• Title/Summary/Keyword: jaundice

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A Case of Hepatocellular Carcinoma with intradural growth Presenting as Obstructive Jaundice (폐쇄성 황달로 내원한 담관내 증식을 동반한 간세포암 1예)

  • Kim, Sung-Bum;Kim, Tae-Nyeun;Kim, Sung-Jun;Lee, Ho-Chan;Park, Jae-Hyun;Eun, Jong-Ryul;Jang, Byung-Ik;Lee, Heon-Ju;Yun, Sung-Su;Bae, Young-Kyung
    • Journal of Yeungnam Medical Science
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    • v.25 no.2
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    • pp.165-170
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    • 2008
  • The incidence of hepatocellular carcinoma presenting as obstructive jaundice is 0.7~9%. The mechanisms of obstructive jaundice include bile duct invasion by tumor, tumor thrombi, blood clots, direct bile duct compression by tumor, and intraductal tumor growth. We report a rare case of hepatocellular carcinoma with intraductal growth. A 46-year-old woman was admitted due to colicky right upper abdominal pain and jaundice for 4 days. Computed tomography showed dilatation of the left intrahepatic duct, and endoscopic retrograde cholangiography showed a filling defect in the left main intrahepatic duct. We performed a left lobectomy with a Roux-en-Y hepaticojejunostomy. The tumor was diagnosed as a hepatocellular carcinoma with intraductal growth.

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Total bilirubin level as a biomarker for dampness-heat differentiation in traditional Korean treatment for jaundice

  • Sohn, Ki Cheul;Jung, Hyun-Jung;Lee, A-Jin;Kim, Sang-Gyung;Shin, ImHee;Kwak, Sang Gyu
    • The Journal of Korean Medicine
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    • v.34 no.4
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    • pp.46-55
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    • 2013
  • Objectives: Classifying the pattern of jaundice during diagnosis will significantly improve the outcome of common KM interventions. This study aimed at determining an objective index for accurately diagnosing heat and dampness KM patterns in patients with jaundice. Methods: We systematically reviewed laboratory findings from case reports published in the scientific literature of Korean medicine. Cases were classified as following either the heat or dampness pattern. Biochemical indices were compared using a Bayesian factor (BF) analysis and standard t-tests. Results: The laboratory findings of 32 patients were evaluated. The heat pattern was observed in 17 patients and the dampness pattern in 15. No significant differences were observed between the 2 groups in terms of white blood cell count (BF=1.659); hemoglobin concentration (BF=2.627); platelet count (BF=1.019); or levels of direct bilirubin (BF=1.453), aspartate aminotransferase (BF=1.226), alanine aminotransferase (BF=1.340), alkaline phosphatase (BF=2.344), or gamma-glutamyl transpeptidase (BF=2.782). However, total bilirubin levels were significantly higher in the dampness pattern group (BF=0.854, P-value=0.070). Conclusions: Patients with high total bilirubin levels may predominantly follow the dampness pattern, while those with low levels may predominantly follow the heat pattern. These results are expected to be useful for the development of timely and efficient KM treatments as well as new integrative therapeutic approaches for jaundice. However, further studies are essential to fully validate the utility of total bilirubin as a biomarker for differentiating between heat and dampness patterns.

The Role of Porta Hepatis Irradiation in Relieving Malignant Obstructive Jaundice (악성 폐쇄성 황달 환자에 있어서 간문에 대한 방사선치료의 역할)

  • Yang, Kwang-Mo;Suh, Hyun-Suk
    • Radiation Oncology Journal
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    • v.8 no.1
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    • pp.79-84
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    • 1990
  • We have analysed 13 patients with malignant obstructive jaundice due to metastasis who were treated with local radiation therapy to the area of porta hepatis at the Radiation Therapy Department of Paik Hospital attached to the Inje University between 1984 and 1988. A good response was observed in 6 out of 7 evaluable paitens receiving a total radiation dose ranging from 2600 to 5480 cGy in 2.6 to 6 weeks. A complete response was noted in 5 patients, a partial response in 1 patient, and no response in 1 patient. The overall median survival for 13 patients was 3 months. But two patients lived more than a year without recurrence of jaundice. Moderate dose, localized field radiation therapy appears to the beneficial in relieving obstructive jaundice and gives a good symptomatic relief.

