• 한국통신학회논문지
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• 제28권8C호
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• pp.803-810
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• 2003

본 논문은 여성 자궁경부암의 원인이 되는 인두유종 바이러스(papillomavirus)를 진단하기 위한 HPY-DNA 칩의 영상으로부터 탐촉자(probe)의 위치를 찾아내고 각 탐촉자에서의 교잡반응(hybridization) 여부를 결정하기 위한영상리 방법의 구현에 관한 것이다. HPV-DNA 칩은 22종의 HPV를 알아내기 위한 탐촉자들과 환자 샘플과 항상 반응하는 마커들로 구성되어 있다. 침 영상에서 탐촉자 들의 위치는 마커와 상대적으로 고정되어 있어서 도터(dotter)와 스캐너(scanner)의 정밀도에 따른 오차만을 갖는다. 한편 각 탐촉자는 진단신뢰도를 높이기 위하여 4번 씩 인쇄된다. 본 논문은 마커들간의 상대거리와 탐촉자의 중복 인쇄라는 사전정보를 템플릿 정합방법과 결합하여 안정적으로 마커를 찾고, 교잡반응 여부를 정확히 분류하는 방법을 제시한다. 정규화된 상관도를 정합도(matching measure)로 채택하여, 마커들의 상대적 위치에 대하여 평균을 취하면 안정적으로 마커를 찾을 수 있다는 것을 실험을 통하여 보인다. 또한 이미 계산된 정합도를 특징(feature) 값으로 사용하여 4개의 중복 탐촉자에 대한 평균 특징 값을 분류(classification)하면 탐촉자의 교잡반응 여부를 정확히 알아낼 수 있다는 실험 결과를 보인다.

• 한국음향학회지
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• 제23권7호
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• pp.540-547
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• 2004

칼만/위너 필터에 근거한 음성향상 알고리즘은 잡음의 선험적 지식을 요구하고, 음성신호와 추정신호의 오차분산을 최소화하는데 중점을 두고 있어, 잡음에 대한 통계적 추정에 오류가 있을 경우 결과에 악영향을 미칠 수 있다. 그러나 H/sub ∞/필터는 잡음에 대한 어떠한 가정이나 선험적 지식을 요구하지 않으며, 최소상계 (Least Upper Bound)를 적용하여 추정된 모든 신호들로부터 최소에러 신호를 갖는 최상의 추정신호를 찾아내므로 칼만/위너 필터보다 잡음의 변화에 강인하다. 본 논문에서는 학습 신호로부터 은닉 마코프 모델의 파라미터를 추정한 후, 오염된 신호를 고정된 개수의 H/sub ∞/필터를 통과시켜 각 출력에 가중된 합으로 향상된 음성 신호를 구하는 다중 H/sub ∞/필터에 의한 강인한 음성향상 방법을 제안한다. 제안된 방법의 성능 평가를 위하여 음성 향상 시간과 신호 대 잡음비를 비교한 결과, 기존의 방법에 비해 계산량은 다소 증가하지만 신호 대 잡음비는 약 1∼2dB 향상 되었다.

• 한국식생활문화학회지
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• 제29권2호
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• pp.212-221
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• 2014

Korean style DASH (Dietary Approaches to Stop Hypertension) and a dietary education program for sodium reduction were developed. Reduced sodium diets (15 and 30% reductions) were developed from general diets for 3 consecutive weeks from Monday through Saturday. Subjects (19 total) were classified into two groups according to dietary education. Experimental period was from June 24 to July 23, 2012. Total sum of adaptation scores for low sodium diets significantly increased in the group that underwent dietary education compared to that without (p<0.05). After the experiment, both groups showed significantly increased values in terms of food group balance, sodium-related nutrition knowledge, attitude, and practice by paired t-test. Especially, group that underwent dietary education showed significantly higher values for attitudes by ANCOVA pre-test as a variation (p<0.01). For the results of the nutrient intake survey, group that underwent dietary education showed significantly increased values for dietary fiber (p<0.01), vitamin A (p<0.001), vitamin K (p<0.001), vitamin C (p<0.01), Folic acid (p<0.001), vitamin B12 (p<0.01), calcium (p<0.01), iron (p<0.05), and zinc (p<0.05) and significantly decreased values for sodium (p<0.05) and chloride (p<0.005). Subjects adapted to reduced sodium diets showed apparent improvements in sodium-related knowledge, attitude, practice and intake of nutrient, and these improvements were even higher in the group that underwent dietary education compared to that without. Thus, adaptation to low sodium diet combined with dietary education can improve dietary habits.

