• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.277-283
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• 1994

We studied the change in intraocular pressure (IOP) in 15 consecutive cataract patients who underwent extracapsular cataract extraction and posterior chamber lens implantation between Feb. 1993 and Apr. 1993 to evaluate the effect of this surgery on postoperative IOP. To evaluate the clinical usefulness of non-contact tonometer, the intraocular pressures were measured with Kowa non-contact tonometer (TM-2000, Japan) as well as Goldmann applanation tonometer. There was a decrease in IOP of $3.4{\pm}2.9$mmHg (p<0.00l) 3 months after this surgery and the intraocular pressure differences between pseudophakic eyes and contralateral phakic eyes at 3 months postoperatively were $2.4{\pm}3.8$mmHg (p<0.05). The correlation coefficient between non-contact tonometer and Goldmann tonometer was 0.8876 (p=0.001) in the postoperative 76 eyes. Therefore, our results suggest that extracapsular cataract extracion and posterior chamber lens implantation alone can be a useful surgical method in cataract patient with ocular hypertension, and non-contact tonometer was relatively accurate in measuring the postoperative intraocular pressure.

• Journal of Veterinary Clinics
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• v.32 no.1
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• pp.130-134
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• 2015

A 13-year-old, castrated male Yorkshire terrier was presented with acute blepharospasm 2 months after phacoemulsification with intraocular lens implantation in the left eye. Menace response was weakly positive in the left eye. Intraocular pressure (IOP) was 98 mmHg in the left eye. On ophthalmic examination using slit lamp biomicroscope, episcleral injection and corneal edema were observed in the left eye. Aqueous flare (1+) and iris bombe with peripheral anterior synechia were also detected in the left eye. In spite of medical treatments, IOP was remained more than 50 mmHg. Synechiolysis and radial iridectomy with irrigation/aspiration of anterior chamber were performed in the left eye. One week after the surgery, tissue plasminogen activator was injected to resolve the blood and fibrin clot in the left anterior chamber. Menace response was recovered completely 1 month after the surgery and IOP was maintained less than 20 mmHg more than 6 months.

• Electronics and Telecommunications Trends
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• v.36 no.5
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• pp.1-8
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• 2021

Over the last three decades, the development of Ti:sapphire femtosecond lasers has led to advancements in scientific and industrial fields. In particular, these advanced lasers show great potential for applications with bio-imaging and medical surgery, such as two-photon microscopy, nonlinear Raman microscopy, optical coherence tomography, and ophthalmic surgery. Herein, we present a detailed description of the theoretical and experimental physics of Kerr-lens mode-locked femtosecond Ti:sapphire lasers and its two-photon microscopy.

• Journal of Yeungnam Medical Science
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• v.11 no.1
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• pp.153-159
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• 1994

Extracapsular cataract extraction with posterior chamber intraocular lens in 24 eyes of 24 diabetics, with and without diabetic retinopathy, were followed up postoperatively for an average of 14 months to determine the incidence of progression of diabetic retinopathy, the final visual acuity and factors predictive of progression of retinopathy and final visual acuity. Overall, retinopathy progressed in 52% of operated-on eyes. Cataract extraction was highly associated with progression of diabetic retinopathy. Women had a significantly increased risk of progression of retinopathy in the operated-on eye compared to men. Visual acuity improved in 22 of 24 orerated-on eyes : however, only 11 eyes achieved a visual acuity of 0.5 or better and only 7 eyes achieved a visual acuity of 0.7 or better. Patients treated with oral hypoglycemic agents had a worse visual prognosis than those treated with insulin. The prognosis of patients with diabetic retinopathy about to undergo cataract surgery, even extracapsular cataract extraction with placement of a posterior chamber lens, is guarded.