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A study on the Change of Conception about Soeumin Hwangdal(jaundice, (黃疸)) between ${\ulcorner}$Dongyi Soose Bowon${\lrcorner}$'GaboBon' and 'SinchukBon' ("동의수세보원(東醫壽世保元)" 갑오본(甲午本)과 신축본(辛丑本)을 통한 소음인(少陰人) 황달(黃疸)에 대한 고찰(考察))

  • Ham, Tong-Il;Hwang, Min-Woo;Kim, Sang-Bok;Lee, Soo-Kyung;Song, Il-Byung;Koh, Byung-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.17 no.2
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    • pp.85-91
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    • 2005
  • 1. Objectives The Purpose of this article is to find out the change of Dong-Mu's concepts about Soeumin Hwangdal(jaundice;황달(黃疸)) 2. Methods This study Was researched as bibliographically with Dong-Mu's writings such as ${\ulcorner}$Dongyi Soose Bowon${\lrcorner}$ written in 1894('GaboBon'), ${\ulcorner}$Dongyi Soose Bowon${\lrcorner}$ published in 1901('Sinch ukBon') 3. Results and Conclusions I) The conception of Soewnin Hwangdal(jaundice, 황달(黃疸)) is a syndrome of indigestion, which needs releasing excessive through the method of decending the interior yin. 2) In the course of Taeum syndrome(태음병(太陰炳)), Soeuwnin Hangdal(jaundice황달(黃疸)) locate beetwen Miman (bloating, 비만(?滿)) and Bujong(edema, 부종(浮腫)) on the point of view of Healthy Energy. 3)In ?SinchukBon? , Soewnin interior disease is divided two syndromes. The one is the syndrome that has diarrhea as major symptom, and the another is the syndrome that has bloating as major symptom 4) In ?SinchukBon? , Dong-Mu suggested that diuresis is an important treatment of the syndrome which has bloating as major symptom.

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Jaundice in Young Children (소아 황달의 영상 평가)

  • Young Hun Choi;Seul Bi Lee;Yeon Jin Cho;Seung Hyun Lee;Su-Mi Shin;Jung-Eun Cheon
    • Journal of the Korean Society of Radiology
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    • v.83 no.5
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    • pp.966-978
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    • 2022
  • Jaundice in children have various etiologies. Among them, physiological jaundice is a very common disease observed in more than half of full-term neonates. When jaundice persists or develops after 2 weeks of age, the total/direct bilirubin is measured in consideration of the possibility of cholestasis. In case of cholestasis, imaging studies differentiate biliary atresia and other disorders of the extrahepatic bile ducts. In this review, we briefly presented the major differential diseases of cholestasis in children and introduced diagnostic imaging techniques, including normal findings.

Usefulness of the transcutaneous bilirubinometer during phototherapy in neonatal jaundice (신생아 황달에서 광선치료 동안에 경피적 빌리루빈 측정기의 유용성)

  • Lee, Yung Kwun;Kim, Kyung Ah;Ko, Sun Young;Lee, Yeon Kyung;Shin, Son Moon
    • Clinical and Experimental Pediatrics
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    • v.49 no.12
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    • pp.1296-1300
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    • 2006
  • Purpose : We studied the usefulness of transcutaneous bilirubinometers in follow-up of bilirubin levels during phototherapy in neonatal jaundice patients. Methods : Transcutaneous bilirubin (TcB) was measured twice per day on 90 neonatal jaundice patients without risk factors of jaundice by transcutaneous bilirubinometer JM-103(Minolta/Hill-Rom Air-shields, Japan). TcB was measured simultaneously on the patched-forehead (TcB-PF), patchedchest(TcB-PC), unpatched-forehead (TcB-UF) and unpatched-chest (TcB-UC) of infants with neonatal jaundice. Plasma bilirubin (PB) was measured by American Optical bilirubinometer (American Optical Co, Buffalo, USA) within 30 minutes after transcutaneous bilirubinometer measurement. Each TcB was compared with PB. Results : In the study group, the mean gestational age was $38.6{\pm}1.3wk$, the mean birthweight was $3,207.0{\pm}472.1g$, the mean age at start of phototherapy was $4.9{\pm}0.9days$ and the mean duration of phototherapy was $1.3{\pm}0.6days$. The correlation between TcB and PB level was observed. The correlation between TcB of the patched part (TcB-PF, TcB-PC) and PB was more significant than that of the unpatched part (TcB-UF, TcB-UC) and PB. The most significant correlation was between PB and TcB-PC. Conclusion : TcB was useful in the follow-up of jaundice during phototherapy as well the screening of jaundice in neonatal jaundice patients. TcB of patched-chest area was the most reliable site in transcutaneous bilirubinometer examination in neonatal jaundice patients.

