• Title/Summary/Keyword: lever

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Influence of early protein undernutrition on the size and composition of the rat brain and other organs (유유기(乳幼期)의 단백질부족(蛋白質不足)이 뇌(腦) 및 기타기관(其他器官)의 발달(發達)에 미치는 영향(影響))

  • Yu, Jong-Yull;Shin, Chung-Rae
    • Journal of Nutrition and Health
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    • v.3 no.2
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    • pp.81-85
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    • 1970
  • These experiments were designed to study the influence of protein undernutrition during lactation period(3 wks) or after-weaning period(8 wks) on growth of organs, and on brain and liver composition of the experimental rats. The following experimental groups were studied. Group No. Rats Lactation(3 wks) (Diet of mother rat) After-weaning period(8wks) Rehabilitation Period(17wks) I 8 25% Casein diet 25% Casein diet 25% Casein diet II 8 12% Casein diet 25% Casein diet 25% Casein diet III 8 25% Casein diet 5% Casein diet 25% Casein diet IV 8 12% Casein diet 5% Casein diet 25% Casein diet After the perriod of rehabilitation(17 wks) with 25% casein diet, the following results were obtained. 1. Most of the organs except the spleen could not catch up with the normal group in their weights for the group of protein undernutrition during lactation(3 wks), even after 17 weeks of rehabilitation. For the group of protein undernutrition during after-weaning period(8 wks) brain, lung, heart, spleen and pancreas could catch up with the normal group after rehabilitation. According to this result it is assumed that the growth of brain, lung, heart and pancreas might be developed mostly during lactation and that the growth of liver and kidney might be developed after-weaning period continuously. 2. For the groups of protein underuntrition during lactation period or after-weaning period the amounts of total lipid, cholesterol and phospholipid of brain were lower than those of normal group. Especially, cholesterol level was significantly lower than normal group. And there was also a significant difference in the phospholipid level of the after-weaning(8 wks) deprivation group. 3. The groups of protein undernutrition during lactation or after-weaning period(8 wks) showed lower level of liver nitrogen and higher level of liver fat. Especially, protein undernutriton during lactation gave a greater influence on the lever of liver fat.

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The Clinical Application of Sound-Protection

  • Tomohiko, Kamio
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1976.06a
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    • pp.87.1-87
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    • 1976
  • Bekesy measured the sound transformation system of the middle ear 49 years ago. According to his reports, a ratio between the size of ear drum and the size of oval window is 17 : 1, and the lever function of the ossicles is physiologically 1.3 : 1. Therefore, the hearing might be aggravated to 27.5㏈ in the case of the vanishment of 3 ossicles. In 1952, Wullstein reported 5 types of tympanop-lasty and the fourth type among them was especially named for the sound-protection. The oval window is only exposed by the sound pressure and the round window is not exposed. According to the application by this idea, the post-operative hearing might be improved until 27.5㏈. Mean while, in 1942, Onchi verified through his experiment that the results of Bekesy's measurement was not completely conformed to Onchi result. Bekesy measured the sound pressure on the stapes plate of the oval window, on the other hand, Onchi measured the sound pressure on the surface of the perilymph of the oval window after removing the stapes plate(Fig. 1).(Figure omitted) The difference of their experiment is recognized that the impedance of the stapes plate exists or not (Fig. 1). Both Audiogrums are compared as Fig. 2. The result of IV type of tympanoplasty is success ful in 54% as the Table 1. (Table Omitted) The reason of unsatisfactory is caused by the thick and unmovable window-membrane and by the closing of air passage to the round window. The closing of the air passage to the round window is occurred by the adhesion between the grafting membrane and the surface of promontorium. In order to preserve this adhesion, I produce to transplantate the mucous membrane of the lip to the bone surface of tympanic cavity after removing the granulation tissue of the tympanic cavity and to form a membranous canal for the sake of air passage (Fig. 3). (Figure Omitted) The post-operative hearing by this method is shown as Fig. 4, 5. In other words, the post-operative sound pressure entered into the cochlea directly, by way of the oval window only, not by way of the round window, as a theorie of the sound protection. (Figure omitted)

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Abuse Liability Assessment of l-Deprenyl by Testing Methamphetamine-like Discriminative Effects (메탐페타민 유사 분별능 시험을 통한 l-디프레닐의 약물남용가능성 평가)

