• Journal of Acupuncture Research
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• 제25권2호
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• pp.151-164
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• 2008

Objectives : This study was designed to compare the effects on Korean Western Ontario and McMaster Universities Osteoarthritis Index(KWOMAC), 36-ltems Short-Form Health Survey(SF-36), Visual Analog Scale(VAS) and Nine Point Scale between 'Intramuscular Bee Venom Herbal Acupuncture' and 'Intracutaneous Bee Venom Herbal Acupuncture' in knee osteoarthritis patients for 4weeks. Methods : All the voluntary subject were diagnosed as knee osteoarthritis. Patients were randomly assigned either to two groups : Intramuscular bee venom herbal acupuncture treatment group(IM-BV group) or Intracutaneous bee venom herbal acupuncture treatment group(IC-BV group). The IM-BV group received bee venom herbal acupuncture intramuscularly on muscles closest to the pathologic site on ultrasonography. The IC-BV group received bee venom herbal acupuncture intracutaneously on $LE_{110}$, $LE_{201}$, $ST_{35}$, $ST_{36}$ and $LR_8$. Bee venom herbal acupuncture was applied twice a week for 4 weeks by an oriental medical doctor at Kyung-hee Oriental Medical Hospital. Both groups were checked of pathologic site by ultrasonography before treatment and follow up after four-week treatment. The patients were assessed by KWOMAC and SF-36 before and after four-week treatment. The changes in patients' pain was measured by VAS before treatment and after one-, two-, three- and four-week treatment. The patients' overall treatment outcome assesment was measured by Nine Point Scale after four-week treatment. Results : The results were as follows ; 1. The IM-BV group showed significant improvement on total, pain, stiffness and physical function in KWOMAC, and the IC-BV group showed significant improvement on total and physical function in KWOMAC after 4weeks compared to the pre-treatment. In KWOMAC, the IM-BV group showed more improvement on average compared to the IC-BV group, but there were no significant difference between two groups. 2. The IM-BV group showed significant improvement on VAS after one-week treatment. The IC-BV group showed significant improvement on VAS after two-week treatment. But there were no significant difference between two groups. 3. The IM-BV group showed significant improvement on physical functioning(PF) and bodily pain(BP) in SF-36, and the IC-BV group showed significant improvement on vitality(VT) and bodily pain(BP) in SF-36 after 4weeks compared to the pre-treatment. But there were no significant difference between two groups. 4. 88.2% of IM-BV group and 93.3% of IC-BV group graded their improvement as 'Fair' or better on Nine Point Scale. But there were no significant difference between two groups. Conclusions : This study suggests that in the treatment of knee osteoarthtitis patients, effects of 'Intramuscular Bee Venom Herbal Acupuncture' were not different from 'Intracutaneous Bee Venom Herbal Acupuncture' statistically. But both treatment showed effects on pain and physical function in knee osteoarthtitis patients.

• 대한방사선기술학회지:방사선기술과학
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• 제28권2호
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• pp.97-103
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• 2005

목 적 : 본 연구에서는 표준인 AP-WB(Weight-Bearing AP) 촬영법과 MTP(Semiflexed or metatarsophalangeal) 촬영법을 소개하고 판독 시 중요하게 여기는 관절간격과 신생골 묘출에 따른 항목을 각각 비교 고찰하여 골관절염 환자의 진단율을 향상시키고자 한다. 대상 및 방법 : 2004년 1월에서 2005년 1월까지 Knee Pain이 있는 환자로 본원의 류마티스내과에 내원한 220명(남:38명, 여:182명, 평균연령:57.3세)의 환자를 대상으로 표준인 AP-WB와 MTP검사를 병행하여 실시하였다. MTP검사는 20명의 모의환자로 발의 위치를 확인하며 슬개골이 슬관절부 정중앙에 위치하고, 관절강의 좌우대칭이 일치하도록 하였다. 관절간격과 신생골을 0(나쁨), 1(보통), 2(좋음), 3(아주좋음)점으로 구분하여 정형외과의사 3명, 류마티스 내과의사 2명, 방사선과 전문의 3명, 방사선사 5명이 PACS 모니터에서 영상을 Blind test하였다. 장비는 PHILIPS(Buckey Diagnostic-TH)를 사용하였고, 100 cm거리에서, 60 Kv, 8 mAs로 설정하였다. 결 과 : 위 방법으로 다음과 같은 결과를 얻을 수 있었다. 1. MTP 촬영법 : 발을 바깥쪽으로 $15^{\circ}$회전하고 무릎을 구부려 카세트 면에 대면 슬개골이 슬관절부의 정중앙에 위치하였고,관절강의 정렬에 따른 좌우대칭이 일치하였다. 2. 관절간격 점수 : AP-WB 촬영법; $1.32{\pm}0.050$, MTP 촬영법; $2.51{\pm}0.046$ 3. 신생골 점수 : AP-WB 촬영법; $2.14{\pm}0.054$, MTP 촬영법; $2.10{\pm}0.054$ 결론 및 고찰 : 이번 연구는 임상적인 판독 방법으로 관절간격과 신생골에 따른 점수를 비교 했을 때, MTP 촬영법이 가장 중요한 관절간격을 영상으로 표출하는데 있어서 기존의 AP-WB 촬영법보다 훨씬 더 우세하다는 결론을 갖게 되었다. 따라서 향후 골관절염 환자의 진단율을 향상시키는 데는 MTP촬영법이 유용할 것으로 사료된다.

