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The effect of Youngyanggaksan on the anticonvulsive, antipyretic, analgesic, sedative and GABAergic system (영양각산(羚羊角散)이 진경(鎭痙), 해열(解熱), 진통(鎭痛), 진정(鎭靜) 및 GABAergic system에 미치는 영향)

  • Kim, Jin-Hee;Moon, Byoung-Soon;Sung, Kang-Kyoung
    • Korean Journal of Oriental Medicine
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    • v.2 no.1
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    • pp.205-225
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    • 1996
  • This study has been carried out to investigate the effects of Youngyanggaksan (YGS) extract on the anticonvulsive, antipyretic, anlgesic, sedative and GABAergic system of experimental animals. The results of this study were as follows : 1. YGS extract prolonged significantly the beginning time to convulsion and time to death induced by strychnine. 2. YGS extract prolonged significantly the time to death induced by electrical shock of ECT unit (3sec, 200F, 25mA). 3. On the experiment of hypothermic effects of YGS extract on the rectal temperature of rats, YGS extract decreased significantly the rectal temperature of rats. 4. On the experiment of antipyretic effects of YGS extract on the febrile induced by the subcutaneous injection of $150{\mu}g/kg$ endotoxin in rats, YGS extract decreased significantly the rectal temperature of rats. 5. On the experiment of analgesic effects of YGS extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1ml/100g in rats, the writhing syndrome was reduced significantly by administration of YGS extract. 6. On the experiment of sedative effects of YGS extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of YGS extract. 7. On the experiment of effects of YGS extract on the activity of GABA-transaminase(GABA-T) in rat brains after 21 days of oral administration of YGS extract, the activity of GABA-T was reduced significantly by administration of YGS extract. 8. On the experiment of effects of YGS extract on the activity concentration of GABA in rat brains after 21 days of oral administration of YGS extract the activity concentration of GABA was reduced significantly by administration of YGS extract. 9. On the experiment of effects of YGS extract on the activity of GAD in rat brains after 21 days of oral adminstration of YGS extract, the activity of GAD was reduced significantly by administration of YGS extract. According to the those results, Youngyanggaksan extract reveals the effects on the anticonvulsive, antipyretic, anlgesic, sedative and GABAergic system.

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THE ADHESIVE PATTERNS OF COMPOMER TO SALIVA-CONTAMINATED DENTIN (타액에 오염된 상아질에 대한 콤포머의 접합양상)

  • Cho, Young-Gon;Kim, Byung-Tae;Lee, Suk-Jong
    • Restorative Dentistry and Endodontics
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    • v.25 no.4
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    • pp.575-586
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    • 2000
  • In this study, adaptation of compomer to saliva contaminated dentin was evaluated with scanning electron microscope(SEM) and confocal laser scanning microscope(CLSM). For the SEM study, the occulusal surfaces of thirty two molar teeth were grounded to exposure dentin surfaces. The specimen were randomly assigned to control and three experimental groups with four samples in each group. In control group, Dyract and F-2000 compomer were bonded on the specimens according to the manufactures direction. Experimental groups were subdivided into three groups. They were contaminated with saliva on dentin surfaces ; Experimental group 1 : Saliva was dried with compressed air. Experimental group 2 : Saliva was rinsed with air-water spray and dried. Experimental group 3 : After polymerization of an adhesive, they were contaminated with saliva, and then saliva was rinsed with air-water spray and dried. Dyract and F-2000 compomer were bonded on saliva-treated dentin surfaces. The interfaces between dentin and compomer were observed with SEM. For the CLSM study, Class V cavities were prepared in buccal and ligual surfacess of thirty two molars. The specimens were divided into control and experimental groups. Class V cavities in experimental group were contaminated with saliva and those surfaces in each experimental groups received the same treatments as for the SEM study. Cavities were applied Prime & Bond 2.1 and F-2000 compomer primer/adhesive that were mixed with fluorescein, and then were filled with Dyract and F-2000 compomer. Specimens were embedded in transparent acrylic resin and sectioned buccolingual1y with diamond wheel saw, and then mounted on cover slide for CLSM study. The interface between cavity and compomer was observed by fluoresence imaging with a CLSM. The results were as follows : 1. In SEM exammination of Dyract group, control group, experimental group 2, 3 showed close adaptation to dentin and hybrid layer of $3{\sim}4{\mu}m$ diameter. Interfacial gap between compomer and dentin in experimental group 1 was wider than in control group. 2. In SEM examination of F-2000 group, adaptation to dentin of control group was closer than Dytact control group, but hybrid-like layer was not observed. Interfacial gap between compomer and dentin in experimental group 1 was wider than in Dyract experimental group 1. 3. In dissolution specimens of Dyract and F-2000 group, resin tags penetrated through dentinal tubules in control group and experimental group 1 and 3, but the penetration of resin tag was irregular and partial in experimental group 1. 4. In CLSM exammination of Dyract and F-2000 group, adhesive patterns of control and experimental groups showed same as in SEM. This result suggests the treatment methods, rinsing & drying, repeating all adhesive procedures, will produce good effect on adaptation of compomer to dentin if the dentin surface or polymerized adhesive is contaminated by saliva.

