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Evaluation of Reciprocal Cross Design on Detection and Characterization of Non-Mendelian QTL in $F_2$ Outbred Populations: I. Parent-of-origin Effect

  • Lee, Yun-Mi;Lee, Ji-Hong;Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.12
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    • pp.1805-1811
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    • 2007
  • A simulation study was conducted to evaluate the effect of reciprocal cross on the detection and characterization of parent-of-origin (POE) QTL in $F_2$ QTL populations. Data were simulated under two different mating designs. In the one-way cross design, six $F_0$ grand sires of one breed and 30 $F_0$ grand dams of another breed generated 10 $F_1$ offspring per dam. Sixteen $F_1$ sires and 64 $F_1$ dams were randomly chosen to produce a total of 640 $F_2$ offspring. In the reciprocal design, three $F_0$ grand sires of A breed and 15 $F_0$ grand dams of B breed were mated to generate 10 $F_1$ offspring per dam. Eight $F_1$ sires and 32 $F_1$ dams were randomly chosen to produce 10 $F_2$ offspring per $F_1$ dam, totaling 320 $F_2$ offspring. Another mating set comprised three $F_0$ grand sires of B breed and 15 $F_0$ grand dams of A breed to produce the same number of $F_1$ and $F_2$ offspring. A chromosome of 100 cM was simulated with large, medium or small QTL with fixed or different allele frequencies in parental breeds. A series of tests between Mendelian and POE models were applied to characterize QTL as Mendelian, paternal, maternal or partial expression QTL. The overall detection powers were similar between the two mating designs. However, the proportions of paternally expressed QTL that were declared as paternal QTL type were greater in the reciprocal cross design than in the one-way cross, and vice versa for Mendelian QTL. When QTL alleles were segregating in parental breeds, a significant proportion of Mendelian QTL were spuriously declared POE QTL, suggesting that care must be taken to characterize imprinting QTL in a QTL mapping population with a small number of $F_1$ parents.

Mechanical properties of tailings with dipping interlayers under high confining pressure

  • Qinglin, Chen;Zugui, Li;Zeyu, Dai;Xiaojun, Wang;Chao, Zhang
    • Geomechanics and Engineering
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    • v.31 no.6
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    • pp.557-571
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    • 2022
  • Landslides are often triggered by weak interlayers initiated in tailings dam foundations, and hazards gradually occur. This is serious for landslides in high tailings dams due to their high potential energy. Tailing samples with a fine-grained interlayer at a set dip angle were prepared. Consolidated undrained (CU) triaxial shear tests were carried out by using a high-pressure triaxial apparatus. The results were compared with the results under a low confining pressure. Four reasons were summarized for high tailings dams more prone to instability than low dams. The shear strength of the samples with dipping interlayers decreases with increasing dip angle. An obvious straight drop in the stress path after the peak occurs in samples with dipping interlayers at an angle of 60°. The effect of the interlayer on the mechanical behaviour of tailings is very sensitive, especially for the sample with a dipping interlayer at an angle of 60°. Shear slipping along the interlayer should be given more attention in tailings dams. Compared with the results under low confining pressure, the stress decreases continuously for the samples with dipping interlayers at large angles under high confining pressure. The positive pore pressure, which reduces the effective stress, occurred in tailings samples under high confining pressure. The residual strength of tailings under high confining pressure is smaller than that under low confining pressure. These factors increase the dam break risk and the disaster impact for high tailings dams.

Genetic Variation in Growth and Body Dimensions of Jersey and Limousin Cross Cattle. 2. Post-Weaning Dry and Wet Season Performance

  • Afolayan, R.A.;Pitchford, W.S.;Weatherly, A.W.;Bottema, C.D.K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.10
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    • pp.1378-1385
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    • 2002
  • The importance of direct genetic, maternal, heterosis and epistatic effects were examined on post-weaning weight, height, length, girth, fat depth and muscle (ratio of stifle to hip width) with dry and wet season gains in these traits. The breeds used were two pure breeds (Jersey and Limousin), the Limousin${\times}$Jersey $F_1$, and two backcrosses ($F_1{\times}$Jersey dams and $F_1{\times}$Limousin dams). Direct genetic effects were large (p<0.001) for all traits except for length. Jersey maternal effects were large for weight, girth, fat depth and muscle in the post-weaning wet season gains which is an evidence of the impact of Jersey dam on progeny beyond weaning. There were large heterosis effects on fat depth and muscle relative to other traits. Epistatic effects were observed for post-weaning performance in weight, girth, fat depth and muscle. There are indications that there were different genetic effects for post-weaning compared to preweaning growth traits. Thus, it could be hypothesized from this study that different quantitative trait loci (QTL) affect early and late growth in Jersey and Limousin cross cattle breeds. The follow up work will examine the different chromosomal gene effects on pre- and post-weaning growth.

