• International Journal of Internet, Broadcasting and Communication
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• v.16 no.1
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• pp.124-131
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• 2024

Breast cancer classification using ultrasound, while widely employed, faces challenges due to its relatively low predictive value arising from significant overlap in characteristics between benign and malignant lesions, as well as operator-dependency. To alleviate these challenges and reduce dependency on radiologist interpretation, the implementation of automatic breast cancer classification in ultrasound image can be helpful. To deal with this problem, we propose a semi-supervised deep learning framework for breast cancer classification. In the proposed method, we could achieve reasonable performance utilizing less than 50% of the training data for supervised learning in comparison to when we utilized a 100% labeled dataset for training. Though it requires more modification, this methodology may be able to alleviate the time-consuming annotation burden on radiologists by reducing the number of annotation, contributing to a more efficient and effective breast cancer detection process in ultrasound images.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.4
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• pp.330-336
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• 2009

Purpose: We established radiolabeling conditions of NOTA and DOTA with a generator-produced PET radionuclide $^{68}$Ga and studied in vitro characteristics such as stability, serum protein binding, octanol/water distribution, and interference with other metal ions. Materials and Methods: Various concentrations of NOTA 3HCl and DOTA 4HCl were labeled with 1 mL $^{68}$GaCl$_3$ (0.18$\sim$5.75 mCi in 0.1 M HCl in various pH. NOTA 3HCl (0.373 mM) was labeled with $^{68}$GaCl$_3$(0.183$\sim$0.232 mCi/0.1 M HCl 1.0 mL) in the presence of CuCl$_2$, FeCl$_2$, InCl$_3$, FeCl$_3$, GaCl$_3$, MgCl$_2$ or CaCl$_2$ (0$\sim$6.07 mM) at room temperature. The labeling efficiencies of $^{68}$Ga-NOTA and $^{68}$Ga-DOTA were checked by ITLC-SG using acetone or saline as mobile phase. Stabilities, protein bindings, and octanol distribution coefficients of the labeled compounds also were investigated. Results: $^{68}$Ga-NOTA and $^{68}$Ga-DOTA were labeled optimally at pH 6.5 and pH 3.5, respectively, and the chelates were stable for 4 hr either in the reaction mixture at room temperature or in the human serum at 37$^{\circ}C$. NOTA was labeled at room temperature while DOTA required heating for labeling. $^{68}$Ga-NOTA labeling efficiency was reduced by CuCl$_2$, FeCl$_2$, InCl$_2$, FeCl$_3$ or CaCl$_3$, however, was not influenced by MgCl$_2$ or CaCl$_2$. The protein binding was low (2.04$\sim$3.32%). Log P value of $^{68}$Ga-NOTA was -3.07 indicating high hydrophilicity. Conclusion: We found that NOTA is a better bifunctional chelating agent than DOTA for $^{68}$Ga labeling. Although, $^{68}$Ga-NOTA labeling is interfered by various metal ions, it shows high stability and low serum protein binding.

• Korean journal of food and cookery science
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• v.12 no.2
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• pp.146-152
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• 1996

Determining the optimal mixing ratio of pumpkin, water, glutinous rice powder, red bean, kidney bean in preparing Hobakjook has been attempted and on the basis of it, Hobakjook with glutinous rice powder was set to be A group, and the one that glutinous rice powder was replaced by brown glutinous rice powder for the purpose of enhancing preference and nutrition was set to be B group. A group and B group with additional 0％, 5％, 10％, 15% perilla powder of pumpkin weight was labeled as Al-A4 and Bl-B4 respectively, and then analyzed nutritionally. Optimal material mixing ratio and preference was investigated by use of sensory evluation and instrumental test. As a result, the optimal material mixing ratio was determined as pumpkin 400 g, water 60 cc, glutinous rice powder 40 g, red bean 30 g, kidney bean 30 g, salt 4 g, sugar 10 g. In sensory evaluation significant difference (P < 0.05) was shown among the samples in color., flavor.1, falvor. II and overall quality. And A3 in viscosity, A2 in color, A4 in sweetness, B2 in flavor 1, Al and B2 in flavor 11, and B2 in overall quality was preferred most. Instrumental measurement shows that B4 in viscosity and A4 in sweentness was highestly recorded and showed significant difference (p<0.05). As the addition of perilla powder increased, the viscosity and sweetness was increased. In color measurement A4 in L value, A3 in a value, and Bl in b value was highestly recorded. And as perilla powder was added, L value and a value was increased while b value was decreased. Color in sensory evaluation was significantly correlated to b value in instrumental measurement. In summary, Hobakjook with brown glutinous rice was superior to the one with glutinous rice in preference and proximate composition, and as the addition of perilla powder was increased, proximate composition was increased but preference was rather decreased, and Hobakiook with 5％ addition of perilla powder to brown glutinous rice powder was preferred most.

