• Genomics & Informatics
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• v.14 no.2
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

• Journal of the Korea Convergence Society
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• v.11 no.9
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• pp.7-13
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• 2020

With the recent World Health Organization (WHO) Declaration of Pandemic for Coronavirus Disease-19 (COVID-19), COVID-19 is a global concern and many deaths continue. To overcome this, there is an increasing need for sharing information between countries and countermeasures related to COVID-19. However, due to linguistic boundaries, smooth exchange and sharing of information has not been achieved. In this paper, we propose a Neural Machine Translation (NMT) model specialized for the COVID-19 domain. Centering on English, a Transformer based bidirectional model was produced for French, Spanish, German, Italian, Russian, and Chinese. Based on the BLEU score, the experimental results showed significant high performance in all language pairs compared to the commercialization system.

• Journal of Korean Elementary Science Education
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• v.24 no.2
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• pp.160-173
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• 2005

In this study, we had tried to present a plan for improving the actual conditions of practical utilization of teaching material for 6th grade science developed by Ministry of Education & Human Resources Development and distributed to all elementary schools in Korea. Also we presented ways of better utilization of the teaching material after investigating the actual conditions of practical utilization. A survey was made to investigate and collect all data in the major metropolitan cities, the Kangwon, Chungcheong, Honam, and Kyeongsang area, respectively. We surveyed 316 6th grader teachers to investigate the actual conditions of distribution and utilization of teaching material as a general research. In addition, we surveyed 46 teachers to investigate the organization and content of teaching material as a particular research. The results are as follows. First, the teaching material was not approximately transmitted and kept to 6th grader teachers. Second, the utilization guide was not made. Third, it was reported that the thematic divisions of teaching material was a strong point, but the less detailed experiment manual was a weak point. Fourth, the consideration of content difficulties and simplicity was necessary to improve the material. Fifth, additional items should be included in the introductory presentation, convenience of reorganization, activity material causing learning interest, guidance of substitution experiment, and more concrete notice of experiment activity. Finally, there were positive responses of more than 4.0 point of Likert scale (1 to 5 point scale) in detail investigations of thematic items, which could have possibility that the teaching material was helpful to elementary school science field.

• Journal of Educational Research in Mathematics
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• v.24 no.3
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• pp.409-428
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• 2014

The purpose of this study is to examine the features of the curriculum of Chosun-Sanhak(朝鮮算學), the mathematics of Chosun Dynasty in the 17th to 18th century. The results of this study are as follows. First, the goal of education, teaching-learning method and assessment of Chosun-Sanhak in the 17th to 18th century had not changed since the 15th century. Second, the changes in the field of the organization of mathematical contents were observed. Chosun-Sanhak in that time was higher in the hierarchy than in the 15th to 16th century. The share of the equation and geometry had increased and various topics of mathematics had been studied as well. Third, in the field of the characteristics of mathematical contents, the influx of European mathematics and the uniqueness of Chosun-Sanhak had been observed. In conclusion, The 17th to 18th century was the time when Chosun-Sanhak had pursued the identity escaping from the effects of Chinese-Sanhak.

• Journal of KIISE
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• v.43 no.1
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• pp.54-60
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• 2016

Brain gene expression information is closely related to the structural and functional characteristics of the brain. Thus, extensive research has been carried out on the relationship between gene expression patterns and the brain's structural organization. In this study, Principal Component Analysis was used to extract features of gene expression patterns, and genes were automatically classified by spatial distribution. Voxels were then clustered with classified specific region expressed genes. Finally, we visualized the clustering results for mouse hippocampal region gene expression with the Allen Brain Atlas. This experiment allowed us to classify the region-specific gene expression of the mouse hippocampal region and provided visualization of clustering results and a brain atlas in an integrated manner. This study has the potential to allow neuroscientists to search for experimental groups of genes more quickly and design an effective test according to the new form of data. It is also expected that it will enable the discovery of a more specific sub-region beyond the current known anatomical regions of the brain.