Modeling the wetting deformation behavior of rockfill dams

  • Guo, Wanli;Chen, Ge;Wu, Yingli;Wang, Junjie
    • Geomechanics and Engineering
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    • v.22 no.6
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    • pp.519-528
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    • 2020
  • A mathematical wetting model is usually used to predict the deformation of core wall rockfill dams induced by the wetting effect. In this paper, a series of wetting triaxial tests on a rockfill was conducted using a large-sized triaxial apparatus, and the wetting deformation behavior of the rockfill was studied. The wetting strains were found to be related to the confining pressure and shear stress levels, and two empirical equations, which are regarded as the proposed mathematical wetting model, were proposed to express these properties. The stress and deformation of a core wall rockfill dam was studied by using finite element analysis and the proposed wetting model. On the one hand, the simulations of the wetting model can estimate well the observed wetting strains of the upstream rockfill of the dam, which demonstrated that the proposed wetting model is applicable to express the wetting deformation behavior of the rockfill specimen. On the other hand, the simulated additional deformation of the dam induced by the wetting effect is thought to be reasonable according to practical engineering experience, which indicates the potential of the model in dam engineering.

Development of One-Dimensional Unsteady Water Quality Model for River (1차원 비정상상태 하천수질모의를 위한 KORIV1-WIN 개발)

  • Chung, Se Woong;Ko, Ick Hwan;Kim, Nam Il
    • Proceedings of the Korea Water Resources Association Conference
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    • 2004.05b
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    • pp.563-567
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    • 2004
  • During drought season, the self-purification capacities of the four major rivers in Korea are significantly controlled by environmental maintenance flows supplied from the mid- or upstream large dams. Therefore, it is obviously important to operate the dams considering not only water quantity aspects but also conservation of downstream water quality and aquatic ecosystems. Mathematical water quality models can be efficiently used to serve as a decision support tool for evaluating the effects of operational alternatives of upstream dams on the downstream aquatic environment. In this study, an unsteady one-dimensional water quality model, KORIV1-WIN was developed based on the theoretical and numerical algorithms for hydrodynamics and water quality simulations of CE-QUAL-RIV1. It consists of hydrodynamic(KORIV1H) and water quality(KORIV1Q) modules, and pre- and post-processors for input data preparations and output displays. The model can be used to predict one-dimensional hydraulic and water quality variations in rivers with highly unsteady flows such as dam outflow change, rainfall-runoff, and chemical spill events.

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Dynamic response of concrete gravity dams using different water modelling approaches: westergaard, lagrange and euler

  • Altunisik, A.C.;Sesli, H.
    • Computers and Concrete
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    • v.16 no.3
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    • pp.429-448
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    • 2015
  • The dams are huge structures storing a large amount of water and failures of them cause especially irreparable loss of lives during the earthquakes. They are named as a group of structures subjected to fluid-structure interaction. So, the response of the fluid and its hydrodynamic pressures on the dam should be reflected more accurately in the structural analyses to determine the real behavior as soon as possible. Different mathematical and analytical modelling approaches can be used to calculate the water hydrodynamic pressure effect on the dam body. In this paper, it is aimed to determine the dynamic response of concrete gravity dams using different water modelling approaches such as Westergaard, Lagrange and Euler. For this purpose, Sariyar concrete gravity dam located on the Sakarya River, which is 120km to the northeast of Ankara, is selected as a case study. Firstly, the main principals and basic formulation of all approaches are given. After, the finite element models of the dam are constituted considering dam-reservoir-foundation interaction using ANSYS software. To determine the structural response of the dam, the linear transient analyses are performed using 1992 Erzincan earthquake ground motion record. In the analyses, element matrices are computed using the Gauss numerical integration technique. The Newmark method is used in the solution of the equation of motions. Rayleigh damping is considered. At the end of the analyses, dynamic characteristics, maximum displacements, maximum-minimum principal stresses and maximum-minimum principal strains are attained and compared with each other for Westergaard, Lagrange and Euler approaches.