• ALGAE
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• 제38권4호
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• pp.253-264
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• 2023

The Ceramiales is the most diverse and species-rich group (2,669 spp.) of red algae, and it is widely distributed from tropical to polar oceans. Mitochondrial genomes (mitogenomes) and other genes have contributed to our knowledge regarding the classification and phylogeny of this diverse red algal group; however, the mitogenome architecture remains understudied. Here, we compared 42 mitogenomes, including 19 newly generated in this study, to expand our knowledge. The number of genes in mitogenome varied from 43 to 68 due to gene duplication. The mitogenome architecture was also variable, categorized into four types (A-D): type A = ancestral type with a basic composition; type B = those with inverse transpositions; type C = those with inverted duplications; and type D = those with both inversion and duplication. The palindromic and inverted repeats were consistently found in flanking regions of the rearrangement, especially near the cob and nad6 genes. The three rearranged mitogenome architectures (types B, C, D) are the first report of these in red algae. Phylogenetic analyses of 23 protein-coding genes supported the current familial classification of the Ceramiales, implying that the diversity of mitogenome architecture preceded the phylogenetic relationships. Our study suggests that palindromic and inverted repeats may drive mitogenome architectural variation.

• 디지털융복합연구
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• 제11권12호
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• pp.673-683
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• 2013

본 연구는 AIDS환자 간호의도에 영향을 미치는 요인들, 즉 지식, 낙인, 편견, AIDS환자 간호에 대한 태도, 사회적 상호작용 간의 인과관계를 확인하고자 시도하였다. 대상자는 서울 및 경기도에 소재한 300병상 이상규모 3개의 종합병원에 근무하고 있는 간호사268명이었고 자료수집 기간은 2012년 6월 20일부터 8월 10일까지였다. AIDS환자 간호의도 가설적 모형에 대한 경로분석을 위해 수집된 자료는 SPSS Window18.0과 AMOS19.0을 이용하여 전산처리하였다. 본 연구에서 지식, 편견, 낙인, AIDS 환자간호에 대한 태도, 사회적 상호작용이 AIDS환자 간호의도 41%를 설명하였다. 간호의도에 직접적으로 영향을 주는 요인은 사회적 상호작용과 AIDS 환자간호에 대한 태도로 확인되었으며 그 중 사회적 상호작용이 가장 큰 직접효과를 주는 것으로 나타났다. 이상의 결과를 종합하여 볼 때 간호의도 제고를 위하여 사회적 상호작용 가능성을 높이고 AIDS 환자간호에 대한 태도를 긍정적으로 변화시키는 방안이 가장 효과적이라고 할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4821-4824
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• 2015

Gastric cancer is the 2nd most common cause of death among all cancers and is the 4th most common cancer in the world. The number of deaths due to gastric cancer is about 800,000 annually. Gastric cancer is more common in men as compared to women and is 3rd most common cancer after colorectal and breast cancers in women. A progressive rise in the incidence rate has been observed in females over the last 5 years. The highest incidence of stomach cancer is in China, South America and Eastern Europe. The incidence of gastric cancer has 20 fold variation worldwide. Global variation is linked by two factors which play important role in developing gastric cancer. One is infection with Helicobacter pylori and the $2^{nd}$ is diet. South Asia is a region with low risk, despite a high prevalence of H.pylori. Gastric carcinoma is common in southern region of India. Gastric cancer is more readily treated if diagnosed early. This study aims to provide awareness about gastric cancer as well as an updated knowledge about risk factors and epidemiology of gastric cancer in Pakistan.

• 천문학회지
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• 제29권2호
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• pp.223-243
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• 1996

We have constructed a line-by-line model of the A-X system of CO in order to analyze the CO bands appearing in the UV spectra of comets. The model includes electronic, rotational, vibrational transitions, excitations by solar UV radiation, and effects of neutral and electron collisions. The major bands of the A-X system occur in the $1200 - 1800{\AA}$ range where the temporal variation of solar irradiation is significant. The solar spectrum in this spectral range shows many emission lines, which cause a significant Swings effect. We derived fluorescence efficiencies of the bands as functions of heliocentric velocity and cometocentric distance using a high resolution spectrum of the sun. We compared our model with a spectrum of comet P/Halley obtained with the IUE, and estimated that the UV Swings effects are less than 20 fluorescence efficiencies for the most bands of the A-X system. We discuss the temporal variation of solar UV irradiation and its effects on the fluorescence efficiencies. The study of the A-X system also requites knowledge of vibrational and rotational fluorescent processes in the infrared and radio regions because the majority of CO molecules in the coma is in the ground rotational states. The solar infrared spectrum near 5 microns, where the fundamental band of CO occurs, contains strong absorption lines of the fundamental band and hot bands of CO and its isotopes. We derived fluorescence efficiencies of the infrared band as functions of heliocentric velocity and cometrocentric distance. The solar absorption lines near 5 microns cause a 20 reduction of the g-factor of the fundamental band at heliocentric velocities close to 0 km/sec. We discuss the effects of neutral and electron collisions on the fluorescence efficiencies of the infrared and UV bands.

