• Journal of the Korean Chemical Society
• /
• v.37 no.1
• /
• pp.136-140
• /
• 1993

New synthetic method for diethyl N-[4-{[(2,4-diamino-6-yl)methyl]-amino}benzoyl]-L-glutamate(10) which is an intermediate of methotrexate is described. p-Nitrobenzoyl-L-glutamate was obtained via a two-step sequence which involves condensation of p-nitrobenzoyl chloride with diethyl-L-glutamate and Fischer esterification reaction with ethanol. Reductive methylation of diethyl-p-nitrobenzoyl-L-glutamate were carried out by reaction with formic acid and paraformaldehyde in the presence of $PtO_2$ catalyst and yielded diethyl N-(4-methylaminobenzoyl)-L-glutamate(7). It was followed by allylation and iodoazidozation to give the diethyl-p-[N-(2-azido-3-iodopropyl)-N-methyl]aminobenzoyl-L-glutamate(9). The cyclization reaction of compound(9) with 2,4,5,6-tetraaminopyrimidine was carried out by intermolecular nucleophilic substitution to give the desired methotrexate diethylester.

• Journal of the Korean Society for Heat Treatment
• /
• v.17 no.2
• /
• pp.87-93
• /
• 2004

Nitrocarburizing was carried out with various $CH_4$ gas composition with 4 torr gas pressure at $570^{\circ}C$ for 3 hours and post oxidation was carried out with 100% $O_2$ gas atmosphere with 4 torr at different temperatures for various time. In the case of plasma nitrocarburizing, It is that the ratio of ${\varepsilon}-Fe_{2-3}$(N, C) and ${\gamma}^{\prime}-Fe_4$(C, N), which comprise the compound layer phase, depend on concentrations of $N_2$ gas and $CH_4$ such that when the concentration of $N_2$ and $CH_4$ increased, the ratio of ${\gamma}^{\prime}-Fe_4$(C, N) decreased, but the ratio of ${\varepsilon}-Fe_{2-3}$(N, C) increased. The thickness of compound layer consistently increased as gas concentration increased regardless of $N_2$ and $CH_4$ expect when the concentration of $CH_4$ was 3.5 volume%, it decreased insignificantly. When oxidizing for 15min in the temperature range of $460{\sim}570{^\circ}C$, the study found small amount of $Fe_3O_4$ at the temperature of $460{^\circ}C$ and also found that amounts of $Fe_2O_3$. and $Fe_3O_4$ on the surface and amount of ${\gamma}^{\prime}-Fe_4$(C, N) in the compound layer increased as the increased over $460^{\circ}C$, but the thickness of the compound layer decreased. Corrosion resistance was influenced by oxidation times and temperature.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.29 no.10C
• /
• pp.1378-1386
• /
• 2004

In this paper, we propose an OFDM scheme to increase the BER performance. The proposed OFDM scheme makes the baseband OFDM signal by using the oversampled OFDM signal values which are obtained by inserting N(=2$\^$k/) zeros and carrying out 2N point IFFT. In the demodulation part, the sampling operation for A/D conversion is carried out with the 2 times high sampling speed. 2 N point FFT is carried out for the data demodulation. In this paper, we show, with the mathematical method and the computer simulation, that the SNR of the proposed OFDM scheme is 3 dB higher than that of the conventional OFDM in the same AWGN channel conditions given.

• Proceedings of the Korean Reliability Society Conference
• /
• 2000.11a
• /
• pp.387-395
• /
• 2000

Circular consecutive-k-out-of-n:F system when the failure of component is dependent is studied. We assume that the failure of a component in the system increase the failure rate of the survivor which is working just before the failed component. In this case, a mean time to failure (MTTF), a average failure number of the system, and the expected cost per unit time are obtained. Then the minimum number of consecutive failed components to cause system failure to minimize the expected cost per unit time is determined as searching paths to system failure. And various numerical examples are studied.

