• Tuberculosis and Respiratory Diseases
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• 제43권5호
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• pp.805-811
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• 1996

저자들은 14세 여아에서 호흡곤란과 흉통이 발생하였으나, 긴장성 기흉등으로 잘못 인식되었던 선천성 낭종성 선종성 기형(CCAM)을 진단하여 수술적 방법으로 치료한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.97-105
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• 1984

홍삼 추출물이 스트레스에 노출된 생쥐의 행동에 미치는 영향을 다음과 같은 실험을 통하여 연구하였다. 1. 줄타기 테스트와 같은 강제적 운동 2. 매달리기와 같은 스트레스에 노출된 생쥐의 기억력의 감퇴 및 직장 체온의 변화 3. 매달리기와 같은 만성적 스트레스에 노출된 생쥐의 성행동능과 학습행동능 4. 매달리기와 같은 만성적 스트레스에 노출된 성숙한 암컷쥐의 성주기 변화 5. $40{\%}$의 알콜을 투여한 후 rotar-rod및 step-through테스트를 통한 운동자율능과 수동성 시도 기피반응 홍삼의 투여는 경구투여 방법을 택하였다. 1. 강제적 운동을 시키기 전에 인삼을 투여하면, 강제적 운동수행능이 증가되었다. 2주동안 하루에 1회 강제적 운동을 시킨 후 바로 인삼을 투여하면. 생쥐의 강제적 운동수행능의 감소가 억제되었다. 2. 4일동안 하루에 1회 스트레스에 노출시킨 후 인삼을 경구 투여하면 step-through와 step-down 테스트에 대한 수동성 기피반응의 쇠퇴를 지연시켰으며, 직장온도의 감소를 억제하였다. 3 인삼투여는 성능력의 감퇴와 수동성 기피반응 수행능의 감퇴를 개선하였고. 수동성 기피반응의 쇠퇴를 지연시켰다. 인삼의 투여는 스트레스에 노출된 후 하루에 한번씩 2주동안 투여하였다. 4. 인삼투여로 스트레스에 의한 성주기의 파괴와 직장온도가 감소되는 것이 방지되었다. 5. 인삼투여로 알콜유발성 운동실조와 기억의 습득 및 회복의 저해가 보호되었다.

• Journal of Radiation Protection and Research
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• 제27권3호
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• pp.155-164
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• 2002

몬테칼로 모사를 통해 여러 가지 진단X선 검사를 받는 성인의 유효선량을 평가하는 방법체계를 구축하였다. 피사체 인형팬텀으로서 MIRD5 남성 팬텀과 ORNL 여성팬텀이 이용되었고 사용 X선 스펙트럼은 SPEC78 코드로 생산하였다. 같은 진단절차에 대해 NRPB 평가결과와 비교함으로써 계산체계를 검증하였다. 계산체계를 이용하여 흉곽, 복부, 두부 및 척추의 진단에서 AP, PA, LLAT 및 RLAT 방향으로 입사하는 X선에 대한 장기 등가선량과 유효선량을 평가하였으며 가장 보편적인 흉곽 PA와 복부 AP의 경우 유효선량이 각각 0.029mSv와 0.44mSv로 나타났다. 흉곽 PA 1회 촬영 시 피폭하는 선량이 전통적 평가치인 0.3mSv(또는 30mrem)보다 매우 작게 나타나는 것은 진단방사선 기술의 발전뿐만 아니라 적용하는 선량개념의 차이에 기인하는 것으로서 여러 방사선 의료절차에 대한 집중적인 환자선량 평가의 필요성을 강조하는 것이다. 여기서 개발된 선량평가 체계는 CT 선량, 임부의 진단으로 인한 태아의 선량, 소아과 X선에 의한 선공 등 다른 방사선 의료절차에도 용이하게 응용될 수 있다.

• 말소리와 음성과학
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• 제12권3호
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• pp.73-83
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• 2020

음질 분석에 매우 유용한 Multi-Dimensional Voice Program (MDVP), Praat, Time-Frequency Analysis software (TF32)는 각각의 음향학적 검사에 사용된 알고리즘 차이로 인해 그 측정치에 차이가 있을 수 있다. 그러므로 본 연구에서는 각각의 음향학적 검사 도구로 음성 측정치를 비교 분석하여 분석 도구에 따른 음향학적 검사 변수의 차이를 살펴보고자 하였다. 정상 성인 총 35명 (남성 19명, 여성 16명)을 대상으로 모음 /아/를 수집한 후, 동일한 음성을 MDVP, Praat, TF32 각각의 음향학적 검사 도구로 분석하였다. 그 결과 jitter 변수(J local, J abs, J rap, J ppq), shimmer 변수(S local, S dB, S apq), noise-to-harmonics ratio (NHR) 평균의 경우, 남성과 여성 모두 MDVP보다 Praat의 수치가 통계적으로 유의하게 낮았다(p<.01). 또한 J local, J abs, S local 평균의 경우, 남성과 여성 모두 MDVP, Praat, TF32 순으로 통계적으로 유의하게 낮아졌다. 결론적으로 각 음향학적 검사 도구에 사용된 알고리즘 차이로 인해 도구 간의 측정치에 차이가 있었다. 그러므로 임상가들이 임상현장에서 각각의 음향학적 검사 도구를 사용할 때 각 도구의 알고리즘에 대해 이해한 후 병적 음성을 분석하는 것이 중요할 것이다.

