• 제목/요약/키워드: laryngitis

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위식도 역류성 질환 관련 인후두성 역류(Laryngopharyngeal Reflux : LPR)증상을 호소하는 환자에서의 니자티딘의 치료효과 연구 (The Therapeutic Effects of Nizatidine in Gastroesophageal Disease with Laryngopharyngeal Reflux Symptoms: Observational Study)

  • 노영수;고중화;김광현;김명구;김병국;김성식;김영모;김영훈;김용복
    • 대한기관식도과학회지
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    • 제9권1호
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    • pp.67-74
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    • 2003
  • Larygopharyngeal reflux(LPR) is one form of the Gastroesophageal Reflux Diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, globus sensation in throat, chronic throat clearing, and chronic cough, Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus and reflux laryngitis should be suspected as LPR-related diseases. The nizatidine(AXID), as a Histamine H2-receptor antagonist, reduces gastric acid secretion and improves gastric motility function. Objectives : The effect of nizatidine using 150mg b.i.d was evaluated for symptom relief and improvement of laryngoscopic findings in patients with LPR. Materials and Methods : In 30 multicenter, observational trial performed nationalwidely in Korea. 308 patients with LPR symptom were observed to evaluate their symptoms and larygnoscopic findings after 4weeks, 8weeks, 12weeks of treatment with nizatidine. Results : The symptoms of LPR including globus sensation, chronic throat clearing and hoarseness, are reduced significantly after 4 weeks, 8weeks, and 12weeks of treatment(p<0.05). The laryngoscopic findings including diffuse erythema, edema and granulation are improved after nizatidine treatment(p<0.05). and the efficacy of nizatidine on LPR-related sympoms after 4 weeks is 88.6%, and those of after 8 weeks and 12weeks were 92.6%, and 99.1% in ITT(Intent To Treatment) group(p<0.05). And PPA(Per Protocol Analysis)group showed 93.7%, 97.3%, and 99.1% of efficacy after 4, 8, and 12 weeks of nizatidine treatment(p<0.05). Conclusion : These results indicate that in patient with LPR, nizatidine 150mg b.i.d treatment very effectively reduces LPR symptoms and improves laryngoscopic findings as well as reduces gastric acid secretion and improves gastric motility function.

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인후두위산역류증(Laryngopharyngeal Reflux : LPR) 관련 증상에 대한 시사프리드(Cisapride)의 효과 (Efficacy Profile of Cisapride in Laryngopharyngeal Reflux(LPR)-Related Symptoms(Open Multicenter Case Study & Open Multicenter Case Study between Cisapride & Ranitidine))

  • 최홍식;고중화;김광문;김광현;김민식;김영모;김찬우;김춘동;김형태
    • 대한후두음성언어의학회지
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    • 제9권2호
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    • pp.115-127
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    • 1998
  • Laryngopharyngeal reflux(LPR) is one firm of the gastroesophageal reflux diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, foreign body sensation in throat, chronic throat clearing, chronic cough, etc. Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus should be suspected as LPR-related diseases. In this multi-center trial, we tried to evaluate the effect of cisapride(10mg tid) on LPR-related symptoms as the part I study(CIS-KOR-051) in 19 centers, and as the part II study(CIS-KOR-052) comparative evaluation of effect between cisapride(10mg tid) and ranitidine(150mg bid) on LPR-related symptoms in 4 centers. In part I study, efficacy of cisapride on LPR-related symptoms after 4 weeks was 53.5% and that of after 8weeks was 77.9% in per protocol(PPA) analysis group. In part II study, efficacy of the cisapride was much better than that of ranitidine not only from 8 weeks trial(p<0.001) but also from 4 weeks trial(p<0.021) in PPA group. In the multiple logistic regression analysis among the parameters which affect the efficacy of the treatment, cisapride prescribed group showed 10 times greater than that of ranitidine prescribed group(p<0.0001, Odds ratio : 10) in PPA group. LPR was proved by 24Hr double probe pHmetry in 13 patients out of 19 patients tested(68.4%). Thus these results indicated that inducing the improvement of motility functions could affect the amelioration of the LPR-related symptoms much better than reducing acid secretion from the stomach. And maybe it suggests that LPR-related symptoms mainly developed by the reduced motility functions of the esophagus and/or delayed gastric emptying.