• Journal of Magnetics
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• v.21 no.3
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• pp.425-430
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• 2016

The aim of this study was to measure the setup variation for X (lateral), Y (longitude), and Z (vertical) by taking magnetic megavoltage computed tomography (MVCT) before treating the brain, oropharynx, lung, and prostate patients on helical tomotherapy. In this study, 30 patients were chosen for each of the treatment areas, and their skin was labeled with a mark on a treatment planning reference point when taking CT. We preceded MVCT prior to tomotherapy and then conducted an auto registration based on the bony landmarks; image registration was used for automatically matching the patient's setup. Lastly, we confirmed and evaluated the translation coordinates of the images for 30 patients. The following shows the comparison result of the setup errors of each part: X (lateral) showed the highest setup errors with $3.44{\pm}2.05$ from Lung; Y (longitude) showed the highest setup errors showing $3.40{\pm}2.87mm$ from Prostate; and Z (vertical) showed the highest setup errors showing $6.62{\pm}4.38mm$ from Lung. This result verifies that the setup error can be prevented by taking MVCT before the treatment, and Planning Target Volume (PTV) margins can be reduced by referring to the resulting value of each treatment part. Ultimately, the dosage of the normal organs can be decreased as well as any side effects.

• The Korean Journal of Nuclear Medicine
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• v.22 no.1
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• pp.77-81
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• 1988

Tumor localizing properties of $^{67}Ga$ citrate and $^{169}Yb$ citrate were studies with sarcoma 180 bearing mice. To compare precisely the accumulation of $^{67}Ga$ citrate and $^{169}Yb$ citrate in tumor tissue itself, $^{67}Ga$ and l63yb were administered simultaneously as a mixture of same chemical form of citrate. The yield of $^{169}Yb$ labeled citrated and the of radiopharmaceuticals purity was identified more than 90% by chromatography on silica gel plates. $^{67}Ga$ and $^{169}Yb$ were injected into mice and the mice were killed at 3, 24, and 48 hours following intraperitoneal injection of the radiopharmaceuticals. The retention value of $^{67}Ga$ and $^{169}Yb$ in tumor was similar but they differ from each other markedly in normal tissue distribution. $^{169}Yb$ citrate is cleared up from blood more rapidly than $^{67}Ga$ citrate, and a high tumor to blood ratio is achieved shortly after injection.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.12
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• pp.6038-6053
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• 2017

In this study, we propose an automatic melody extraction algorithm using deep learning. In this algorithm, feature images, generated using the energy of frequency band, are extracted from polyphonic audio files and a deep learning technique, a convolutional neural network (CNN), is applied on the feature images. In the training data, a short frame of polyphonic music is labeled as a musical note and a classifier based on CNN is learned in order to determine a pitch value of a short frame of audio signal. We want to build a novel structure of melody extraction, thus the proposed algorithm has a simple structure and instead of using various signal processing techniques for melody extraction, we use only a CNN to find a melody from a polyphonic audio. Despite of simple structure, the promising results are obtained in the experiments. Compared with state-of-the-art algorithms, the proposed algorithm did not give the best result, but comparable results were obtained and we believe they could be improved with the appropriate training data. In this paper, melody extraction and the proposed algorithm are introduced first, and the proposed algorithm is then further explained in detail. Finally, we present our experiment and the comparison of results follows.

