• Archives of Pharmacal Research
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• 제27권9호
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• pp.968-972
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• 2004

A 1, 2-diglyceride-based multi-step colorimetric assay to measure the pancreatic lipase activ-ity was applied for the determination of the kinetic profiles of the lipase inhibition with a slight modification and the validity verification. With this assay method, our study revealed that platy-codin D, one of major constituents of Platycodi Radix, inhibits the pancreatic lipase activity in a competitive type, with the value of $K_1$ being 0.18${\pm}$0.02 mM. In addition, PO has affected the val-ues of $K_{m}$, app/ and $K_{cat}$/$K_{m}$ in a dose-dependent manner. The results shed a meaningful light on how PO mediates lipid metabolism in the intestinal tracts. On the other hand, since the revised assay is sensitive, rapid, and does not affect the accuracy to the kinetic properties, it is applica-ble not only to evaluation of the kinetic properties of the pancreatic lipase, but also to high-throughput screening of pancreatic lipase activity.

• Archives of Pharmacal Research
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• 제27권9호
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• pp.930-936
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• 2004

Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflamma-tory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-$\alpha$ and IL-6 in lipopolisaccharide-stimu-lated microglial cells. While wogonin reduced the activity of NF-$textsc{k}$B, it did not change the activ-ity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharide-stimulated production of NO and cytokines was significantly blocked by vari-ous kinds of NF-$textsc{k}$B inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-$textsc{k}$B signaling pathway

• 한국간호교육학회지
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• 제15권1호
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• pp.53-61
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• 2009

Purpose: This study was conducted to evaluate the need for education for emergency care in nursing homes. Method: 312 people who were engaged in caring for the elderly at nursing homes in D-metropolitan c! ity answered the questionnaires about the experiences, the need, and the ideal methods of education for basic emergency care, from Jul. 1. 2007 to Jul. 30. 2007. Result: 69.9% were female. Only 7.1% were nurses and the rest did not have majors in the medical field. 83.0% had experienced education for emergency care, and 89.2%, 78.4% and 44.8% of them had been educated about cardiopulmonary resuscitation, airway obstruction care, and fracture/sprain/dislocation care respectively. Fifty-three who had not experienced education answered 'no opportunity' as a cause of non-education. The need for emergency care education was 4.53/5.00, and the desire to receive education was 2.81/3.00. Mainly workers wanted to be educated abo! ut airway obstruction (88.1%), and breathing assistance & cardiac massage (72.4%). Workers preferred to be educated 1-2 times per year for 2-3 subjects, through programs including both lecture and practice. Conclusion: It is essential to create an adequate program and apply it to the people engaged in caring for the elderly.

• 의료법학
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• 제12권2호
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• pp.189-217
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• 2011

According to the current law of national health insurance, the Minister of Health and Welfare can impose a suspension of business or license, and a fine with medical institutions who violate the law. In case that medical institutions raise an action for ity with each penalty, they ask for replacing the suspension of business with a fine during the pendency of the action. But there is a long gap of time between an offense and administrative measures. One violation cause several types of administrative measures (suspension of business or fine, suspension of license etc.) and different government departments impose these penalties. It takes a lot of time to organize their opinions and they are liable to impose penalties after considerable space of time because of overwhelming tasks. Then the medical institutions can sustain a loss by getting unexpected administrative measures after their offense against the law. Thus, this article review whether extinctive prescription apply to the right of imposing fine on the law of national health insurance or not. Meanwhile, we have no regulations imposing a same fine to co-representatives of medical institution who infringe the law of national health insurance. On this point, this study review whether they have equal duty on that or not.

• 한국주거학회논문집
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• 제4권1호
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• pp.47-55
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• 1993

The research was carried out by posing a questionnaire, making middle and high schoolstudents 549 in Taehu an object of this research, in order to grasp the residential outlook of juveniles.1. The first order of reason why they have resided in present their houses was by a school group and their parents' choice and work place and second order of reason was by their parents' choice, life convenience in present house add traffice convenience And there was littledifference in the first and second residential reasons according to sew.2. In compareson with past and present house type, past and present house type shewed same tendency and future wanted house type was separate house absolutely.3. Points to be considered in selectong future were in the order of facilities, traffice,, surrounding, educational, social and economical circumstances. There was little difference in almost items to be considered in choosing accordant to sew. But in case of schoolgirls, they consisered more items in selecting houses than in schoolboys.4. As a result of researching ideal house of juvenile, happy family was most Preferred and the desire to possess house was expressed strongly.5. The first value on house was health of family, the stability, the stabi]ity and the residential convenience. And schoolboys attacged more importance to the gealth of family, ghe stability and the education fer children than in case of school-girls but on the other hand school girls attached more importance to economical value house and happy and harmonious family.

