• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.499-500
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• 2004

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.8
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• pp.1294-1301
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• 2004

Soy foods are a unique dietary source of isoflavones, which have effects relevant to prostate cancer prevention. The present study determines the effects of a short-term isoflavone supplement on serum PSA (prostate specific antigen), lipid profile, antioxidant status, and immune system in prostate cancer patients. Ten prostate cancer patients were supplemented daily with 150 mg of isoflavone for 2 months. Blood samples were collected baseline and 2 month after for analysis of PSA, serum lipid profiles, total antioxidant status (TAS), grade of DNA damage in lymphocytes, IL-6, VEGF and TNF -$\alpha$. After 2 month isoflavone supplementation, increased significantly a total of estimated urinary isoflavone excretion and did not change PSA. Serum lipid profiles showed significant change in serum total cholesterol level (p=0.007). However, there was no significant change in HDL- and LDL-cholesterol levels. TAS was increased but not significant after isoflavone supplementation. Tail moment (TM) was decreased and especially tail length (TL) was decreased significantly (p=0.043). IL-6 level was decreased but VEGF level and TNF -$\alpha$ level were increased. The results of the present study led to the conclusion that the isoflavone dosage (150 mg) in supplement had positive effects on the serum total cholesterol level and DNA damage.

• Journal of the Korean Society of Safety
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• v.37 no.6
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• pp.166-173
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• 2022

A variety of input parameters are taken into consideration while performing a Level 3 PSA. Some parameters related to plume segments, spatial grids, and particle size distribution have flexible input formats. Fine modeling performed by splitting a number of segments or grids may enhance the accuracy of analysis but is time-consuming. Analysis speed is highly important because a considerably large number of calculations is required to handle Level 2 PSA scenarios for a single-unit or multi-unit Level 3 PSA. This study developed a sensitivity analysis supporting interface called MACCSsense to compare the results of the trials of plume segmentation with the results of the base case to determine its impact (in terms of time and accuracy) and to support the development of a modeling approach, which saves calculation time and improves accuracy. MACCSense is an automation tool that uses a large amount of plume segmentation analysis results obtained from MUST Converter and Mr. Manager developed by KAERI to generate a sensitivity report that includes impact (time and accuracy) by comparing them with the base-case result. In this study, various plume segmentation approaches were investigated, and both the accuracy and speed of offsite consequence analysis were evaluated using MACCS as a consequence analysis tool. A simultaneous evaluation revealed that execution time can be reduced using multi-threading. In addition, this study can serve as a framework for the development of a modeling strategy for plume segmentation in order to perform accurate and fast offsite consequence analyses.

• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.107-115
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• 2020

This paper introduces the first vital area identification (VAI) process for the physical protection of nuclear power plants (NPPs) during low power and shutdown (LPSD) operation. This LPSD VAI is based on the 3rd generation VAI method which very efficiently utilizes probabilistic safety assessment (PSA) event trees (ETs). This LPSD VAI process was implemented to the virtual NPP during LPSD operation in this study. Korea Atomic Energy Research Institute (KAERI) had developed the 2nd generation full power VAI method that utilizes whole internal and external (fire and flooding) PSA results of NPPs during full power operation. In order to minimize the huge burden of the 2nd generation full power VAI method, the 3rd generation full power VAI method was developed, which utilizes ETs and minimal PSA fault trees instead of using the whole PSA fault tree. In the 3rd generation full power VAI method, (1) PSA ETs are analyzed, (2) minimal mitigation systems for avoiding core damage are selected from ETs by calculating system-level target sets and prevention sets, (3) relatively small sabotage fault tree that has the systems in the shortest system-level prevention set is composed, (4) room-level target sets and prevention sets are calculated from this small sabotage fault tree, and (5) the rooms in the shortest prevention set are defined as vital areas that should be protected. Currently, the 3rd generation full power VAI method is being employed for the VAI of Korean NPPs. This study is the first development and application of the 3rd generation VAI method to the LPSD VAI of NPP. For the LPSD VAI, (1) many LPSD ETs are classified into a few representative LPSD ETs based on the functional similarity of accident scenarios, (2) a few representative LPSD ETs are simplified with some VAI rules, and then (3) the 3rd generation VAI is performed as mentioned in the previous paragraph. It is well known that the shortest room-level prevention sets that are calculated by the 2nd and 3rd generation VAI methods are identical.

• Journal of Pharmacopuncture
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• v.14 no.4
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• pp.81-88
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• 2011

Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values. Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had monitored the changes of PSA value. Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment. Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.

