• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권2호
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• pp.99-115
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• 2023

Purpose: Exclusive breastfeeding promotes gut microbial compositions associated with lower rates of metabolic and autoimmune diseases. Its cessation is implicated in increased microbiome-metabolome discordance, suggesting a vulnerability to dietary changes. Formula supplementation is common within our low-income, ethnic-minority community. We studied exclusively breastfed (EBF) neonates' early microbiome-metabolome coupling in efforts to build foundational knowledge needed to target this inequality. Methods: Maternal surveys and stool samples from seven EBF neonates at first transitional stool (0-24 hours), discharge (30-48 hours), and at first appointment (days 3-5) were collected. Survey included demographics, feeding method, medications, medical history and tobacco and alcohol use. Stool samples were processed for 16S rRNA gene sequencing and lipid analysis by gas chromatography-mass spectrometry. Alpha and beta diversity analyses and Procrustes randomization for associations were carried out. Results: Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria were the most abundant taxa. Variation in microbiome composition was greater between individuals than within (p=0.001). Palmitic, oleic, stearic, and linoleic acids were the most abundant lipids. Variation in lipid composition was greater between individuals than within (p=0.040). Multivariate composition of the metabolome, but not microbiome, correlated with time (p=0.030). Total lipids, saturated lipids, and unsaturated lipids concentrations increased over time (p=0.012, p=0.008, p=0.023). Alpha diversity did not correlate with time (p=0.403). Microbiome composition was not associated with each samples' metabolome (p=0.450). Conclusion: Neonate gut microbiomes were unique to each neonate; respective metabolome profiles demonstrated generalizable temporal developments. The overall variability suggests potential interplay between influences including maternal breastmilk composition, amount consumed and living environment.

• 한국도서관정보학회지
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• 제54권2호
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• pp.43-65
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• 2023

모든 공공도서관은 지역주민의 지적 및 독서 활동을 위한 지식정보서비스, 문화향유 및 평생학습 기회를 제공하는 프로그램 서비스, 공동체 발전에 기여할 제3의 공간과 시설을 제공하는데 목적이 있다. 이를 위해서는 충실한 인프라 구축을 전제로 사회적 요구가 적시에 반영되어야 한다. 이에 본 연구는 대구시 공공도서관을 대상으로 공인통계에 근거하여 핵심지표 중심의 현황을 분석한 후 설문조사와 연계하여 보완 또는 주력해야 할 정책적 과제를 제안하였다. 그 결과, 전국 대비 대구시의 핵심지표는 제3의 대도시에 부합하지 않을 정도로 취약할 뿐만 아니라 기초자치단체별 편차도 상당히 심하였다. 그리고 대구 시민은 일상생활에서 공공도서관을 중시한 반면에 교통 불편, 필요한 자료 및 희망 프로그램 부족, 각종 규제의 순으로 불만족률이 높았다. 따라서 대구시는 자료구입비 증액과 신간 장서개발 강화, 전문사서 확충, 기초자치단 체별 서비스 격차해소를 위한 공공도서관 건립 확대, 접근편의성 제고, 이용 저해요인 개선 등에 주력해야 한다. 그 외에 2024년 대구도서관 건립·운영을 계기로 공공도서관 운영시스템 구축, 다른 지식문화기관과의 상생협력을 통한 외연 확장 등을 통해 대구시 공공도서관을 발전시키고 시민을 위한 지식문화서비스를 강화해야 한다.

• Journal of Plant Biology
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• 제13권1호
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• pp.33-46
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• 1970

Pinus densiflora stands are common secondary forest communities on infertile soils in Korea. The stands are results of long severe past biotic pressure such as cutting, burning and grazing. These could be regarded as biotic climax in Korea. Because of their prevalent occurrence, relatively simple species and age composition, and their domestic economic importance, study of their distributional patterns may give some basic knowledge for better utilization of land resources in Korea. To detect distributional patterns and interspecific associations ten pine stands, each of which was homogenious with respect to topography and physiognomy, were subjectively selected from pine stands in Kyunggi Province near Seoul in 1969 and were made object of this study. Four contiguous systematic samples of count for trees, shrubs and seedlings from belt transects were collected from homogeneous areas within ten natural pine stands. The belt transect was 64m or 128m in length, and 1m, 2m or 4m in width. Basic units within the transect ranged from 64 to 256. The data from the contiguous transects were analysed in terms of multiple split-plot experiment. Departure from randomness of stem distribution, i.e., pattern, was tested in terms of variance mean ratio. For the detection of association between species, correlation coefficient was calculated for different block sizes. The values of ${\gamma}$ were tested by the usual t-test. Fine trees within one of the stands showed significant regular distribution through out the blocks. Within other eight stands pines were randomly distributed at basic unit with 4$\times$4m, 2$\times$2m, 2$\times$1m and 1$\times$1m. One significantly clumped distribution at basic unit 2$\times$2m, however, was observed from one of the pine stands. These randomly distributed groups were themselves significantly regularly distributed throughout the blocks for four pine stands. For the other four pine stands, in addition to the random distribution at the basie unit(the primary random group), randomly distributed groups with 32m dimension(the secondary random groups) were also observed. Both the primary and the secondary random groups were significantly regularly distributed at the rest of blocks. Pine seedlings were not distributed randomly thoughout the blocks. Within three of the ten stands they were contagiously distributed. Important shrub species underneath pines such as Querus serrata, Q. acutissima, Leapedeza intermedia, Rhododendron Yedoense var. poukhanenae, Juniperus utilis, Rhododendron mucronulatum var. ciliatum shnwed consistently similar distributional pattern with the pine at each stand. The shrub species pairs; Rhododendron Yedoense var. poukhanenae/Quercus serrata, Rhododendron mucronulatum var. ciliatum/Lespedeza intermedia were significantly negatively associated from 1m to 4m dimensional block sizes but became significantly positively associated from 8m sized blocks on. On the other hand the shrub species pairs; Lespedeza intermedia/Robinia Pseudoacacia, and Lespedeza bicolor var, japonica/Lespedeza intermedia were also significnalty negatively associated from 1m to 8m sized blocks but became significantly positively associated from 16m sized blocks on. The associational pattern between Rhododendron mucronul tun var. poukhanenae and Lespedeza intermedia was not consistent throughout the stands. In some stands negative associations were observed throughout the blocks except NS 32. From these observatons micro-edaphic variation within the pine stands seems not to be great enough to cause distributinal difference of pine trees within the ten pine stands. Among each species and pine seedings, however, the edaphic variation within the pine stands may be great enought to cause distributional variation.