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애성을 주소로 한 후두질환의 임상 통계적 고찰 (A Clinical Study of Hoarseness)

  • 윤완규;조규모;송기준;김홍수
    • 대한기관식도과학회:학술대회논문집
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    • 대한기관식도과학회 1983년도 제17차 학술대회연제순서 및 초록
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    • pp.6.4-7
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    • 1983
  • 애성은 후두의 발성기능 장애로 생기는 후두질환의 대표적인 주 증상이고 또한 초기에 나타나는 증상이기도 하며 문화가 발달하고 경제수준이 높아짐에 따라 환자자신들이 각종 후두질환에 대한 관심이 커지고 특히 암에 대한 의심 때문에 내원하는 경우가 많아지고 있다. 최근에 각종 후두질환에 대한 연구가 활발해지고 있으며 특히 음성 자체의 질에 대한 관심도가 증가하고 있다. 이런 점에 비추어 저자들은 애성을 주 증상으로 하는 후두질환의 실태를 파악하고 정확한 진단을 내리는데 도움이 되고자 1980년 1 월부터 1982년 12월까지 만 3년간 애성을 주 증상으로 본 교실 이비인후과 외래로 내원한 환자에 대해 다음과 같은 임상통계적 결과를 얻었다. 1) 이비인후과 외래 신환 총 10110명 중 애성을 주소로 내원한 환자는 228명으로 약 2.3 %였다. 2) 애성환자 228 명 중 남자는 115명, 여자는 113명으로 남녀 비는 거의 비슷하였다. 3) 원인질환 별로는 급성후두염이 43예(18.9%)로 가장 많았으며 만성후두염 36예(15.8%), 성대결절 30예(13.2%), 후두폴립 30예(13.2%), 성대마비 26예(11.4%), 후두악성 종양 18예(7.9%) 및 후두결핵 15예(6.6%) 의 순이었다. 기타 후두질환들로는 30 예로 13.2 %를 차지하였다. 4) 연령별 빈도는 40대에서 26.8 %로 가장 많았고 30대 18.9 %, 50대 17.1 %, 20대 15.8% 및 60대 9.6 %의 순이었다. 5) 발병부터 초진까지의 기간은 11일∼1개월(22.8 %)이 가장 많았으며 1개월∼3개월(19.7 %), 3개월∼6개월 (18.9 %), 10일이내 (13.6 %), 6개월 ∼1년(13.2 %), 1년∼3년(7.9 %)및 3년이상(3.9 %) 순이었다. 6) 각질환에 따른 발병부터 초진까지의 최다기간은 급성 후두염이 10일 이내, 만성후두염은 3개월∼6개월, 성대결절은 1개월∼3개월, 후두폴립은 3개월∼1년, 성대마비는 11일∼1개월, 악성암은 3개월∼1년 및 후두결핵은 11일∼1개월 등이었다. 7) 애성과 동반하여 나타나는 증상들로는 인두통이 25 %를 차지하며 가장 많았고 객담 8.8 %, 연하운동장애 7.9 %, 기침 6.6%, 호흡곤란 6.1% 순이었으며 애성 만을 호소했던 경우는 84예로 36.8%를 차지하였다.

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역설적 성대운동을 보이는 3명의 환자에 대한 임상분석 (Clinical Evaluation of 3 patients with Paradoxical Vocal Cord Movement)

  • 최선명;임길채;한광우;남순열
    • 대한기관식도과학회지
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    • 제9권1호
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    • pp.83-86
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    • 2003
  • Background and Objectives : Paradoxical vocal cord movement is a series of paroxysmal adduction of the anterior two-thirds of the vocal cords during respiration or during phonation. The choking, stridor, and wheezing in this condition occur primarily on inhalation, rather than on exhalation. The two pathognomonic diagnostic criterias that need to be assessed during an acute presentation are laryngoscopy with direct visualization of paradoxical adduction of the vocal cords and pulmonary function testing. Materials and Methods : A retrospective review of 3 patients who were referred to otolaryngologist from pulmonology department, and were confirmed by typical laryngoscopic findings with paradoxical adduction of the vocal cords was conducted. Results The patients were misdiagnosed as exercised-induced asthma, and unresponsive to corticosteroid and bronchodilators. Improvement was achieved only by diagnosis with paradoxial vocal cord movement. Biofeed back therapy, voice therapy, treatment for reflux laryngitis improved symptoms. Conclusion The etiology of paradoxical vocal cord movement is unknown. It may be functional or emotional. The functional factors that were proposed are neurologic deficit and gastroesophageal reflux. Management methods of this condition consist of psychological counselling, voice therapy, and antireflux medication.

