• International Journal of Advanced Culture Technology
• /
• v.9 no.3
• /
• pp.23-33
• /
• 2021

"China's Western Development Policy" has brought multiple opportunities to the development of tourism in Southwest China including Sichuan, Guizhou, Yunnan, Chongqing and Tibet. The 4 provinces and 1 municipality overall show a certain degree of accumulation effect and coordinated development in tourism due to their location, traffic and traditional economic cooperation. This study takes the Southwest China as the research object and utilized the spatial dislocation model and the tourism spatial misalignment index to estimate the mismatch degree between tourism resources and tourism income among provinces and try to find out the internal reason background. The results show that each of the five provinces has its own advantages in index of economy, tourism resources, human resource, and transportation, leading to differences in the center of gravity of the entire region in all aspects. In view of the results of spatial dislocation analysis, suggestions for improvement and optimization are put forward to promote the high-quality development of tourism in Southwest region. development.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2019.10a
• /
• pp.70-70
• /
• 2019

Hepatic fibrosis is a common chronic liver diseases, characterized by the excessive deposition of extracellular matrix (ECM). Activation of hepatic stellate cells (HSC) is proliferative and fibrogenic and accumulating ECM. Transforming growth factor $(TGF)-{\beta}1$ is a critical mediator of HSC activation and ECM accumulation leading to fibrosis. Tenebrio molitor (TM), known as yellow mealworms, is reported in many countries as the nutritional value of foods. Our study has aims of finding liver function improvement effect of S. cerevisiae fermented Tenebrio molitor (SCTM) in vitro model. SCTM regulates $TGF-{\beta}1$ induced hepatic fibrosis via regulation of the $TGF-{\beta}1/Smad$ signaling. Also, we compared the components increased by yeast fermentation. It is possible to make a useful insect-derived alternative food in the improvement of hepatic liver disease.

• Membrane and Water Treatment
• /
• v.13 no.6
• /
• pp.259-290
• /
• 2022

Carbon nanotubes (CNTs), due to their excellent physical, chemical and mechanical properties and their ability to prepare new membranes with attractive properties, have found applications in water and wastewater technology. CNT functionalization, which involves the introduction of different types of functional groups into pure CNTs, improves the capabilities of CNT membranes for water and wastewater treatment. It turns out that CNT-based membranes have many advantages, including enhanced water permeability, high selectivity and anti-fouling properties. However, their full-scale application is still limited by their high cost. With their tremendous separation efficiency, low biofouling potential and ultra-high water flux, CNT membranes have the potential to be a leading technology in water treatment in the future, especially in desalination.

• Asia Marketing Journal
• /
• v.21 no.3
• /
• pp.47-64
• /
• 2019

We analyze and study competition in differentiated product market using public data source. Understanding competitive market structure is critical for firms to assess how their products compete against other firms in a given market. In this paper, we estimate consumer demand, extend clout and vulnerability framework, and study competition among multi-product manufacturers in differentiated product market. For our empirical analysis, we adopt choice-based aggregate demand model and estimate consumer demand while accounting for unobserved product characteristics. Once we estimate consumer demand, we compute full price elasticity matrix and investigate intra- and inter- manufacturer substitutions among consumers. This research offers a framework for marketers to analyze and understand market structures, leading them to informed decisions.

• Journal of Korean Neurosurgical Society
• /
• v.66 no.3
• /
• pp.298-307
• /
• 2023

Remarkable advances in neonatal care have significantly improved the survival of extremely low birth weight infants in recent years. However, intraventricular hemorrhage (IVH) continues to be a major complication in preterm infants, leading to a high incidence of cerebral palsy and cognitive impairment. IVH is primarily caused by disruption of the fragile vascular network of the subependymal germinal matrix, and subsequent ventricular dilatation adversely affects the developing infant brain. Based on recent research, periventricular white matter injury is caused not only by ischemia and morphological distortion due to ventricular dilatation but also by free iron and inflammatory cytokines derived from hematoma and its lysates. The current guidelines for the treatment of posthemorrhagic hydrocephalus (PHH) in preterm infants do not provide strong recommendations, but initiating treatment intervention based on ultrasound measurement values before the appearance of clinical symptoms of PHH has been proposed. Moreover, in the past decade, therapeutic interventions that actively remove hematomas and lysates have been introduced. The era is moving beyond cerebrospinal fluid shunt toward therapeutic goals aimed at improving neurodevelopmental outcomes.

• Advances in nano research
• /
• v.17 no.1
• /
• pp.51-59
• /
• 2024

Nanotechnology, the science of manipulating matter at the nanoscale, offers remarkable opportunities for innovation across various fields. Nanomaterials, which form the cornerstone of advanced materials, drive forward new ideas and groundbreaking applications. In the textile industry, traditional antibacterial and antifungal garments are typically treated with chemical compounds to inhibit bacterial growth. However, these treatments often lack durability, losing effectiveness after multiple washes. To address this limitation, the application of green nanotechnology in developing high-performance textiles emerges as a promising solution. This study explores the integration of nanocomposites into the polymer layers of footballs to enhance their stability and performance. By embedding nanoparticles within the polymer matrix, the durability and resilience of the footballs are significantly improved, leading to better control and performance on the field. This innovative approach not only extends the lifespan of the footballs but also provides economic advantages by reducing the frequency of replacements. Additionally, the enhanced stability contributes to a more consistent and reliable playing experience, promoting improved safety and performance for athletes.