• Journal of radiological science and technology
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• v.28 no.2
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• pp.123-128
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• 2005

It is necessary to obtain images of high diagnosis worth based on ability and skill of radiological technologist in case of acquisition of medical radiologaphy information. In addition, we need the various kinds of education considering individual radiological technologist variation and the organization of clinical education according to the large amount of learning and more expensive knowledge of radiology. In this paper, we implement CAI system for cervical vertebrae fracture radiograph with multimedia authoring tools on web environments. The CAI system can train a new radiological technologist and study a lot of radiological technologist on the cervical vertebrae fracture radiography acquisition based on more objective and systematical data in radiography room. The proposed CAI system is also expected as a useful program which can help to cure patients based on accurate diagnosis as well as obtain radiography more quickly using a technology of radiography acquisition for cervical vertebrae fracture.

• Korean Journal of Comparative Education
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• v.28 no.2
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• pp.77-95
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• 2018

This study introduces the Classroom Assessment Scoring System (CLASS) and explores the characteristics of CLASS for observing classroom. The CLASS is a standardized observation instrument that was largely developed for use in the USA. The CLASS attempts to provide a conceptual framework for categorizing classroom interactions and consists of three broad domains of quality (emotional supports, classroom organization, instructional supports). We simulated this method to the elementary school classes. The professional-teacher makes the best use of student's initiation behaviors, and the novice teacher focused on the leading the contents of subject. The novice teacher tyr to make more positive climate and to present more frequent feedback to students than professional teacher's classroom. The professional teacher would like to reveal the student's opinions, questions and subtle emotional state. The CLASS can be used to collect data on a wide range of specific aspects of the teaching and learning process at any given time.

• Journal of Fisheries and Marine Sciences Education
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• v.12 no.1
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• pp.83-97
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• 2000

This article refers to the processions and the improvement of the 7th revised curriculum development for the Fisheries and Merchant Marine High School, published at Dec. 30, 1997. The general point of the 7th revised curriculum development was to cultivate creative Korean who will lead the epoch of globalization and information and to perform the learner-centered curriculum. Moreover, it defines the nature of Business High School not as completive but as continuing education. Based on this view, the improvment of 7th revised curriculum has been searched in varous sides. The group of general researchers and cooperators consisted of 12 members who were of university professors, teachers, related business men and executives in the administration branches, and the total researchers of 7th revised curriculum development were 90 members. The basic orientation of the research for the revised curriculum development was as following : The improvement of basic ability, job-analysis ability, integrity of theory and practice, acquisition of the certificate of national qualification, interrelation and cooperative role division between school and industrial fields, extension of self-decision ability of school and local society, protection of learner-selection right and maintaining close relations with the business-educational organization under life-long education system. Thus on the whole, the research for educational goals and contents, instructions, learning theory and evaluation is being processed with a high activity, based on the above mentioned plan of 7th revised curriculum development. At the same time, the methods and the models are being investigated. At last, it is to be noted that, in such as the 7th revised curriculum development research in this case, the effort should not be spared to harmonize the basic technological knowledge of the specialists in the Fisheries and Merchant Marine field and the cultural, liberal arts of personality education.

• The Journal of the Korea Contents Association
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• v.19 no.1
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• pp.472-483
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• 2019

Why can't we be free from diverse crises threatening our lives in a high-tech future society? Disasters interrupt habitual and institutionalized patterns of behavior and bring about a kind of social shock to make people follow social and individual changes. An interesting fact revealed in the study finding is that the role of disaster management control tower was proper during the Great Flood ofthe Eulchuk Year(1925) and the unified disaster management system facilitated smooth cooperation with relevant authorities. Also, motivating disaster management organizations positively influenced organizational commitment. This implies that if we constantly ask to improve current institutions by introspecting and learning, based on historical records, we may be able to find insights for a safe society of the future.

• Journal of Korean Philosophical Society
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• v.144
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• pp.17-31
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• 2017

In the beginning of the 21st century, UNESCO (The United Nations Educational, Scientific and Cultural Organization) thinks the key to the battle is "morality," and thus proposes the norm of ethic, morals and values. Not only have countries all over the world responded to the proposal, but we in Taiwan are also involved in the campaign, hoping through the new movement, the deviant values are to be modified. "Doctrine of the mean" is the best essence in Confucianism when it comes to the idea of government ruling by a virtuous king, who possesses sincerity, a crucial element to inspire better character. Moral teachings nowadays emphasize the fact that a person should own ethic virtue and behave accordingly. Only via constant practice and training can people obtain sincerity and virtues in the learning process, in which Confucianists rely mostly on self-discipline while more tactics are applied to modern education.