Diagnosis of Cholestatic Jaundice in Neonates and Infants (영유아에서 담즙정체성 황달의 진단과 치료)

  • Lee, Sung Soo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.11 no.sup2
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    • pp.35-43
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    • 2008
  • Jaundice is common in breast-fed infants. Any infant noted to be jaundiced at 2 weeks of age need to be evaluated for cholestasis with measurement of total and direct serum bilirubin. The most common causes of cholestatic jaundice in infants are biliary atresia and neonatal hepatitis. Genetic causes of the neonatal hepatitis syndrome are increasingly recognized and idiopathic neonatal hepatitis is decreasing. Cholestasis should be investigated using a structured protocol. Early detection and timely, accurate diagnosis is important for successful treatment and a favorable prognosis. In particular, a Kasai portoenterostomy for biliary atresia has the best outcome if performed before the infant is 8 weeks of age. The management of cholestasis is mainly supportive, including nutritional support and alleviation of symptoms to improve the quality of life. Specific treatments are available for some causes of neonatal hepatitis syndrome and should be started as soon as possible. For decompensated liver disease, liver transplantation yields a better outcome.

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Transient carnitine transport defect with cholestatic jaundice: report of one case in a premature baby

  • Cho, Hyun-Seok;Choo, Young-Kwang;Lee, Hong-Jin;Lee, Hyeon-Soo
    • Clinical and Experimental Pediatrics
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    • v.55 no.2
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    • pp.58-62
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    • 2012
  • Carnitine (${\beta}$-hydroxy-${\gamma}$-trimethylaminobutyric acid) is involved in the transport of long-chain fatty acids into the mitochondrial matrix and the removal of potentially toxic acylcarnitine esters. Transient carnitine transport defect is a rare condition in newborns reported in 1/90,000 live births. In this paper, we describe a case of transient carnitine transport defect found in a premature baby who had prolonged cholestatic jaundice and poor weight gain, and who responded dramatically to oral carnitine supplementation.

Neonatal isoerythrolysis in Thoroughbred foals

  • Kwon, Do Yeon;Choi, Seong Kyoon;Cho, Young Jae;Cho, Gil Jae
    • Korean Journal of Veterinary Research
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    • v.51 no.1
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    • pp.55-58
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    • 2011
  • Two 4-day-old Thoroughbred foals with acute clinical signs of depression, elevated pulse and respiratory rates, anemia, and jaundice were referred to the equine hospital of Korea Racing Authority. The foals were seemingly normal at birth, but showed clinical signs such as abnormal behavior, jaundice and anemia suddenly after ingestion of the mare's colostrum, followed by death at 4 days after birth. According to the results of the hematology, serum chemistry analysis, jaundice foal agglutination test, and blood groups test, the foals were diagnosed as neonatal isoerythrolysis (NI) caused by the mare's antibodies. These results suggested that the pregnant mares have a potential for NI.

Usefulness of CTF guided PTBD in ER patients with obstructive jaundice (응급실로 내원한 폐쇄성 황달 환자에서 CT Fluoroscopy 유도 PTBD의 유용성)

  • Park Hyoo Soon;Bea Suk Hwan;Jung Chang Min;KO Kyung Nam;Park Yeon Tae
    • Journal of The Korean Radiological Technologist Association
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    • v.29 no.1
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    • pp.31-34
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    • 2003
  • Purpose : To evaluate technical feasibility and clinical usefulness of CT fluoroscopy (CTF) guided PTBD immediately after CT scanning in ER Patients with obstructive jaundice. Materials and Method : ER patients diagnose4 as obstructive jaundice through cl

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