• Knee surgery & related research
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• 제30권4호
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• pp.311-318
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• 2018

Purpose: The purpose of this study was to evaluate changes in the coronal alignment of the knee and ankle joints after open wedge high tibial osteotomy (OWHTO) to determine factors related to the recurrence (R) of the varus deformity by serial analysis. Materials and Methods: Sixty-four OWHTOs were enrolled in this study. The weight bearing line (WBL) ratio, joint line convergence angle (JLCA), knee joint inclination, mechanical axis-tibial plateau angle, talar inclination (TI), and distal tibia articular angle (DTAA) were serially assessed. Serial correlation analysis between all parameters was performed. Patients were divided into R group and no recurrence (NR) group according to the WBL ratio (55%) at postoperative one year. Results: The preoperative WBL ratio showed significantly negative correlation with serial changes of JLCA, TI, and DTAA (p<0.05). The JLCA, TI, and DTAA as well as WBL ratio showed a significantly larger degree of varus alignment in the R group than in NR group at postoperative 6 weeks and 1 year after OWHTO (p<0.05). Conclusions: Sufficient correction of the WBL and restoration of the JLCA during OWHTO are essential to prevention of the R of varus deformity after the surgery because they are the only modifiable factors during surgery. Level of Evidence: IV, Case series.

• 동서간호학연구지
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• 제16권2호
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• pp.164-171
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• 2010

Purpose: The aim of study was to investigate relationship between compliance and recovery of patients with osteoarthritis of the knee patients after knee arthroplasty. Methods: 193 patients living in Seoul were participated in this study. Data were collected using the Knee Society Clinical Rating System and Medical Outcomes Study Short Form 36(SF-36) and analyzed by ANCOVA, t-test, and repeated measure ANOVA. Results: There was a significant difference of physiological recovery based on the number of co-morbidity patients have. Physical recovery level was different according to age, religion, and the number of co-morbidity. Age and education level of patients were different in emotional recovery. The level of physiological and physical recovery were significantly different consistent with compliance. Compared to preoperative scores, physiological and physical scores showed significant improvement at six weeks, three months, and six months after surgery while emotional scores did not showed significant improvement. Conclusion: The results of this study suggest that nursing interventions to increase compliance are needed for better recovery of patients after knee arthroplasty.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 춘계학술대회 논문집
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• pp.1205-1206
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• 2012

• 대한관절경학회:학술대회논문집
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• 대한관절경학회 제21차 추계 학술대회
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• pp.83-84
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• 2009

• 대한방사선과학회:학술대회논문집
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• 대한방사선과학회 2005년도 춘계학술대회
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• pp.152.2-152.2
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• 2005

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 추계학술대회 논문집
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• pp.653-654
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• 2010

• 한국응용과학기술학회지
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• 제37권4호
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• pp.830-838
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• 2020

본 연구는 MIA로 퇴행성관절염을 유도한 랫드에 방사선 형질전환 차조기가 골 대사 및 염증 반응에 미치는 효과를 평가하였다. 방사선 형질전환 차조기를 2주 동안 25, 50, 100 mg/kg/day의 용량으로 경구 투여하고 랫드의 우측 관절 내 공간에 MIA를 주입하였다. 이후 동일한 용량을 4주 동안 지속 투여하였다. 혈청 바이오마커와 무릎 관절 분석의 형태학 및 조직병리학적 분석에 기초한 치료 효과를 평가하였다. 대조군 랫드와 비교하였을 때 방사선 형질전환 차조기는 혈청 내 염증 및 골 대사 마커(COX-2, LTB4, MMP-3, COMP)의 생성량을 유의하게 감소시켰다. 이와는 다르게 TIMP-1 및 calcitonin의 생성이 크게 증가하였다. 또한, 방사선 형질전환 차조기는 무릎 연골과 활막을 효과적으로 보존하였다. 그 결과, 방사선 형질전환 차조기는 퇴행성관절염 증상을 예방하고 완화였다. 따라서, 방사선 형질전환 차조기는 퇴행성관절염 관리를 위한 식·의약품 소재로 사용될 수 있다.

• Journal of Microbiology and Biotechnology
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• 제28권7호
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• pp.1199-1208
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• 2018

Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study aimed to evaluate the effect of ID-CBT5101 (tyndallized Clostridium butyricum) on bone metabolism and the inflammatory response in a monosodium iodoacetate-induced rat model of osteoarthritis. ID-CBT5101 was administered orally at doses of $10^8$ or $10^{10}CFU/day$ for 2 weeks before direct injection of monosodium iodoacetate ($3mg/50{\mu}l$ of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral ID-CBT5101 for another 4 weeks. We evaluated the treatment effects based on serum biomarkers, mRNA expression, morphological and histopathological analyses of the knee joints, and weight-bearing distribution analysis. Compared with those in control rats, the ID-CBT5101 treatments significantly reduced the serum concentration of inflammation and bone metabolism markers (i.e., COX-2, IL-6, $LTB_4$, and COMP), and significantly increased the concentration of $IFN-{\gamma}$ and glycosaminoglycans. In addition, the ID-CBT5101 treatments inhibited the mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases (i.e., MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and TIMP-2). Furthermore, the ID-CBT5101 treatments effectively preserved the knee cartilage and synovial membrane, and significantly decreased the amount of fibrous tissue. Moreover, compared with that of the negative control group, the ID-CBT5101 treatments increased the weight-bearing distribution by ${\geq}20%$. The results indicate that ID-CBT5101 prevented and alleviated osteoarthritis symptoms. Thus, ID-CBT5101 may be a novel therapeutic option for the management of osteoarthritis.