• 제목/요약/키워드: laboratory's safety

검색결과 578건 처리시간 0.026초

A Case-Study of Implementation of Improved Strategies for Prevention of Laboratory-acquired Brucellosis

  • Castrodale, Louisa J.;Raczniak, Gregory A.;Rudolph, Karen M.;Chikoyak, Lori;Cox, Russell S.;Franklin, Tricia L.;Traxler, Rita M.;Guerra, Marta
    • Safety and Health at Work
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    • 제6권4호
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    • pp.353-356
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    • 2015
  • Background: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories. Methods: We summarize the first implementation of the United States Centers for Disease Control and Prevention 2013 revised recommendations for monitoring such exposures: (1) risk classification; (2) antimicrobial postexposure prophylaxis; (3) serologic monitoring; and (4) symptom surveillance. Results: Over 30 people were assessed for exposure and subsequently monitored for development of illness. No cases of laboratory-associated brucellosis occurred. Changes were made to gaps in laboratory biosafety practices that had been identified in the investigation. Conclusion: Achieving full compliance for the precise schedule of serologic monitoring was challenging and resource intensive for the laboratory performing testing. More refined exposure assessments could inform decision making for follow-up to maximize likelihood of detecting persons at risk while not overtaxing resources.

Very long life fatigue behaviors of 16Mn steel and welded joint

  • Liu, Yongjie;He, Chao;Huang, Chongxiang;Khan, Muhammad K.;Wang, Qingyuan
    • Structural Engineering and Mechanics
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    • 제52권5호
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    • pp.889-901
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    • 2014
  • Very long life fatigue tests were carried out on 16Mn steel base metal and its welded joint by using the ultrasonic fatigue testing technique. Specimen shapes (round and plate) were considered for both the base metal and welded joint. The results show that the specimens present different S-N curve characteristics in the region of $10^5-10^9$ cycles. The round specimens showed continuously decreasing tendency while plate specimens showed a steep decreasing step and an asymptotic horizontal one. The fatigue strength of round specimen was found higher than plate specimen. The fatigue strength of as-welded joint was 45.0% of the base material for butt joint and 40% for cruciform as-welded joint. It was found that fracture can still occur in butt joint beyond $5{\times}10^6$ cycles. The cruciform joint has a fatigue limit in the very long life fatigue regime ($10^7-10^9$ cycles). Fatigue strength of butt as-welded joint was much higher as compared to cruciform as-welded joint. Improvement in fatigue strength of welded joint was found due to UPT. The observation of fracture surface showed crack mainly initiated from welded toe at fusion areas or geometric discontinuity sites at the surface in butt joint and from welded toe in cruciform joint.

Development and validation of FRAT code for coated particle fuel failure analysis

  • Jian Li;Ding She;Lei Shi;Jun Sun
    • Nuclear Engineering and Technology
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    • 제54권11호
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    • pp.4049-4061
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    • 2022
  • TRISO-coated particle fuel is widely used in high temperature gas cooled reactors and other advanced reactors. The performance of coated fuel particle is one of the fundamental bases of reactor safety. The failure probability of coated fuel particle should be evaluated and determined through suitable fuel performance models and methods during normal and accident condition. In order to better facilitate the design of coated particle fuel, a new TRISO fuel performance code named FRAT (Fission product Release Analysis Tool) was developed. FRAT is designed to calculate internal gas pressure, mechanical stress and failure probability of a coated fuel particle. In this paper, FRAT was introduced and benchmarked against IAEA CRP-6 benchmark cases for coated particle failure analysis. FRAT's results agree well with benchmark values, showing the correctness and satisfactory applicability. This work helps to provide a foundation for the credible application of FRAT.

