• Proceedings of the Korean Geotechical Society Conference
• /
• 2008.10a
• /
• pp.1365-1369
• /
• 2008

A large diameter sampler (KICT-type large diameter sampler) was developed to take undisturbed samples from not only soft ground but also sandy and weathered ground. The KICT-type large diameter sampler was manufactured with the principle of triple core barrel sampling. In this study, the applicability to offshore ground sampling of the KICT-type large diameter sampler was confirmed at Inchoen Port construction site. And, in order to compare the quality of samples taken by the sampler with that of the traditional piston sampler, a series of laboratory tests were performed. From the test results, the samples taken by the KICT-type large diameter sampler showed higher quality than the traditional thin-walled tube samples.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2000.11a
• /
• pp.353-360
• /
• 2000

We developed large diameter sampler (we called KICT type large diameter sampler) to obtain undisturbed clay and sand samples. In-situ test carried out in the In-Chon international airport and Kim-Hae. Also we obtained undisturbed sample with a hydraulic piston sampler in the nearly site and carried out unconfined compression test, consolidation test and triaxial test. The result, unconfined compression strength, secant modules, preconsolidation pressure and undrained shear strength of samples to obtain KICT type large diameter sampler are larger than that of samples to obtain hydraulic piston sampler. But failure strains and volume changes at the consolidation of samples to obtain KICT type large diameter sampler are smaller than that of samples to obtain hydraulic piston sampler

• Journal of the Korean GEO-environmental Society
• /
• v.9 no.3
• /
• pp.29-34
• /
• 2008

A large diameter sampler was developed to take undisturbed samples from not only soft ground but also sandy and weathered ground. The large diameter sampler which was developed in Korea Institute of Construction Technology(KICT-type large diameter sampler) was manufactured based on the principle of triple core barrel sampling. A specially designed cutting device was used to cut and contain various kinds of samples in the sampler during a sampling and retrieval procedure. By adjusting the stiffness of the spring located at the top of the sampler, the distance between the cutting shoe and auger can be controlled in accordance with the ground condition. In order to investigate the applicability of the developed sampler and compare the quality of the samples taken by the sampler with that by the traditional thin-walled tube sampler, samples were taken at various sites according to the ground condition. And a series of laboratory tests such as the unconfined compress ion test, triaxial compression test, oedometer test, large diameter Rowe cell consolidation test (D: 150 mm) were performed. The test results showed that the samples by the KICT-type large diameter sampler show higher quality than the samples by the thin-walled tube sampler. And the validity and applicability of the developed KICT-type large diameter sampler was confirmed accordingly.

• Proceedings of the Korean Geotechical Society Conference
• /
• 1999.10a
• /
• pp.331-336
• /
• 1999

A great deal of attention has been given in recent years to large diameter specimen for evaluation of soft soil characteristics, and many studies and developments of the apparatus for obtaining large diameter undisturbed soil samples are in progress attempting to minimize the disturbance of samples for precise strength and consolidation tests in the laboratory. This paper introduces a new large diameter sampler(over 300mm diameter), which can take prefectly undisturbed sampling at any depths applying a new sampling technique. By comparing the results of consolidation tests it is shown that the samples obtained by this new apparatus are of a superior quality to that of samples obtained by conventional sampler(Nx, 75mm dia.) at the same depths.

• Journal of the Korean GEO-environmental Society
• /
• v.6 no.3
• /
• pp.5-15
• /
• 2005

A large diameter sampler that can take undisturbed samples from soft ground was developed by KICT. In order to compare the quality of samples taken by the sampler with those of the traditional piston sampler, a series of laboratory tests were performed. Samples were taken at different sites such as Incheon, Gimhae, Yangsan and Busan. The results showed that the values of unconfined compression strength, secant modulus, pre-consolidation pressure, undrained shear strength, and shear modulus exhibited higher in samples taken by the large scale sampler. Strains at shear failure and volumetric strains were low for the new sampler. It was proved from the comparison that better quality samples could be obtained by the KICT sampler.