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신경회로망을 이용한 ARS 장애음성의 식별에 관한 연구 (Classification of Pathological Voice from ARS using Neural Network)

  • 조철우;김광인;김대현;권순복;김기련;김용주;전계록;왕수건
    • 음성과학
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    • 제8권2호
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    • pp.61-71
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    • 2001
  • Speech material, which is collected from ARS(Automatic Response System), was analyzed and classified into disease and non-disease state. The material include 11 different kinds of diseases. Along with ARS speech, DAT(Digital Audio Tape) speech is collected in parallel to give the bench mark. To analyze speech material, analysis tools, which is developed local laboratory, are used to provide an improved and robust performance to the obtained parameters. To classify speech into disease and non-disease class, multi-layered neural network was used. Three different combinations of 3, 6, 12 parameters are tested to obtain the proper network size and to find the best performance. From the experiment, the classification rate of 92.5% was obtained.

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편측 성대발적 6례에 대한 임상적 고찰 (Unilaterally Injected Vocal Fold : Clinical Aspects in 6 Patients)

  • 최홍식;서진원;문형진;김광문
    • 대한후두음성언어의학회지
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    • 제8권2호
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    • pp.239-244
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    • 1997
  • 편측 성대발적을 보였던 6례중 후두결핵이 4례, 성문부 편평세포암이 1례. 만성 후두염이 1례였으며 각 후두질환에 대한 진단과 적절한 치료를 위해서는 후두생검을 통한 보다 적극적인 조직병리학적 확진이 필요함을 문헌고찰과 함께 보고하는 바이다.

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한국산 토룡의 기초성분 분석 -Lamnodrilus gotai Hatai를 대상으로- (Analysis of Basic Constituents in Korean Earthworm About Lamnodrilus gotai Hatai)

  • 정용;이윤실;이효민
    • 약학회지
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    • 제31권4호
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    • pp.224-229
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    • 1987
  • The earthworm(Annelid) is a herbicine which has traditionally been used in the treatment of infectious fever, jaundice, infection of middle ear, laryngitis, pharyngitis, nephritis, headache, toothache and certain urinary tract infections from the olden times. Before the isolation and purification of biologically active components we analyzed the basic constituents(proteins, amino acids, mineral, etc.) with lyophilized powder of Lamnodrilus gotai Hatai. The results were as follows: Minerals detected and quantitatively analyzed were $Ca^#$, $Mg^#$, Fe, Zn, Mn, Cu, Co, Cr, Ni, Ge and Se. Amino acids detected were alanine, phenylalanine, leucine, glutamic acid, tyrosine, threonine, arginine, aspartic acid, methionine, lysine, serine, histidine, isoleucine, glycine, proline and etc. The constituents of proteins, fat, fiber, ash and phosphorous were measured. These constituents were compared and discussed with those of other investigations.

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애성환자에 있어서 원인 및 치료에 따른 고찰 (Clinical Study of Patients with Hoarseness in According to Causes and Therapies)

  • 안철민;권기환;박효진;이용배
    • 대한후두음성언어의학회지
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    • 제6권1호
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    • pp.16-21
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    • 1995
  • Clinical study was performed on 128 cases who complained of hoarsseness in according to causes therapies. which causes were newly known and advanced treatment methods were developed. The following results were obtained : 1) Among 128 cases, male was 45.3%, and female 54.7%, so sex ratio was 1:1.2. 2) The highest incidence of age causing hoarseness in order of frequency were 4th decade 30.5%, 5th decade 26.6% and 6th decade 24.8%. 3)The underlying diseases causing hoarsensess in oder of frequency were functional dysphonia 26.5%, laryngeal nodule 17.7% and chroic laryngitis 16.3%. 4) In view of the occupation. sterss group was 84.1% and non-stress group 15.9%. 5) The highest incidence of associated diseases in order of frequency were gastro intestinal diseases 29.7%, hypertension 9.4% and pulmonary tuberculosis 2.3%. 6) Vocal hygiene and voice therapy are the most needful therapeutic modalities.