• The Korean Journal of Pain
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• 제27권3호
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• pp.266-270
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• 2014

Background: Knowledge of the anatomical variation of the vertebral artery has clinical importance not only for the performance of interventional or surgical procedures itself but also to ensure their safety. We conducted a study of the anatomical variation by reviewing multi-detector computed tomography (MDCT) images of the cervical spine from 460 Korean patients. Methods: 16-row MDCT data from 460 patients were used in this study. We observed 920 vertebral arteries. Examination points included level of entrance of the artery into the transverse foramen of the cervical vertebra, origin site of the vertebral artery, course of a vertebral artery with aberrant entrance. Result: The vertebral artery in 2 (0.2%) cases in this study entered into the transverse foramen of the 7th cervical vertebra from the left. In 45 (4.9%) cases, the vertebral artery entered into the transverse foramen of the 5th cervical vertebra. Of these, the entrance was on the right in 15 (1.6%) and on the left in 30 (3.3%). We found 17 (1.8%) cases in which the artery entered into the transverse foramen of the 4th cervical vertebra, 10 (1.1%) on the right and 7 (0.7%) on the left side. As is commonly acknowledged, the 6th cervical vertebra was the most common site of entry; the vertebral artery entered the transverse foramen of the 6th cervical vertebra in the remaining 855 (93.0%) cases, on the right in 434 (47.2%) and on the left in 421 (45.8%). Conclusions: In conclusion, the possibility of an atypical course of the vertebral artery in segments V1 and V2 should be evaluated with magnetic resonance imaging (MRI) or CT images before carrying out procedures involving the anterior cervical vertebrae.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.181-184
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• 2006

Knowledge of the ionospheric peak parameter foF2 (the critical frequency of F2 layer) is one of key essential factors for predicting ionospheric characteristics and delay correction of satellite positioning. However, the foF2 was almost estimated using an empirical model of International Reference Ionosphere (IRI) or other expensive observing techniques, such as ionosondes and scatter radar. In this paper, the ionospheric peak parameter foF2 is the first observed by ground-based GPS with all weather, low-cost and near real time properties. Compared with the IRI-2001 and independent ionosondes at or near the GPS receiver stations, the foF2 obtained from ground-based GPS is in better agreement, but closer to the ionosonde. However, during nighttime, the IRI model overestimated the GPS observed values during winter and equinox months.Furthermore, seasonal variation trend of the foF2 in 2003 is studied using foF2 monthly median hourly data measured over South Korea. It has shown that the systematic diurnal changes of foF2 are apparent in each season and the higher values of foF2 are observed during the equinoxes (semiannual anomaly) as well as in mid-daytime of each season.

• Journal of Genetic Medicine
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• 제7권2호
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• pp.111-118
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• 2010

염색체 microarray 검사는 유전체 전체를 한번에 검색하여 초현미경적인 염색체 이상을 매우 정밀하고 정확하게 검출할 수 있다. 외국에서는 현재 자주 활용되는 임상 진단 검사로 자리잡았고, 염색체 검사 또는 표적 부위를 검출하는 FISH 검사나 PCR 기반의 분자유전학적 방법을 대체하고 있다. 최근 발표된 consensus 들은 염색체 microarray 검사를 비특이적인 다발성 기형, 발달지연 또는 정신지체, 자폐증상질환의 환자에서는 염색체 검사보다 먼저 시행할 수 있는 검사로 제안하였다. 염색체 microarray 검사는 핵형 분석에서 검출된 염색체 불균형을 검증하기 위해 염색체 검사에 보조적으로 활용할 수 있고, 염색체 이상에 대한 보다 정확하고 종합적인 분석이 가능하다. 그러나 염색체 microarray 검사는 균형재배열의 염색체 이상과 low-level 모자이시즘을 검출하기 어렵고, 임상적 중요성이 불명확한 CNV에 대한 해석과 검사비용이 고가라는 한계점이 있다. 이러한 이유로 인해 현재로서는 염색체 microarray 검사가 산전 진단 목적으로는 고식적인 염색체 검사를 대신할 수는 없다는 의견이다. 임상검사실에서 염색체 microarray 검사 시행 시, 유전학적 및 세포유전학적 지식과 경험이 결과 분석과 해석 과정에서 요구되며, 적절한 검증 과정 단계와 유전상담이 동반되어야 한다.