• Journal of Advanced Marine Engineering and Technology
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• 제23권3호
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• pp.300-310
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• 1999

A constant-volume combustion chamber is developed to measure the burnt gas temperature over the wide ranges of equivalence ratio from 1.5 to 2.7 and pressure from 0.1 to 2.7 and pressure from 0.1 to 6 MPa by two-color method. The combustion temperature is also calculated by the conventional two-region model. The premixed fuel rich propane-oxygen-inert gas mixtures under high pressures are simultaneously ignited by eight spark plugs located on the circumference of combustion chamber with 45 degree intervals. The eight converging flames compress the end gases to high pressures. The transmissiv-ity in the chamber center during the final stage of combustion at the highest pressure is measured by in situ laser extinction method. Comparisons are made with the combustion temperatures between two-color method and two-region model. It is found that the burnt gas temperature mea-sured by two-color method is higher than that calculated by two-region model because of being the negative temperature gradient on the calculation and the temperature distribution of light path-length on the measurement and the burnt gas temperature for the turbulent combustion is higher than that of the laminar combustion under the same conditions because the heat loss for turbulent combustion is lower due to the shorter combustion period.

• 한국의류학회지
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• 제14권4호
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• pp.305-313
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• 1990

The purpose of this study was to examine the relationship between self-esteem and demo- graphic variables of adult males and females upon clothing behaviors. The questionnaire were admistered to 249 unmarried females, 202 married females, 228 unmarried males, 179 married males in Pusan. The data was analyzed statisitically using to Pearson's correlation, t-test, Multiple regres-sion. The major findings of this research can be summarized as following; 1. There was significant relationship between the self-esteen and Conformity, Modesty, Management of the clothing behavior subscales. There was significant relationship among the clothing behavior subscales except Interest-Modesty, Conformity-Aesthetics, Conformity- Fashion, Modesty- Psychological dependence and Modesty-Aesthetics. 2. There was significant difference in the self-esteem and all clothing behavior subscales except Conformity according to sex. 3. There was significant difference in Interest, Psychological dependence, Fashion, Conform- ity and Modesty according to marriage status. 4. Sex and school career have significant effect on the self-esteem. Sex have significant effect on Importance, Interest, Modesty, psychological dependence, Aesthetics, Management and Fashion. School career significant effect on Conformity and income effect on Fashion. 5. Sex and school career have significant effect on the self-esteem as intervening variables, the clothing behaviors as dependent variables. Sex, age, school career and income have significant direct effect on the clothing behavior subscales.

• 설비공학논문집
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• 제17권2호
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• pp.173-182
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• 2005

The Performance of U-tube ground heat exchanger for geothermal heat Pump systems depends on the thermal properties of the soil, as well as grout or backfill materials in the borehole. In-situ tests provide a means of estimating some of these properties. In this study, in-situ thermal response tests were completed on two vertical boreholes, 130 m deep with 62 mm diameter high density polyethylene U-tubes. The tests were conducted by adding a monitored amount of heat to water over a $17\~18$ hour period for each vertical boreholes. By monitoring the water temperatures entering and exiting the loop and heat load, overall thermal conductivity values of grout/soil formation were determined. Two parameter estimation models for evaluation of thermal response test data were compared when applied on the same temperature response data. One model is based on line-source theory and the other is a numerical one-dimensional finite difference model. The average thermal conductivity deviation between measured data and these models is of the magnitude $1\%$ to $5\%$.

• Preventive Nutrition and Food Science
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• 제8권4호
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• pp.349-355
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• 2003

Effects of extraction conditions, gamma-irradiation and storage conditions on bioactivities of Citrus (Citrus unshiu) peel extract were investigated. The Hunter color $L^{*}$- and $a^{*}$-values of the extract increased but $b^{*}$-value decreased with an increase in absorbed irradiation dose. DPPH radical scavenging, tyrosinase inhibition and nitrite scavenging activities were not affected by irradiation but reduced by increased storage time. Nitrite scavenging activity of the extract was the highest at pH 1.2 followed by pH 4.2 and 6.0 and not changed by storage. Results indicated that there is potential for using citrus peel byproducts as a bioactive ingredient, and that gamma irradiation brightens the color of the extract without adversely altering its biological activity.ity.

• 한국자원식물학회지
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• 제33권6호
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• pp.586-596
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• 2020

Chionanthus retusus has been used for landscaping and gardening trees, foods and medicines. This study was carried out to analyze the effect of fertilization on the growth performance of container seedlings (1-year-old) in C. retusus. We used multifeed 19 (MF) as a fertilizer, and measured the height, root collar diameter (RCD), biomass, seedling quality index (SQI) chlorophyll contents and chlorophyll fluorescence of the seedlings. The findings of this paper showed that the height, RCD, H/D ratio, T/R ratio and the fresh and dry weight of seedlings increased after fertilization. The moisture content of the stem and root did not show any significant difference among fertilizations, except in the case of the leaf. Production distribution such as the dry weight ratio of leaves and the stem dry weight ratio of fertilized seedlings had a higher value than that of non-treatment. SQI was the highest in MF 1,000 mg/L and 2,000 mg/L treatment. Chlorophyll contents (SPAD value) also increased with the increase in fertilization concentrations. Chlorophyll fluorescence (F_v/F_m) showed the highest value of 0.8 in MF 2,000 mg/L treatment.