• Bulletin of the Korean Chemical Society
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• v.34 no.3
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• pp.899-906
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• 2013

Using generated conformations from docking analysis by Gold algorithm, some 3D-QSAR models; CoMFA and CoMSIA have been created on 39 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues. These molecules inhibit the polymerization of tubulin into microtubules and thus they have been studied for the development of antitumor drugs. Training set for the CoMFA and CoMSIA models using 30 docked conformations gives $q^2$ Leave one out (LOO) values of 0.756 and 0.617, and $r^2$ ncv values of 0.988 and 0.956, respectively. The ability of prediction and robustness of the models were evaluated by test set, cross validation (leave-one-out and leave-ten-out), bootstrapping, and progressive scrambling approaches. The all-orientation search (AOS) was used to achieve the best orientation to minimize the effect of initial orientation of the structures. The docking results confirmed CoMFA and CoMSIA contour maps. The docking and 3D-QSAR studies were thoroughly interpreted and discussed and confirmed the experimental $pIC_{50}$ values.

• Journal of the Korean Society of Food Science and Nutrition
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• v.25 no.3
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• pp.379-383
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• 1996

To evaluate the methanol extract from Pinus strobus leave as a possible ingredient of health food, the sensory analysis and an animal experiment were designed using cookie, candy or chewing gum containing the methanol extract. Cookie, candy and chewing gum which contained 0.4%, 0.25% and 0.3% of the methanol extract, respectively, were prepared by Haitai Confectionary CO.. Sensory analysis of the products was evaluated by hedonic scale. Our results indicated that the addition of the methanol extract to the products provides better sensory perception in hedonic score and higher preference number than control, especially in candy and cookie. In the animal experiment, the chickens fed diet containing 10% of the cookie powder for 2 weeks exhibited a reduction of the serum cholesterol level by 18%, compared with the chickens fed basal diet. This result suggested that the methanol extract from P. strobus leave contained a potential ingredient to reduce the concentration of serum cholesterol. Therefore, extract from Pinus strobus leaves can be used as an ingredient of health food.

• Health Policy and Management
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• v.7 no.2
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• pp.1-18
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• 1997

This study was conducted to analyze patient days and medical care benefits of finger-amputated patients due to industrial accident. The 161 personal data on medical care for finger-amputated patients due to industrial accident(88 in 1994, 73 in 1995) of Regional Labor Office and hospital characteristics were analyzed. The major results of this study were as follows : According to stepwise multiple regression analysis of patient days, number of amputated finger, location of hospital, bed capacity of hospital, presence of plastic surgery in hospital, number of orthopedic specialist per 100 beds, sick leave benefits per day were the major significant variables in order. In stepwise multiple regression analysis with medical care benefits as a dependent variable, presence of plastic surgery in hospital, number of orthopedic specialist per 100 beds, number of amputated finger, sick leave benefits per day, age, bed capacity of hospital were the major significant variables in order. The minimum optimal size with the lowest medical care benefits was a hospital with 300 beds. This shows that the economy of scale is also applicable for hospital industry. In summary, presence of plastic surgery in hospital, number of orthopedic specialist per 100 beds, number of amputated finger, sick leave benefits per day, bed capacity of hospital were the major significant variables in both patient days and medical care benefits.

• Journal of Digital Convergence
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• v.10 no.9
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• pp.417-427
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• 2012

This study is to recognize the relationship between better life index, nursing performance and intents to leave among hospital nurses by comparison. From July 1to July 20, 2012. we collected survey results subjecting on total 700 nurses by random sampling of hospital-class medical institutes over 200 beds located on Busan & Gyeongnam, and analyzed final 677 copies. We recognized the degrees and the differences of happiness index, professionalism, intents to leave among hospital nerses and analyzed the factors impacting on intents to leave among hospital nerses through correlation analysis and multiple regression analysis between variables. The main result is as follows: First, the average of the item related to happiness index of nurse was 3.03 (5 points of scale) and the average score of professionalism was 3.09 (medium degree) but the average score of turnover intention was 3.35 (relatively high); Second, professionalism and turnover intention according to characteristics of subjects were significant statistically (p<0.05) and turnover intention indicated a significant negative relation with happiness index and professionalism; Third, a factor which mostly impact on turnover intention indicated a significant level (p<0.05) in professionalism, happiness index, general hospital, 2.01 to 2.5 million of average pay. Based on such results, as happiness index and professionalism are indicated as major factors to turnover intention, multi-dimensional viewpoint of follow-up study including further variables is required and the plan to apply nursing intervention program for reducing turnover intention is also required.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.3
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• pp.1-7
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• 2018

The purpose of this study is to compare and analyze the response time of three mobile portal sites in Korea using distributions. The research subjects are the mobile portal site of Naver, Daum, and Nate. The experiment period is six years from April 18, 2012 when mobile portals started to activate, to April 17, 2018. The number of experiments is 4,060. Histograms and percentages were used for the distribution comparisons. For the theoretical comparison, Chi-Square test is adopted as a parametric method, and Kolmogorov-Smirnov test is as a nonparametric method. Naver was the fastest of all four methods, the next was Nate, the next was the slowest. The same result was obtained in terms of average response speed. These results are in contradiction to the results of the wired portal. Naver is a strategy to increase the response speed in accordance with the characteristics of media. Daum is a strategy to increase the contents at the cost of response speed. As for classification, we divide the response time into "Comfortable", "Tolerable", "Feedback", "Leave" according to response time. The ratio of more than 7 seconds that users leave called as "Leave" is 1.18% for Naver, 11.70% for Daum, and 1.5% for Nate. As Daum is overwhelmingly high, the response time is very much in need of improvement. In addition, we show the response time of three mobile portals needs to be reduced We hope that the results of this paper will facilitate technology competition to increase the response speed of mobile portals.