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Running Safety Analysis of Railway Vehicle Depending on Railway Inclination Change Under Actual Track Conditions (실제 선로조건에서의 레일 경좌 변화에 따른 철도차량의 주행안전성 해석)

  • Kim, Moon Ki;Eom, Beom Gyu;Lee, Hi Sung
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.11
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    • pp.1437-1443
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    • 2013
  • Railways are currently subject to the enforcement of speed limits for each curve as prescribed by the Railway Operating Rules in Korea. However, research is required to determine the maximum speed of trains passing through each curve that allows them to run without the risk of derailment in relation to the speed enhancement of existing railway tracks. In addition, factors affecting the running safety of railway vehicles can be classified into those in terms of vehicle aspects and those in terms of track aspects. This study sought to analyze the running safety of railway vehicles according to changes in the inclination of the rail from among the factors affecting the enhancement of safety against derailment. To increase the speed of trains passing through curves that have high derailment risk, this study also analyzed the running safety of railway vehicles according to the inclination of the rail and changes in running speed while a vehicle passes through each curve section in both the up and the down train line sections between Namsunghyun and Chungdo, which represent the actual conditions of railway tracks.

Study on the Relationship between Family Support and Functional Recovery in Cerebrovascular Accident Patients with Rehabilitation Treatment of Oriental Medicine (한방재활치료를 받은 뇌졸중 환자가 지각한 가족지지와 기능회복에 관한 연구)

  • Kim, Kwang-Joo;Lee, Hyang-Yeon
    • Journal of East-West Nursing Research
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    • v.2 no.1
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    • pp.22-36
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    • 1997
  • Functional recovery of cerebrovascular accident (CVA) patients were studied by examining functional independence measure (FIM) to evaluate the functional state of the patients at admission to and at discharge from the hospital and its relationship with the family support. Study subjects consisted of 129 CVA patients, who were admitted and received rehabilitation treatment at K Medical Center of Oriental Medicine from August 3 to December 18, 1997. The results were as follows: 1) Total FIM score was $72.37{\pm}25.16$ at admission and $101.67{\pm}22.13$ at discharge. The difference of average score was 29.30, which was statistically significant by paired t-test. 2) The largest difference between FIM scores at admission and at clischarge was observed in items of walking and wheel-chair riding, and the smallest clifference in items of social interaction. 3) The recovery was faster with motor function than with cognitive function, because the difference of FIM scores at admission and at discharge was much larger with motor function. 4) Recovery was better in groups under age 49 than in groups above age 70. Functional recorvery was prominent especially in groups with normal sensory state and speech functions, and groups without urinary incontinence. Recovery was less significantly in patients with paraplegic patients hospitalized longer than 2 months, patients with family all the time, and patients with CVA over 11 days. 5) We could not find any relationship between functional recovery and family support. FIM scores were lower in groups of old age(r=-0.325), long stayed in hospital (r=-0.426), and long period of time after the onset of disease(r= -0.339) with a reciprocal correlation between FIM scores and these parameters. 6) Stepwise multiple regression analysis was done to evaluate factors to affect the recovery from CVA. FIM score at admission could explain 51.2 % of the functional recovery. Important factors were periods of hospitalization, state of sensory function, age, and education (listed in decreasing order of importance). In total, they could explain 64.89% of the functional recovery. These results indicate that functional recovery of CVA patients, who were admitted to oriental medicine hospital for rehabilitation treatment, could be estimated by measuring FIM scores. Recovery was significantly better at discharge from the hospital than at admission and motor function recovery rate was much faster than that of cognitive function. 2. Recommendation Based on these results, we recommend following further studies. 1) Comparative study of recovery of motor function and of sensory function would be necessary by measuring FIM scores once a week to evaluate the recovery of CVA patients. 2) It would be interesting to see whether there is any difference of functional recovery between patients treated with either western medicine or oriental medicine. 3) Psychological factors affecting the recovery of CVA patients need to be studied.