• Proceedings of the Korean Nuclear Society Conference
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• 2002.05a
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• pp.411.2-411
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• 2002

• Journal of Radiation Protection and Research
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• v.43 no.2
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• pp.50-58
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• 2018

Background: In terms of the Level 3 probabilistic safety assessment (Level 3 PSA), ingestion of food that had been exposed to radioactive materials is important to assess the intermediate- and long-term radiological dose. Because the ingestion dose is considerably dependent upon the agricultural and dietary characteristics of each country, the reliability of the assessment results may become diminished if the characteristics of a foreign country are considered. Thus, this study intends to evaluate and analyze the ingestion dose of Korean during a severe accident by completely considering the available agricultural and dietary characteristics in Korea. Materials and Methods: This study uses COMIDA2, which is a program based on dynamic food chain model. It sets the parameters that are appropriate to Korean characteristics so that we can evaluate the inherent ingestion dose of Korean. The results were analyzed by considering the accident date and food category with regard to the $^{137}Cs$. Results and Discussion: The dose and contribution of the food category depicted distinctive differences based on the accident date. Particularly, the ingestion dose during the first and second years depicted a considerable difference by the accident date. However, after the third year, the effect of foliar absorption was negligible and exhibited a similar tendency along with the order of root uptake rate based on the food category. Conclusion: In this study, the agricultural and dietary characteristics of Korea were analyzed and evaluated the ingestion dose of Korean during a severe accident using COMIDA2. By considering the inherent characteristics of Korean, it can be determined that the results of this study will significantly contribute to the reliability of the Level 3 PSA.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2555-2558
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• 2014

Pirpose: The aim of this study to analyze the association between history of diabetes mellitus (DM) with risk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materials and Methods: 50 patients with DM and 50 patients without DM who undervent radical prostatectomy (RP) were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSA levels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from all patients. Histologic material obtained at biopsy was given a Gleason score; tumours with a Gleason score ${\geq}7$ were considered high grade and <7 were considered low grade. Results: The mean age at the time of biopsy was 63.7 in patients with DM and 61.6 in patients without DM. Diabetic men had significantly lower PSA levels (p=0.01). Mean PSA level $7.04{\pm}2.85$ in patients with DM and $8.7{\pm}2.86$ in patients without DM, respectively. Also, diabetic men had higher RP tumor grade than men without DM (p=0.04). We found that HbA1c levels were higher in patients who have high grade prostate cancer (p<0.05). Conclusions: Diabetic men undergoing RP have lower PSA levels and have significantly higher grade PCa. We must be careful for screening PCa in patients with DM. Although the patients had lower PSA levels, they might have high grade disease.

• Journal of radiological science and technology
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• v.41 no.4
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• pp.313-319
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• 2018

The purpose of this study was to investigate the influence of metabolic syndrome (MS) on the lower urinary tract symptoms (LUTS), prostate specific antigen (PSA), and prostate volume in Korean men. We analyzed the data from 2654 men over the age of 40 who visited our health promotion center for regular health checkups. Of the total 2654 men, mean age, PSA level, International Prostate Symptom Score (IPSS), and prostate volume were 54.6 years, 1.21ng/ml, 6.2 points, and 27.8ml, respectively. All examinees were divided into MS group (46.5%, 1235 men) and non-MS group (53.5%, 1419). Age and prostate volume were significantly higher in the MS group. The patients were divided into three groups according to their ages: 40's, 50's, and over 60 years old. Prostate volume of the MS group in the younger age groups (40-49 years and 50-59 years) was significantly larger than that of the non-MS group. However, no difference was revealed in the age group of 60-69 years. No significant differences were found in the PSA level and LUTS between the MS and non-MS groups. In the multivariate regression analysis, central obesity was the strongest risk factor for the enlargement of prostate over 30ml among the metabolic components.

• Journal of Radiation Protection and Research
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• v.43 no.2
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• pp.39-49
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• 2018

Background: A model to assess the activity concentration of agricultural products and the public ingestion dose as result of a nuclear accident is necessarily required to manage the contaminated agricultural systems by the accident, or to estimate the effects of chronic exposure due to food ingestion at a Level 3 PSA. Materials and Methods: A dynamic compartment model, which is composed of three sub-modules, namely, an agricultural plant contamination assessment model, an animal product contamination assessment model, and an ingestion dose assessment model has been developed based on Korean farming characteristics such as the growth characteristics of rice and stockbreeding. Results and Discussion: The application study showed that the present model can predict well the characteristics of the activity concentration for agricultural products and ingestion dose depending on the deposition date. Conclusion: The present model is very useful to predict the radioactivity concentration of agricultural foodstuffs and public ingestion dose as consequence of a nuclear accident. Consequently, it is expected to be used effectively as a module for the ingestion dose calculation of the Korean agricultural contamination management system as well as the Level 3 PSA code, which is currently being developed.