Effect of bogie fairings on the snow reduction of a high-speed train bogie under crosswinds using a discrete phase method

  • Gao, Guangjun;Zhang, Yani;Zhang, Jie;Xie, Fei;Zhang, Yan;Wang, Jiabin
    • Wind and Structures
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    • 제27권4호
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    • pp.255-267
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    • 2018
  • This paper investigated the wind-snow flow around the bogie region of a high-speed train under crosswinds using a coupled numerical method of the unsteady Realizable $k-{\varepsilon}$ turbulence model and discrete phase model (DPM). The flow features around the bogie region were discussed and the influence of bogie fairing height on the snow accumulation on the bogie was also analyzed. Here the high-speed train was running at a speed of 200 km/h in a natural environment with the crosswind speed of 15 m/s. The mesh resolution and methodology for CFD analysis were validated against wind tunnel experiments. The results show that large negative pressure occurs locally on the bottom of wheels, electric motors, gear covers, while the positive pressure occurs locally on those windward surfaces. The airflow travels through the complex bogie and flows towards the rear bogie plate, causing a backflow in the upper space of the bogie region. The snow particles mainly accumulate on the wheels, electric motors, windward sides of gear covers, side fairings and back plate of the bogie. Longer side fairings increase the snow accumulation on the bogie, especially on the back plate, side fairings and brake clamps. However, the fairing height shows little impact on snow accumulation on the upper region of the bogie. Compared to short side fairings, a full length side fairing model contributes to more than two times of snow accumulation on the brake clamps, and more than 20% on the whole bogie.

Optimization of the anti-snow performance of a high-speed train based on passive flow control

  • Gao, Guangjun;Tian, Zhen;Wang, Jiabin;Zhang, Yan;Su, Xinchao;Zhang, Jie
    • Wind and Structures
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    • 제30권4호
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    • pp.325-338
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    • 2020
  • In this paper, the improvement of the anti-snow performance of a high-speed train (HST) is studied using the unsteady Reynolds-Averaged Navier-Stokes simulations (URANS) coupled with the Discrete Phase Model (DPM). The influences of the proposed flow control scheme on the velocity distribution of the airflow and snow particles, snow concentration level and accumulated mass in the bogie cavities are analyzed. The results show that the front anti-snow structures can effectively deflect downward the airflow and snow particles at the entrance of the cavities and alleviate the strong impact on the bogie bottom, thereby decrease the local accumulated snow. The rotational rear plates with the deflecting angle of 45° are found to present well deflecting effect on the particles' trajectories and force more snow to flow out of the cavities, and thus significantly reduce the accretion distribution on the bogie top. Furthermore, running speeds of HST are shown to have a great effect on the snow-resistance capability of the flow control scheme. The proposed flow control scheme achieves more snow reduction for HST at higher train's running speed in the cold regions.

Isolation and Characterization of Bacillus sp. Producing Broad-Spectrum Antibiotics Against Human and Plant Pathogenic Fungi

  • Chen, Na;Jin, Min;Qu, Hong-Mei;Chen, Zhi-Qiang;Chen, Zhao-Li;Qiu, Zhi-Gang;Wang, Xin-Wei;Li, Jun-Wen
    • Journal of Microbiology and Biotechnology
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    • 제22권2호
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    • pp.256-263
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    • 2012
  • A strain of bacterium producing antifungal antibiotic was isolated and identification of the strain was attempted. We could identify the bacterium as being a Bacillus sp., based on morphological observation, physiological characteristics, and 16S rDNA sequence analysis, thus leading us to designate the strain as Bacillus sp. AH-E-1. The strain showed potent antibiotic activity against phytopathogenic and human pathogenic fungi by inducing mycelial distortion and swelling and inhibiting spore germination. The antibiotic metabolite produced by the strain demonstrated excellent thermal and pH (2-11) stability, but was labile to autoclaving. From these results, we could find a broader antifungal activity of Bacillus genus. Isolation and characterization of the active agent produced by the strain are under progress.

Safety assessment of generation III nuclear power plant buildings subjected to commercial aircraft crash part III: Engine missile impacting SC plate

  • Xu, Z.Y.;Wu, H.;Liu, X.;Qu, Y.G.;Li, Z.C.;Fang, Q.
    • Nuclear Engineering and Technology
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    • 제52권2호
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    • pp.417-428
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    • 2020
  • Investigations of the commercial aircraft impact effect on nuclear island infrastructures have been drawing extensive attention, and this paper aims to perform the safety assessment of Generation III nuclear power plant (NPP) buildings subjected to typical commercial aircrafts crash. At present Part III, the local damage of the rigid components of aircraft, e.g., engine and landing gear, impacting the steel concrete (SC) structures of NPP containment is mainly discussed. Two typical SC target panels with the thicknesses of 40 mm and 100 mm, as well as the steel cylindrical projectile with a mass of 2.15 kg and a diameter of 80 mm are fabricated. By using a large-caliber air gas gun, both the projectile penetration and perforation test are conducted, in which the striking velocities were ranged from 96 m/s to 157 m/s. The bulging velocity and the maximal deflection of rear steel plate, as well as penetration depth of projectile are derived, and the local deformation and failure modes of SC panels are assessed experimentally. Then, the commercial finite element program LS-DYNA is utilized to perform the numerical simulations, by comparisons with the experimental and simulated projectile impact process and SC panel damage, the numerical algorithm, constitutive models and the corresponding parameters are verified. The present work can provide helpful references for the evaluation of the local impact resistance of NPP buildings against the aircraft engine.