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Analysis of Permanent Deformation under Repetitive Load Based on Degraded Secant Modulus (할선탄성계수를 이용한 반복하중 하 지반의 영구변형 해석)

  • Ahn, Jaehun;Oh, Jeongho;Shin, Hosung
    • Journal of the Korean Geotechnical Society
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    • v.29 no.2
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    • pp.15-21
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    • 2013
  • The analysis of long-term performance of pavement sections under wheel loads is normally conducted in two separated steps. First the resilient behavior of the pavement is calculated assuming the pavement is a layered or discrete elastic medium, and then the permanent deformation is evaluated based on empirical permanent displacement equations. Material properties required in both steps can be obtained from cyclic triaxial tests, in other words, resilient and permanent deformation tests. While this analytical approach is simple and convenient, it does not consider the modulus degradation caused by cyclic loads, and some types of reinforcements such as geosynthetic cannot be modeled in this type of analysis. A model for degraded secant modulus is proposed and suggested to be used for the analysis of permanent behavior of unpaved roadway sections. The parameter for suggested model can be obtained from cyclic triaxial tests, regular practice in pavement engineering. Examples to estimate the model parameters are presented based on both laboratory permanent deformation test and large-scale plate load test.

EFFECT OF CURING METHODS OF RESIN CEMENTS ON BOND STRENGTH AND ADHESIVE INTERFACE OF POST (레진시멘트의 중합방법이 포스트의 결합강도와 접착계면에 미치는 영향)

  • Kim, Mun-Hang;Kim, Hae-Jung;Cho, Young-Gon
    • Restorative Dentistry and Endodontics
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    • v.34 no.2
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    • pp.103-112
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    • 2009
  • The purpose of this study was to compare the effect of curing methods of adhesive resins and resin cements in the root canal. Crown portions of 32 single-rooted mandibular premolars were removed. Routine endodontic treatment was done, and 9 mm deep post spaces were prepared within root canals. No.3 FRC Postec posts (Ivoclar-Vivadent AG, Liechtensteih) were cemented in the post spaces by self-(SC) or light-curing (LC) using two dual-cured adhesives (Adper Scotchbond multi-purpose plus and Exite DSC )and resin cements (RelyX ARC and Variolink II). They were assigned to 4 groups (n=8): R-SC, R-LC, V-SC, V-LC group. After stored in distilled water for 24 hours, each root was transversally sectioned with 1.5 mm thick and made three slices. The specimens were subjected to push-out test in a universal testing machine (EZ Test, Shimadzu Co., Japan) with a crosshead speed of 1 mm/min. The data were analyzed with repeated ANOVA and one-way ANOVA. Also the interface of post-resin cement and resin cement-canal wall of each group was observed under FE-SEM. When fiber posts were cemented into the root canal using total-etch adhesives, the bond strength and adaptation between post and root canal dentin was affected by curing method. Self-cure of adhesives and resin cements showed higher bond strength and closer adaptation than light-cure of them.

