• The Korean journal of internal medicine
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• 제33권6호
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• pp.1194-1202
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• 2018

Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System. Methods: A total of 279 H/VH risk MDS patients registered in the Korean MDS Working Party database were retrospectively analyzed. Results: HMA therapy was administered to 205 patients (73.5%), including 31 patients (11.1%) who then received allogeneic hematopoietic cell transplantation (allo-HCT), while 74 patients (26.5%) received BSC or allo-HCT without HMA. The 3-year overall survival (OS) rates were $53.1%{\pm}10.7%$ for allo-HCT with HMA, $75%{\pm}21.7%$ for allo-HCT without HMA, $17.3%{\pm}3.6%$ for HMA, and $20.8%{\pm}6.9%$ for BSC groups (p < 0.001). In the multivariate analysis, only allo-HCT was related with favorable OS (hazard ratio [HR], 0.356; p = 0.002), while very poor cytogenetic risk (HR, 5.696; p = 0.042), age ${\geq}65years$ (HR, 1.578; p = 0.022), Eastern Cooperative Oncology Group performance status (ECOG PS) 2 to 4 (HR, 2.837; p < 0.001), and transformation to acute myeloid leukemia (AML) (HR, 1.901; p = 0.001) all had an adverse effect on OS. Conclusions: For the H/VH risk group, very poor cytogenetic risk, age ${\geq}65years$, ECOG PS 2 to 4, and AML transformation were poor prognostic factors. HMA showed no benefit in terms of OS when compared to BSC. Allo-HCT was the only factor predicting a favorable long-term outcome. The use of HMA therapy did not seem to have an adverse effect on the transplantation outcomes. However, the conclusion of this study should be carefully interpreted and proven by large scale research in the future.

• Journal of Breast Cancer
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• 제21권4호
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• pp.363-370
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• 2018

Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database. We selected candidates from the differentially expressed miRNAs and then evaluated every possible molecular signature formed by the candidates. The best signature was validated in independent serum samples from 113 early breast cancer patients and 47 healthy controls using reverse transcription quantitative real-time polymerase chain reaction. Results: The miRNA candidates in our method were revealed to be associated with breast cancer according to previous studies and showed potential as useful biomarkers. When validated in independent serum samples, the area under curve of the final miRNA signature (miR-21-3p, miR-21-5p, and miR-99a-5p) was 0.895. Diagnostic sensitivity and specificity were 97.9% and 73.5%, respectively. Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.409-414
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• 2021

수상함이 전투 환경에서 우수한 임무수행능력과 생존성을 구현하기 위해서는 구획을 차단하는 수밀/기밀 성능이 중요하다. 위와 같은 요구사항을 충족을 위해 함정 건조 후 시운전에서 구조요소(격실 및 탱크)에 대한 밀폐성과 특정부위에 대한 강도의 적합성을 검사하며, 특히 수선에 인접한 격실들의 격실기밀시험(Air test)을 수행한다. 격실기밀시험은 대상 격실에 공기를 주입하여 시운전 평가서 상의 요구압력까지 압을 적용하고, 일정 시간동안 압력강하 값을 확인하여 해당 구역의 요구조건 충족여부를 판단한다. 검사 기준은 10분 동안 감소된 압력이 시운전 평가서의 압력강하 허용치 이내이어야 한다. 하지만 외기온도의 영향이 큰 여름철에 격실기밀시험 진행 간 유입되는 열이 내부 공기의 온도를 상승시키고, 이로 인해 공기가 팽창하여 격실 내 압력이 증가하는 현상이 식별되었다. 이러한 현상은 격실기밀시험에서 최종 압력강하 값을 정확히 판단할 수 없게 하고 평가결과에 대한 신뢰성을 결여시킬 수 있다. 본 연구를 통해 격실 내 온도변화 영향을 보정하기 위한 시스템을 고안하였다. 개발된 시스템은 격실 내 온도변화에 의한 압력 변화량을 계산하여 보정값을 출력한다. 이상기체 방정식을 통해 압력변화량을 계산하며, 격실기밀시험 간 온도유지 및 증가/감소를 반영할 수 있도록 개발되었다. 계산된 압력 보정값을 NIST REFPROP의 데이터 베이스와 비교하였을 때, 최소 0.126 %에서 최대 0.253 %의 차이를 보였다.