• 한국대기환경학회지
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• 제32권1호
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• pp.114-126
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• 2016

Many cohort studies have reported associations of individual-level long-term exposures to $PM_{10}$ and health outcomes. Individual exposures were often estimated by using exposure prediction models relying on $PM_{10}$ data measured at national regulatory monitoring sites. This study explored spatial and temporal characteristics of regulatory $PM_{10}$ measurement data in South Korea and suggested $PM_{10}$ concentration metrics as long-term exposures for assessing health effects in cohort studies. We obtained hourly $PM_{10}$ data from the National Institute of Environmental Research for 2001~2012 in South Korea. We investigated spatial distribution of monitoring sites using the density and proximity in each of the 16 metropolitan cities and provinces. The temporal characteristics of $PM_{10}$ measurement data were examined by annual/seasonal/diurnal patterns across urban background monitoring sites after excluding Asian dust days. For spatial characteristics of $PM_{10}$ measurement data, we computed coefficient of variation (CV) and coefficient of divergence (COD). Based on temporal and spatial investigation, we suggested preferred long-term metrics for cohort studies. In 2010, 294 urban background monitoring sites were located in South Korea with a site over an area of $415.0km^2$ and distant from another site by 31.0 km on average. Annual average $PM_{10}$ concentrations decreased by 19.8% from 2001 to 2012, and seasonal $PM_{10}$ patterns were consistent over study years with higher concentrations in spring and winter. Spatial variability was relatively small with 6~19% of CV and 21~46% of COD across 16 metropolitan cities and provinces in 2010. To maximize spatial coverage and reflect temporal and spatial distributions, our suggestion for $PM_{10}$ metrics representing long-term exposures was the average for one or multiple years after 2009. This study provides the knowledge of all available $PM_{10}$ data measured at national regulatory monitoring sites in South Korea and the insight of the plausible longterm exposure metric for cohort studies.

• Journal of Animal Science and Technology
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• 제58권4호
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• pp.14.1-14.9
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• 2016

Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candidate genes in a mixed sample panel composed of several cattle breeds with different meat quality, validate single nucleotide polymorphisms (SNPs) in a local crossbred population (Angus - Hereford - Limousin) and evaluate their effects on meat quality traits (backfat thickness, intramuscular fat content and fatty acid composition), supporting the association tests with bioinformatic predictive studies. Results: Globally, nine SNPs were detected in the PPARG and CEBPA genes within our mixed panel, including a novel SNP in the latter. Three of these nine, along with seven other SNPs selected from the Single Nucleotide Polymorphism database (SNPdb), including SNPs in the RXRA gene, were validated in the crossbred population (N = 260). After validation, five of these SNPs were evaluated for genotype effects on fatty acid content and composition. Significant effects were observed on backfat thickness and different fatty acid contents (P < 0.05). Some of these SNPs caused slight differences in mRNA structure stability and/or putative binding sites for proteins. Conclusions: PPARG and CEBPA showed low to moderate variability in our sample panel. Variations in these genes, along with RXRA, may explain part of the genetic variation in fat content and composition. Our results may contribute to knowledge about genetic variation in meat quality traits in cattle and should be evaluated in larger independent populations.

