• Bulletin of the Korean Chemical Society
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• 제15권10호
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• pp.842-845
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• 1994

Iodine-induced lactonization of ${\alpha}$-Phenylsulfonyl-${\gamma},{\delta}$-Unsaturated Amides provided 2,4-trans-substitued ${\gamma}$-butyrolactones in high selectivity. NBS-or NCS-induced lactonization of N,N-dimethyl-2-(phenylsulfonyl)-4-pentenamide in DME-$H-2O(2:1 vol)$ gave 2-halo-4-(halomethyl)-2-(phenylsulfonyl)-${\gamma}$-butyrolactone.

• Bulletin of the Korean Chemical Society
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• 제16권10호
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• pp.903-905
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• 1995

• 대한화학회지
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• 제59권5호
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• pp.471-474
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• 2015

• 약학회지
• /
• 제37권3호
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• pp.290-294
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• 1993

An efficient synthetic route to the trisubstituted cyclopentane as an useful synthetic intrermediate for carbaprostacyclin is described. Ireland Claisen rearrangement of a hydroxylactone has been employed as a key reaction.

• Bulletin of the Korean Chemical Society
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• 제13권6호
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• pp.579-580
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• 1992

• Bulletin of the Korean Chemical Society
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• 제29권11호
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• pp.2247-2251
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• 2008

• 약학회지
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• 제34권3호
• /
• pp.166-170
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• 1990

An efficient synthetic route to macrolide is described. Eight-membered lactone was synthesized via palladium catalyzed intramolecular alkylation of allylic carbonate in high yield.

• Bulletin of the Korean Chemical Society
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• 제30권2호
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• pp.289-290
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• 2009

• Applied Biological Chemistry
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• 제37권1호
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• pp.25-29
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• 1994

Ethyl acetoacetate를 빵효모가 환원해 생산한 ethyl-(S)-3-hydroxy-butyrate(2a)를 키 랄 출발물질로 하여 수목에 피해를 끼치는 해충인 carpenter bee의 수컷이 분비하는 성 페로몬인 cis-2-methyl-5-hexanolide(1)을 diastereomer로 합성하였다. 역합성적 분석을 통한 합성계획으로부터 T-Goal로 Wittig반응을 잡고 출발물질을 환원하여 얻은 알데히드 4와 triethyl 2-phosphonopropionate(7)을 Horner-Emmons반응시켜 ${\alpha},{\beta}$-불포화 에스테르 5를 얻은 뒤 catalytic hydrogenation과 lactonization을 시켜 carpenter bee 페로몬 1을 전체수율 37%로 쉽고 간단하게 합성하였다.

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1012-1020
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• 2009

We developed an efficient three-step synthetic protocol of $\gamma$-hydroxybutenolides starting from the Baylis-Hillman adducts: (i) bromination, (ii) Barbier reaction and (iii) one-pot $K_2CO_3$-mediated synthesis of $\gamma$-hydroxybutenolides. In addition, we showed the synthetic applicability of butenolides including self-dimerization, conjugate addition reaction, and alkylations.