  • Lee, Sun-Hee;Kim, Pu-Young
    • YAKHAK HOEJI
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    • v.42 no.1
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    • pp.101-107
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    • 1998
  • The antiparkinsonian agent l-deprenyl, a selective monoamine oxidase (MAO)-B inhibitor, is metabolized in part to l-methamphetamine and l-amphetamine. l< /I>-Deprenyl was evaluated for amphetamine and methamphetamine-like discriminative stimulus effects in rats and its mechanism of action was investigated. Rats were trained under a 5-response, fixed ratio schedule of stimulus-shock termination or a 10-response. Fixed-ratio schedule of food-presentation which discriminate between d-amphetamine (1mg/kg, i.p.) and saline or d-methamphetamine (1mg/kg, i.p.) and saline in a two-lever, operant conditioning procedure. Full generalization was obtained to d-amphetamine (1~3mg/kg). d-methamphetamine (1~3mg/kg) and l-deprenyl (17~30mg/kg) under both the food presentation and stimulus shock termination schedule. l-Deprenyl has dose-dependent amphetamine-and methamphetamine-like discriminative stimulus properties in rats only at doses of 17 and 30mg/kg. Reversible MAO-B inhibitor, RO 16-6491 didn`t show any amphetamine-like discriminative properties. Aromatic amino acid decarboxylase inhibitor, NSD 1015 decreased % responding of l-deprenyl in the methamphetamine-trained rats under the stimulus-shock termination schedule. SKF-525A produced partial inhibition of methamphetamine-like discriminative effects of l-deprenyl under the food presentation schedule. These results suggest that l-deprenyl has no abuse liability at the therapeutic range but there needs some caution at high doses and furthermore, drug discrimination studies under the food presentation and shock termination schedule are useful for the assessment of abuse liability of psychostimulants.

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A Study on the Design/Simulation and Manufacturing for Localization of Parts in Scoop Control Assembly of Small Military Boat (소형 선박 제어 헤드 조립체의 국산화를 위한 설계/해석, 제작에 관한 연구)

  • Yeog, Gyeong-Hwan;Kim, Jae-Hyun;Jin, Chul-Kyu;Chun, Hyeon-Uk
    • Journal of the Korean Society of Industry Convergence
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    • v.24 no.5
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    • pp.597-608
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    • 2021
  • The control head components used in small military vessels are designed to be domestically produced, prototypes, structural analysis, and casting methods are designed and cast. The control head assembly consists of a lever, an aluminum outside cover, Middle, front gear cover, back gear cover, and a zinc worm gear. In order to reverse the design of each component, 3D scanning device was used, 3D modeling was performed by CATIA, and prototype productions were carried out by 3D printer. In order to reduce the cost of components, gating system is used by gravity casting method. The SRG ratio of 1:0.9:0.6 was set by applying non-pressurized gating system to aluminum parts, 1:2.2:2.0 and pressurized gating system to zinc parts, and the shapes of sprue, runner and gate were designed. The results of porosity were also confirmed by casting analysis in order to determine whether the appropriate gating system can be designed. The results showed that all parts started solidification after filling completely. ANSYS was used for structural analysis, and the results confirmed that all five components had a safety factor of 15 more. All castings are free of defects in appearance, and CT results show only very small porosity. ZnDC1 zinc alloy worm gear has a tensile strength of 285 MPa and an elongation of 8%. The tensile strength of the four components of A356 aluminum alloy is about 137-162 MPa and the elongation is 4.8-6.5%.

The Mechanism of Labor Motivation as a Determinant of Economic Security of Enterprises in Competitive Conditions

  • Lagodiienko, Volodymyr;Samoilenko, Viktoria;Pasko, Maryna;Ovod, Larysa;Matsulevych, Yevgeniy
    • International Journal of Computer Science & Network Security
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    • v.22 no.2
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    • pp.385-393
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    • 2022
  • In the study of the mechanism of labor motivation as a determinant of economic security of the enterprise in competitive conditions, it was found that motivation is determinant in creating the conditions for production and ensuring the active functioning of the enterprise. It is substantiated that the motivational mechanism is the presence of a system of levers, incentives, measures and other elements for economic and administrative incentives for employees, which are used for incentives to work, increase productivity and safety, and more. The motivational mechanism plays an important role in ensuring the economic security of the enterprise and at the same time is a lever to increase competitiveness in the market. The functions of the mechanism of labor motivation are singled out, among which: explanatory-substantiating, regulative, communicative, socialization, regulating. The stages of occurrence of the motive for the employee are classified. The interrelation of motives and incentives in the mechanism of labor motivation as determinants of economic security of the enterprise in competitive conditions is proved. It is proved that the mechanism of labor motivation as a determinant of economic security of the enterprise in competitive conditions should be aimed at: assistance in forming and achieving goals and objectives of the enterprise and achieving balance and equilibrium of economic goals and social responsibility of the enterprise; ensuring close cooperation between management and employees of the enterprise; focus on building a flexible mechanism; transition to a democratic style of governance and involvement of employees in decision-making.