• 생명과학회지
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• 제21권1호
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• pp.9-14
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• 2011

심박수(heart rate) 및 산소 소비량(oxygen consumption) 등의 생리학적 변수는 운동자각도(RPE)와 밀접한 관련이 있으며, RPE의 남녀차이에 의한 예측 운동강도의 정확성은 아직 밝혀지지 않고 있고, 본 연구는 남녀 대학생의 심장 혈관 및 신진대사의 반응을 평가하고 남녀의 차이를 밝히는 데 있다. 남자대학생($25.1{\pm}1.56$ yr)과 여자대학생($25.0{\pm}4.12$ yr) 각각 10명이 본 연구에 자발적으로 참여를 하였고, 본 연구를 위하여 설정된RPE는 Borg의 15 범주에서 결정을 하였으며, 점증적 운동부하(graded exercise testing)는 Bruce Treadmill Protocol을 이용하였다. 남녀의 평균 slope (p=0.501)와 RPE의 plotting rates와 최대산소섭취율(% $VO_2$max)은 유의한 차이가 나타나지 않았다. 각자의 상대적 최대산소섭취량은 남학생의 경우52.36${\pm}$7.35 ml/kg/min, 여학생은 41.44${\pm}$6.71 ml/kg/min로 나타나 두 그룹간에 유의하게 큰 차이가 있었으며, 절대적 최대산소섭취량은 남학생은 4.05${\pm}$0.36 l/min, 여학생은 2.53${\pm}$0.39 l/min로 나타나 두 그룹간에 큰 차이가 나타냈다. 남학생과 여학생간의 slope, y-intercept, SEE는 통계적으로 유의한 차이는 없었다. 본 연구에서 운동강도에 따른 남학생과 여학생의 RPE 의 차이는 유의하게 나타나지 않았다. 이상의 결과로 보아 RPE는 운동중 산소섭취량에 대한 운동강도의 예측에 남녀별 차이가 없어 유효한 예측인자라고 사료된다.

• 근관절건강학회지
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• 제4권1호
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• pp.87-97
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• 1997

This study is descriptive research clarifying the relations between physical inconvenience, social aptitude and sense of satisfaction In life of the chronic arthritis patients. This research has been conducted from 115 patients by structured self-reporting questionnaires and direct interview of the adult patients over the age of 16 years old who had been under treatment in 3 University hospitals in Seoul from Oct. 4, 1996 through Oct. 24, 1996 for 20 days. The collected materials have been under t-test and F-test(ANOVA) per variables after computerizing using SPSS package and the correlation between various causes was conducted by pearson's correlation coefficient method. The results are as the follows : 1) Generally the age of starling the disease was 40-60 with 91 in female(79.0%) and male 88(76.5%), the persons who had the religion showed the high rate of being taken ill and the persons with over high school education have fallen ill by 46.1%. The monthly income has shown that 77.5% was over 1,000,000won or over, the periods of the disease in average was 4 years 3 months showing it was the chronic disease, the degree of recognizing the disease was 19.0%, spouse and children were most concerned about their disease and the part of Joint attacked was knee(73.0%), wrist(43.5%) and others which showed that they have been very inconvenient in daily life. 2) The variables affecting to physical inconvenience were by age (F=9.06, p=.000), education level(F=7.14, p=000), economic standards (F=2.18, p=.05), the period of disease(F=3.09, p=.03), hospitalized or not(F=3.23, p=.002), showing such correlations. 3) The variables affecting to the social adaptation were by age (F=3.47, p=.018), education level(F=4.98, p=.001), periods of taken ill (F=419, p:.007), hospitalized or not (F=3.23, p=.004) and the operation or not (F=1.30, p=.028) showing such correlations. 4) The variables affecting to life satisfaction were by sex(t=2.08, p=.045), economic status(F=3.15, p=.01) being able to explain statistically. Through the above correlations, they are required to receive self-management education positively to elevate the effect of rehabilitation treatment and effective nursing arbitration and also they required to be reduced physical inconvenience at the early stage and be helped to be able to lead the quality life in satisfaction by elevating the diverse adaptation to the society by correcting the transformed joint.

• Tuberculosis and Respiratory Diseases
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• 제77권3호
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• pp.136-140
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• 2014

Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient's condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.

