• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.205-210
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• 2018

Salvianolic acid B, which is a compound in the Salvia miltiorrhiza, has diverse biological activities, In particular, the antioxidative effects were reported to be involved in the protection of hepatocytes, neurons, and various cell types. On the other hand, some phenolic compounds, such as ferulic acid, which is regarded as an antioxidant, plays a pro-oxidative role in the specific transitional metal environment, which could explain the anticancer effect. This study examined the pro-oxidative effects of salvianolic acid B in the presence of $Cu^{2+}$. Treatment with both salvianolic acid B and $Cu^{2+}$ induced the transition of supercoiled DNA to the open circular or linear form but not in the sole salvianolic acid B or $Cu^{2+}$ treatments. Salvianolic acid B reduced the $Cu^{2+}$ to $Cu^+$ using neocuproine, a $Cu^+$ specific chelator. In addition, catalase, an enzyme that breaks down the $H_2O_2$ to water and molecular oxygen, inhibited the DNA breakage. $H_2O_2$, a reactive oxygen species, has detrimental effects on biological molecules, particularly DNA. Overall, the reduction of $Cu^{2+}$ by salvianolic acid B could lead to the production of $H_2O_2$ followed by DNA breakage. These results suggest that the pro-oxidative effects could be the one of the anti-cancer mechanisms of salvianolic acid B, which remains to be explained.

• Restorative Dentistry and Endodontics
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• v.26 no.5
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• pp.418-435
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• 2001

Root canal preparation process is of utmost importance in successful treatment of root canal. Also, one of the most important purpose of the root canal preparation is to enlarge the root canal three dimensionally without changing the curvature of the root canal However as the curvature of the root canal increases, there are many difficulties involved in formation of optimum root canal. Therefore in order to solve the above mentioned problems, new developments in methods of root canal preparation and equipments for such purposes were made. Recently, vigorous studies about newly introduced engine-driven nickel-ti-tanium rotary file are conducted. As shown in research results to dates, it is well established that the use of nickel-titanium file is better suited for curved root canal than stainless steel file in maintaining the curvature or root canal and reducing the deformation of root canal. However it is also acknowledged that there are a few discrepancies in research results according to protocol, due to failure to remove variables in experiments. In addition, although it is recommended by the manufacturer that the GT rotary file should maintain a low rotational speed of 150~350rpm and 'light pressure' as light as not to break the lead of a pencil, academic studies about the vertical force which is not yet standardized are not sufficiently explored. Therefore, this research devised and utilized a special research equipment to standardize the appropriate range of vertical force for GT rotary file through experiments by breaking of the lead of a pencil as expressed by the manufacturer and to accurately measure factors involved through repeating and recreating the environment of root canal preparation. Forming nine experimental groups by varying the vertical forces (150g. 220g, 300g) and rpm (150rpm, 250rpm, 350rpm), the effects of changing vertical forces and rpm on working efficiency were measured in terms of time expended in root canal preparation by crown-down method using a transparent resin block with 35 degree curvature and GT rotary file (z-test). The following research using this special research equipment that involved nine experimental groups and varying the vertical force for root canal preparation from 300g which is within the normal vertical force range to 700g and 1000g which fall outside the normal rpm range. The results were as follows : 1. Analysis of the experiment results revealed that the time spent in root canal preparation decreased as the vertical forces and rpm increased (p<0.05). Also, the effects of rpm were greater than those of the vertical forces within the normal vertical force range ($\beta$-weight test). 2. Observation of the deformation of GT rotary file revealed that deformation increases in a direct correlation with the vertical force increase and in a reverse correlation with the rpm decrease. In the case of the vertical forces close to the normal range, the probability of GT rotary file deformation were quite different depending on the rpm changes. In the case of greater vertical forces, the occurrences of deformation of the file were more frequent regardless of the rpm changes. 3. Deformation and breakage of file were also commonly observed in the expended time measurement experiments and GT rotary file deformation experiments in which low speed rpm (150rpm) was used and at the curved portion of the resin block.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.881-887
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• 2005

A total knee replacement is an extremely 'position-sensitive' operation; a malposition or a malalignment of the components will lead to a breakage of the component, a fracture around the knee prosthesis, and the limitation of range of the motion, etc. In a conventional total knee replacement, surgeons have to select an appropriate prosthesis according to the shape of the surgical region. A wrong selection may give rise to side effects or to need re-operation. Nevertheless, it is so difficult to choose the most proper prosthesis out of various kinds of prosthesis. This paper presents a surgical planning system for the total knee replacement with an operation simulating method in order to determine the parameters for the total knee replacement operation. We select an alignment axis and a resection angle as major operation parameters in the total knee replacement operation, and introduce the method to determine the major operation parameters with the operation simulator we developed. The simulator is used to determine operation parameters for optimized operations, to select the most appropriate prosthesis, and to analyze the prospective problems of the operation.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.8
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• pp.96-106
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• 2001

As the drilling depth increases, the cutting torque increases and fluctuates, which can lead to the machine tool vibration, severe tool wear, and catastrophic tool breakage. Hence, cutting torque control is very important to improve productivity in drilling. In this paper, a PID controller was designed to control the drilling torque. The plant including the feed drive system, cutting process and spindle drive system was modeled for controller design. The Ziegler-Nichols method was used to determine the controller gain and control action times and the root locus plot was used to tune the controller gain for a certain cutting condition. Also, suggested was a simple method to obtain the tuned controller gain for an arbitrary cutting condition not using the Ziegler-Nichols method and the root locus plot. The performance of the designed controller and the effect of controller gain tuning were verified from experiments.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.13 no.2
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• pp.51-59
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• 2017

