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Inhibitors of Melanogenesis from the Roots of Peucedanum praeruptorum  

Kim, Won-Chan (Cosmetics R&D Center, LG Household & Health Care)
Jin, Mu-Hyun (Cosmetics R&D Center, LG Household & Health Care)
Kim, Ho-Jeong (Cosmetics R&D Center, LG Household & Health Care)
Kang, Sang-Jin (Cosmetics R&D Center, LG Household & Health Care)
Kang, Seh-Hoon (Cosmetics R&D Center, LG Household & Health Care)
Jung, Min-Hwan (Analytical R&D Center, LG Chem.)
Lim, Young-Hee (Analytical R&D Center, LG Chem.)
Kim, Cheong-Taek (Cosmetics R&D Center, LG Household & Health Care)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.4, 2002 , pp. 395-398 More about this Journal
Abstract
A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structlues of isolated compounds were identified as 3',4'- diangeloyl-cis-khellactone, 3'-angeloyl- 4'- senecioyl-cis-khel- lactone and,3', 4'-disenecioyl-cis-khellactone by $^1H\;NMR$, $^{13}C\;NMR$ and mass spectral studies and by comparisons of spectral data with reported literatures.
Keywords
Peucedanum praeruptorum Dunn; 3',4'-diangeloyl-cis-khellactone; 3'-angeloyl-4'-senecioyl-cis-khellactone; 3',4'-disenecioyl-cis-khellactone; Bl6 mouse melanoma cell lines; melanogenesis; melanin;
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