• Journal of Chest Surgery
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• v.55 no.2
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• pp.101-107
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• 2022

Background: Spread through air spaces (STAS) has recently emerged as a prognostic factor in lung adenocarcinoma, but little is known about the association of STAS and its grade with recurrence in neuroendocrine tumors (NETs). This study investigated the prognostic effect of STAS grade in NETs after curative resection. Methods: Seventy-seven patients were retrospectively reviewed, including 9 with typical carcinoid (TC), 6 with atypical carcinoid (AC), 26 with large cell neuroendocrine carcinoma (LCNEC), and 36 with small cell carcinoma (SCC). STAS was defined as the presence of floating tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. STAS was classified as grade 1 or 2 depending on whether it was found within or beyond one ×10 objective lens field away from the main tumor margin, respectively. Results: Fifty-four patients (70%) had STAS, including 22% with TC, 50% with AC, 69% with LCNEC, and 86% with SCC. Patients with STAS had more nodal metastasis, lymphatic and vascular invasion, tumor necrosis, and tumor subtypes other than TC. Among STAS cases, grade 2 STAS was present in 33% of AC, 78% of LCNEC, and 87% of SCC. The 5-year recurrence-free survival (RFS) rate was 81%, 63%, and 35% in patients with no STAS, grade 1, and grade 2 STAS, respectively. Multivariate analysis found that grade 2 STAS was an independent negative prognostic factor for RFS. Conclusion: Although STAS itself was not associated with a poor prognosis, grade 2 STAS was an independent negative prognostic factor for RFS.

• Biomedical Science Letters
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• v.8 no.3
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• pp.127-135
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• 2002

Anterior subcapsular cataract was developed by opacification with transdifferentiation and abnormal proliferation of lens epithelial cells (LECs) and pathological accumulation of extracellular matrix (ECM). After-cataract also be caused by a similar transdifferentiation of LECs remaining after surgery and the accompanying increase of ECM deposits. It is blown that prostaglandin E2 and cytokine, such as TGF-$\beta$, bFGF, and IL-1, were associated with abnormal proliferation and transdifferentiation of LECs. The aim of this study was to detect the expression of transforming growth factor-$\alpha$ (TGF-$\alpha$), transforming growth factor-$\beta_1$(TGF-$\beta_1$) and basic fibroblast growth factor (bFGF) in LECs of senile and diabetic cataract. The expressions of these growth factors in lens epithelial cells were determined. The sample for growth factor determination were collected in senile cataract patients without metabolic disorder, especially diabetes mellitus and diabetic cataract patients. The mRNA expression of growth factors was detected by semi-quantitative reverse transcription - polymerase chain reaction (RT-PCR) followed by Southern blot analysis. Statistics were analysed using Wilcoxon rank sum test. Semi-quantitative RT-PCR/southern analysis of RNA obtained from thirty surgical specimens demonstrated that the level of mRNA expression of TGF-$\alpha$, -$\beta_1$ and bFGF was increased in diabetic cataract lens tissues compared with senile cataract specimens but non-significant, bFGF and TGF-$\beta_1$ mRNA expression were detected in most patients, expression level of TGF-$\beta_1$ was most high on the basis of normal ocular concentration. Detection rate of TGF-$\alpha$ in diabetic cataract was 1.5 fold higher than in senile cataract (P=0.098). TGF-$\alpha$, TGF-$\beta_1$, and bFGF mRNA expression of LECs were detected in senile and diabetic cataract. In both patient groups, expression level of TGF-$\beta_1$, mRNA was high, so We suggest TGF-$\beta_1$ strong influence in development of senile cataract and of diabetic cataract also. TGF-$\alpha$ expression level was similar but more frequently detected in diabetic cataract than in senile cataract. In conclusion, TGF-$\alpha$ may be associated with early development of diabetic cataract.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.285-293
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• 2014

Purpose: In order to find suitable size of soft contact lens for different ages group of elementary student to adults, visible iris diameter(horizontal, vertical) and palpebral aperture size were measured. Methods: Visible iris diameter (horizontal, vertical) and palpebral aperture size were measured in different age groups of total 514 subjects (1028 eyes) who have no eye disease and none history of surgery included cosmetic purpose. Results: No significant difference was found in iris diameter of both horizontal and vertical direction for different groups of age and sex but horizontal direction of palpebral aperture size in middle school students and university students groups and vertical direction of palpebral aperture size in high school student group shows significant difference (p<0.05) by sex. Horizontal visible iris diameter, vertical visible iris diameter, horizontal palpebral aperture size and vertical palpebral aperture size shows significant difference in difference age and sex. Conclusions: Visible iris diameter and palpebral aperture size are affective factor for soft contact lens diameter decision, especially it should considered more intensive for removing uncomfortable feeling of lens wearer.

