• Title/Summary/Keyword: large area cell

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Numb Chin Syndrome as the First Symptom of Diffuse Large B-cell Lymphoma

  • Oh, Duwon;Woo, Keoncheol;Kim, Seong Taek;Ahn, Hyung Joon;Choi, Jong-Hoon;Kwon, Jeong-Seung
    • Journal of Oral Medicine and Pain
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    • v.41 no.4
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    • pp.200-204
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    • 2016
  • Numb chin syndrome, or mental neuropathy is a rare sensory neuropathy characterized by abnormal sensation such as hypoesthesia, paresthesia, or dysesthesia in the chin and lower lip innervated by the mental nerve. Sensory neuropathy of mental nerve is somewhat familiar to dentists because it can occur following nerve damage by trauma or dental treatment such as implant surgery or third molar extraction. It can also result from dental causes including abscess or osteomyelitis. However, it can be the first sign of the systemic disease or malignancy if it is not related to dental causes. In this study, we present the case of a patient who present with hypoesthesia and pain in chin area without other symptoms and is later diagnosed with diffuse large B-cell lymphoma.

Discharge characteristics of FFL as the variation of cell structure (셀 구조 변화에 따른 FFL(Flat Fluorescent Lamp)의 방전특성)

  • 윤성현;박철현;조민정;임민수;권순석;임기조
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2000.07a
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    • pp.600-603
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    • 2000
  • Recently, Display devices have become important in the information-oriented society and flat display devices are greatly demanded. Liquid crystal display(LCD) represents one of the most promising devices for large size desk-top monitors, notebook PC and car navigation system. However LCD cannot give forth light itself and must have backlight system. The most popular backlighting system is composed of a lighting-guide plate and CCFL as a lighting source. The number of CCFL must increase up if the area of display is increased. So a new backlighting source with high luminance is needed for large LCDs. In this paper, we proposed a surface discharge FFL with the new electrode structure like the needle shaped electrode as the variation of cell structure to high luminance and low power consumption. In comparison with different electrode structure it has low discharge voltage and current and good optical characteristics. So it has better discharge characteristics than different surface discharge FFL and can be fungible for a backlight as a lighting source in LCDs.

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Redox Regulation of Apoptosis before and after Cytochrome C Release

  • Chen, Quan;Crosby, Meredith;Almasan, Alex
    • Animal cells and systems
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    • v.7 no.1
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    • pp.1-9
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    • 2003
  • Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis of higher organisms. Mitochondria, known to play a central role in regulating cellular metabolism, was found to be critical for regulating apoptosis induced under both physiological and pathological conditions. Mitochondria are a major source of reactive oxygen species (ROS) but they can also serve as its target during the apoptosis process. Release of apoptogenic factors from mitochondria, the best known of which is cytochrome c, leads to assembly of a large apoptosis-inducing complex called the apoptosome. Cysteine pretenses (called caspases) are recruited to this complex and, following their activation by proteolytic cleavage, activate other caspases, which in turn target for specific cleavage a large number of cellular proteins. The redox regulation of apoptosis during and after cytochrome c release is an area of intense investigation. This review summarizes what is known about the biological role of ROS and its targets in apoptosis with an emphasis on its intricate connections to mitochondria and the basic components of cell death.

Cell Management and Handover Method in IEEE 802.16e-based Femto-cell Systems (펨토셀 시스템의 기지국간 셀 관리 및 핸드오버 방법)

  • Cho, Kwang-Hyun;Kim, Dong-Ho
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.36 no.3A
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    • pp.240-249
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    • 2011
  • In this paper, we consider a cell management and handover method in an IEEES02.16e based femto-cell systems. In a femto-cell system, Mobile Stations (MS) and Base Stations (BS) are temporarily overloaded during the process of MOB_NBR-ADV message because it includes huge information of macro-cell and a large number of femto-cells. Also, MS can be handover into another cell frequently, i.e. ping-pong phenomenon, if it is located in a overlapped cell area. In a femtocell system, so-called ping-pong phenomenon will burden the network opreation. In this paper, we propose construction of MOB_NBR-ADV message and it provides fast scanning and efficent handover by means of preselecting the candidate target femto-cells. Also, an adaptive method of hysteresis margin for handover is proposed. The simulation results show that the proposed schemes improve the MS's handover-related performance in terms of scanning power and scanning time compared with the conventional managements scheme of femto-cell systems.