THE EFFECT OF DIFFERENT CURING MODES ON COMPOSITE RESIN/DENTIN BOND STRENGTH IN CLASS ICAVITIES (1급 와동에서 상아질과 복합레진의 결합강도에 대한 중합방법의 효과)

  • Baek, Shin-Young;Cho, Young-Gon;Song, Byeong-Choon
    • Restorative Dentistry and Endodontics
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    • v.33 no.5
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    • pp.428-434
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    • 2008
  • The purpose of this study was to compare the microtensile bond strength in Class I cavities associated with different light curing modes of same light energy density. Occlusal enamel was removed to expose a flat dentin surface and twenty box-shaped Class I cavities were prepared in dentin. Single Bond (3M Dental product) was applied and Z 250 was inserted using bulk technique. The composite was light-cured using one of four techniques, pulse delay (PD group), soft-start (SS group), pulse cure (PC group) and standard continuous cure (CC group). The light-curing unit capable of adjusting time and intensity (VIP, Bisco Dental product) was selected and the light energy density for all curing modes was fixed at $16J/cm^2$. After storage for 24 hours, specimens were sectioned into beams with a rectangular cross-sectional area of approximately $1mm^2$ Microtensile bond strength $({\mu}TBS)$ test was per- formed using a univel·sal testing machine (EZ Test, Shimadzu Co.). The results were analyzed using oneway ANOVA and Tukey's test at significance level 0.05. The ${\mu}TBS$ of PD group and SS group was higher than that of PC group and CC group. Within the limitations of this in vitro study, modification of curing modes such as pulse delay and soft start polymerization can improve resin/dentin bond strength in Class I cavities by controlling polymerization velocity of composite resin.

An Experimental Study on the Antiepileptic Effects of Cheonmagudeungyeum (천마구등음(天麻鉤藤飮)의 항한질성(抗癎疾性) 효과(效果)에 대한 실험적(實驗的) 연구(硏究))

  • Jeong, Dae-Young;Lee, In;Moon, Byung-Soon
    • The Journal of Internal Korean Medicine
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    • v.18 no.2
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    • pp.65-82
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    • 1997
  • This study has been carried out to investigate the effects of Cheonmagudeungyeum(CGY) extract on anti-convulsive, antipyretic, analgesic, sedative and GABAergic system of experimental animals. The results of this study were as follows : 1. CGY extract prolonged significantly the beginning time to convulsion and death induced by strychnine. 2. CGY extract prolonged significantly the time to death induced by electrical shock of ECT unit(3 sec, 200 F, 25 mA) 3. On the experiment of hypothermic effects of CGY extract on the rectal temperature of mice, CGY extract decreased the rectal temperature of mice. 4. On the experiment of antipyretic effects of CGY extract on the febrile induced by the subcutaneous injection of $150\;{\mu}g/kg$ endotoxin in mice, CGY extract decreased significantly the rectal temperature of mice. 5. On the experiment of analgesic effects of CGY extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1 ml/100g in mice, the writhing syndrome induced by acetic acid was reduced significantly by administration of CGY extract. 6. On the experiment of effects of CGY extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of CGY extract 7. On the experiment of effects of CGY extract on the activity of GABA - transaminase (GABA-T) in mouse brains after 21 days of oral administration of CGY extract, the activity of GABA-T was reduced significantly by administration of CGY extract. 8. On the experiment of effects of CGY extract on the activity concentration of GABA in mouse brain after 21 days of oral administration of CGY extract, the activity concentration of GABA was reduced significantly by administration of CGY extract. 9. On the experiment of effect of CGY water extract on the activity of GAD in mouse brain after 21 days of oral administration of CGY extract, the activity of GAD was reduced significantly by administration of CGY extract. According to the these results, Cheonmagudeungyeum extracts reveal the effects on the anti-convulsive, antipyretic, analgesic, sedative and GABAergic system.