• 디지털융복합연구
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• 제19권3호
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• pp.187-194
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• 2021

다양한 형태로 표면 웹에 급증하고 있는 공개정보(OSINT)는 프로파일링 기법을 사용하여 범죄 수사에도 활용할 수 있다. 이러한 기술은 미국 등 외국의 수사기관에서는 상당히 보편화되었으며 일부는 고도화 작업도 진행하고 있다. 반면에 국내의 경우 많이 사용하지 못할 뿐 아니라 수사 인력의 개인적 경험과 지식수준에 따라 획득하는 정보의 양과 질에 있어서 큰 편차를 보이고 있다. 본 논문에서는 가장 잘 알려진 Bazzell의 모델과 달리 한국적 웹 환경을 고려하고 시간 정보까지 제공해주는 한국형 공개정보 기반 프로파일링 기법을 개선된 워크플로우를 중심으로 제시한다. 아울러 프로파일링의 효율성 향상을 목적으로 설계한 검색 데이터베이스의 스키마도 제시한다. 이곳에서 제시한 기법을 사용하면 범죄 수사에서 있어서 일정 수준의 양과 질을 보장하는 검색 결과를 얻을 수 있을 뿐 아니라, 관련 수사 인력에 대한 표준 훈련 과정으로도 사용할 수 있다. 아울러 이 기법을 활용한 범죄 수사의 실효성과 효율성을 높이려면 법률적 기반강화 및 동화된 기술 도입이 더 필요하다.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제11권7호
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• pp.217-224
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• 2022

오늘날 기술과 산업의 발전으로 특수건물이 늘어남에 따라 특수건물 내 화재 사고가 증가하고 있다. 그러나 정보통신기술의 빠른 발전에도 불구하고 낙후되고 실효성을 갖추지 못한 실내 화재 경보 시스템을 사용함으로 인해 인명 피해가 꾸준히 발생하고 있다. 본 연구에서는 음향경보를 이용하는 기존 실내 화재 경보 시스템이 건물 내 인원들에게 충분한 경보를 전달하지 못하는 '경보의 사각지대 문제'를 개선하고자 에지 컴퓨팅과 비콘을 활용한 화재 경보 시스템을 설계하고 구현하였다. 제안하는 개선된 화재 경보 시스템은 말단 센서 노드와 에지 노드, 사용자 애플리케이션, 서버로 구성된다. 말단 센서 노드는 실내 환경 데이터를 수집하여 에지 노드로 전송하고, 에지 노드는 전송받은 정보를 기반으로 화재 발생 여부를 모니터링 한다. 또한 에지 노드는 비콘 신호를 지속적으로 발생시켜 신호 범위 내의 사용자 애플리케이션이 설치된 스마트기기의 정보를 수집하여 서버 데이터베이스에 저장하고, 화재 발생 시 수집한 기기들의 정보를 바탕으로 모든 재실 인원에게 애플리케이션 푸시 형태로 화재 경보를 전송한다. 구현한 화재 경보 시스템의 적용 가능성을 검증하기 위해 강의실이 밀집한 대학교의 한 건물에서 신호 유효 범위 측정 실험을 진행한 결과, 에지 노드의 비콘 신호 범위 내에서 정상적으로 기기 정보를 수집하고, 수집한 정보를 바탕으로 특정 사용자들에게 신속하게 화재 경보를 전송함을 확인하였다. 이를 통해 수시로 변하는 출입자들의 정보를 유동적으로 수집하고, 이를 바탕으로 사용자와 매우 인접한 스마트기기로 경보를 전송함으로써 '경보의 사각지대 문제'를 해결하는데 적용할 수 있음을 확인하였다. 또한 실험 결과 분석을 통해 제안하는 화재 경보 시스템을 실내 공간의 특징에 따라 효과적으로 적용하는 방안을 제시하였다.

• Journal of Chest Surgery
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• 제55권1호
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• pp.10-19
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• 2022

Background: According to the eighth TNM (tumor-node-metastasis) staging system, the presence of separate tumor nodules in the same lobe is designated as a T3 descriptor. However, it remains unclear whether adjuvant chemotherapy confers survival advantages in this setting. Methods: We retrospectively identified 142 pathologic T3N0M0 patients with additional pulmonary nodules in the same lobe from a single-institutional database from 2004 to 2019. The main outcomes were overall survival and recurrence-free survival. Multivariable Cox regression was used to identify the benefit of adjuvant chemotherapy while adjusting for other variables. Results: Sixty-one patients received adjuvant chemotherapy (adjuvant group) and 81 patients did not receive adjuvant therapy after surgery (surgery-only group). There were no demonstrable differences between the 2 groups regarding hospital mortality and postoperative complications, indicating that treatment selection had not significantly occurred. However, the use of adjuvant chemotherapy was associated with improved 5-year overall survival (70% vs. 59%, p=0.006) and disease-free survival (60% vs. 46%, p=0.040). A multivariable Cox model demonstrated that adjuvant chemotherapy was associated with a survival advantage (adjusted hazard ratio, 0.54; p<0.001). In exploratory analyses of subgroups, the effect of adjuvant chemotherapy seemed to be insufficient in those with small main tumors (<4 cm). Conclusion: Adjuvant chemotherapy was associated with better survival in T3 cancers with an additional tumor nodule in the same lobe. However, the role of adjuvant chemotherapy in patient subgroups with small tumors or those without risk factors should be determined via large studies.

