• The Journal of Internal Korean Medicine
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• v.37 no.3
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• pp.560-567
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• 2016

Objectives: The medical records, including laboratory test results, of a patient with autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome were reviewed to observe changes in steroid-induced adverse reactions before and after herbal medicine treatment.Methods: We investigated the records of a 44-year-old female patient with AIH-PBC overlap syndrome treated at the Kyung Hee University Korean Medicine Hospital. Injinchunggan-tang and its modified decoctions were administered, and any changes inclinical manifestations as well as laboratory test results were monitored.Results and Conclusions: Significant decreases in ALP, GGT, ALT, and AST levels were observed after oral administration of the herbal medicines. Improvements in steroid-induced symptoms (hyperglycemia, fatigue, and moon face) were also observed. Injinchunggan-tang and its modified prescriptions are promising candidates for proper management of AIH-PBC overlap syndrome.

• Korean Journal of Ichthyology
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• v.21 no.2
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• pp.106-117
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• 2009

A taxonomic study of the family Macrouridae was conducted using fish collections deposited in the Department of Biology, Chonbuk National University, Chonju, Korea and the East Sea Fisheries Research Institute, Korea. Among these collections were specimens of four species belonging to the genera Coryphaenoides and Coelorinchus: Coryphaenoides marginatus, C. microps, Coelorinchus (Abyssicola) macrochir, and C. formosanus. These specimens represent the first records of the species from Korean waters and from the East Sea (Japan Sea). Only four species (Coelorinchus longissimus, C. multispinulosus, C. japonicus, and C. parallelus) had previously been recorded from the East Sea. The Korean names "Keun-nun-gin-ga-si-min-te" (for Coryphaenoides marginatus), "Jak-eun-nun-gin-ga-si-min-te" (for C. microps), "Gin-pal-kko-ri-min-te" (for Coelorinchus macrochir), and "Ta-i-wan-kko-ri-min-te" (for Coelorinchus formosanus) are herein given to these species.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.97-106
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• 2020

The purpose of this study is to determine how to apply ISO/IEC/IEEE 29119 software test procedures and ISO/IEC 25023 software test evaluation items to software-accredited testing laboratories based on the ISO/IEC 17025 international standard requirements. As a method, the overall requirements for their application to a test laboratory were analyzed by mapping ISO/IEC/IEEE 29119 and ISO/IEC 25023 based on ISO/IEC 17025. According to the mapping analysis, a total of 29 documents were created, including quality manuals, procedures, and test guidelines for the operation of the test laboratory. As a result of the study, a test laboratory management system was developed using Confluence 6.15 software by applying the analyzed results of the overall requirements. The test procedures, documents, and records were stored in, and operated from, this system. Verification of suitability for operation of the test laboratory was conducted by KOLAS evaluators through a document review and an on-site audit at the LG Electronics SW Accredited Test Laboratory in Seoul. In conclusion, it was confirmed through the KOLAS evaluation that the test laboratory management system and the operation of the test laboratory are appropriate and, compared with previous cases, the test laboratory operates effectively, and the overall schedule of accreditation could be shortened.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.262-272
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• 2018

Background: Massive hemorrhage due to trauma is one of the major causes of death in trauma patients, and the quick supply of appropriate blood products is critical in order to reduce the mortality rate. We introduced a massive transfusion protocol (MTP) for safe and rapid transfusion of trauma patients. Using records collected since its adoption, we compared the characteristics of MTP applied group (MTP group) and MTP not applied group (non-MTP group) to determine whether there is an indicator for predicting patients to be treated with MTP. Methods: We retrospectively reviewed the electronic medical records and laboratory findings of patients who received massive transfusions in the trauma emergency room of a single tertiary hospital from February to August 2018. We analyzed various laboratory test results, the amount and ratio of the transfused blood products, and the time required for blood products to be released for the MTP group and the non-MTP group. Results: Of the 54 trauma patients who received massive transfusions, 31 were in the MTP group and 22 in the non-MTP group. There was no significant difference in initial vital signs (except blood pressure) and laboratory test results. Also there was no difference in the amount and ratio of blood products, but the time required for blood product release was shorter in the MTP group. Conclusion: There was no significant difference in clinical findings such as initial vital signs and laboratory test results between the MTP and non-MTP groups, but required blood products were prepared and released more quickly for the MTP group.