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COMPARISON OF SURFACE ROUGHNESS OF VARIOUS LAMINATE VENEER PORCELAIN ACCORDING TO POLISHING METHODS (라미네이트 도재 수복물의 연마 방법에 따른 표면 거칠기의 비교)

  • Kwon, Young-Sook;Lee, Keun-Woo
    • The Journal of Korean Academy of Prosthodontics
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    • v.34 no.2
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    • pp.246-265
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    • 1996
  • After adjusting glazed surface of laminate veneer porcelain by reduction in the clinical procedure, an additional polishing procedure is required to smoothen the roughened surface by reduction, as it is difficult to glaze it again in the furnace. In this study, four kinds of laminate veneer porcelain were ground with diamond points as done in the clinical procedure. The adjusted porcelain surface was polished with Durawhite stone, Ceramiste points, Exa cerapol, Porcelain polishing wheel, Diamond polishing paste. The degree of surface roughness was evaluated with SEM and profilometer at each step, The self glazed surface and the glazed surface with glazing powder were compared with the polished surface and surface roughness of four kinds of laminate veneer porcelain according to the polishing method and step were obserbed. The following results were obtained : 1. There was no difference in the average surface roughness Ra value and the surface roughness obserbed under SEM according to the polishing methods and steps used, among the four kinds of laminate veneer porcelain including Colorlogic, Exelco, Vintage, and Vitadur alpha product. 2. Due to porosities, the surface in the course of polishing by polishing instruments was rougher than the glazed surface, evaluated with a SEM. 3. Insta-Glaze diamond polishing paste has no statistical difference with self glazed group 1, although it has a lower value in average surface roughness Ra value. 4. Group 2 which was glazed with galzing powder was lowest in view of SEM, but it revealed higher surface roughness Ra value than group 1, the glazed surface and group 8, polished by diamond polishing paste, due to surface waveness. 5. Proper surface smoothness could not be in the surface roughness analysis of SEM and profilometer by Shofu laminate polishing kit composed of Diamond point, Durawhite stone and Ceramiste points. Based on the results of this study, the following conclusions can be drawn. We obtain low surface roughness than glazed surface by polishing instruments, but not perfect results clinically. In order to obtain a perfect clinical result or a surface smoothness comparable to glazed porcelain there is a need for further improvement of porcelain materials, condensa-tion techniques, polishing instruments and polishing methods. Furthermore card should be taken not to breakdown the glazed surface during the clinical and laboratory procedure.

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Tracking Control of 3-Wheels Omni-Directional Mobile Robot Using Fuzzy Azimuth Estimator (퍼지 방위각 추정기를 이용한 세 개의 전 방향 바퀴 구조의 이동로봇시스템의 개발)

  • Kim, Sang-Dae;Kim, Seung-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.10
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    • pp.3873-3879
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    • 2010
  • Home service robot are not working in the fixed task such as industrial robot, because they are together with human in the same indoor space, but have to do in much more flexible and various environments. Most of them are developed on the base of the wheel-base mobile robot in the same method as a vehicle robot for factory automation. In these days, for holonomic system characteristics, omni-directional wheels are used in the mobile robot. A holonomicrobot, using omni-directional wheels, is capable of driving in any direction. But trajectory control for omni-directional mobile robot is not easy. Especially, azimuth control which sensor uncertainty problem is included is much more difficult. This paper develops trajectory controller of 3-wheels omni-directional mobile robot using fuzzy azimuth estimator. A trajectory controller for an omni-directional mobile robot, which each motor is controlled by an individual PID law to follow the speed command from inverse kinematics, needs a precise sensing data of its azimuth and exact estimation of reference azimuth value. It has imprecision and uncertainty inherent to perception sensors for azimuth. In this paper, they are solved by using fuzzy logic inference which can be used straightforward to perform the control of the mobile robot by means of the fuzzy behavior-based scheme already existent in literature. Finally, the good performance of the developed mobile robot is confirmed through live tests of path control task.