• Geomechanics and Engineering
• /
• v.9 no.6
• /
• pp.743-755
• /
• 2015

It is well known that the quality of sample significantly determines the accuracy of soil parameters for laboratory testing. Although sampling disturbance has been studied over the last few decades, the theoretical investigation of soil disturbance due to sampling penetration has been rarely reported. In this paper, an analytical solution for estimating the soil disturbance due to sampling penetration was presented using cavity expansion method. Analytical results in several cases reveal that the soil at different location along the sample centerline experiences distinct phases of strain during the process of sampling penetration. The magnitude of induced strain is dependent on the position of the soil element within the sampler and the sampler geometry expressed as diameter-thickness ratio D/t and length-diameter ratio L/D. Effects of sampler features on soil disturbance were also studied. It is found that the induced maximum strain decreases exponentially with increasing diameter-thickness ratio, indicating that the sampling disturbance will reduce with increasing diameter or decreasing wall thickness of sampler. It is also found that a large length-diameter ratio does not necessarily reduce the disturbance. An optimal length-diameter ratio is suggested for the further design of improved sampler in this study.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2008.10a
• /
• pp.1359-1364
• /
• 2008

It is well known that the standard penetration test (SPT) has been used in all over the world to get geotechnical properties of the ground. However, it is difficult to apply the SPT to the dense sand, gravel, weathered rock, etc. For the application of the SPT in these grounds, it is necessary to change in the diameter and the impact energy of the SPT. For the improvement of site investigation technology, Large Penetration Testing device (KICT-type LPT) was developed and applied to the in situ condition. The drop height and weight of the hammer in developed system were decided as 760mm and 150kg, respectively. And the developed sampler has the inner diameter of 63 mm and the length of 500 mm with the adjustment of energy ratio to the SPT of 1.5. In this study, the performance of KICT-type LPT was evaluated by using a calibration chamber system and pile driving analyzer (PDA)

• Proceedings of the Korean Geotechical Society Conference
• /
• 2007.09a
• /
• pp.603-610
• /
• 2007

It is well known that the standard penetration test (SPT) has been used in all over the world to get geotechnical properties of the ground. However, it is difficult to apply the SPT to the dense sand, gravel, weathered rock, etc. For the application of the SPT in these grounds, it is necessary to change in the diameter and the impact energy of the SPT. For the improvement of site investigation technology, Large Penetration Testing device (KICT-type LPT) was developed and applied to the in situ condition. The drop height and weight of the hammer in developed system were decided as 760 mm and 150 kg, respectively. Semi-auto hammer drop system identical with KS F2307 and JI A1259S was adopted. And the developed sampler has the inner diameter of 63 mm and the length of 500 mm with the adjustment of energy ratio to the SPT of 1.5. The hammer energy level was measured during the performance of the KICT-type LPT using SPI system (quality control system from driven piles).

• Journal of Environmental Health Sciences
• /
• v.20 no.4
• /
• pp.1-9
• /
• 1994

In order to investigate the regional level of air pollutants at Kangwha island situated on the western coast in Korea, the suspended particulate matter samples were collected by using the low volume air sampler on ten interval from March 1992 to February 1993 and the mass concentration of suspended particulate matter (SPM) and the chemical composition of water-soluble major ionic components in SPM samples were measured. During the sampling period, the average concentration of SPM under diameter 10 $\mu$m was found to be 48 $\mu$g/m$^3$ (+ 12). The seasonal concentration of SPM was showed in order of spring>fall>winter>summer. It was considered that higher concentration on spring than other season was affected by the long-range transport of Yellow sand particulate from China continent and lower concentration on summer by the washout and rainout effect of large rainfall. The content of water-soluble component in SPM samples was founded to be about 31% (14.69 $\mu$g/m$^3$) and 65% was unknown or unanalyzed. The content of cationic component showed in order of NH$_4^+$ (44.6%)>Na$^+$ (21.2%)>K$^+$ (14.7%)>Ca$^{2+}$ (13.6%)>Mg$^{2+}$ (5.9 %) and the content of anionic component SO$_4^{2-}$ (62.5%)>NO$_3^-$ (22.3%)>Cl$^-$ (15.2%), respectively. This fact indicates that ammonium and sulfate ion of water-soluble component in SPM sample were dominant in this region. From the chemical composition of water-soluble component, the most of Na$^+$, Mg$^{2+}$ and Cl$^-$ were originated from seawater source but K$^+$, Ca$^{2+}$ and SO$_4^{2-}$ were originated from other non-marine source. The contribution of seasalt to the composition of precipitation was 23%.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2006.11a
• /
• pp.65-74
• /
• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.