• Parasites, Hosts and Diseases
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• v.52 no.2
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• pp.169-175
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• 2014

There are 60 species of blood-feeding land leeches, 50 species belonging to the family Haemadipsidae and 10 species belonging to the family Xerobdellidae. Despite recent papers on the land leeches, their taxonomic identification is not fully understood, especially at a species level. In Korea, there have been no historical records of the terrestrial leeches, but recently an unrecorded blood-feeding land leech was discovered at Gageo-do (Island), Korea. Molecular analysis was used to identify the species of 29 leeches collected from Mt. Dock-Sil in Gageo-do. Conventional PCR was conducted using nuclear 18S rRNA and mitochondrial cytochrome c oxidase subunit 1 (CO1) genetic marker. The 18S rRNA sequences revealed that the leeches share 99.9% identity with Haemadipsa rjukjuana (inhabiting Taiwan), and the CO1 sequences revealed that the leeches are very close to H. rjukjuana (inhabiting Taiwan). The CO1 sequences were separated into 2 categories, 1 with 94.6% and the other with 94.3% similarity to the H. rjukjuana L00115A (inhabiting Taiwan). This new finding of the land leech is the first record in Korea. In addition, the north range of the distribution of the blood-feeding leech (Hirudiniformes: Haemadipisidae) should be reconsidered including Korea.

• The Korean Journal of Quaternary Research
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• v.17 no.2
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• pp.157-159
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• 2003

Much of northern Asia is lacking in high-resolution palaeoclimatic data coverage. This vast region thus represents a sizeable gap in data sets used to reconstruct hemispheric-scale temperature trends for the past millennium. To improve coverage, we present a regional-scale composite of four tree-ring width records of Siberian pine and Siberian larch from temperature-sensitive alpine timber-line sites in Mongolia. The chronologies load closely in principal components analysis (PCA) with the first eigenvector accounting for over 53% of the variance from ad 1450 to 1998. The 20-year interval from 1974 to 1993 is the highest such growth period in this composite record, and 17 of the 20 highest growth years have occurred since 1946. Thus these trees, unlike those recently described at some northern sites, do not appear to have lost their temperature sensitivity, and suggest that recent decades have been some of the warmest in the past 500 years for this region. There are, however, comparable periods of inferred, local warmth for individual sites, e.g., in 1520-1580 and 1760-1790. The percent common variance between chronologies has increased through time and is highest (66.1%) in the present century. Although there are obvious differences among the individual chronologies, this result suggests a coherent signal which we consider to be related to temperature. The PCA scores show trends which strongly resemble those seen in recent temperature reconstructions for the Northern Hemisphere, very few of which included representation from Eurasia east of the Ural Mountains. The Mongolia series therefore provides independent corroboration for these reconstructions and their indications of unusual wanning during the twentieth century.

• Kosin Medical Journal
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• v.33 no.3
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• pp.307-317
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• 2018

