 연구에서는 LG CNS에 도입하여 성공적으로 운영하고 있는 액션러닝의 역량강화 사례를 살펴보고 그 효과성을 분석해 봄으로서 글로벌 경쟁에서 살아남고 더 나아가 글로벌 IT서비스 기업과 대등한 수준에서 경쟁하기 위해 역량 강화를 원하는 여러 IT서비스 업체들에게 역량 향상을 위한 하나의 방향성을 제시하고자 한다.

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Detection of a Moving Object by Multi-channel SQUID Magnetometer System (다중채널 고온초전도 양자간섭소자 자력계 시스템을 이용한 이동 물체 탐지)

  • Lee, H.J.;Lee, S.-M.;Lee, H.N.;Yun, J.H.;Moon, S.H.;Lim, S.H.;Kim, D.Y.;Oh, B.
    • Progress in Superconductivity
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    • v.3 no.1
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    • pp.56-59
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    • 2001
  • We have constructed a multi-channel SQUID magnetometer system for localization and classification of magnetic targets. Ten SQUID magnetometers were arranged to measure 5 independent components of 3 $\times$ 3 magnetic field gradient tensor. To get gradient from the difference of magnetic field measurements, we carefully balanced magnetometers. SQUIDs with slotted washer were used for operation in an unshielded laboratory environment, and noise characteristic in the laboratory was measured. With the multi-channel SQUID magnetometer system, we have successfully traced the motion of a bar magnet moving around it at a distance of about 1 m. In the urban environment, the drift of uniform magnetic field due to the irregular motion of a large magnetic body at distance and earth field causes an error in the position calculation, and this results in the distortion of the calculated trajectory. In this paper, we present the architecture and the performance of the system.

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