• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.252-255
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• 2005

Mandibular first premolars obtained from the middle-aged men about the ages of 50 were scanned using a Micro-CT. A Jig was made for a Micro-CT measurement to get reliable data from irregular teeth shape. Data were measured from the scanned 2-D images by way of measurement software. the methodology fer measurement of the mandibular first premolar was presented and according to this, the standardized mandibular first premolars of middle aged Korean males and females were made by using a rapid prototyping system.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.3
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• pp.9-25
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• 1996

수치제어(Numerical control)의 개념은 1800년대부터 시작되었다. 프랑스의 Joseph Jacquard는 1801년에 구멍을 낸 카드(Perforated cards)를 이용하여 베틀기계에 직물의 모양을 Design하는데 자동적으로 Control 하는 방법을 창조해냈다. 그 후 구멍을 낸 카드를 이용하여 페달을 밟아 얻어진 공기를 Air motor와 Valve 를 조정하므로서 자동적으로 Piano를 연주하게 하는 방법도 역시 수치제어다. 이 NC의 개념이 실제 공작기계 에 적용된 것은 제2차 대전후의 일이다. 미공군(US Air force)에서는 복잡한 형상의 항공기부품가공과 그것을 검사할 검사용 Gauge를 고정밀도로 효율있게 제작할 필요성이 절실해졌다. 미국 Michigan주 Traverse시에 있던 Parsons회사도 Helicopter의 Rotor blade의 윤곽을 정확하게 검사하는 Plate gauge를 가공할 수 있는 기계를 개발하고 있었으며 그 회사의 사장 John T. Parsons씨는 Jig boringmachine을 전자적으로 제어하는 Plate gauge를 가공하는 방법을 미공군에 제안을 하였다. 1948년 미공군에서는 설계번경이 수없이 일어나는 Missile 의 부품을 단시간 내로 제작하기 위해서 Persons사와 기술계약을 맺고 새로운 공작기계 개발에 착수하므로서 NC공작기계 연구를 시작한 역사적인 시발점이 되었다.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.605-612
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• 2006

765kV substation facilities are most important as electric power supply network in the 21 century. So, in order to prevent interruption of electric power supply under earthquake, 765kV substation facilities have to secure the safety against the earthquake. However, even though each substation facility is interconnected mutually, seismic interaction effect doesn't be considered in the initial design. Therefore, seismic capacity evaluation of 765kV substation facilities is carried out considering the seismic interaction effect on a basis of seismic design criteria for Korean transmission and substation facilities.

• Journal of Interdisciplinary Genomics
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• v.1 no.2
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• pp.15-18
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• 2019

Gaucher disease (GD) is an autosomal recessive inborn error of metabolism resulting from a deficiency in ${\beta}$-glucocerebrosidase (GBA) activity that leads to the accumulation of glucocerebroside in macrophages in multiple organs, such as the bone marrow, liver, spleen, and brain. GD can be classified into three clinical types: type 1 (non-neuropathic form, OMIM #230800); type II (acute neuropathic form, OMIM #230900); and type III (chronic neuropathic form, OMIM #231000). Type III is the subacute form of neuropathic GD. The best available treatment for GD is long-term enzyme (imiglucerase) replacement therapy (ERT) performed every two weeks. This report describes the long-term clinical course of a patient with type III GD who was treated with ERT for 18 years.

• Journal of Interdisciplinary Genomics
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• v.3 no.2
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• pp.30-34
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• 2021

Campomelic dysplasia (CD) is a rare genetic disorder characterized by multiple skeletal anomalies and the abnormal development of male reproductive organs. To date, the SOX9 gene is the only known causal gene for CD, and approximately 90 causative mutations in SOX9 have been identified worldwide. CD is diagnosed based on clinical characteristics of skeletal dysplasia (e.g., short bowed long bones, kyphoscoliosis, bell-shaped thoracic cage with 11 pairs of ribs, and hypoplastic scapulars), typical facial features of Pierre Robin sequence with cleft palate, and gonadal dysgenesis in 46,XY individuals. Most patients with CD exhibit life-threatening respiratory failure owing to laryngotracheomalacia and hypoplastic thorax during the neonatal period. Although fatal complications decrease after infancy, several medical conditions continue to require proper management. A better understanding of this rare but lethal condition may lead to more appropriate treatments for patients.

