• Title/Summary/Keyword: knowledge gaps

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Bioinformatics in Fish: its Present Status and Perspectives with Particular Emphasis on Expressed Sequence Tags

  • Nam, Yoon-Kwon;Kim, Dong-Soo
    • Journal of Aquaculture
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    • v.14 no.1
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    • pp.9-16
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    • 2001
  • Characterization of a single pass of cDNA sequence, an expressed sequence tag (EST) has been a fast growing activity in fish genomics. Despite its relatively short history, fish EST databases (dbESTs) have already begun to play a significant role in bridging the gaps in our knowledge on the gene expression in fish genome. This review provides a brief description of the technology for establishing fish dbESTs, its current status, and implication of the ESTs to aquaculture and fisheries science with particular emphasis on the discovery of novel genes for transgenic application, the use of polymorphic EST markers in genetic linkage mapping and the evaluation of signal-responsive gene expression.

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Reconstruction algorithm for archaeological fragments using slope features

  • Rasheed, Nada A.;Nordin, Md Jan
    • ETRI Journal
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    • v.42 no.3
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    • pp.420-432
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    • 2020
  • The reconstruction of archaeological fragments in 3D geometry is an important problem in pattern recognition and computer vision. Therefore, we implement an algorithm with the help of a 3D model to perform reconstruction from the real datasets using the slope features. This approach avoids the problem of gaps created through the loss of parts of the artifacts. Therefore, the aim of this study is to assemble the object without previous knowledge about the form of the original object. We utilize the edges of the fragments as an important feature in reconstructing the objects and apply multiple procedures to extract the 3D edge points. In order to assign the positions of the unknown parts that are supposed to match, the contour must be divided into four parts. Furthermore, to classify the fragments under reconstruction, we apply a backpropagation neural network. We test the algorithm on several models of ceramic fragments. It achieves highly accurate results in reconstructing the objects into their original forms, in spite of absent pieces.

Development of an Arden Syntax Translator for Building a Clinical Decision Support System with XML

  • Doo, Sung-Hyun;Jung, Chai Young;Bae, Jong-Min
    • Journal of the Korea Society of Computer and Information
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    • v.20 no.11
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    • pp.119-126
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    • 2015
  • CDSS provides clinical doctors with knowledge to be required when they diagnose or make decision about treatment strategy. Arden Syntax is one of the language with which we write MLM that is a component of CDSS. It was designated as a standard by HL7/ANSI. ArdenML is an XML version of Arden Syntax. In this paper we propose a tool which translates Arden Syntax MLMs into ArdenML MLM. To this end we first defines the corresponding relation between two languages. Next we presents a modified version of Arden Syntax grammar to improve performance of lexical analysis and minimize parsing conflicts. Finally we presents syntax and semantics gaps between the both languages, which are a structural representation problem, a data type problem, and a disrelation problem. Our translator resolves such issues and generates exact ArdenML codes for an arbitrary Arden Syntax MLM.

Concepts and applications for integrating Unmanned Aerial Vehicles (UAV's) in disaster management

  • Naser, M.Z.;Kodur, V.K.
    • Advances in Computational Design
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    • v.5 no.1
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    • pp.91-109
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    • 2020
  • Over the past few decades, the impact of natural, manmade and natech (natural hazard triggering technological disasters) disasters has been devastating, affecting over 4.4 billion people. In spite of recent technological advances, the increasing frequency and intensity of natural disasters and the escalation of manmade threats is presenting a number of challenges that warrant immediate attention. This paper explores the integration of drones or Unmanned Aerial Vehicles (UAV's) into infrastructure monitoring and post-disaster assessment. Through reviewing some of the recent disasters, effectiveness of utilizing UAV's in different stages of disaster life cycle is demonstrated and needed steps for successful integration of UAV's in infrastructure monitoring, hazard mitigation and post-incident assessment applications are discussed. In addition, some of the challenges associated with implementing UAV's in disaster monitoring, together with research needs to overcome associated knowledge gaps, is presented.

PRA: A PERSPECTIVE ON STRENGTHS, CURRENT LIMITATIONS, AND POSSIBLE IMPROVEMENTS

  • Mosleh, Ali
    • Nuclear Engineering and Technology
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    • v.46 no.1
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    • pp.1-10
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    • 2014
  • Probabilistic risk assessment (PRA) has been used in various technological fields to assist regulatory agencies, managerial decision makers, and systems designers in assessing and mitigating the risks inherent in these complex arrangements. Has PRA delivered on its promise? How do we gage PRA performance? Are our expectations about value of PRA realistic? Are there disparities between what we get and what we think we are getting form PRA and its various derivatives? Do current PRAs reflect the knowledge gained from actual events? How do we address potential gaps? These are some of the questions that have been raised over the years since the inception of the field more than forty years ago. This paper offers a brief assessment of PRA as a technical discipline in theory and practice, its key strengths and weaknesses, and suggestions on ways to address real and perceived shortcomings.