Steam jets ejected from a rupture zone of high energy pipes may cause damage to adjacent structures. This event could lead to more serious accidents in nuclear power plants. Therefore, to prevent serious accidents, high energy pipes of nuclear power plants are designed according to the ANSI / ANS 58.2 technical standard. However, the US Nuclear Regulatory Commission (USNRC) has recently pointed out non-conservatism in existing high energy pipe fracture evaluation methods, and required the assessment of the unsteady load of the jet caused by a potential feedback mechanism as well as the impact range of steam jet, the jet impact loads and the blast wave effects at the initial breakage stage. The potential feedback mechanism refers to a phenomenon in which a vortex formed by impingement jets amplifies vortex itself and induces jet vibration in a shear layer. In this study, CFD methodology using the LES turbulence model is established and numerical analysis is carried out to evaluate the dynamic behavior of impingement jets and the potential feedback mechanism during jet impingement. Obtained results have been compared with an empirical correlation and experiment.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.209-216
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• 2016

Holes of rivets, bolts and nuts may cause stress concentration on the plates used in aircraft, ship and other structures. Excessive stress concentration may lead to severe breakage of the plates. Thus, accurate analysis of the stress concentration at the design stage will be important. In this paper, accuracy of EDISON program in stress concentration analysis was examined. By changing hole size on a narrow plate, the change of the stress concentration factor(K) was investigated. Additionally, the same experiment was conducted about series of holes on plate to investigate the interaction between adjacent holes. Then, these numerical results were compared with the analytic prediction. EDISON program showed very high accuracy about stress concentration, since the numerical results was correlated well with the analytic prediction.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.21 no.2
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• pp.64-72
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• 2022

Gear designers need to select the proper tolerances for deviations in both the center distance and parallelism of axes because these deviations cause high stresses and lead to fatigue breakage of the teeth. In this study, a three-dimensional finite element analysis model was developed for a helical gear used in metro vehicles, and a bending stress analysis method for gear pairs was established according to the contact position change. Using this model, the effect of shaft misalignment due to the center distance and shaft parallelism deviations on the bending stress of the gear was analyzed. As a result, the magnitude of the bending stress changed nearly linearly with the change in the center distance deviation. The tooth contact of the helical gear is biased toward the end of the tooth width when the parallelism deviations of the shaft occur, and the tooth root bending stress increases.

• IE interfaces
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• v.21 no.4
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• pp.411-417
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• 2008

An impeller is a type of high-speed rotor that is used to compress or transfer fluid under high-speed and pressure at high temperatures. The impeller is composed of an axial hub and several blades attached along the hub. The weight and shape of an impeller must be balanced, because their imbalances can cause noise and vibration, which can lead to the breakage of the impeller blades during operation. Thus, the hub and blades of an impeller are commonly machined in a 5-axis NC machine to obtain qualified surfaces. The impeller machining strategy or process plan can not be easily obtained due to the complex, overlapped and twisted shapes of impeller blades. Skillful machining process planners may generate appropriate machining strategies based on their experiences and floor data. However, in practice most shop floor data for the impeller machining is not well-structured such that it does not effectively provide a process planner with information for machining strategies and/or process plans. This paper reports the development of a case-based machining strategy support system (CBMS) that employs case-based reasoning to obtain the machining strategy of an impeller by using the existing machining strategies of the shop floor. The CBMS generates impeller machining strategies through a stepwise reasoning process considering the similarity features between the blade shapes and machining regions. A case study is provided to demonstrate that CBMS can generate useful machining strategies facilitating process planners. The developed system can simulate the tool paths of impeller machining and runs on the web.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.13 no.2
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• pp.124-130
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• 2014

In a mass manufacturing system of optical fibers, the sufficient cooling of glass fibers freshly drawn from a draw furnace is essential, asinadequately cooled glass fibers can lead to poor resin coating on the fiber surface and possibly fiber breakage during the process. In order to improve fiber cooling at a high drawing speed, it is common to use a helium injection into a glass fiber cooling unit in spite of the high cost of the helium supply. The present numerical analysis carried out three-dimensional thermo-fluid computations of the cooling gas flow and heat transfer on moving glass fiber to determine the cooling performance of glass fiber cooling depending on the method of helium injection. The results showed that afront injection of helium is most effective compared to a uniform or rear injection for reducing air entrainment into the unit and thus cooling the glass fibers at a high fiber drawing speed. However, above a certain amount of injected helium, there was no more increase of the cooling effect regardless of the helium injection method.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.6
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• pp.491-498
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• 2016

Stress on plates may increase in the neighborhood the edges or the holes for rivets or bolts. Excessive stress concentration may lead to severe breakage of the plates. Thus, it is important to conduct optimization of arrangement of holes at the design stage. In this paper, accuracy of FEM analysis was examined for such stress concentration. By changing the hole size on a narrow plate, change of the stress concentration factor(K) was investigated. Additionally, the same experiment was conducted about series of multiple holes on plate to investigate interaction between the adjacent holes. Then, the FEM results were compared to the reference predictions respectively. Finally, a method by which simple stress concentrating situations can be optimized, will be suggested. This method was examined by FEM, and showed similar tendency with the expectation. Therefore, this method can be valuable when arranging the holes on a plate.