• Korean Security Journal
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• no.35
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• pp.63-86
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• 2013

Security officers' intent to leave their job would have devastating effects on national security related industries. That is because excessive turnover would result in wasting the money for recruiting and training for organizations as well as putting the level of national security at risk. Therefore, this study has a goal to investigate the factors influencing the intent of leave job among security staff working for one of public institution, airports(n=198). Specifically, this study has a focus on examining the effect of job satisfaction, job commitment and security staff's level of commitment on national security on their turnover intent. The results of the multivariate ordinary lest square regression analysis reveal that job satisfaction, job commitment, and the level of national security commitment directly influence turnover intent. Also, the job satisfaction and the level of national security commitment has indirect impact on the turnover intent via job commitment. However, the results indicate that gender, age, and educational level are not related with security staff's decision to leave their job. Policy implications and study contribution were discussed in this study.

• Survey Research
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• v.10 no.3
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• pp.59-83
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• 2009

The purpose of this study is to understand why female labor force participation rates decline in early times after their marriage. Data were derived from the 4th(2001) to 9th(2006) Korea Labor & Income Panel Study. 194 Korean married women in twenties and thirties who had a job before marriage were analyzed. Survival analysis was used to explore the first labor force exit of married women longitudinally. The major findings are as follows. First, nearly half of them went away from labor market in the first 3 years after marriage. Second, child birth was the most significant factor in predicting women's labor force exit. Married women's employment discontinuity tend to be lowered after child birth, with working hour decreasing, and with the number of available family-friendly policies increasing. Married women's income encouraged them to hold on their career, though husband's income and household income were not significant. Third, married women tended to leave their job before giving birth. Women who remained in the labor market at child birth or until a year after birth were inclined to continue their job thereafter. Fourth, maternity leave and childcare leave diminished the probability of employment discontinuity. Many working wives could not use a maternity leave or childcare leave. This study shows married women usually underwent labor market exit in their newly married time. They cannot help facing conflict between the role of mother's and a worker's. Family-friendly policies could encourage working wives to rear child and continue work at the same time. The findings of this study could serve as fundamental material for further studies and would be a key to find effective solution for problematic issues on reconciling work and family.

• The Journal of the Korea Contents Association
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• v.11 no.5
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• pp.369-383
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• 2011

The purpose of this study was to investigate the determinants of intent to leave among IT industry employees, based on the Price's structural model of employee turnover. The sample used in this study were composed of 370 employees from 10 IT firms located in Seoul and Gyeonggi-Do. Data were collected with self-administered questionnaires and analyzed using structural equation modelling technique. This study found that four task reward variables(job variety, job autonomy, job challenge, and role ambiguity), two social reward variables (supervisory support and coworker support), three organizational reward variables(promotional chances, job security, and distributive justice) and one environmental variable(job opportunity), had significant effects on IT industry employees' intent to leave in terms of total effects and his directions of those significant effects were consistent with theoretical predictions; and that two mediating variables, job satisfaction and organizational commitment had the most important effects on IT industry employees' intent to leave in terms of total effects. The theoretical and practical implications of the research findings were discussed and the directions for future research were suggested.

• Journal of Life Science
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• v.29 no.1
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• pp.29-36
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• 2019

We investigated the fermentation conditions for extracts of leave/branches and sap from Korean Dendropanax morbifera (D. morbifera) using Lactobacillus plantarum (L. plantarum) ilchiwhangchil 1785 and L. plantarum ilchiwhangchil 2020. Log growth phase cultured L. plantarum ilchiwhangchil 1785 and L. plantarum ilchiwhangchil 2020 were used for fermentation. The pH and growth of the microorganisms in broth were monitored during the fermentation period. The results revealed that the optimum fermentation conditions for 20 wt% of leave/branches extracts and 1 wt% of sap extract was 2 days incubation at $37^{\circ}C$. The minimum inhibitory concentration (MIC) method and a disk diffusion assay were used to evaluate the antimicrobial activity of the fermented extracts of the leave/branches and sap against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antimicrobial activity increased in all three strains grown on the medium containing fermented extracts of the leave/branches and sap as compared with that of the strains grown on medium containing non fermented extracts. Furthermore, the antimicrobial activity increased in proportion to the contents of the fermented extracts. Our data suggest that fermented extracts of leave/branches and sap of D. morbifera have applications as natural bio functional materials, such as preservatives, cosmetic materials, and natural packaging materials.

• 한국노년학
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• v.31 no.2
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• pp.277-290
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• 2011

The present study examined the impact of work stress and job satisfaction on intention to leave among staff including social workers, nurses, and care workers. The study subject included 235 staff in a welfare organization that provides long-term care services. Data was analyzed using multiple linear regression. The findings of the study show that work stress and job satisfaction affect intention to leave in the context of welfare organizations. Demographic variables were not the main focus of this study and thus these results are incidental. Staff with higher levels of work stress were more likely to think about leaving, while those with grater job satisfaction were less likely. There were several limitations in this study. Generalizability of the findings are limited to staff working in the province of Jeonnam. The results have important implications for the development of strategies to minimize turnover intention in long-term care. Reducing the intent to leave is desirable for issues of both cost reduction and quality of care. Managers could perhaps start to consider decreasing work overload assigned to staff. This study also provides some insight into the work status of new staff. Clearly this finding needs to be explored in further research studies. A more comprehensive model is likely required to adequately explain intention to leave the job.