How does Voluntary Carbon Disclosure (VCD) Induce Changes in Carbon Performance? With the Role of Management Capability

  • Kim, Seonae;Kim, Jong Dae
    • Journal of Environmental Science International
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    • v.30 no.10
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    • pp.863-877
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    • 2021
  • While there a growing interest in Voluntary Carbon Disclosure (VCD), comparatively little is discussed whether the improved quality of voluntary carbon disclosure can lead to subsequent changes in a company's carbon reduction performance. Drawing on companies under the Korean Emission Trading Scheme (ETS) with the contents analysis of their sustainable reports, the present research seeks to address the existing knowledge gaps in the current literature on environmental disclosure. Findings empirically show that an increase in the voluntary carbon disclosure score is positively transformed into changes in carbon performance and further develop that the effect of voluntary carbon disclosure on carbon performance varies depending on changes in management capability with the moderation effect.

Monitoring and Management of Contaminated Suspended Solid (오염 부유물질의 관측과 관리)

  • Kim, Geonha
    • Journal of Korean Society on Water Environment
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    • v.27 no.6
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    • pp.932-937
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    • 2011
  • Main objectives of this paper were; firstly, to explain impacts of suspended solid in the water body on the relationship between water quantity and water quality; secondly, study on the inter-relationship between organic materials, nutrients, pathogens, and suspended solids considering eco-friendly water resources. Relationship between water quality and water quantity is not easy to understand as it includes physicochemical-biological reactions and diffuse pollutions. Especially, suspended solid makes water resource management difficult. Eroded soil in the upper land transported to the downstream by water flows carrying biological and physicochemical information and sedimented in the downstream. As sediment scoured under high flow condition and environmental change, suspended solid and sediment should be emphasized for understanding the inter-relationship between water quality and water quantity. Knowledge gaps between known monitored data and management of suspended solid were identified as well for future study.

Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis

  • Lee, Eunjin;Oh, Ji Eun
    • Molecules and Cells
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    • v.44 no.6
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    • pp.392-400
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    • 2021
  • It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV-2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, and highlight gaps in the current knowledge.

The Occurrence Climatology of Equatorial Plasma Bubbles: A Review

  • Kil, Hyosub
    • Journal of Astronomy and Space Sciences
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    • v.39 no.2
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    • pp.23-33
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    • 2022
  • Electron density irregularities in the equatorial ionosphere at night are understood in terms of plasma bubbles, which are produced by the transport of low-density plasma from the bottomside of the F region to the topside. Equatorial plasma bubbles (EPBs) have been detected by various techniques on the ground and from space. One of the distinguishing characteristics of EPBs identified from long-term observations is the systematic seasonal and longitudinal variation of the EPB activity. Several hypotheses have been developed to explain the systematic EPB behavior, and now we have good knowledge about the key factors that determine the behavior. However, gaps in our understanding of the EPB climatology still remain primarily because we do not yet have the capability to observe seed perturbations and their growth simultaneously and globally. This paper reviews the occurrence climatology of EPBs identified from observations and the current understanding of its driving mechanisms.

Coronavirus disease 2019 (COVID-19) vaccine platforms: how novel platforms can prepare us for future pandemics: a narrative review

  • Lee, Jae Kyung;Shin, Ok Sarah
    • Journal of Yeungnam Medical Science
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    • v.39 no.2
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    • pp.89-97
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    • 2022
  • More than 2 years after the explosion of the coronavirus disease 2019 (COVID-19) pandemic, extensive efforts have been made to develop safe and efficacious vaccines against infections with severe acute respiratory syndrome coronavirus 2. The pandemic has opened a new era of vaccine development based on next-generation platforms, including messenger RNA (mRNA)-based technologies, and paved the way for the future of mRNA-based therapeutics to provide protection against a wide range of infectious diseases. Multiple vaccines have been developed at an unprecedented pace to protect against COVID-19 worldwide. However, important knowledge gaps remain to be addressed, especially in terms of how vaccines induce immunogenicity and efficacy in those who are elderly. Here, we discuss the various vaccine platforms that have been utilized to combat COVID-19 and emphasize how these platforms can be a powerful tool to react quickly to future pandemics.