A Study on the Multi-sensor Toilet (다중센서 양변기에 관한 연구)

  • Lim, Jeong-Been;Park, Nam-Ki;Choi, Bo-Gyeom;Kim, Yeon-Koung;Kim, Jae-Wook
    • The Journal of the Korea institute of electronic communication sciences
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    • v.17 no.1
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    • pp.201-206
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    • 2022
  • In this paper, a flushing system with automatic opening and closing function of the toilet cover was studied. It works by an infrared sensor attached to the cover is detected or not. When the infrared sensor of the open function detects it, the servomotor is driven on the toilet cover to raise the cover, and when the infrared sensor with the close function detects the infrared sensor, the cover is set to be lowered. A tilt sensor is attached to the inside of the cover to operate when the cover goes down, and when this is activated, the servomotor connected to the toilet lever opens the stopper of the supply port and sends water down. In addition, we minimized the inconveniences for the next user when they use the toilet by using the non-contact water level sensor and LED function to notice the water is clogged during the flushing process. Also, we implemented UV-LED function to prevent bacterial growth while the toilet is closed.

Diagnostic Accuracy of Clinical Test for Anterior Cruciate Ligament Injury: Systematic Review

  • Deniz Yasemin;Sang-Woo Pyun;HyungSu Lee;Seong-Eun Kim;SunGyu Han;Dongyeop Lee;Ji-Heon Hong;Jae-Ho Yu;Jin-Seop Kim;Seong-gil Kim
    • The Journal of Korean Physical Therapy
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    • v.35 no.3
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    • pp.57-63
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    • 2023
  • Purpose: The aim of this study was to conduct a systematic review of randomized controlled studies from 2012 to present that explore the diagnostic accuracy of clinical tests used for diagnosing anterior cruciate ligament (ACL) injury. Methods: Study design: Systematic review. Literature search of the PubMed and Scholar databases was conducted using keywords related to diagnostic accuracy of clinical tests for ACL injury. The PRISMA Guidelines were followed to conduct this study. The Cochrane Risk of Bias Tool was utilized to assess the quality of each included study. Results: As a result, 8 studies were included, and 6 clinical tests used in ACL tears were evaluated for diagnostic accuracy. The pivot shift test was reported as having the highest +LR (29.5) value with a sensitivity of 59% and a specificity of 98%. However, the test with the lowest -LR value was the lever test, and the values were as follows: -LR (0.08), +LR (4.7), specificity (80%), sensitivity (94%). Conclusion: In this study, it was concluded that a single clinical test is not sufficient to determine the presence of ACL injury. Test combinations have a higher diagnostic accuracy than a single test. In this study, the accuracy of the clinical tests was examined without considering the amount of ACL rupture and acute-chronic condition. Further research is required to examine the impact of these two factors on diagnostic accuracy of clinical test.

Primary Arthroplasty for Unstable and Failed Intertrochanteric Fractures: Role of Multi-Planar Trochanteric Wiring Technique

  • Javahir A. Pachore;Vikram Indrajit Shah;Sachin Upadhyay;Shrikunj Babulal Patel
    • Hip & pelvis
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    • v.35 no.2
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    • pp.108-121
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    • 2023
  • Purpose: The primary objective of the current study is to demonstrate the trochanteric wiring technique. A secondary objective is to evaluate the clinico-radiological outcomes of use of the wiring technique during primary arthroplasty for treatment of unstable and failed intertrochanteric fractures. Materials and Methods: A prospective study including follow-up of 127 patients with unstable and failed intertrochanteric fractures who underwent primary hip arthroplasty using novel multi-planar trochanteric wiring was conducted. The average follow-up period was 17.8±4.7 months. Clinical assessment was performed using the Harris hip score (HHS). Radiographic evaluation was performed for assessment of union of the trochanter and any mechanical failure. P<0.05 was considered statistically significant. Results: At the latest follow-up, the mean HHS showed significant improvement from 79.9±1.8 (at three months) to 91.6±5.1 (P<0.05). In addition, no significant difference in the HHS was observed between male and female patients (P=0.29) and between fresh and failed intertrochanteric fractures (P=0.08). Union was achieved in all cases of fractured trochanter, except one. Wire breakage was observed in three patients. There were five cases of limb length discrepancy, three cases of lurch, and three cases of wire-related bursitis. There were no cases of dislocation or infection. Radiographs showed stable prosthesis in situ with no evidence of subsidence. Conclusion: Use of the proposed wiring technique was helpful in restoring the abductor level arm and multi-planar stability, which enabled better rehabilitation and resulted in excellent clinical and radiological outcomes with minimal risk of mechanical failure.