• 산업경영시스템학회지
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• 제37권2호
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• pp.70-76
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• 2014

In industrial situation, electronic and electro-mechanical systems have been using different type of batteries in rapidly increasing numbers. These systems commonly require high reliability for long periods of time. Wider application of battery for low-power design as a prime power source requires us knowledge of failure mechanism and reliability of batteries in terms of load condition, environment condition and other explanatory variables. Battery life is an important factor that affects the reliability of such systems. There is need for us to understand the mechanism leading to the failure state of battery with performance characteristic and develop a method to predict the life of such battery. The purpose of this paper is to develope the methodology of monitoring the health of battery and determining the condition or fate of such systems through the performance reliability to predict the remaining useful life of primary battery with load condition, operating condition, environment change in light of battery life variation. In order to evaluate on-going performance of systems and subsystems adopting primary batteries as energy source, The primitive prototype for performance reliability analysis device was developed and related framework explained.

• 한국세라믹학회지
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• 제53권3호
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• pp.317-324
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• 2016

Continued miniaturization and increasingly exact requirements for thin film deposition in the semiconductor industry is driving the search for new effective, efficient, selective precursors and processes. The requirements of defect-free, conformal films, and precise thickness control have focused attention on atomic layer deposition (ALD). ALD precursors so far have been developed through a trial-and-error experimental approach, leveraging the expertise and tribal knowledge of individual research groups. Precursors can show significant variation in performance, depending on specific choice of co-reactant, deposition stage, and processing conditions. The chemical design space for reactive thin film precursors is enormous and there is urgent need for the development of computational approaches to help identify new ligand-metal architectures and functional co-reactants that deliver the required surface activity for next-generation thin-film deposition processes. In this paper we discuss quantum mechanical simulation (e.g. density functional theory, DFT) applied to ALD precursor reactivity and state-of-the-art automated screening approaches to assist experimental efforts leading toward optimized precursors for next-generation ALD processes.

• Advances in environmental research
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• 제2권3호
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• pp.203-227
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• 2013

Global demand for dwelling energy and implications of changing climatic conditions on buildings confront the built environment to build sustainable dwellings. This study investigates the variability of future climatic conditions on newly built detached dwellings in the UK. Series of energy modelling and simulations are performed on ten detached houses to evaluate and predict the impact of varying future climatic patterns on five building performance indicators. The study identifies and quantifies a consistent declining trend of building performance which is in consonance with current scientific knowledge of annual temperature change prediction in relations to long term climatic variation. The average percentage decrease for the annual energy consumption was predicted to be 2.80, 6.60 and 10.56 for 2020s, 2050s and 2080s time lines respectively. A similar declining trend in the case of annual natural gas consumption was 4.24, 9.98 and 16.1, and that for building emission rate and heating demand were 2.27, 5.49 and 8.72 and 7.82, 18.43 and 29.46 respectively. The study further analyse future heating and cooling demands of the three warmest months of the year and ascertain future variance in relative humidity and indoor temperature which might necessitate the use of room cooling systems to provide thermal comfort.

• Earthquakes and Structures
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• 제5권4호
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• pp.439-459
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• 2013

Main objective of the present study is to determine the statistical properties and suitable probability distribution functions of spectral displacements from nonlinear static and nonlinear dynamic analysis within the frame work of Monte Carlo simulation for typical low rise and high rise RC framed buildings located in zone III and zone V and designed as per Indian seismic codes. Probabilistic analysis of spectral displacement is useful for strength assessment and loss estimation. To the author's knowledge, no study is reported in literature on comparison of spectral displacement including the uncertainties in capacity and demand in Indian context. In the present study, uncertainties in capacity of the building is modeled by choosing cross sectional dimensions of beams and columns, density and compressive strength of concrete, yield strength and elastic modulus of steel and, live load as random variables. Uncertainty in demand is modeled by choosing peak ground acceleration (PGA) as a random variable. Nonlinear static analysis (NSA) and nonlinear dynamic analysis (NDA) are carried out for typical low rise and high rise reinforced concrete framed buildings using IDARC 2D computer program with the random sample input parameters. Statistical properties are obtained for spectral displacements corresponding to performance point from NSA and maximum absolute roof displacement from NDA and suitable probability distribution functions viz., normal, Weibull, lognormal are examined for goodness-of-fit. From the hypothesis test for goodness-of-fit, lognormal function is found to be suitable to represent the statistical variation of spectral displacement obtained from NSA and NDA.

• 품질경영학회지
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• 제40권4호
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• pp.497-512
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• 2012

Purpose: Most major countries have their own set of qualifications called national quality awards to measure the quality of companies and organizations. This study analyzes 3 different national quality awards and compare with the result from Korean quality awards conducted by Ministry of knowledge and Economy and Korea institute for advancement of technology. Methods: We tested 17 technoparks out of 18 technoparks in Korea and see how different the results can be depends on the value weights. We closely looked at each qualifications and tables of different countries' awards and compared with one used in Korea. Finally we proposed some suggestions to use not only domestic model but also international ones to be objective and add efficiency to organizations. Results: Depend on similarity of qualifications and weights, there were countries with different results and these caused score and ranking changes. Nevertheless, there was a comparison that did not make any changes on both score and ranking. Conclusion: We recognized the limitation that a standardized quality variation cannot be enough sources to test and analyze technoparks with different size and criteria. Integrating global standards and flow would be the first step to help grow technoparks and organizations placed in Korea in days to come.