• Medical Lasers
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• v.8 no.1
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• pp.19-23
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• 2019

Background and Objectives The picosecond 755 nm alexandrite laser was first approved by the US FDA in 2012. A previous study described the use of a 1,064 nm picosecond laser with a micro-lens array (MLA) in peri-areolar scarring from breast reconstruction surgery and reported significant improvement in the texture and aesthetic appearance of the scar without other wound complications. The purpose of this study was to evaluate the improvement of overall scarring, not just pigmentation, in the picosecond laser treatment of patients with pigmentations. Materials and Methods Sixteen patients who underwent 1,064 nm picosecond laser treatment from June 2016 to December 2018 were enrolled in this study. Patients received two to six sessions of picosecond laser treatment at intervals of 4 weeks. Before and after the laser treatment, the patients evaluated their own satisfaction score and a physician evaluated the Vancouver Scar Scale. To evaluate the satisfaction score and complication rate, a retrospective chart review was done. Results Seven were female and nine were male. The mean of the patients' satisfaction score before the treatment was 1.44 (interquartile range [IQR], 1-2) and 3.00 (IQR 2.25-3.75) six months after treatment. The mean of the Vancouver Scar Scale before the treatment was 9.69 (IQR 8-11), and 6.25 (IQR 5-7.75) six months after treatment. All the results were statistically significant (p<0.01). Conclusion This study provides evidence that the use of a 1,064 nm picosecond laser treatment for pigmented scars can be effective in improving the pigmentation and overall scar status, including vascularity, height, and pliability, with the results of a decrease in the VSS scores between treatments.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.4
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• pp.337-344
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• 2006

Purpose: To evaluate the vision-specific Quality of Life according to modes of refractive error correction in myopia. Method: This study included subjects from two different universities in Korea during March 2005 to June 2005. The following subjects (470) were university students, university faculty members, and their immediate families; all of whom were over the age of 19 and all who had refractive error of some sort. The four focus groups consisted of 171 spectacle wearers, 154 contact lens wearers, 123 refractive surgery patients, and 22 post-refractive surgery patients who returned to wearing glasses. The study of Vision-Specific Quality of Life used QIRC - The Quality of Life Impact of refractive Correction Questionnaire, which was translated by our group from English into Korean. Using analysis of co-variance (ANCOVA) and adjusting for age, sex, job, economic status, and education level, we examined and compared the QOL mean scores of the three groups (glass & contact lenses wears, refractive surgery patients, and post-refractive surgery patients who returned to wearing glasses). Results: After adjusting for major compounding variance, the research results showed the highest QOL mean score of 43.2 for the group who had received refractive surgery, 37.1 for the glasses & contact lenses group, and 33.4 for patients who had returned to wearing glasses after refractive surgery. There were significant differences between the three groups (p=0.001). Conclusion: Refractive surgery has shown a significant contribution to improve the QOL in myopia patients. However, upon our investigation, patients who underwent refractive surgery and returned to wearing glasses had a lower QOL compared to non-refractive surgery patients who wore glasses/contact lenses. Upon concluding our studies that shows that refractive surgery does not always conclusively bring higher QOL, we would like patients to carefully consider their options before undergoing refractive surgery in the future.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.1
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• pp.23-34
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• 2016

Purpose: In the present study, the effect of circle contact lenses wear on contrast sensitivity and glare sensitivity in a refractive surgery group was investigated. Methods: The contrast sensitivity and glare sensitivity were evaluated using by CGT-1000 for a non-refractive surgery group as control group(40 eyes) and a refractive surgery group(30 eyes) applied plano circle contact lenses, and pupil size was also measured. The correlation between contrast/glare sensitivity and the pupil size was analyzed. Results: In the refractive surgery group, contrast sensitivity in the range of high spatial frequency decreased with wearing circle contact lenses, and amount of decrease for the refractive surgery group was larger than for the control group. The correlation between pupil size and the change of contrast sensitivity was decreased by wearing circle contact lenses, and the correlation was lower in the refractive surgery group than the control group. Furthermore, the wear of circle contact lenses affected on glare sensitivity. In analyzing the change of glare sensitivity by pupil size, the glare was larger in the refractive surgery group than control group. Circle contact lenses in refractive surgery group were not fitted on the center of cornea. Conclusions: In the present study, it is suggested that the sufficient understanding and consideration about the decrease of contrast sensitivity and the increase of glare by wearing circle contact lenses after the refractive surgery is necessary.