• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.6
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• pp.834-841
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• 2012

We in this paper propose a mobile application for supporting medical treatment based on Korean medicine ontology. It has three processes for treating patients. First, after a pattern is decided for patient' symptoms, a formula for the pattern is selected and medicinal materials constituting the formula is added or removed. Second, formulas are searched and prescribed for patient's symptoms without the process of the pattern decision. Third, after medicinal materials are searched for patient's symptoms, formulas consisting of the medicinal materials are prescribed. Our application aims to help korean medicine doctors treat patients through providing decision supporting functions such as the recommendation of symptoms of diseases accompanying patient's symptom. Doctors generally diagnosis patients according to their experiences and knowledges. Nevertheless, our application can help them, providing diverse forms of information that they may miss in the medical treatment.

• Journal of Digital Convergence
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• v.10 no.5
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• pp.315-320
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• 2012

The purpose of this study is to establish management and support system for traditional medical manuscripts using bibliographical, linguistic and traditional medical methods in order to protect disappearing and take advantage of traditional medicine. We'll translate selective traditional medical manuscripts into Korean and build a database and computerized database, which improve value of future diverse application and restore and give shape to traditional medical documents by providing methods for ontology of traditional medicine. We also arrange and analyze the old traditional medical books with diverse study system and evaluate medical usefullness. We intend to provide practical use of the prescription in based medicine as well as clinical medicine by reinterpretation from modem viewpoint.

• Journal of Pharmacopuncture
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• v.16 no.3
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• pp.30-38
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• 2013

Objectives: Modified regular ginseng extract (MRGX) has stronger anti-cancer activity-possessing gensenoside profiles. Methods: To investigate changes in gene expression in the MRGX-treated lung cancer cells (A549), we examined genomic data with cDNA microarray results. After completing the gene-ontology-based analysis, we grouped the genes into up-and down-regulated profiles and into ontology-related regulated genes and proteins through their interaction network. Results: One hundred nine proteins that were up- and down-regulated by MRGX were queried by using IPA. IL8, MMP7 and PLAUR and were found to play a major role in the anti-cancer activity in MRGX-treated lung cancer cells. These results were validated using a Western blot analysis and a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. Conclusions: Most MRGX-responsive genes are up-regulated transiently in A549 cells, but down-regulated in a sustained manner in lung cancer cells.

• Journal of Society of Preventive Korean Medicine
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• v.14 no.1
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• pp.59-76
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• 2010

Background : The system for collecting and managing the terminologies of Korean oriental medicine is essential to facilitate researches of developing intelligent information architecture based on ontology. Objectives : The purpose of this paper is to develop system for collecting and managing system for terminologies of Korean oriental medicine. Methods : First we defined roles of users used in this system, and define the system workflow based on them. Then we developed web-based collecting and managing system in which multiuser can work simultaneously, and it is compose of relational database system. Results : The terminologies of Korean Oriental Medicine can be efficiently collected, purified, inspected, and utilized by using proposed system. Conclusions : The system, proposed in this paper, can be used the whole field of oriental medicines for basic technology and has great contributions to make intelligent information architecture of oriental medicine based on ontology concept.

• Journal of Sasang Constitutional Medicine
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• v.9 no.1
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• pp.1-12
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• 1997

Neiging Medicine(內經醫學) based on Yin-Yang and Five elements was the main stream of Korea Traditional Medicine until the end of 19th century. And the establishment of Sasang Constitutional medicine. In this paper, author proved that the Yin-Yang of Sasang Constitutional Medicine was different from that of Neiging Medicine and that explained the Yin-Yang of Sasang Constitutional Medicine as our own medicine. After considering the philosophical and medical background of Sasang Constitutional Medicine, and author researched the Yin-Yang of ontology, structure, function, symptoms in Sasang Constitutional Medicine. Also we compared this with that of Neiging medicine. The results were as follows 1. Neiging Medicine was based on the Yin-Yang and Five elements centering on the nature and Sasang joy, and pleasure centering on the human. 2. The ontology of Sasang Constitutional Medicine were the mind as a unitary substance, the mind and body as a dual substance, and affair, mind, body, and objects as a four substance which were the basic theory of philosophy. 3. Sasang Constitutional Medicine explained social phenomenon with a four substancial structure consisted of affairs, mind, body, and objects, a complex four substancial structure consisted of heaves, human, nature and order, and a three dimension structure including time. 4. On the other hand Neiging Medicine recognized seven emotions as five emotions, Sasang Constitutional Medicine recognized seven emotions as qi, nature, and emotions which consisted of sorrow, anger, joy, and pleasure. The qi had an effect on internal and external part of body and the nature and the emotion had an effect on the upward and downward of body. 5. It was taked great importance to control the up and down balance and the internal and external balance in Sasang Constitutional Medicine instead of reinforcing and reducting method of Neiging Medicine. 6. The Yin-Yang of Korean Traditional Medicine developed centering on the human from centering on the nature and Sasang Constitutional Medicine was a practical medicine compared with Neiging Medicine.