• Journal of the Korean association of regional geographers
• /
• v.6 no.3
• /
• pp.169-184
• /
• 2000

Industrial clusters and their boundaries are identified by factor and hot spot analyses for the greater Cincinnati metropolitan area in USA. While traditional input-output approach identified aspatial industrial clusters, this study combines traditional approach with GIS techniques to identify their boundaries. Combining the results of input-output industrial clusters with the leading industries groups, we have identified five leading industry clusters. They are food (20), chemicals (28), metal manufacturing (32), metal products (33), and machinery (35). We also used hot spot analysis to visualize each industry cluster on the research area by using Arcview software. Determining the degree to which such industries are associated spatially and their spatial delimitation may be an additional approach to measuring the efficiency of the spatial organization of an economy. It is hoped that the industrial clusters and industrial spatial clusters approaches may also proved the basis for the development of new models of the spatial arrangement of industry at a level more aggregated than that of the single plant or firm.

• Biomolecules & Therapeutics
• /
• v.25 no.6
• /
• pp.625-633
• /
• 2017

Sphingosylphosphorylcholine (SPC) is one of the bioactive phospholipids that has many cellular functions such as cell migration, adhesion, proliferation, angiogenesis, and $Ca^{2+}$ signaling. Recent studies have reported that SPC induces invasion of breast cancer cells via matrix metalloproteinase-3 (MMP-3) secretion leading to WNT activation. Thrombospondin-1 (TSP-1) is a matricellular and calcium-binding protein that binds to a wide variety of integrin and non-integrin cell surface receptors. It regulates cell proliferation, migration, and apoptosis in inflammation, angiogenesis and neoplasia. TSP-1 promotes aggressive phenotype via epithelial mesenchymal transition (EMT). The relationship between SPC and TSP-1 is unclear. We found SPC induced EMT leading to mesenchymal morphology, decrease of E-cadherin expression and increases of N-cadherin and vimentin. SPC induced secretion of thrombospondin-1 (TSP-1) during SPC-induced EMT of various breast cancer cells. Gene silencing of TSP-1 suppressed SPC-induced EMT as well as migration and invasion of MCF10A cells. An extracellular signal-regulated kinase inhibitor, PD98059, significantly suppressed the secretion of TSP-1, expressions of N-cadherin and vimentin, and decrease of E-cadherin in MCF10A cells. ERK2 siRNA suppressed TSP-1 secretion and EMT. From online PROGgene V2, relapse free survival is low in patients having high TSP-1 expressed breast cancer. Taken together, we found that SPC induced EMT and TSP-1 secretion via ERK2 signaling pathway. These results suggests that SPC-induced TSP-1 might be a new target for suppression of metastasis of breast cancer cells.

• Journal of Engineering Education Research
• /
• v.20 no.6
• /
• pp.43-51
• /
• 2017

As the need for entrepreneurship to create new values and innovate in the rapidly changing social environment is emerging, education for entrepreneurial is emerging in university education. The purpose of this study is to understand the current status of entrepreneurship education and to derive the priority of education based on actual indicators of importance-performance. For this study, we surveyed 227 female college students in E Woman's University by using the Importance-Performance Analysis (IPA) method for entrepreneurship factors. The result showed that the means of importance of all factors and sub-factors of entrepreneurship were higher than the means of performance of them, and the difference was statistically significant except for the determination. In addition, the results of the IPA matrix analysis showed that the factors that needed urgent improvement in self-confidence, future-orientation, active/innovative activities, and proactivity. Based on the results of this study, the implications of the development of entrepreneurship curriculum for college students in engineering field were discussed. This study is meaningful that it provided practical basic information of curriculum design leading to the manifestation of entrepreneurship of women in engineering field by analyzing entrepreneurship of female engineering students and deriving priority factors of educational treatment.

• Journal of Radiation Protection and Research
• /
• v.42 no.4
• /
• pp.177-188
• /
• 2017

Background: Radiation-induced pneumonitis and pulmonary fibrosis are common dose-limiting complications in patients receiving radiotherapy for lung, breast, and lymphoid cancers. In this study, we investigated the characteristics of effective immune cells related to pneumonitis and fibrosis after irradiation. Materials and Methods: After anesthesia, the whole thorax of C57BL/6 mice was irradiated at 14 Gy. The lung tissue and bronchoalveolar lavage fluid were collected at defined time points post-irradiation for the determination of histological and immunohistochemical analysis and inflammatory cell population infiltrated into the lung. Results and Discussion: Whole thoracic irradiation increased the deposition of extracellular matrix (ECM), lung weight, and pleural effusions, which started to die from 4 months later. At 4 months after irradiation, the numbers of macrophages and lymphocytes as well as neutrophils were increased dramatically in the lung. Interestingly, the macrophages that were recruited into the lung after irradiation had an enlarged foamy morphology. In addition, the expressions of chemokines (CCL-2, CCL-3, CXCL-10) for the attraction of macrophages and T cells were higher in the lung of irradiated mice. The high expressions of these chemokines were sustained up to 6 months following irradiation. In thoracic irradiated mice, infiltrated macrophages into the lung had the high levels of Mac-3 antigens on their surface and upregulated the hallmarks of alternatively activated macrophages such as arginase-1 and CD206. Furthermore, the levels of IL-4 and IL-13 were higher in a BAL fluid of irradiated mice. Conclusion: All results show that thoracic irradiation induces to infiltrate various inflammation-related immune cells, especially alternatively activated macrophages, through enhancing the expression of chemokines, suggesting that alternatively activated macrophages are most likely important for leading to pulmonary fibrosis.