• 핵의학기술
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• 제26권2호
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• pp.37-42
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• 2022

Purpose Since 1985, the Korean society of nuclear medicine technology (KSNMT) has been engaged in academic activities related to nuclear medicine imaging. From 2017 to 2021, the papers published in the journal were classified by the specific fields to examine the trends in the research and the direction of nuclear medicine in comparison with the papers submitted to the Korean Society of Nuclear Medicine (KSNM) during the same period. Materials and Methods From 2017 to 2021, papers submitted to KSNMT and KSNM were classified and databaseization using the Excel program by submission type, examination equipment, and examination field. Through this data, the number of papers published in journals by year, the number of papers submitted by detailed fields, and key words by era were analyzed and compared. Results The papers included by journal was 57 KSNMT and 280 KSNM. The major large classification of equipment, PET, Planar and SPECT was 26.3%, 21.1%, 19.3% in the KSNMT, KSNM was 49.6%, 6.4%, and 9.3%, with 66.7% and 65.3%, respectively. the major medium classification of equipment, industrial safety, urogenital system, nervous system, and quality control accounted for 54.4% of the total papers of the total ratio in the KSNMT, while the medium classification of oncology, endocrine system, urogenital system, therapy, and nervous system accounted for 61.1% of KSNM. In the major small classification of image acquisition, improvement effect, and exposure management accounted for 70.2% in KSNMT, while the items of image acquisition, report, and improvement effect accounted for 60.7% in KSNM. The major keywords except for equipment-related keywords such as PET/CT, PET/MR, and SPECT were SUV, Planar Image, and Respiration Gating Method in KSNMT and Ga68, Thyroid, and Lymphoma in the KSNM. Conclusion When checking the last 5 years of submissions, we can see that KSNMT is mainly concerned with image acquisition using existing radiotracers, while KSNM has focused on new radiotracers such as ⁶⁸Ga, ¹⁷⁷Lu, etc., and new medical technologies of theranostic. It has been confirmed that more PET-related papers than other examination equipment will account for a greater number of papers, and it is believed that future submissions will also account for a higher proportion of PET-related papers than other equipment.

• 대한한의학회지
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• 제44권2호
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• pp.106-118
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• 2023

Objectives: Network pharmacology is a method of constructing and analyzing a drug-compound-target network to predict potential efficacy and mechanisms related to drug targets. In that large-scale analysis can be performed in a short time, it is considered a suitable tool to explore the function and role of herbal medicine. Thus, we investigated the potential functions and pathways of Chongmyunggongjin-dan (CMGJD) on Alzheimer's disease (AD) via network pharmacology analysis. Methods: Using public databases and PubChem database, compounds of CMGJD and their target genes were collected. The putative target genes of CMGJD and known target genes of AD were compared and found the correlation. Then, the network was constructed using Cytoscape 3.9.1. and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results: The result showed that total 104 compounds and 1157 related genes were gathered from CMGJD. The network consisted of 1157nodes and 10034 edges. 859 genes were interacted with AD gene set, suggesting that the effects of CMGJD are closely related to AD. Target genes of CMGJD are considerably associated with various pathways including 'Positive regulation of chemokine production', 'Cellular response to toxic substance', 'Arachidonic acid metabolic process', 'PI3K-Akt signaling pathway', 'Metabolic pathways', 'IL-17 signaling pathway' and 'Neuroactive ligand-receptor interaction'. Conclusion: Through a network pharmacological method, CMGJD was predicted to have high relevance with AD by regulating inflammation. This study could be used as a basis for effects of CMGJD on AD.

• 대한중풍순환신경학회지
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• 제7권1호
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• pp.34-39
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• 2006

Objectives and methods : The Euibujipsung is the one of the huge-scale encyclopedias about Oriental Medicine. To investigate the most frequently used acupoints for hemiparesis after stroke, we used Euibujipsung CR-ROM database with several key words concerned with motor weakness (半身不遂 不遂不隨 癱瘓 中臟 中腑 風痱, etc.). Results : In the result, we found five popular acupoints (GV20, LI11, LI15, ST36 and GB39), and four meridians (Stomach, Gall bladder, Large intestine and Small intestine). We also found that the Yang meridians were cited more frequently than the Yin. Conclusion : Therefore we think that these findings can give further ideas to clinical practice and research fields for stroke rehabilitation in Oriental medicine.

• 대한중풍순환신경학회지
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• 제8권1호
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• pp.28-33
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• 2007

Objectives and methods : The Euibujipsung is one of the huge-scale encyclopedias about Oriental Medicine. To search the most frequently used aupoints for dysarthria after stroke, we used Euibujipsung CD-ROM database with several chinese character keyword concerned with vernal function(語, 言, 音, 啞, 瘖, etc). Results : We found four popular acupoints(PC5, GV20, GV16, TE6), and five meridians (Governor vessel, Gall Bladder, Heart, Large Intestine and Triple Energizer). We also found that the extra meridians were used more frequently than other type of meridians. Conclusion : We think that these findings can give further ideas to clinical practice and research fields for stroke rehabilitation in Oriental medicine.