• BMB Reports
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• v.31 no.1
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• pp.48-52
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• 1998

$p16^{INK4}$, which is a 16-kDa polypeptide protein, inhibits the catalytic activity of the CDK4-cyclinD complex to suppress rumor growth. Both unlabeled and isotope-labeled human tumor suppressor $p16^{INK4}$ protein were overexpressed and purified to characterize biochemical and structural properties. The purified p16 binds to monomeric GST-CDK4 and exists in a monomer conformation for several weeks at $4^{\circ}C$. The circular dichroism (CD) data indicates that p16 contains high percentage of ${\alpha}$-helix and that the helix percentage maximized at pH value of 7.0. One-and two-dimensional nuclear magnetic resonance (NMR) data suggest that purified p16 from our construct has a unique folded conformation under our experimental conditions and exhibits quite stable conformational characteristics.

• Korean Journal of Human Ecology
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• v.18 no.4
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• pp.923-932
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• 2009

This study aims to present a marketing strategy in the infant wear market with regard to consumer segments by analyzing benefits infant clothing purchases. For this study the consumer's evaluation criteria, usage of information source and characteristics of purchase behavior were analyzed by clustered consumers' groups. The results of the study are as follows: 1) Four factors were revealed as the result of the factor analysis on the benefits in infant clothing purchases. The factors were labeled fashionability, brand value, individuality, and practicality. 2) The result of the cluster analysis showed that it was most appropriate to categorize consumers into four groups based on the benefits of infant clothing purchases. 3) There were a significant difference in evaluation criteria, usage of information source, and characteristics of purchase behavior in terms of buying plan, retail store, purchase frequency, amount money spent, named brand purchase, and vicarious satisfaction among the groups.

• Journal of the Optical Society of Korea
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• v.13 no.3
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• pp.379-385
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• 2009

The vergence control of binocular stereoscopic camera is the most essential factor for acquiring high quality stereoscopic images. In this paper, we proposed a binocular stereoscopic camera vergence control method using disparity information by the simple image processing and estimate the quantity of vergence control using the Lagrange interpolation equation. The method of extracting disparity information through image processing is as follows: first the key-object in left & right images was extracted through labeling of the central area of the image, and then a simple method was used for calculating the disparity value of the same key-object in the labeled left and right images. The vergence control method uses disparity information and keeps the convergence distance of left & right cameras and the distance of the key-object the same. According to the proposed method, variance in the distance of the key-object and application of calculated disparity information of obtained left & right images to the quadratic Lagrange interpolation equation could estimate the quantity of vergence control, which confirmed that the method of stereoscopic camera vergence control can be simplified through experiments on various key-objects and other convergence distance.

• Korean Journal of Child Studies
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• v.13 no.1
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• pp.16-37
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• 1992

The purpose of this study was the development of a scale to assess maternal anxiety after mother-child separation. Subjects consisted of 384 mothers who had children from 6 to .36 months of age. A questionnaire consisting of eighty Likert-type items and Spielberger's(1970) State Anxiety Scale were administered to mothers and data were analyzed using item analysis. factor analysis. multiple regression. Cronbach's ${\alpha}$. Pearson's correlation and F-test. Sixty of the eighty items were significant and deemed acceptible through item discrimination method with indices ranging from. 32 to .95. Factor analytic procedures have selected 54 items of the 60-item scale and supported a 5-factor solution. The subscales labeled 'Maternal Separation Anxiety'. 'Perception of Separation Effects on the Child', 'Desire for Physical Cuddling and Closeness'. 'Attitudes toward the Value or Importance of Exclusive Maternal Care' and 'Employment-related Separation Concerns,' Finally. a multiple regression analysis conducted to reduce the length of the scale yielded a 39-item form for the Maternal Separation Anxiety Scale(MSAS). Internal consistency of the MSAS was high(Cronbach's ${\alpha}$ =.85). The correlation of the MSAS with the Spielberger's State Anxiety measure yielded a coefficient of .36, revealing a moderate and positive relationship.