Multi-Layer QCA 4-to-1 Multiplexer Design with Multi-Directional Input (다방위 입력이 가능한 다층구조 QCA 4-to-1 멀티플렉서 설계)

  • Jang, Woo-Yeong;Jeon, Jun-Cheol
    • The Journal of the Convergence on Culture Technology
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    • v.6 no.4
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    • pp.819-824
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    • 2020
  • In this paper, we propose a new multiplexer using quantum dot cellular automata (QCA), a next-generation digital circuit design technology. A multiplexer among digital circuits is a circuit that selects one of the input signals and transfers the selected input to one line. Since it is used in many circuits such as D-flip-flops, resistors, and RAM cells, research has been conducted in various ways to date. However, the previously proposed planar structure multiplexer does not consider connectivity, and therefore, when designing a large circuit, it uses an area inefficiently. There was also a multiplexer proposed as a multi-layer structure, but it does not improve the area due to not considering the interaction between cells. Therefore, in this paper, we propose a new multiplexer that improves 38% area reduction, 17% cost reduction, and connectivity using a cell-to-cell interaction and multi-layer structure.

Application of Local Axial Flaps to Scalp Reconstruction

  • Zayakova, Yolanda;Stanev, Anton;Mihailov, Hristo;Pashaliev, Nicolai
    • Archives of Plastic Surgery
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    • v.40 no.5
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    • pp.564-569
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    • 2013
  • Background Scalp defects may be caused by various etiological factors, and they represent a significant surgical and aesthetic concern. Various surgical techniques can be applied for reconstructive work such as primary closure, skin grafting, pedicled or free flaps. In this article, the authors share their clinical experience with scalp operations using the technique of local flaps and discuss the application of this method from the perspective of not only the size of the defect, but also in relation to the anatomical area, quality of surrounding tissue, and patient's condition. Methods During the period from December 2007 to December 2012, 13 patients with various scalp defects, aged 11 to 86 years, underwent reconstruction with local pedicle flaps. The indications were based on the patients' condition (age, sex, quality of surrounding tissue, and comorbidities) and wound parameters. Depending on the size of the defects, they were classified into three groups as follows: large, 20 to 50 $cm^2$; very large, 50 to 100 $cm^2$; extremely large, 100 $cm^2$. The location was defined as peripheral (frontal, temporal, occipital), central, or combined (more than one area). We performed reconstruction with 11 single transposition flaps and 1 bipedicle with a skin graft on the donor area, and 2 advancement flaps in 1 patient. Results In all of the patients, complete tissue coverage was achieved. The recovery was relatively quick, without hematoma, seroma, or infections. The flaps survived entirely. Conclusions Local flaps are widely used in scalp reconstruction since they provide healthy, stable, hair-bearing tissue and require a short healing time for the patients.

Copper Sulfide Nanowires for Solar Cells (태양전지용 $Cu_2S$ 나노와이어의 제작 및 특성분석)

  • Lim, Young-Seok;Kang, Yoon-Mook;Kim, Won-Mok;Kim, Dong-Hwan
    • 한국신재생에너지학회:학술대회논문집
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    • 2006.06a
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    • pp.166-169
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    • 2006
  • We fabricated hexagonal copper sulfide $Cu_2S$ nanowires to obtain a larger contact area of $Cu_2S/CdS$ solar cell. Copper sulfide nanowires were grown on Cu foil at room temperature by gas-sol id reaction. The size, density and shape of nanowires seemed to be affected by the change or reaction time temperature, crystallographic orientation of Cu foil, and molar ratio of the mixed gas. We controled the length and the diameter of the nanowires and we obtained suitable nanowire arrays which has fitting size for uniform deposition with n-type CdS. CdS layer was deposited on the nanowire array by electrodeposition and it seemed to be uniform. The $Cu_2S/CdS$ nanowires/CdS junction showed diode characteristics, A large contact area is expected with the $Cu_2S/CdS$ nanowire structure as compared with the $Cu_2S/CdS$ thin film.