Development of limit equilibrium method as optimization in slope stability analysis

  • Mendjel, D.;Messast, S.
    • Structural Engineering and Mechanics
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    • 제41권3호
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    • pp.339-348
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    • 2012
  • The slope stability analysis is usually done using the methods of calculation to rupture. The problem lies in determining the critical failure surface and the corresponding factor of safety (FOS). To evaluate the slope stability by a method of limit equilibrium, there are linear and nonlinear methods. The linear methods are direct methods of calculation of FOS but nonlinear methods require an iterative process. The nonlinear simplified Bishop method's is popular because it can quickly calculate FOS for different slopes. This paper concerns the use of inverse analysis by genetic algorithm (GA) to find out the factor of safety for the slopes using the Bishop simplified method. The analysis is formulated to solve the nonlinear equilibrium equation and find the critical failure surface and the corresponding safety factor. The results obtained by this approach compared with those available in literature illustrate the effectiveness of this inverse method.

Numerical study on tensioned membrane structures under impact load

  • Zhang, Yingying;Zhao, Yushuai;Zhang, Mingyue;Zhou, Yi;Zhang, Qilin
    • Structural Engineering and Mechanics
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    • 제71권2호
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    • pp.109-118
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    • 2019
  • This paper presents the numerical simulation of membrane structure under impact load. Firstly, the numerical simulation model is validated by comparing with the test in Hao's research. Then, the effects of the shape of the projectile, the membrane prestress and the initial impact speed, are investigated for studying the dynamic response and failure mechanism, based on the membrane displacement, projectile acceleration and kinetic energy. Finally, the results show that the initial speed and the punch shape are related with the loss of kinetic energy of projectiles. Meanwhile, the membrane prestress is an important factor that affects the energy dissipation capacity and the impact resistance of membrane structures.

Associations Between Body Fat Percentage and Fitness among Police Officers: A Statewide Study

  • Violanti, John M.;Ma, Claudia C.;Fekedulegn, Desta;Andrew, Michael E.;Gu, Ja K.;Hartley, Tara A.;Charles, Luenda E.;Burchfiel, Cecil M.
    • Safety and Health at Work
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    • 제8권1호
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    • pp.36-41
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    • 2017
  • Background: Police work is generally sedentary although there may be situations that require physical endurance and strength, such as foot chases and arresting suspects. Factors such as excessive body fat can impede an officer's physical ability to deal with such occurrences. Our objective was to examine associations between officers' body fat percentage (BF%) and performance on a standardized fitness protocol. Methods: Data were obtained from fitness screening among 1,826 male and 115 female officers in a large US police agency. The screening consisted of a 2.4-km run, push-ups, sit-ups, and sit-and-reach test. Sex-specific body fat percentages were estimated from skinfold thickness measured using calipers. Linear regression models were used to examine unadjusted and adjusted mean scores of fitness tests across BF% tertiles. Results: The prevalence of overall fitness was 4.3 times greater in male officers and 3.6 times greater in female officers having the lowest BF% tertile compared with the highest tertile (30.3% vs 7.1% and 46.0% vs 12.8%, respectively). BF% was linearly and positively associated with the time of 2.4-km run (p < 0.001), and linearly and inversely associated with the number of push-ups (p < 0.001), sit-ups (p < 0.001), and the distance of sit-and-reach (p < 0.001) in men. Similar associations were observed in women with the exception of sit-and-reach (p = 0.122). Associations were independent of age, race/ethnicity, rank, and duty station. Conclusion: Overall, BF% was inversely associated with fitness levels in male and female officers. Future longitudinal studies should be initiated to explore the potentially causal relationship between BF% and fitness in law enforcement officers.