• Proceedings of the Korean Biophysical Society Conference
• /
• 1998.06a
• /
• pp.22-22
• /
• 1998

Conformational energy calculations have been carried out for proline-containing alanine-based pentadecapeptides with the sequence Ac-(Ala)/sun n/-Pro-(Ala)$_{m}$-NHMe (n ＋ m = 14), in order to figure out the positional preference of proline in $\alpha$-helices. The conformational energy was computed a sum of the potential energy (ECEPP/3) and the hydration free energy computed by the hydration shell model.(omitted)d)

• Journal of the Institute of Electronics Engineers of Korea TE
• /
• v.42 no.3
• /
• pp.45-50
• /
• 2005

A UV camera is being used in various application regions such as industry, medical science, military, and environment monitoring. A ROIC(ReadOut IC) is developed and can read the responses from UV photodiode sensors which are made with III-V nitride semiconductors of GaN series haying high resolution and high efficiency. To design FPA(Focal Plane Array) UV $8{\times}8$ ROIC, the photodiode type sensor devices are modeled as the capacitor type ones. The ROIC reads out signals from the detector at)d outputs sequentially pixel signals after amplifying and noise filtering of them. The ROIC is fabricated using the $0.5{\mu}m$ 2Poly 3Metal N-well CMOS process. And then, it and photodiode array are hybrid bonded by gold stud bumping process using ACP(Anisotropic Conductive Paste). After the packaging, UV images appearing on PC verified the operations of the ROIC.

• Communications of the Korean Mathematical Society
• /
• v.33 no.4
• /
• pp.1331-1339
• /
• 2018

In this paper the decomposition of basic equations of $(LCS)_n$-manifolds is carried out into horizontal and vertical projections. Further, we study the integrability of the distributions $D,D{\oplus}[{\xi}]$ and $D^{\perp}$ totally geodesic of semi-invariant submanifolds of $(LCS)_n$-manifold.

• Korean Journal of Materials Research
• /
• v.8 no.6
• /
• pp.526-531
• /
• 1998

A hydride vapor phase epitaxy (HVPE) method was performed to grow the $10~240\mu{m}$ thick GaN films on (111) spinel $MgAl_2O_4$ substrate. The GaN films on $MgAl_2O_4$ substrate revealed a photoluminescence (PL) characteristics of the impurity doped GaN by the out-diffusion and auto-doping of Mg from $MgAl_2O_4$ substrate during GaN growth. The PL spectrum measured at 10K consists of free and bound excitons related recombination transitions and impurity-related donor-acceptor pair recombination and its phonon replicas. However, the deep-level related yellow band emission was not observed. The peak energy of neutral donor bound excitonic emission and the frequency of Raman $E_2$ mode were exponentially decreased with increasing the GaN thicknesses. and the frequency of E, Raman mode was shifted with the relation of $\Delta$$\omega$=3.93$\sigma$($cm^{-1}$/GPa), where l1 (GPa) is the residual strain in the GaN epilayers.

• Archives of Pharmacal Research
• /
• v.5 no.2
• /
• pp.93-96
• /
• 1982

By using recemic 3-bromo-5-isobutyl-5-methylhydantoin (3a') in dry N, N-dimethylformamide which is a model reagent for asymmetric bromolactonization, bromolactonization of a series of olefinic acids was carried out to furnish corresponding bromolactones in moderate yields.

• International Journal of Reliability and Applications
• /
• v.7 no.1
• /
• pp.79-87
• /
• 2006

In this paper, some characterization results of the NBUCA class of life distributions are obtained. Behavior of the life distributions of the present class is developed in terms of the monotonicity of the residual life of k-out of-n systems given that the (n-k)th failure has occurred at time $t{\geq}0$. Similar conclusions based on the residual life of parallel system are also presented. Next, we focus upon the aging process of a system with independent but not necessarily identical NBUCA components. Finally, it is proved that if the lifetimes of a series systems with a random number of identical components have the NBUCA property then its units also have the same property.