A dynamic reliability approach to seismic vulnerability analysis of earth dams

  • Hu, Hongqiang;Huang, Yu
    • Geomechanics and Engineering
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    • v.18 no.6
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    • pp.661-668
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    • 2019
  • Seismic vulnerability assessment is a useful tool for rational safety analysis and planning of large and complex structural systems; it can deal with the effects of uncertainties on the performance of significant structural systems. In this study, an efficient dynamic reliability approach, probability density evolution methodology (PDEM), is proposed for seismic vulnerability analysis of earth dams. The PDEM provides the failure probability of different limit states for various levels of ground motion intensity as well as the mean value, standard deviation and probability density function of the performance metric of the earth dam. Combining the seismic reliability with three different performance levels related to the displacement of the earth dam, the seismic fragility curves are constructed without them being limited to a specific functional form. Furthermore, considering the seismic fragility analysis is a significant procedure in the seismic probabilistic risk assessment of structures, the seismic vulnerability results obtained by the dynamic reliability approach are combined with the results of probabilistic seismic hazard and seismic loss analysis to present and address the PDEM-based seismic probabilistic risk assessment framework by a simulated case study of an earth dam.

Application of a support vector machine for prediction of piping and internal stability of soils

  • Xue, Xinhua
    • Geomechanics and Engineering
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    • v.18 no.5
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    • pp.493-502
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    • 2019
  • Internal stability is an important safety issue for levees, embankments, and other earthen structures. Since a large part of the world's population lives near oceans, lakes and rivers, floods resulting from breaching of dams can lead to devastating disasters with tremendous loss of life and property, especially in densely populated areas. There are some main factors that affect the internal stability of dams, levees and other earthen structures, such as the erodibility of the soil, the water velocity inside the soil mass and the geometry of the earthen structure, etc. Thus, the mechanism of internal erosion and stability of soils is very complicated and it is vital to investigate the assessment methods of internal stability of soils in embankment dams and their foundations. This paper presents an improved support vector machine (SVM) model to predict the internal stability of soils. The grid search algorithm (GSA) is employed to find the optimal parameters of SVM firstly, and then the cross - validation (CV) method is employed to estimate the classification accuracy of the GSA-SVM model. Two examples of internal stability of soils are presented to validate the predictive capability of the proposed GSA-SVM model. In addition to verify the effectiveness of the proposed GSA-SVM model, the predictions from the proposed GSA-SVM model were compared with those from the traditional back propagation neural network (BPNN) model. The results showed that the proposed GSA-SVM model is a feasible and efficient tool for assessing the internal stability of soils with high accuracy.

Health Monitoring for Large Structures using Brillouin Distributed Sensing

  • Thevenaz, L.;Chang, KT.;Nikles, M.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.25 no.6
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    • pp.421-430
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    • 2005
  • Brillouin time-domain analysis in optical fibres is a novel technique making possible a distributed measurement of temperature and strain over long distance and will deeply modify our view about monitoring large structures, such as dams, bridges, tunnels and pipelines, Optical fibre sensing will certainly be a decisive tool for securing dangerous installations and detecting environmental and industrial threats.

Short-Array Beamforming Technique for the Investigation of Shear-Wave Velocity at Large Rockfill Dams (대형 사력댐에서의 전단파속도 평가를 위한 단측선 빔형성기법)

  • Joh, Sung-Ho;Norfarah, Nadia Ismail
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.1
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    • pp.207-218
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    • 2013
  • One of the input parameters in the evaluation of seismic performance of rockfill dams is shear-wave velocity of rock debris and clay core. Reliable evaluation of shear-wave velocity by surface-wave methods requires overcoming the problems of rock-debris discontinuity, material inhomogeneity and sloping boundary. In this paper, for the shear-wave velocity investigation of rockfill dams, SBF (Short-Array Beamforming) technique was proposed using the principles of conventional beamforming technique and adopted to solve limitations of the conventional surface-wave techniques. SBF technique utilizes a 3- to 9-m long measurement array and a far-field source, which allowed the technique to eliminate problems of near-field effects and investigate local anomalies. This paper describes the procedure to investigate shear-wave velocity profile of rockfill dams by SBF technique and IRF (Impulse-response filtration) technique with accuracy and reliability. Validity of the proposed SBF technique was verified by comparisons with downhole tests and CapSASW (Common-Array-Profiling Spectral-Analysis-of-Surface-Waves) tests at a railroad embankment compacted with rock debris.