Background: Detection of antibodies to extractable nuclear antigens (ENAs) is needed for the diagnosis in systemic autoimmune diseases. In this study, we compared three reagents using line immunoblot assay (LIA) or multiplex bead immunoassay for detecting the anti-ENAs. Methods: A total of 89 sera were tested by 3 different assays: EUROASSAY Anti-ENA Profile (Euroimmune, Germany), Polycheck Autoimmune Test (Biocheck GmbH, Germany), and $FIDIS^{TM}$ Connective Profile (Biomedical Diagnostics, France). The following individual ENAs were investigated: Sm, SS-A (Ro), SS-B (La), Scl-70, Jo-1 and RNP. We reviewed medical records to investigate the discrepant results among three methods. Results: Overall percent agreements were 96.1% between EUROASSAY Anti-ENA Profile and $FIDIS^{TM}$ Connective profile; 90.4% between EUROASSAY Anti-ENA Profile and Polycheck Autoimmune Test using the manufacturers' cutoff; 96.4% between EUROASSAY Anti-ENA Profile and Polycheck Autoimmune Test using a upward cutoff; 90.4% between $FIDIS^{TM}$ Connective profile and Polycheck Autoimmune Test the manufacturers' cutoff; and 96.4% between $FIDIS^{TM}$ Connective profile and Polycheck Autoimmune Test a upward cutoff. Conclusions: The three assays showed excellent agreement with each other. With appropriate cutoff, the all three assays for six of the anti-ENA tests investigated in this study can be used in clinical laboratories for detecting the anti-ENAs.

• Structural Engineering and Mechanics
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• v.46 no.5
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• pp.673-693
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• 2013

This paper presents a systematic design and training procedure for the feed-forward back-propagation neural network (NN) modeling of both forward and inverse behavior of a rotary magnetorheological (MR) damper based on experimental data. For the forward damper model, with damper force as output, an optimization procedure demonstrates accurate training of the NN architecture with only current and velocity as input states. For the inverse damper model, with current as output, the absolute value of velocity and force are used as input states to avoid negative current spikes when tracking a desired damper force. The forward and inverse damper models are trained and validated experimentally, combining a limited number of harmonic displacement records, and constant and half-sinusoidal current records. In general the validation shows accurate results for both forward and inverse damper models, where the observed modeling errors for the inverse model can be related to knocking effects in the measured force due to the bearing plays between hydraulic piston and MR damper rod. Finally, the validated models are used to emulate pure viscous damping. Comparison of numerical and experimental results demonstrates good agreement in the post-yield region of the MR damper, while the main error of the inverse NN occurs in the pre-yield region where the inverse NN overestimates the current to track the desired viscous force.

• Ocean and Polar Research
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• v.31 no.4
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• pp.389-399
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• 2009

Subsurface pressure gauge has many advantages in measuring a wide range of wave spectra in coastal waters from wind waves to long waves. However, a shortcoming of the gauge is related to the difficulties in recovering surface wave spectra from subsurface pressure records. In this study, the effect of current on the pressure transfer function of the pressure gauge, and hence on the surface wave energy spectrum, was investigated by analyzing the subsurface pressure data based on the linear wave theory. For this purpose, laboratory experiments were carried out in a wave-current flume. Subsurface pressure records, as well as the surface elevation data, were obtained simultaneously under different wave and current conditions. Pressure transfer functions were obtained and compared with those estimated from the linear wave theory, both with and without inclusion of the current-effect. It was established that wave spectra obtained from subsurface pressure gauge were in closer agreement with those from surface wave gauge when current-effect on the pressure transfer function was taken into consideration for analysis.

• Genomics & Informatics
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• v.11 no.4
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• pp.186-190
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• 2013

The advances in electronic medical records (EMRs) and bioinformatics (BI) represent two significant trends in healthcare. The widespread adoption of EMR systems and the completion of the Human Genome Project developed the technologies for data acquisition, analysis, and visualization in two different domains. The massive amount of data from both clinical and biology domains is expected to provide personalized, preventive, and predictive healthcare services in the near future. The integrated use of EMR and BI data needs to consider four key informatics areas: data modeling, analytics, standardization, and privacy. Bioclinical data warehouses integrating heterogeneous patient-related clinical or omics data should be considered. The representative standardization effort by the Clinical Bioinformatics Ontology (CBO) aims to provide uniquely identified concepts to include molecular pathology terminologies. Since individual genome data are easily used to predict current and future health status, different safeguards to ensure confidentiality should be considered. In this paper, we focused on the informatics aspects of integrating the EMR community and BI community by identifying opportunities, challenges, and approaches to provide the best possible care service for our patients and the population.