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A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx

  • Kim, Hyunjung;Cho, Sung-Weon;Oh, Harim;Byeon, Hyung Kwon
    • Parasites, Hosts and Diseases
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    • 제57권2호
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    • pp.175-177
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    • 2019
  • A 46-year old man visited our outpatient clinic with complaint of foreign body sensation in throat after consuming raw freshwater fish 5 days ago. Laryngoscopic examination revealed a motile worm attached on posterior pharyngeal wall. The worm was removed using biopsy forceps under transnasal endoscopy and evidently identified as Clinostomum complanatum after microscopic examination. Patient's subjective foreign body sensation of throat and hyperemia of laryngeal mucosa remained for approximately 2 weeks post-removal, which were eventually resolved after administration of non-steroidal anti-inflammatory drug and anti-refluxant drug for 2 weeks. Treatment was ended at three weeks since the first visit. C. complanatum infections in humans are rare, and only four cases have been reported in Korea. Symptoms resembling pharyngitis or laryngitis occurs by consumption of raw, infected freshwater fish and treatment is done by mechanically removing the parasite.

사성을 주소한 이비인후과 질환에 대한 임상적 관찰 (A Clinico-Statistical Analysis of Patient with Hoarseness in E.N.T. field)

  • 이숙자;강영;유방환
    • 대한기관식도과학회:학술대회논문집
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    • 대한기관식도과학회 1977년도 제11차 학술대회연제 순서 및 초록
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    • pp.6.2-7
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    • 1977
  • 사성은 후두의 정상 발성기능이 장애되있을때 생기며, 후두질환의 가장 중요하고 특유한 증상이다. 1885년 Morgagni가 최초로 후두암에 대해서 보고한 이래 최근 후두암에 대한 인식이 높아짐과 동시에 사회적으로 날로 심각한 문제가 되고 있는 공해 특히 대기오염으로 인한 기도증상으로 야기되는 후두질환증후인 사성을 호소하는 환자들이 증가되고 있는지 연구 고찰함이 의의가 있다고 생각되어, 저자들은 1970년 1월부터 1976년 12월까지 만 7년간 한일병원 이비인후과 외래에 사성을 주소로 내원한 400명의 환자에 대한 임상적 고찰을 하여 다음 몇가지 지견을 얻었기에 문헌적 고찰을 가하여 보고하는 바이다. 1. 이비인후과 신 외래환자 총 14,731명중 사성 환자가 400명으로 약 2.7%이였다. 2. 성별로는 남여비가 211 : 189로 약 1.1 : 1로써 남子가 약간 많았다. 3. 질환별로는 급성후두염 158례(39.5%). 만성후두염 103례(27.3%), 성대결절 37례(9.3%), 성대마비 34례(8.5%), 성대 polyp 32례(8%), 후두질 13례(3.25%), 후두결핵 9례(2.25%)의 순이었다. 4. 연령별로는 30세대가 113례(28.23%)로 가장 많았고 다음으로 40대, 20대, 순이였으며, 10대, 20대, 60대 이상은 비교적 저율이였다. 5. 성별질환분포는 후두암이 12 : 1, 후두polyp 27 : 5, 후두유두종 4 : 1로 남성에서 압도적으로 많았으며, 그 외질환은 남여 비슷한 율을 보였다. 6. 연령별질환분포는 50세대까지는 급만성후두염이 가장 많았고 30대에선 후두 polyp, 30대 및 40대에선 성대결절, 40대 및 50대에선 후두결핵과 성대미비, 50 대에서는 후두암이 최고율이였다. 7. 월별분포는 고루 산재되어 있었으며 그중 3월∼6월사이가 비교적 고율이었고 동절엔 비교적 낮았다. 8. 발병부터 초진까지의 기간은 10일이내가 103례(26%)로 가장 많았고 약 80%에서 발병 1년이내에 내원하였다.

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