• 한국수정란이식학회지
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• 제32권3호
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• pp.209-220
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• 2017

The estrogen-mediated effect of mesenchymal stem cells (MSCs) is a highly critical factor for the clinical application of MSCs. However, the present study is conducted on MSCs derived from adult donors, which have different physiological status with steroid hormonal changes. Therefore, we explores the important role of $17{\beta}$-estradiol (E2) in MSCs derived from female and male newborn piglets (NF- and NM-pBMSCs), which are non-sexually matured donors with steroid hormones. The results revealed that in vitro treatment of MSCs with E2 improved cell proliferation, but the rates varied according to the gender of the newborn donors. Following in vitro treatment of newborn MSCs with E2, mRNA levels of Oct3/4 and Sox2 increased in both genders of MSCs and they may be correlated with both estrogen receptor ${\alpha}$ ($ER{\alpha}$) and $ER{\beta}$ in NF-pBMSCs, but NM-pBMSCs were only correlated with $ER{\alpha}$. Moreover, E2-treated NF-pBMSCs decreased in ${\beta}$-galactosidase activity but no influence on NM-pBMSCs. In E2-mediated differentiation capacity, E2 induced an increase in the osteogenic and chondrogenic abilities of both pBMSCs, but adipogenic ability may increased only in NF-pBMSCs. These results demonstrate that E2 could affect both genders of newborn donor-derived MSCs, but the regulatory role of E2 varies depending on gender-dependent characteristics even though the original newborn donors had not been affected by functional steroid hormones.

• 한국발생생물학회지:발생과생식
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• 제22권1호
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• pp.85-94
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• 2018

Endocrine disruptors have been concerned in toxicology but now challenged as physiological point especially concerned with exposing dose and period. In this study the low-dose chronic administration of di(2-ethylhexyl) phthaltae (DEHP) during reproductive period was examined to evaluate the possible roles. Adult male and female CD-1 mice were exposed to DEHP with drinking water containing $133{\mu}g/L$ and $1,330{\mu}g/L$ DEHP in water according to OECD 433 guide line and sacrificed just after weaning. The weights of uterus and ovary were decreased by drinking of $1,330{\mu}g/L$ DEHP water. There was not adverse effects on either accumulated mating rate and mating rate depend on estrus stage, pregnancy duration, and sex ration at birth. However, the accumulated rate of successful delivery and litter size were significantly high at $1,330{\mu}g/L$ DEHP water. The number of epididymal sperm was significantly increased by drinking of $1,330{\mu}g/L$ DEHP water. In addition, the number of follicles (primary, secondary, tertiary) were more many than control at $1,330{\mu}g/L$ DEHP water drunk mother. Though further studies are needed to identify what are the mechanism of DEHP in folliculogenesis and spermatogenesis. From this study we firstly report the effect of low-dose chronic administration of DEHP with drinking could change the ovarian follicle population size and spermatogenesis rate. Put together, those finding is different from previous high-dose effects and suggest the physiological role of DEHP in gonads and uterus.

• 대한방사선기술학회지:방사선기술과학
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• 제41권1호
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• pp.13-24
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• 2018

Liver size is an important component in the diagnosis and follow-up of diffuse liver disease when testing for liver disease using ultrasonography. However, difficulties lies in determining the presence of hepatomegaly and liver atrophy because the method used for measuring liver size differs from one examiner to another and there is no relevant standard based on body build. The present study aims to propose a more objective method for liver size measurement and a reference range based on body build. A total of 260 normal adults (130 males, 130 females) participated in the study. Ultrasonography was performed in all participants to measure the size of the right lobe, left lobe, quadrate lobe, and caudate lobe of liver. Based on Physique Index(PI), a value derived from multiplying weight(kg) by height($m^2$), size of physique was divided into three groups including Group I with PI<150, Group II with $150{\leq}PI{\leq}250$, and Group III with PI>250. Thus, mean liver size by PI and a reference range with 95% reliability were suggested. The superoinferior diameter of right lobe was $12.34{\pm}1.18cm$ in males and $11.07{\pm}0.93cm$ in females, and its reference range was 10.64~11.0cm for Group I, 11.78~12.12cm for Group II, and 13.02~13.84cm for Group III. The anteroposterior diameter(T) of left lobe was $5.93{\pm}1.09cm$ in males and $5.18{\pm}0.99cm$ in females, and its reference range was 4.77~5.17cm for Group I, 5.49~5.79cm for Group II, and 6.68~7.44cm for Group III. The transverse diameter was $3.51{\pm}0.60cm$ in male participants and $3.42{\pm}0.49cm$ in female participants and its reference range was 3.29~3.51cm for Group I, 3.36~3.55cm for Group II, and 3.52~4.0cm for Group III. The caudate lobe index was $11.65{\pm}2.88cm^2$ in males and $9.62{\pm}2.18cm^2$ in females and its reference range was $8.83{\sim}9.75cm^2$ for Group I, $10.62{\sim}11.47cm^2$ for Group II, and $11.89{\sim}14.26cm^2$ for Group III. As a basic measurement method of liver size, the present study suggests measuring the superoinferior diameter for right liver lobe, the anteroposterior diameter for left liver lobe, the transverse diameter for quadrate lobe, and the caudate lobe index for caudate lobe. It is expected that this method along with its relevant reference range can be used as useful indicators in determining hepatomegaly and liver atrophy upon the diagnosis and follow-up testing of diffuse liver disease.