• Women's Health Nursing
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• v.19 no.1
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• pp.1-12
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• 2013

Purpose: This study was performed to propose an ontology methodology based on standardized nursing process as framework in obstetric and gynecologic nursing practice. Methods: The instrument used in this study was based on the nursing diagnosis classification established by North American Nursing Diagnosis Association (NANDA) (2009-2011), fifth edition of the Nursing Interventions Classification (NIC) (2008), forth edition of the Nursing Outcomes Classification (NOC) (2008) developed by Iowa State University and systematized nomenclature of medicine clinical terms (SNOMED CT). The nursing records data were collected from electronic medical records of one hospital from August to October 2010. Results: One hundred and forty-one nursing diagnosis statements used in obstetric and gynecologic nursing unit were linked standardized nursing classifications and constructed nursing diagnosis ontology including interoperability. Conclusion: Not only will this result be helpful to complete nurse's lack of knowledge and experience, it will also help to determine nursing diagnosis logically by using standardized nursing process. It will be utilized as the method to construct ontology including interoperability in other nursing units. It will be presented nursing interventions according to nursing diagnosis and thus will be easier to establish nursing planning. This can provide immediate feedback of the nursing process application.

• The Journal of Korean Medicine
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• v.37 no.3
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• pp.87-96
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• 2016

Objectives: Through this study, it would be expected to compare the characteristics of medicinal and acupuncture treatment. Method: Ontology DB of traditional Korean medicine has been used comparing medicinal and acupuncture treatment. Terms of the efficacy and the method of treatment were divided to predicate and object. And two groups were compared through contrasting the frequency of occurrence of significant words. Results: Predicates utilized more in medicinal treatment are the character ryeom[斂], go[固], pa[破], nae[內], and tu [透]. Predicates utilized more in acupuncture treatment are the character so[疏], jo[調], and seo[舒]. Object utilized more in acupuncture treatment is the character gi[氣]. Object utilized more in medicinal treatment is the character jeong[精]. Conclusions: In terms about the efficacy of acupuncture, there are many expressions associated with Qi[氣]. But expressions associated with Jing[精] are rare compare to medicinal treatment. There is a difference in language that represents the efficacy between medicinal and acupuncture treatment. In addition, there are some terms about efficacy that are not shared with each other due to the differences in disease treatment and the different branches of the two theories.

• Journal of Korean Medical classics
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• v.28 no.2
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• pp.163-181
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• 2015

Objectives : In order to select the key factors of formulae and to identify the relationship of formulae with comparing these factors. Methods : We selected the five key factors that the source, the name of formula, the efficacy, the constituent herbs, and the capacity of herbs. When we compared between two formulae with five key factors, there was 32 cases. So we investigated the example which is corresponded to each cases and analyzed the relationship of formulae. Results : Among the 32 cases, analyzed two formulae was same in 8 cases, altered from same formula in different ways in 14 cases, and different with each other in 20 cases. Conclusions : These five key factors play a decisive role to comparing formulae and analyzing the relationship of them. So these factors and the relationship of formulae would be considerated to construct formula ontology.

• Korean Journal of Exercise Nutrition
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• v.25 no.3
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• pp.28-35
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• 2021

[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.

• Healthcare Informatics Research
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• v.24 no.4
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• pp.376-380
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• 2018

Objectives: This research presents the design and development of a software architecture using natural language processing tools and the use of an ontology of knowledge as a knowledge base. Methods: The software extracts, manages and represents the knowledge of a text in natural language. A corpus of more than 200 medical domain documents from the general medicine and palliative care areas was validated, demonstrating relevant knowledge elements for physicians. Results: Indicators for precision, recall and F-measure were applied. An ontology was created called the knowledge elements of the medical domain to manipulate patient information, which can be read or accessed from any other software platform. Conclusions: The developed software architecture extracts the medical knowledge of the clinical histories of patients from two different corpora. The architecture was validated using the metrics of information extraction systems.