• Journal of Interdisciplinary Genomics
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• v.3 no.1
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• pp.1-6
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• 2021

Maturity-onset diabetes of the young (MODY) is characterized by a heterogeneous group of monogenic diabetes. MODY has autosomal dominant inheritance, a primary defect in pancreatic β-cell, and an early onset. Discriminating MODY from type 1 or type 2 diabetes is often challenging at first. To date, 14 different disease causing mutations have been identified in MODY patients worldwide. Targeted DNA sequencing is the gold standard to diagnose MODY and their asymptomatic relatives. Next-generation sequencing may help successfully to diagnose MODY patients and identify new MODY genes. In this review, the current perspectives on diagnosis and treatment of MODY and discrepancy in the disease-causing mutations between the Asian and Caucasian patients with MODY are summarized.

• Journal of Korean Association for Spatial Structures
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• v.18 no.4
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• pp.89-96
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• 2018

The paper presents the damage estimation of bridge structures in Daegu city based on the scenario-based earthquakes. Since the fragility curves for domestic bridge strucures are limited, the Hazus methodology is employed to derive the fragility curves and estimate the damage. A total of four earthuquake scenarios near Daegu city are assumed and structure damage is investigated for 81 bridge structures. The seismic fragility function and damage level of each bridge had adopted from the analytical method in HAZUS and then, the damage probability using seismic fragility function for each bridge was evaluated. It was concluded that the seismic damage to bridges was higher when the magnitude of the earthquake was large or nearer to the epicenter.

• Journal of Interdisciplinary Genomics
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• v.1 no.1
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• pp.1-5
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• 2019

Progressive weakness of skeletal muscle is the hallmark of muscular dystrophies. It is often accompanied by cardiomyopathy and respiratory insufficiency. It has generally been perceived as incurable diseases, while the advent of genetic therapy is changing the paradigm. Most research and achievements have been for the treatment of Duchenne muscular dystrophy, while it is promising to hope for therapies for other myopathies. Drugs for nonsense read-through and exon skipping are already approved for clinical use in Europe and the United States, respectively. Gene therapy using adeno-associated virus is in early phase of clinical trial. In this review, most promising genetic therapies will be briefly described.

• Journal of Interdisciplinary Genomics
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• v.3 no.1
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• pp.13-20
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• 2021

Developmental and epileptic encephalopathies are the most devastating early-onset epilepsies, characterized by early-onset seizures that are often intractable, electroencephalographic abnormalities, developmental delay or regression, and various comorbidities. A large number of underlying genetic variants of developmental and epileptic encephalopathies have been identified over the past few decades. However, the most thorough sequencing studies leave 60-65% of patients without a molecular diagnosis. This review explores the genetic basis of developmental and epileptic encephalopathies that start within the first year of life, including Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, infantile spasms, and Dravet syndrome. The purpose of this review is to give an overview and encourage the clinicians to start considering genetic testing as an important investigation along with electroencephalogram for better understanding and management of developmental and epileptic encephalopathies.

• Journal of the Korean Wood Science and Technology
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• v.30 no.3
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• pp.85-90
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• 2002

This study was carried out to investigate the dimensional stability of bentwoods by three treatments: steaming, urethane varnish coating, and polyethylene glycol (PEG) treatment. Bentwood processing employed a bending-jig with only 4 cm radius of curvature (ROC). The used species were bitter wood (Picrasma quassioides), painted maple (Acer mono), and birch (Betula schmidtiii). The bending properties of these are well-known in bentwood production (Jung et al., 2002). The bentwoods were treated repeated at room temperature [20℃, RH 80% (12 hours) and 40℃ under RH 10% (12 hours)]. To estimate the dimensional stability of bentwoods, we measured the radius of curvature and end-distance. The best results could be attained with PEG treatment. Steaming was the worst treatment. Comparing the properties of the different species, the dimensional stability of bitter wood was excellent. It was concluded that the steaming treatment was unsuitable for dimensional stability of bentwoods.