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Development and Operation of 5kW-Class Polymer Electrolyte Membrane Fuel Cell System (5kW급 고분자 연료전지 시스템의 개발과 운전)

  • Chun, Y.G.;Peck, D.H.;Jeon, K.S.;Kim, C.S.;Shin, D.R.
    • Proceedings of the KIEE Conference
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    • 1999.07d
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    • pp.1876-1878
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    • 1999
  • Developed was a 5kW-class polymer electrolyte membrane fuel cell(PEMFC) system comprised of fuel cell stack, fuel processing, thermal and water management subsystems and ancillary equipments. Several large single cells have been fabricated with different gas flow field patterns and paths, and the gas flow field pattern for the stack has been determined based on the single cell performance of thin film membrane electrode assembly (MEA). The PEMFC stack was consisted of 100 cells with an electrode area of $300cm^2$, having serpentine flow pattern. Fuel processing was developed including an autothermal methanol reformer and two preferential CO oxidation reactors. The fuel processing was combined to PEMFC operation system consisted of air compressor and thermal and water management subsystems. The PEMFC stack showed performance of 5kW under the supply of $H_2$ and air, but its performance was lowered to 3.5kW under the supply of reformed gas.

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Plasma Surface Modification of Patterned Polyurethane Acrylate (PUA) Film for Biomedical Applications

  • Yun, Young-Shik;Kang, Eun-Hye;Yun, In-Sik;Kim, Yong-Oock;Yeo, Jong-Souk
    • Proceedings of the Korean Vacuum Society Conference
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    • 2015.08a
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    • pp.223.2-223.2
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    • 2015
  • Polyurethane acrylate (PUA) has been introduced to utilize as a mold material for sub-100 nm lithography as it provides advantages of stiffness for nanostructure formation, short curing time, flexibility for large area replication and transparency for relevant biomedical applications. Due to the ability to fabricate nanostructures on PUA, there have been many efforts to mimic extracellular matrix (ECM) using PUA especially in a field of tissue engineering. It has been demonstrated that PUA is useful for investigating the nanoscale-topographical effects on cell behavior in vitro such as cell attachment, spreading on a substrate, proliferation, and stem cell fate with various types of nanostructures. In this study, we have conducted surface modification of PUA films with micro/nanostructures on their surfaces using plasma treatment. In general, it is widely known that the plasma treated surface increases cell attachment as well as adsorption of ECM materials such as fibronectin, collagen and gelatin. Effect of plasma treatment on PUA especially with surface of micro/nanostructures needs to be understood further for its biomedical applications. We have evaluated the modified PUA film as a culture platform using adipose derived stem cells. Then, the behavior of stem cells and the level of adsorbed protein have been analyzed.

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Viable Alternatives to in vivo Tests for Evaluating the Toxicity of Engineered Carbon Nanotubes

  • Kwon, Soon-Jo;Eo, Soo-Mi
    • Journal of Environmental Health Sciences
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    • v.38 no.1
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    • pp.1-7
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    • 2012
  • Carbon nanotubes (CNTs) stand at the frontier of nanotechnology and are destined to stimulate the next industrial revolution. Rapid increase in their production and use in the technology industry have led to concerns over the effects of CNT on human health and the environment. The prominent use of CNTs in biomedical applications also increases the possibility of human exposure, while properties such as their high aspect ratio (fiber-like shape) and large surface area raise safety concerns for human health if exposure does occur. It is crucial to develop viable alternatives to in vivo tests in order to evaluate the toxicity of engineered CNTs and develop validated experimental models capable of identifying CNTs' toxic effects and predicting their level of toxicity in the human respiratory system. Human lung epithelial cells serve as a barrier at the interface between the surrounding air and lung tissues in response to exogenous particles such as air-pollutants, including CNTs. Monolayer culture of the key individual cell types has provided abundant fundamental information on the response of these cells to external perturbations. However, such systems are limited by the absence of cell-cell interactions and their dynamic nature, which are both present in vivo. In this review, we suggested two viable alternatives to in vivo tests to evaluate the health risk of human exposure to CNTs.