Deformation mechanisms of shallow-buried pipelines during road widening: Field and numerical investigation

  • Long Chen;Chenlei Xie;Zi Ye;Yonghui Chen;Zhewei Chai;Yun Li
    • Geomechanics and Engineering
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    • v.38 no.1
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    • pp.15-28
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    • 2024
  • The rapid development of the economy has compelled the widen of highways, and the main challenge of this undertaking lies in the uneven settlement of road embankments. Through field and numerical experiments, this study explores the deformation mechanism of shallow buried pipelines due to road widening. The utilization of Plaxis3D software, which is adapt at simulating complex engineering geological conditions, enables the simulation of the settlement of both the central and right-side road embankments. Comparing with other numerical software such as ABAQUS and COMSOL, Plaxis provided more constitutive models including HS, HSS and Hoek-Brown model. The work concludes that the uneven settlement of road cross-sections is positively correlated with the horizontal distance from the pipeline, with a maximum settlement of 73 mm observed after construction. Furthermore, based on the Winkler's assumption, theoretical settlement and stress calculation methods are established. Results indicate that the maximum difference between the calculated values of this formula and simulated values is 1.9% and 7%, respectively. Additionally, the study investigates the stress and settlement of the pipeline's top under different angles to understand its behavior under various conditions. It finds that with traffic loads applied to the new embankment, a lever effect occurs on the lower pipeline, with the fulcrum located within the central isolation zone, leading to a transition in curve type from "single peak and single valley" to "double peak and single valley." Moreover, the settlement of pipelines on both sides of the central isolation zone and the normal stress of the pipeline's top section are symmetrical.

The Pattern of Initial Displacement in Lingual Lever Arm Traction of 6 Maxillary Anterior Teeth According to Different Material Properties: 3-D FEA (유한요소모델에서 레버암을 이용한 상악 6전치 설측 견인 시 초기 이동 양상)

  • Choi, In-Ho;Cha, Kyung-Suk;Chung, Dong-Hwa
    • Journal of Dental Rehabilitation and Applied Science
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    • v.24 no.2
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    • pp.213-230
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    • 2008
  • The aim of this study was to analyze the initial movement and the stress distribution of each tooth and periodontal ligament during the lingual lever-arm retraction of 6 maxillary incisors using FEA. Two kinds of finite element models were produced: 2-properties model (simple model) and 24-properties model (multi model) according to the material property assignment. The subject was an adult male of 23 years old. The DICOM images through the CT of the patient were converted into the 3D image model of a skull using the Mimics (version 10.11, Materialise's interactive Medical Image Control System, Materialise, Belgium). After series of calculating, remeshing, exporting, importing process and volume mesh process was performed, FEA models were produced. FEA models are consisted of maxilla, maxillary central incisor, lateral incisor, canine, periodontal ligaments and lingual traction arm. The boundary conditions fixed the movements of posterior, sagittal and upper part of the model to the directions of X, Y, Z axis respectively. The model was set to be symmetrical to X axis. Through the center of resistance of maxilla complex, a retraction force of 200g was applied horizontally to the occlusal plane. Under this conditions, the initial movements and stress distributions were evaluated by 3D FEA. In the result, the amount of posterior movement was larger in the multi model than in the simple model as well as the amount of vertically rotation. The pattern of the posterior movement in the central incisors and lateral incisors was controlled tipping movement, and the amount was larger than in the canine. But the amount of root movement of the canine was larger than others. The incisor rotated downwardly and the canines upwardly around contact points of lateral incisor and canine in the both models. The values of stress are similar in the both simple and multi model.